-
公开(公告)号：US20210353568A1
公开(公告)日：2021-11-18
申请号：US17276800
申请日：2019-09-17
申请人： Yale University
发明人： Michael Girardi , Julia Lewis
IPC分类号： A61K31/165 , A61K9/00 , A61K45/06
摘要： Described herein are methods and compositions useful to reduce (partially/inhibit or completely—prevent) skin cancer development in an individual in need thereof.
-
公开(公告)号：US20180256480A1
公开(公告)日：2018-09-13
申请号：US15573807
申请日：2016-05-11
申请人： Yale University
CPC分类号： A61K9/5153 , A61K8/0241 , A61K8/11 , A61K8/345 , A61K8/8147 , A61K8/86 , A61K8/922 , A61K9/0019 , A61K9/5031 , A61K31/00 , A61K31/7076 , A61K47/6935 , A61K47/6937 , A61K2800/624 , A61K2800/654 , A61P35/00 , A61Q17/005 , A61Q17/04 , A61Q19/00
摘要： Core-shell particles have a hydrophobic core and a shell formed of o containing hyperbranched polymers (HP). The HP can be covalently bound to the one or more materials that form the core or coated thereon. The HP coating can be modified to adjust the properties of the particles. For example, unmodified HP coatings resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HP coating can be chemically modified to form functional groups that react with functional groups on tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HP coated nanoparticles. In some embodiments, the particles include cosmetic, therapeutic, diagnostic, nutraceutical, and/or prophylactic agents, such as those used as sunblock compositions.
-
公开(公告)号：US11918695B2
公开(公告)日：2024-03-05
申请号：US15573807
申请日：2016-05-11
申请人： Yale University
IPC分类号： A61K31/337 , A61K8/02 , A61K8/11 , A61K8/34 , A61K8/81 , A61K8/86 , A61K8/92 , A61K9/00 , A61K9/50 , A61K9/51 , A61K31/00 , A61K31/7076 , A61K47/69 , A61P35/00 , A61Q17/00 , A61Q17/04 , A61Q19/00
CPC分类号： A61K9/5153 , A61K8/0241 , A61K8/11 , A61K8/345 , A61K8/8147 , A61K8/86 , A61K8/922 , A61K9/0019 , A61K9/5031 , A61K31/00 , A61K31/7076 , A61K47/6935 , A61K47/6937 , A61P35/00 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61K2800/624 , A61K2800/654
摘要： Core-shell particles have a hydrophobic core and a shell formed of o containing hyperbranched polymers (HP). The HP can be covalently bound to the one or more materials that form the core or coated thereon. The HP coating can be modified to adjust the properties of the particles. For example, unmodified HP coatings resist non-specific protein absorption. Alternatively, the hydroxyl groups on the HP coating can be chemically modified to form functional groups that react with functional groups on tissue to adhere the particles to the tissue, cells, or extracellular materials, such as proteins. Such functional groups include, but not limited to, aldehydes, amines, and O-substituted oximes. Topical formulation for application to the skin contain these HP coated nanoparticles. In some embodiments, the particles include cosmetic, therapeutic, diagnostic, nutraceutical, and/or prophylactic agents, such as those used as sunblock compositions.
-
公开(公告)号：US12076302B2
公开(公告)日：2024-09-03
申请号：US17276800
申请日：2019-09-17
申请人： Yale University
发明人： Michael Girardi , Julia Lewis
IPC分类号： A61K31/165 , A61K9/00 , A61K45/06
CPC分类号： A61K31/165 , A61K9/0014 , A61K45/06
摘要： Described herein are methods and compositions useful to reduce (partially/inhibit or completely—prevent) skin cancer development in an individual in need thereof.
-
公开(公告)号：US20230355801A1
公开(公告)日：2023-11-09
申请号：US18314688
申请日：2023-05-09
申请人： Yale University
CPC分类号： A61K47/6937 , A61K9/127 , A61P35/00 , A61K9/0019
摘要： Encapsulation of MPLA in HPG-PLA nanoparticles having bioadhesive functional groups on the surface (“BNPs”) prolongs the local antitumor immune response in melanoma and boosts the adaptive immune response conferred by MPLA due to the polymer's bioadhesive properties. Delivery of MPLA in BNP prolongs the host's antitumor response with lower quantities of MPLA. Studies in mice showed that NPs delivered intratumorally have good lymphatic drainage and accumulate in lymph nodes, with prolonged dendritic cell maturation in vivo with intratumoral delivery of BNP-MPLA compared to free MPLA and NNP-MPLA.
-
公开(公告)号：US11179417B2
公开(公告)日：2021-11-23
申请号：US15323219
申请日：2015-07-03
申请人： TRANSIMMUNE AG , YALE UNIVERSITY
发明人： Gunter Bauer , Justin Duckworth , Robert Tigelaar , Richard Edelson , Michael Girardi , Karsten Henco , Adrian Hayday
IPC分类号： A61K35/15 , C12N5/0784 , A61K39/395 , C12N5/0786
摘要： The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer.
-
公开(公告)号：US20180080086A1
公开(公告)日：2018-03-22
申请号：US15688834
申请日：2017-08-28
申请人： Yale University
发明人： Michael Girardi , Jason Weed , Juliet Gibson , Julia Lewis
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： Described herein are probes useful to detect gene copy number alterations of genes characteristic/indicative of cutaneous T cell lymphoma (CTCL), such as CTCL with blood involvement, including probes specific to genes amplified or deleted in cutaneous T cell lymphoma (CTCL), such as CTCL with blood involvement; methods of detecting a (one or more) genetic abnormality, such as one or more gene copy number alteration (GCNA), characteristic/indicative of cutaneous T cell lymphoma (CTCL), such as CTCL with blood involvement, in a biological sample obtained from an individual; and methods of determining if an individual has cutaneous T cell lymphoma (CTCL), such as CTCL with blood involvement, or is likely to develop cutaneous T cell lymphoma (CTCL) with blood involvement.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.016 秒)
