公开(公告)号：US20150126404A1

公开(公告)日：2015-05-07

申请号：US14533349

申请日：2014-11-05

申请人： Yanqing Tian ,  Liqiang Zhang ,  Fengyu Su ,  Deirdre Meldrum ,  Sean Buizer ,  Clifford L. Anderson ,  Laimonas Kelbauskas ,  Kristen Lee

发明人： Yanqing Tian ,  Liqiang Zhang ,  Fengyu Su ,  Deirdre Meldrum ,  Sean Buizer ,  Clifford L. Anderson ,  Laimonas Kelbauskas ,  Kristen Lee

IPC分类号： G01N33/50 ,  G01N21/64 ,  G01N33/84

CPC分类号： G01N33/84 ,  G01N21/6428 ,  G01N33/66

摘要： A triple sensor structured for simultaneous measurement of glucose, oxygen, and pH. The sensor components are in thin film states such as sensing films or membranes, with a glucose probe associated with emission of radiation in the blue part of the spectrum, an oxygen probe associated with radiation in red portion of the spectrum, and a pH probe—with a green portion of the spectrum. The optical probes are chemically grafted or immobilized in a suitable polymer matrix, alleviating the leaching of the probes from the matrix, improving the thin film sensing stability, and enabling the repeatable use of the same sensing films.

摘要翻译： 三重传感器，用于同时测量葡萄糖，氧气和pH值。 传感器组件处于薄膜状态，例如感测膜或膜，葡萄糖探针与光谱蓝色部分中的辐射相关，与红色光谱中的辐射相关的氧探针，以及pH探针 - 具有绿色部分的光谱。 光学探针被化学接枝或固定在合适的聚合物基质中，减轻了探针从基体中的浸出，改善了薄膜感测的稳定性，并使得能够重复使用相同的传感膜。

公开(公告)号：US11045807B2

公开(公告)日：2021-06-29

申请号：US16479729

申请日：2018-02-26

申请人： Deirdre Meldrum ,  Laimonas Kelbauskas ,  Yanqing Tian ,  Honor Glenn ,  Clifford Anderson ,  Kristen Lee ,  Ganquan Song ,  Liqiang Zhang ,  Jeff Houkal ,  Fengyu Su ,  Benjamin Ueberroth ,  Jacob Messner ,  Hong Wang ,  Kimberly Bussey

发明人： Deirdre Meldrum ,  Laimonas Kelbauskas ,  Yanqing Tian ,  Honor Glenn ,  Clifford Anderson ,  Kristen Lee ,  Ganquan Song ,  Liqiang Zhang ,  Jeff Houkal ,  Fengyu Su ,  Benjamin Ueberroth ,  Jacob Messner ,  Hong Wang ,  Kimberly Bussey

IPC分类号： B01L3/00 ,  G01N15/14 ,  G02B21/34 ,  G01N15/10

摘要： An integrated technological platform enabling real-time quantitative multiparameter metabolic profiling, utilizing either or both of extra and intracellular optical sensors, individually or simultaneously. A scalable embedded micropocket array structure, generally fabricated on fused silica substrates, facilitates the integration of multiple, spatially separated extracellular sensors for multiparameter analysis in a container formed with the use of an activation mechanism forming part of a device configured to hold the container during the measurements. The creation of hermetically sealed microchambers is carried out with a pneumatically and/or mechanically and/or electromechanically driven device that is “floating” within the holding device and that is optionally equipped with a vacuum/suction mechanism to hold a component of the container at its surface.

公开(公告)号：US20160202247A1

公开(公告)日：2016-07-14

申请号：US14996170

申请日：2016-01-14

申请人： Yanqing Tian ,  Hong Wang ,  Ganquan Song ,  Fengyu Su ,  Liqiang Zhang ,  Deirdre Meldrum ,  Laimonas Kelbauskas ,  Benjamin Ueberroth

发明人： Yanqing Tian ,  Hong Wang ,  Ganquan Song ,  Fengyu Su ,  Liqiang Zhang ,  Deirdre Meldrum ,  Laimonas Kelbauskas ,  Benjamin Ueberroth

IPC分类号： G01N33/52 ,  G01N21/64

CPC分类号： G01N33/84 ,  G01N31/221 ,  G01N31/225

摘要： The present disclosure relates to an optical luminescence dual sensor comprising a polymerized form of a probe for sensing pH; a polymerized form of a probe for sensing oxygen; a polymerized form of an internal reference probe; and a matrix. The present disclosure also relates to methods of preparing an optical luminescence dual sensor and methods of using them.

摘要翻译： 本公开涉及一种光学发光双传感器，其包括用于感测pH的探针的聚合形式; 用于感测氧的探针的聚合形式; 内部参考探针的聚合形式; 和矩阵。 本公开还涉及制备光学发光双传感器的方法及其使用方法。

公开(公告)号：US20150253333A1

公开(公告)日：2015-09-10

申请号：US14197422

申请日：2014-03-05

申请人： Yanqing Tian ,  Liqiang Zhang ,  Fengyu Su ,  Deirdre Meldrum ,  Sean Buizer

发明人： Yanqing Tian ,  Liqiang Zhang ,  Fengyu Su ,  Deirdre Meldrum ,  Sean Buizer

IPC分类号： G01N33/66 ,  G01N33/50

CPC分类号： G01N33/66 ,  G01N33/52 ,  G01N33/84

摘要： A triple sensor structured for simultaneous measurement of glucose, oxygen, and pH. The sensor components are in thin film states such as sensing films or membranes, with a glucose probe associated with emission of radiation in the blue part of the spectrum, an oxygen probe associated with radiation in red portion of the spectrum, and a pH probe—with a green portion of the spectrum. The optical probes are chemically grafted or immobilized in a suitable polymer matrix, alleviating the leaching of the probes from the matrix, improving the thin film sensing stability, and enabling the repeatable use of the same sensing films.

摘要翻译： 三重传感器，用于同时测量葡萄糖，氧气和pH值。 传感器组件处于薄膜状态，例如感测膜或膜，葡萄糖探针与光谱蓝色部分中的辐射相关，与红色光谱中的辐射相关的氧探针，以及pH探针 - 具有绿色部分的光谱。 光学探针被化学接枝或固定在合适的聚合物基质中，减轻了探针从基体中的浸出，改善了薄膜感测的稳定性，并使得能够重复使用相同的传感膜。

公开(公告)号：US20140200319A1

公开(公告)日：2014-07-17

申请号：US13985260

申请日：2012-02-13

申请人： Yanqing Tian ,  Deirdre Meldrum ,  Xianfeng Zhou ,  Fengyu Su ,  Roger H. Johnson ,  Cody Youngbull

发明人： Yanqing Tian ,  Deirdre Meldrum ,  Xianfeng Zhou ,  Fengyu Su ,  Roger H. Johnson ,  Cody Youngbull

IPC分类号： C08F226/06 ,  C08F230/04 ,  C07D498/08

CPC分类号： C08F226/06 ,  C07D498/08 ,  C07D519/00 ,  C07F15/0093 ,  C08F230/04 ,  C08G2261/226 ,  C08G2261/3223 ,  G01N33/84

摘要： This disclosure relates generally to potassium ion sensors and monomers derived from such sensors. The disclosure also provides for polymers (e.g., random copolymers, nanoparticles, polymer thin films, and sensors) having polymerized monomeric potassium ion sensors as described herein. These compounds and polymers are useful for measuring intracellular and extracellular potassium ion concentrations.

摘要翻译： 本公开一般涉及衍生自这种传感器的钾离子传感器和单体。 本公开还提供了具有如本文所述的聚合的单体钾离子传感器的聚合物（例如，无规共聚物，纳米颗粒，聚合物薄膜和传感器）。 这些化合物和聚合物可用于测量细胞内和细胞外钾离子浓度。

公开(公告)号：US09181375B2

公开(公告)日：2015-11-10

申请号：US13985260

申请日：2012-02-13

申请人： Yanqing Tian ,  Deirdre Meldrum ,  Xianfeng Zhou ,  Fengyu Su ,  Roger H. Johnson ,  Cody Youngbull

发明人： Yanqing Tian ,  Deirdre Meldrum ,  Xianfeng Zhou ,  Fengyu Su ,  Roger H. Johnson ,  Cody Youngbull

IPC分类号： C08F226/06 ,  C07D498/08 ,  C07D519/00 ,  G01N33/84 ,  C07F15/00 ,  C08F230/04

CPC分类号： C08F226/06 ,  C07D498/08 ,  C07D519/00 ,  C07F15/0093 ,  C08F230/04 ,  C08G2261/226 ,  C08G2261/3223 ,  G01N33/84

摘要： This disclosure relates generally to potassium ion sensors and monomers derived from such sensors. The disclosure also provides for polymers (e.g., random copolymers, nanoparticles, polymer thin films, and sensors) having polymerized monomeric potassium ion sensors as described herein. These compounds and polymers are useful for measuring intracellular and extracellular potassium ion concentrations.

摘要翻译： 本公开一般涉及衍生自这种传感器的钾离子传感器和单体。 本公开还提供了具有如本文所述的聚合的单体钾离子传感器的聚合物（例如，无规共聚物，纳米颗粒，聚合物薄膜和传感器）。 这些化合物和聚合物可用于测量细胞内和细胞外钾离子浓度。

公开(公告)号：US20070065954A1

公开(公告)日：2007-03-22

申请号：US11520663

申请日：2006-09-14

申请人： Minoru Taya ,  Fengyu Su ,  Chunye Xu ,  Kazuko Handa ,  Senitiroh Hakomori ,  Kimie Murayama

发明人： Minoru Taya ,  Fengyu Su ,  Chunye Xu ,  Kazuko Handa ,  Senitiroh Hakomori ,  Kimie Murayama

IPC分类号： G01N33/551

CPC分类号： G01N33/57423 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N33/54373 ,  G01N33/57415 ,  G01N33/57434 ,  G01N33/57446 ,  G01N33/57492

摘要： The present invention provides an SPR system and corresponding methods of use, for determining the presence or concentration of tumor-associated antigens in cancer patient samples. The SPR system may have multiple channels, with each channel having operably affixed thereto an antibody specific for a tumor-associated antigen, so as to allow detection of multiple tumor-associated antigens simultaneously. When a biological sample from a patient is applied to the SPR system, the presence of two or more tumor-associated antigens can be determined by measuring an SPR signal shift from each channel. The SPR system may detect the presence or concentration of a tumor-associated carbohydrate antigen, where the sensor surface contains affixed thereto an antibody specific for the glycosyl epitope, as well as an antibody specific for the polypeptide to which the carbohydrate antigen is naturally associated in cancer patients.

摘要翻译： 本发明提供一种SPR系统和相应的使用方法，用于确定癌症患者样品中肿瘤相关抗原的存在或浓度。 SPR系统可以具有多个通道，每个通道具有可操作地附着于其上的针对肿瘤相关抗原特异的抗体，以便同时检测多种肿瘤相关抗原。 当将来自患者的生物样品应用于SPR系统时，可以通过测量每个通道的SPR信号移位来确定两个或多个肿瘤相关抗原的存在。 SPR系统可以检测肿瘤相关碳水化合物抗原的存在或浓度，其中传感器表面含有固定于其上的糖基表位特异的抗体，以及对于碳水化合物抗原天然相关的多肽具有特异性的抗体 癌症患者。