公开(公告)号：US09181375B2

公开(公告)日：2015-11-10

申请号：US13985260

申请日：2012-02-13

申请人： Yanqing Tian ,  Deirdre Meldrum ,  Xianfeng Zhou ,  Fengyu Su ,  Roger H. Johnson ,  Cody Youngbull

发明人： Yanqing Tian ,  Deirdre Meldrum ,  Xianfeng Zhou ,  Fengyu Su ,  Roger H. Johnson ,  Cody Youngbull

IPC分类号： C08F226/06 ,  C07D498/08 ,  C07D519/00 ,  G01N33/84 ,  C07F15/00 ,  C08F230/04

CPC分类号： C08F226/06 ,  C07D498/08 ,  C07D519/00 ,  C07F15/0093 ,  C08F230/04 ,  C08G2261/226 ,  C08G2261/3223 ,  G01N33/84

摘要： This disclosure relates generally to potassium ion sensors and monomers derived from such sensors. The disclosure also provides for polymers (e.g., random copolymers, nanoparticles, polymer thin films, and sensors) having polymerized monomeric potassium ion sensors as described herein. These compounds and polymers are useful for measuring intracellular and extracellular potassium ion concentrations.

摘要翻译： 本公开一般涉及衍生自这种传感器的钾离子传感器和单体。 本公开还提供了具有如本文所述的聚合的单体钾离子传感器的聚合物（例如，无规共聚物，纳米颗粒，聚合物薄膜和传感器）。 这些化合物和聚合物可用于测量细胞内和细胞外钾离子浓度。

公开(公告)号：US4895573A

公开(公告)日：1990-01-23

申请号：US172026

申请日：1988-03-23

申请人： James B. Koeneman ,  Joseph A. Longo ,  Roger H. Johnson ,  Thomas M. Hansen ,  Allan M. Weinstein ,  Thomas P. Murray

发明人： James B. Koeneman ,  Joseph A. Longo ,  Roger H. Johnson ,  Thomas M. Hansen ,  Allan M. Weinstein ,  Thomas P. Murray

IPC分类号： A61F2/30 ,  A61F2/36

CPC分类号： A61F2/36 ,  A61F2/30965 ,  A61F2/3672 ,  A61F2002/3686

摘要： A femoral-side hip-joint prosthetic device for use in hip-joint replacement. The device includes an elongate stem whose surface defines maximally spaced infero-medial and supero-lateral surface curves, and which is characterized by a surface rotation which carries the supero-lateral surface curve about 15.degree.-30.degree. forward with respect to the infero-medial surface curve, on progressing upward along the upper surface portion of the stem, with the device in operative position. The rotation of the stem surface produces a close approximation to the cavity formed in the proximal femur by removal of the cancellous bone in the natural cavity formed by a wall of densified cancellous bone. A 3.degree.-15.degree. proximal anteversion of the neck is adapted to place a hip-joint ball carried on the stem at a position closely approximating that of the head in the natural femur. In the method of the invention, the cavity which receives the prosthesis stem is formed by a rasp/broach-type tool whose surface conforms closely to that of the stem.

摘要翻译： 用于髋关节置换的股骨侧髋关节假体装置。 该装置包括细长的杆，其表面限定了最大间隔的内侧和外侧表面曲线，其特征在于表面旋转，该表面旋转将超过15°-30°的超侧表面曲线相对于下 - 内表面曲线沿着杆的上表面部分向上延伸，同时该装置处于操作位置。 茎表面的旋转通过去除由致密化的松质骨壁形成的自然腔中的松质骨而产生近似于在股骨近端形成的空腔。 颈部的3°-15°近端前倾适于将携带在茎上的髋关节球放置在与天然股骨中的头部近似的位置处。 在本发明的方法中，接纳假体柄的腔由表面与杆的表面相一致的锉刀/拉刀式工具形成。

公开(公告)号：US5402460A

公开(公告)日：1995-03-28

申请号：US100778

申请日：1993-08-02

申请人： Roger H. Johnson ,  Alan C. Nelson ,  Robert M. Fisher

发明人： Roger H. Johnson ,  Alan C. Nelson ,  Robert M. Fisher

IPC分类号： G01N23/04 ,  G21K7/00 ,  G01N23/087 ,  A61B6/03 ,  G01N23/083

CPC分类号： G01N23/046 ,  G21K7/00 ,  A61B6/583 ,  G01N2223/419 ,  Y10S378/901

摘要： A microtomographic system (10) for generating high-resolution, three dimensional images of a specimen (16) is disclosed. The microtomograph system includes an x-ray generator (12) that produces an x-ray beam (14), a specimen holder (18) that holds the specimen in the beam, and an x-ray detector (20) that measures the attenuation of the beam through the specimen. Two projections of each view of the specimen are made with this microtomographic system. Each projection is made with a different intensity x-ray beam. After the projections of one view of the specimen are made, the specimen is rotated on the specimen holder and another set of projections are made. The projections of each view of the specimen are analyzed together to provide a quantitative indication of the phase fraction of the material comprising the specimen. The projections of the different views are combined to provide a three-dimensional image of the specimen.

摘要翻译： 公开了一种用于产生样本（16）的高分辨率三维图像的微图系统（10）。 显微图像系统包括产生X射线束（14）的X射线发生器（12），将样本保持在束中的样本保持器（18）和测量衰减的X射线检测器（20） 的光束通过样品。 用该微图系统制作样本的每个视图的两个突出部分。 每个投影都由不同强度的X射线束制成。 在制作样本的一个视图的突起之后，将样本在样本保持器上旋转，并且制作另一组突起。 一起分析样品的每个视图的突起，以提供包含样品的材料的相分数的定量指示。 组合不同视图的投影以提供样本的三维图像。

公开(公告)号：US4738681A

公开(公告)日：1988-04-19

申请号：US753711

申请日：1985-07-10

申请人： James B. Koeneman ,  Joseph A. Longo ,  Roger H. Johnson ,  Thomas M. Hansen ,  Allan M. Weinstein ,  Thomas P. Murray

发明人： James B. Koeneman ,  Joseph A. Longo ,  Roger H. Johnson ,  Thomas M. Hansen ,  Allan M. Weinstein ,  Thomas P. Murray

IPC分类号： A61F2/32 ,  A61F2/30 ,  A61F2/36

CPC分类号： A61F2/30965 ,  A61F2/36 ,  A61F2/3672 ,  A61F2002/3686

摘要： A femoral-side hip-joint prosthetic device for use in hip-joint replacement. The device includes an elongate stem whose surface defines maximally spaced infero-medial and supero-lateral surface curves, and which is characterized by a surface rotation which carries the supero-lateral surface curve about 18.degree.-30.degree. forward with respect to the infero-medial surface curve, on progressing upward along the upper surface portion of the stem, with the device in operative position. The rotation of the stem surface produces a close approximation to the cavity formed in the proximal femur by removal of the cancellous bone in the natural cavity formed by a wall of densified calcellous bone. A 3.degree.-15.degree. proximal anteversion of the neck is adapted to place a hip-joint ball carried on the stem at a position closely approximating that of the head in the natural femur. In the method of the invention, the cavity which receives the prothesis stem is formed by a rasp/broach-type tool whose surface conforms closely to that of the stem.

摘要翻译： 用于髋关节置换的股骨侧髋关节假体装置。 该装置包括细长的杆，其表面限定了最大间隔的内侧和外侧表面曲线，其特征在于表面旋转，该表面旋转将超过侧面曲线约18°-30°， 内表面曲线沿着杆的上表面部分向上延伸，同时该装置处于操作位置。 茎表面的旋转通过去除由密实的钙质骨壁形成的自然腔中的松质骨而产生近似于在股骨近端形成的空腔。 颈部的3°-15°近端前倾适于将携带在茎上的髋关节球放置在与天然股骨中的头部近似的位置处。 在本发明的方法中，接收假体柄的空腔由表面与杆的表面相一致的锉刀/拉刀式工具形成。

公开(公告)号：US06944322B2

公开(公告)日：2005-09-13

申请号：US10308309

申请日：2002-12-03

申请人： Roger H. Johnson ,  Alan C. Nelson

发明人： Roger H. Johnson ,  Alan C. Nelson

IPC分类号： G01N15/14 ,  G01N21/03 ,  G01N21/05 ,  G01N21/17 ,  G01N21/59 ,  G01N21/64 ,  G01N21/78 ,  G01N23/04 ,  G01N33/543 ,  G01N33/554 ,  G01N33/60 ,  G06T1/00 ,  G06T3/00 ,  G06T11/00 ,  G06K9/00

CPC分类号： G01N21/4795 ,  G01N15/14 ,  G01N15/147 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/6456 ,  G01N23/046 ,  G01N2021/0307 ,  G01N2021/0392 ,  G01N2021/052 ,  G01N2021/1772 ,  G01N2021/1787 ,  G01N2021/5919 ,  G01N2021/5923 ,  G01N2021/5957 ,  G01N2201/0696 ,  G01N2223/419 ,  G06T11/006

摘要： A parallel-beam optical tomography system for imaging an object of interest includes a parallel ray beam radiation source that illuminates the object of interest with a plurality of parallel radiation beams. After passing through the object of interest the pattern of transmitted or emitted radiation intensities is magnified by a post specimen optical element or elements. An object containing tube is located within an outer tube, wherein the object of interest is held within or flows through the object containing tube. A motor may be coupled to rotate and/or translate the object containing tube to present differing views of the object of interest. One or more detector arrays are located to receive the emerging radiation from the post specimen magnifying optic. Two- or three-dimensional images may be reconstructed from the magnified parallel projection data.

摘要翻译： 用于对感兴趣对象进行成像的平行光束光学层析成像系统包括用多个平行辐射束照亮感兴趣对象的平行射线束辐射源。 在通过感兴趣的对象之后，透射或发射的辐射强度的图案被后检体光学元件放大。 物体容纳管位于外管内，其中感兴趣的物体保持在物体容纳管内或流过物体容纳管。 马达可以联接以旋转和/或平移物体容纳管，以呈现感兴趣物体的不同视图。 定位一个或多个检测器阵列以接收来自后检体放大镜的新出射的辐射。 可以从放大的平行投影数据重构二维或三维图像。

公开(公告)号：US20140200319A1

公开(公告)日：2014-07-17

申请号：US13985260

申请日：2012-02-13

申请人： Yanqing Tian ,  Deirdre Meldrum ,  Xianfeng Zhou ,  Fengyu Su ,  Roger H. Johnson ,  Cody Youngbull

发明人： Yanqing Tian ,  Deirdre Meldrum ,  Xianfeng Zhou ,  Fengyu Su ,  Roger H. Johnson ,  Cody Youngbull

IPC分类号： C08F226/06 ,  C08F230/04 ,  C07D498/08

CPC分类号： C08F226/06 ,  C07D498/08 ,  C07D519/00 ,  C07F15/0093 ,  C08F230/04 ,  C08G2261/226 ,  C08G2261/3223 ,  G01N33/84

摘要： This disclosure relates generally to potassium ion sensors and monomers derived from such sensors. The disclosure also provides for polymers (e.g., random copolymers, nanoparticles, polymer thin films, and sensors) having polymerized monomeric potassium ion sensors as described herein. These compounds and polymers are useful for measuring intracellular and extracellular potassium ion concentrations.

摘要翻译： 本公开一般涉及衍生自这种传感器的钾离子传感器和单体。 本公开还提供了具有如本文所述的聚合的单体钾离子传感器的聚合物（例如，无规共聚物，纳米颗粒，聚合物薄膜和传感器）。 这些化合物和聚合物可用于测量细胞内和细胞外钾离子浓度。

公开(公告)号：US07907765B2

公开(公告)日：2011-03-15

申请号：US11532648

申请日：2006-09-18

申请人： Mark E. Fauver ,  Eric J. Seibel ,  Michael G. Meyer ,  Alan C. Nelson ,  J. Richard Rahn ,  Thomas Neumann ,  Roger H. Johnson

发明人： Mark E. Fauver ,  Eric J. Seibel ,  Michael G. Meyer ,  Alan C. Nelson ,  J. Richard Rahn ,  Thomas Neumann ,  Roger H. Johnson

IPC分类号： G06K9/00

CPC分类号： G01N21/4795 ,  G01N15/147 ,  G01N15/1475

摘要： An optical tomography system for imaging an object of interest including a light source for illuminating the object of interest with a plurality of radiation beams. The object of interest is held within an object containing tube such that it is illuminated by the plurality of radiation beams to produce emerging radiation from the object containing tube, a detector array is located to receive the emerging radiation and produce imaging data used by a mechanism for tracking the object of interest.

摘要翻译： 一种光学断层摄影系统，用于对感兴趣的物体成像，包括用多个辐射束照射感兴趣物体的光源。 感兴趣的物体被保持在物体容纳管内，使得其被多个辐射束照射以产生来自物体容纳管的出射辐射，检测器阵列被定位成接收新出现的辐射并产生由机构使用的成像数据 用于跟踪感兴趣的对象。

公开(公告)号：US20100322494A1

公开(公告)日：2010-12-23

申请号：US11532648

申请日：2006-09-18

申请人： Mark E. Fauver ,  Eric J. Seibel ,  Michael G. Meyer ,  Alan C. Nelson ,  J. Richard Rahn ,  Thomas Neumann ,  Roger H. Johnson

发明人： Mark E. Fauver ,  Eric J. Seibel ,  Michael G. Meyer ,  Alan C. Nelson ,  J. Richard Rahn ,  Thomas Neumann ,  Roger H. Johnson

IPC分类号： G06K9/00

CPC分类号： G01N21/4795 ,  G01N15/147 ,  G01N15/1475

摘要： An optical tomography system for imaging an object of interest including a light source for illuminating the object of interest with a plurality of radiation beams. The object of interest is held within an object containing tube such that it is illuminated by the plurality of radiation beams to produce emerging radiation from the object containing tube, a detector array is located to receive the emerging radiation and produce imaging data used by a mechanism for tracking the object of interest.

摘要翻译： 一种光学断层摄影系统，用于对感兴趣的物体成像，包括用多个辐射束照射感兴趣物体的光源。 感兴趣的物体被保持在物体容纳管内，使得其被多个辐射束照射以产生来自物体容纳管的出射辐射，检测器阵列被定位成接收新出现的辐射并产生由机构使用的成像数据 用于跟踪感兴趣的对象。