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公开(公告)号：US20120109678A1
公开(公告)日：2012-05-03
申请号：US13319567
申请日：2010-05-05
IPC分类号： G06Q50/24
摘要： A method (10) for clinical decision support by comparison of multiple molecular signatures of biological data is provided. The method comprises comparing at least two of said molecular signatures are different kinds of molecular signatures. Furthermore, a device (70), a system (100), and a computer program product (200) and a use for clinical decision support, performing the steps according to the method (10) is provided.
摘要翻译： 提供了一种用于通过比较生物数据的多个分子特征的临床决定支持的方法（10）。 所述方法包括比较所述分子特征中的至少两个是不同种类的分子标记。 此外，提供了根据方法（10）的设备（70），系统（100）和计算机程序产品（200）和用于临床决策支持的用途，执行步骤。
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公开(公告)号：US08924232B2
公开(公告)日：2014-12-30
申请号：US13319567
申请日：2010-05-05
摘要： A method (10) for clinical decision support by comparison of multiple molecular signatures of biological data is provided. The method comprises comparing at least two of said molecular signatures are different kinds of molecular signatures. Furthermore, a device (70), a system (100), and a computer program product (200) and a use for clinical decision support, performing the steps according to the method (10) is provided.
摘要翻译： 提供了一种用于通过比较生物数据的多个分子特征的临床决定支持的方法（10）。 所述方法包括比较所述分子特征中的至少两个是不同种类的分子标记。 此外，提供了根据方法（10）的设备（70），系统（100）和计算机程序产品（200）和用于临床决策支持的用途，执行步骤。
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公开(公告)号：US09858392B2
公开(公告)日：2018-01-02
申请号：US12992169
申请日：2009-05-06
申请人： Angel J. Janevski , Nevenka Dimitrova , Sitharthan Kamalakaran , Yasser Alsafadi , Nilanjana Banerjee , Anca Ioana Daniela Bacur , Jasper Van Leeuwen , Vinay Varadan
发明人： Angel J. Janevski , Nevenka Dimitrova , Sitharthan Kamalakaran , Yasser Alsafadi , Nilanjana Banerjee , Anca Ioana Daniela Bacur , Jasper Van Leeuwen , Vinay Varadan
摘要： The present invention relates to effective diagnosis of patients and assisting clinicians in treatment planning. In particular, invention provides a medical analysis system that enables refinement of molecular classification. The system provides a molecular profiling solution that will allow improved diagnosis, prognosis, response prediction to provide the right chemotherapy, and follow-up to monitor for cancer recurrence.
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公开(公告)号：US20110077964A1
公开(公告)日：2011-03-31
申请号：US12992169
申请日：2009-05-06
申请人： Angel J. Janevski , Nevenka Dimitrova , Sitharthan Kamalakaran , Yasser Alsafadi , Nilanjana Banerjee , Anca Ioana Daniela Bacur , Jasper Van Leeuwen , Vinay Varadan
发明人： Angel J. Janevski , Nevenka Dimitrova , Sitharthan Kamalakaran , Yasser Alsafadi , Nilanjana Banerjee , Anca Ioana Daniela Bacur , Jasper Van Leeuwen , Vinay Varadan
IPC分类号： G06Q50/00
摘要： The present invention relates to effective diagnosis of patients and assisting clinicians in treatment planning. In particular, invention provides a medical analysis system that enables refinement of molecular classification. The system provides a molecular profiling solution that will allow improved diagnosis, prognosis, response prediction to provide the right chemotherapy, and follow-up to monitor for cancer recurrence.
摘要翻译： 本发明涉及患者的有效诊断，并协助临床医师进行治疗计划。 特别地，本发明提供了能够细化分子分类的医学分析系统。 该系统提供了一个分子谱分析解决方案，可以改进诊断，预后，反应预测，提供正确的化学疗法和随访监测癌症复发。
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公开(公告)号：US08494871B2
公开(公告)日：2013-07-23
申请号：US12668431
申请日：2008-07-11
申请人： James David Schaffer , Mark R. Simpson , Nicolas Wadih Chbat , Nilanjana Banerjee , Yasser H. Alsafadi
发明人： James David Schaffer , Mark R. Simpson , Nicolas Wadih Chbat , Nilanjana Banerjee , Yasser H. Alsafadi
IPC分类号： G06Q10/00
摘要： A medical apparatus (901, 100) assists clinicians, nurses or other users in choosing an intervention for the treatment of a patent suffering from an acute dynamic disease, e.g. sepsis. The medical apparatus is based on a method where a model of the disease is adapted or personalized to the patient. To ensure that the apparatus remains capable of predicting the health of the patient, the apparatus is continuously provided with new, more recent patient values and the model is continuously adapted to the new patient values. Since the medical apparatus is configured to be continuously adapted to current state of health, the apparatus is able to assist the user by generating disease management information, e.g. suggestions for medications, to an output device (902, 104).
摘要翻译： 医疗器械（901,100）帮助临床医生，护士或其他用户选择治疗患有急性动态疾病的专利的干预措施，例如， 败血症 该医疗装置是基于对患者的疾病模型进行适应或个性化的方法。 为了确保该装置能够预测患者的健康状态，该装置被连续地提供有新的更新的患者值，并且该模型连续地适应于新的患者值。 由于医疗装置被配置为连续地适应当前健康状态，因此该装置能够通过产生疾病管理信息来辅助用户，例如， 对药物的建议，输出设备（902,104）。
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公开(公告)号：US20100256457A1
公开(公告)日：2010-10-07
申请号：US12668431
申请日：2008-07-11
申请人： James D. Schaffer , Mark R. Simpson , Nicolas W. Chbat , Nilanjana Banerjee , Yasser H. Alsafadi
发明人： James D. Schaffer , Mark R. Simpson , Nicolas W. Chbat , Nilanjana Banerjee , Yasser H. Alsafadi
IPC分类号： A61B5/00
摘要： The present invention relates to a medical apparatus (901, 100) for assisting clinicians, nurses or other users in choosing an intervention for the treatment of a patent suffering from an acute dynamic disease, e.g. sepsis. The medical apparatus is based on a method where a model of the disease is adapted or personalised to the patient. To ensure that the apparatus remains capable of predicting the health of the patient, the apparatus is continuously-provided with new patient values and the model is continuously adapted to the new patient values. Since the medical apparatus is configured to be continuously adapted to current state of health, the apparatus is able to assist the user by generating disease management information, e.g. suggestions for medications, to an output device (902, 104).
摘要翻译： 本发明涉及一种用于帮助临床医生，护士或其他用户选择用于治疗患有急性动态疾病的专利的干预的医疗设备（901,100），例如， 败血症 该医疗装置是基于对患者的疾病模型进行适应或个性化的方法。 为了确保该装置能够预测患者的健康状态，该装置被连续地提供新的患者值，并且该模型连续地适应于新的患者值。 由于医疗装置被配置为连续地适应当前健康状态，因此该装置能够通过产生疾病管理信息来辅助用户，例如， 对药物的建议，输出设备（902,104）。
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公开(公告)号：US10340027B2
公开(公告)日：2019-07-02
申请号：US13877346
申请日：2011-10-04
申请人： Nilanjana Banerjee , Angel Janevski , Sitharthan Kamalakaran , Vinay Varadan , Nevenka Dimitrova , Robert Lucito
发明人： Nilanjana Banerjee , Angel Janevski , Sitharthan Kamalakaran , Vinay Varadan , Nevenka Dimitrova , Robert Lucito
摘要： The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said biomedical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10, FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, 1 diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer, is provided, as well as a corresponding method for classifying a subject comprising and a medical decision support system.
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公开(公告)号：US20120265446A1
公开(公告)日：2012-10-18
申请号：US13321723
申请日：2010-05-18
IPC分类号： G06F19/00
摘要： A method (10) for forming novel signatures of biological data is provided. The method comprises ranking features based on a trend value, which is created based on multiple signatures identified by a pattern discovery method. Furthermore, a device (30) and a computer program product (40), performing the steps according to the method (10) is provided. Uses of the method, for statistically analyzing clinical data, designing assays based on multiple molecular signatures and interpreting assays based on multiple molecular signatures are also provided.
摘要翻译： 提供了一种用于形成生物数据新特征的方法（10）。 该方法包括基于基于由模式发现方法识别的多个签名创建的趋势值对特征进行排序。 此外，提供了执行根据方法（10）的步骤的设备（30）和计算机程序产品（40）。 还提供了该方法的用途，用于统计分析临床数据，基于多个分子特征设计测定和基于多个分子特征的解释测定。
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9.发明授权Method of determining a reliability indicator for signatures obtained from clinical data and use of the reliability indicator for favoring one signature over the other 有权确定从临床数据获得的签名的可靠性指标的方法，以及使用可靠性指标以有利于一个签名公开(公告)号：US08762072B2
公开(公告)日：2014-06-24
申请号：US13119742
申请日：2009-09-24
摘要： This invention relates to a method and an apparatus for determining a reliability indicator for at least one set of signatures obtained from clinical data collected from a group of samples. The signatures are obtained by detecting characteristics in the clinical data from the group of sample sand each of the signatures generate a first set of stratification values that stratify the group of samples. At least one additional and parallel stratification source to the signatures obtained from group of sample sis provided, the at least one additional and parallel stratification source to the signatures being independent from the signatures and generates a second set of stratification values. A comparison is done for each respective sample, where the first stratification values are compared with a true reference stratification values, and where the second stratification values are compared with the true reference stratification values. The signatures are assigned with similarity measure indicators indicating whether the first and the second stratification values match with the true reference stratification values. These are then implementing as input in determining the reliability of the signatures.
摘要翻译： 本发明涉及一种用于确定从从一组样本收集的临床数据中获得的至少一组签名的可靠性指标的方法和装置。 通过检测来自样品组的临床数据的特征来获得这些特征，每个签名产生分层样本的第一组分层值。 至少一个附加和平行分层源提供从样本组提供的签名，所述签名的至少一个附加和平行分层源独立于签名并产生第二组分层值。 对每个相应的样本进行比较，其中将第一分层值与真实的参考分层值进行比较，并且将第二分层值与真实的参考分层值进行比较。 赋予签名的相似性度量指示符指示第一和第二分层值是否与真实的参考分层值相匹配。 然后在确定签名的可靠性时，将其作为输入。
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公开(公告)号：US20140040264A1
公开(公告)日：2014-02-06
申请号：US13983651
申请日：2012-01-30
申请人： Vinay Varadan , Prateek Mittal , Sitharthan Kamalakaran , Nevenka Dimitrova , Angel Janevski , Nilanjana Banerjee
发明人： Vinay Varadan , Prateek Mittal , Sitharthan Kamalakaran , Nevenka Dimitrova , Angel Janevski , Nilanjana Banerjee
IPC分类号： G06F19/00
CPC分类号： G06F19/324 , G16B5/00 , G16B25/00 , G16B40/00
摘要： The present invention relates to a method for stratifying a patient into a clinically relevant group comprising the identification of the probability of an alteration within one or more sets of molecular data from a patient sample in comparison to a database of molecular data of known phenotypes, the inference of the activity of a biological network on the basis of the probabilities, the identification of a network information flow probability for the patient via the probability of interactions in the network, the creation of multiple instances of network information flow for the patient sample and the calculation of the distance of the patient from other subjects in a patient database using multiple instances of the network information flow. The invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy wherein the biomedical marker or group of biomedical markers comprises altered biological pathway markers, as well as to an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer. Furthermore, a corresponding clinical decision support system is provided.
摘要翻译： 本发明涉及一种用于将患者分层为临床相关组的方法，其包括鉴定来自患者样品的一组或多组分子数据内的改变概率与已知表型的分子数据的数据库相比较， 基于概率推断生物网络的活动，通过网络中的交互概率识别患者的网络信息流概率，创建患者样本的多个网络信息流实例和 使用网络信息流的多个实例来计算患者与患者数据库中的其他受试者的距离。 本发明进一步涉及生物医学标记物或生物医学标记物组，其与受试者对癌症治疗的响应性的高可能性相关联，其中生物医学标记物或生物医学标记物组包括改变的生物学途径标志物，以及用于检测 ，诊断，毕业，监测或预测医学状况，或用于检测，诊断，监测或预测受试者对于针对所述医学病症，特别是卵巢癌的治疗的反应性。 此外，提供了相应的临床决策支持系统。
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