公开(公告)号：US4318923A

公开(公告)日：1982-03-09

申请号：US243447

申请日：1981-03-13

申请人： Yasuhiko Hamazaki ,  Nobuo Ishiyama ,  Toshiyuki Yamamoto ,  Kenji Seri ,  Reiko Sato

发明人： Yasuhiko Hamazaki ,  Nobuo Ishiyama ,  Toshiyuki Yamamoto ,  Kenji Seri ,  Reiko Sato

IPC分类号： A61K31/215 ,  A61K31/19 ,  A61P3/06 ,  C07C67/00 ,  C07C231/00 ,  C07C233/68 ,  C07C233/73 ,  C07D213/30 ,  C07D277/64 ,  C07D295/088 ,  C07D307/42 ,  C07D317/54 ,  A61K31/24 ,  C07C101/30

CPC分类号： C07D213/30 ,  C07D277/64 ,  C07D295/088 ,  C07D307/42 ,  C07D317/54

摘要： Benzaminoethylphenoxycyclohexylacetic acid derivatives having the formula ##STR1## wherein R.sup.1 represents hydrogen atom, a halogen atom, hydroxyl group, a lower alkyl group or a lower alkoxy group; n is 1 or 2; and R.sup.2 represents hydrogen atom, a lower alkyl group which can have a substituent of phenyl group, a lower alkoxycarbonyl group, 3,3,5-trimethylcyclohexyloxycarbonyl group or a heterocyclic group; hexadecyl group; phenyl group which can have a substituent of a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or a halogen atom; a cyclohexyl group or .alpha.-[4-(4-chlorobenzaminoethyl) phenoxy]-.alpha.-cyclohexylacetoxycyclohexyl group a antihyperlipidemic compositions thereof.

摘要翻译： 具有式“IMAGE”的苯甲氨基乙基苯氧基环己基乙酸衍生物，其中R 1表示氢原子，卤素原子，羟基，低级烷基或低级烷氧基; n为1或2; R 2表示氢原子，可以具有苯基，低级烷氧基羰基，3,3,5-三甲基环己基氧基羰基或杂环基的取代基的低级烷基; 十六烷基; 可以具有低级烷基，低级烷氧基，低级烷氧基羰基或卤素原子的取代基的苯基; 环己基或α-[4-（4-氯苯甲基氨基乙基）苯氧基]-α-环己基乙酰氧基环己基，其抗高脂血症组合物。

公开(公告)号：US4278678A

公开(公告)日：1981-07-14

申请号：US94950

申请日：1979-11-16

申请人： Yasuhiko Hamazaki ,  Kenji Seri ,  Nobuo Ishiyama ,  Toshiyuki Yamamoto ,  Masao Sakasai ,  Reiko Sato

发明人： Yasuhiko Hamazaki ,  Kenji Seri ,  Nobuo Ishiyama ,  Toshiyuki Yamamoto ,  Masao Sakasai ,  Reiko Sato

IPC分类号： C07C69/712 ,  A61K31/19 ,  A61K31/215 ,  A61K31/216 ,  A61K31/44 ,  A61K31/4406 ,  A61P3/06 ,  C07C41/24 ,  C07C51/00 ,  C07C59/13 ,  C07C59/72 ,  C07C67/00 ,  C07D213/63 ,  C07D213/65

CPC分类号： C07C59/72 ,  C07D213/63

摘要： Novel substituted oxy-cyclohexylacetic acid derivatives as antihyperlipidemic agents are given. The compounds have the formula ##STR1## wherein n is 1 or 2; m is 0, 1 or 2; R.sub.1 represents a halogen atom, trifluoromethyl, a lower alkyl, a lower alkoxy, a lower alkylcarbonyl, dimethylphenylmethyl, cyclohexyl, phenyl, halogenophenyl, phenoxy or halogenophenoxy group, and two of R.sub.1 groups can be bonded to form an orthocondensed saturated alkylene ring; Hal represents a halogen atom; and R.sub.2 represents a hydrogen atom or a lower alkyl group.

摘要翻译： 给出了新的取代的氧代 - 环己基乙酸衍生物作为抗高血脂药物。 该化合物具有式（1）其中n为1或2的式（Ⅰ）化合物：其中n为1或2; m为0,1或2; R 1表示卤素原子，三氟甲基，低级烷基，低级烷氧基，低级烷基羰基，二甲基苯基甲基，环己基，苯基，卤代苯基，苯氧基或卤代苯氧基，并且可以键合两个R 1基团以形成正辛基饱和亚烷基环; Hal代表卤原子; 并且R 2表示氢原子或低级烷基。

公开(公告)号：US4153724A

公开(公告)日：1979-05-08

申请号：US860478

申请日：1977-12-14

申请人： Yasuhiko Hamazaki ,  Toshiyuki Yamamoto ,  Shozo Kawabata ,  Kenji Seri ,  Masao Sakasai ,  Reiko Sato ,  Nobuo Ishiyama

发明人： Yasuhiko Hamazaki ,  Toshiyuki Yamamoto ,  Shozo Kawabata ,  Kenji Seri ,  Masao Sakasai ,  Reiko Sato ,  Nobuo Ishiyama

IPC分类号： C07C59/90 ,  C07C69/95 ,  A61K31/19 ,  A61K31/215 ,  C07C65/20

CPC分类号： C07C59/90

摘要： Benzoyl phenoxy acetic acid derivatives having the formula ##STR1## wherein R.sub.1 represents hydrogen or halogen atom or a lower alkyl group or a lower alkoxyl group; and R.sub.2 represents hydrogen atom or a lower alkyl group which impart excellent antihyperlipidemic activity are provided.

摘要翻译： 具有式“IMAGE”的苯甲酰基苯氧基乙酸衍生物，其中R 1表示氢或卤素原子或低级烷基或低级烷氧基; R2表示氢原子或提供优异的抗高脂血症活性的低级烷基。

公开(公告)号：US4971985A

公开(公告)日：1990-11-20

申请号：US424129

申请日：1989-10-19

申请人： Katsuyuki Otsuka ,  Nobuo Ishiyama ,  Makoto Watanabe ,  Kenji Seri ,  Kazuko Sanai ,  Kanji Muraoka

发明人： Katsuyuki Otsuka ,  Nobuo Ishiyama ,  Makoto Watanabe ,  Kenji Seri ,  Kazuko Sanai ,  Kanji Muraoka

IPC分类号： A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/443 ,  A61K31/4433 ,  A61P9/08 ,  A61P9/10 ,  C07D213/53 ,  C07D405/06 ,  C07D409/06 ,  C07D409/12

CPC分类号： C07D213/53 ,  C07D409/12

摘要： A pyridylketoxime ether compound of the formula: ##STR1## wherein Ar is a phenyl, naphthyl, or heterocyclic group unsubstituted or substituted by a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylamino group, a C.sub.1 -C.sub.8 alkoxy group, a C.sub.1 -C.sub.8 alkoxycarbonyl group, a trifluoromethyl group, a nitro group or a halogen atom, X is a --(CH.sub.2).sub.m -- group wherein m is an integer of from 1 to 5, a --(CH.sub.2).sub.m --Y-- group wherein Y is an oxygen or sulfur atom and m is as defined above, or a --CH.sub.2 --(CH.dbd.CH).sub.n -- group wherein n is an integer of 1 or 2, and R is a phenyl, naphthyl, C.sub.3 -C.sub.8 cycloalkyl or heterocyclic group unsubstituted or substituted by a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylamino group, a C.sub.1 -C.sub.8 alkoxy group, a C.sub.1 -C.sub.8 akloxycarbonyl group, a trifluoromethyl group, a nitro group or a halogen atom, or a salt thereof.

公开(公告)号：US5095016A

公开(公告)日：1992-03-10

申请号：US562577

申请日：1990-08-03

申请人： Katuyuki Ohtuka ,  Nobuo Ishiyama ,  Yasuhito Iida ,  Kenji Seri ,  Takeshi Murai ,  Kazuko Sanai ,  Yoshihiro Ishizaka

发明人： Katuyuki Ohtuka ,  Nobuo Ishiyama ,  Yasuhito Iida ,  Kenji Seri ,  Takeshi Murai ,  Kazuko Sanai ,  Yoshihiro Ishizaka

IPC分类号： C07D311/58 ,  A61K31/35 ,  C07D311/68 ,  C07D311/70

CPC分类号： C07D311/70 ,  C07D311/68

摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R.sup.1 is a hydrogen atom, a substituted or unsubstituted C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.2-6 alkynyl group or a R.sup.7 --CO-- group (wherein R.sup.7 is a C.sub.1-6 alkyl group, a phenyl group, a C.sub.2-6 alkenyl group which may be substituted by a phenyl group, or a C.sub.1-6 alkoxy group);R.sup.2 is a hydrogen atom, a substituted or unsubstituted C.sub.1-8 alkyl group, or a phenyl group;R.sup.3 is a hydrogen atom, and R.sup.4 is a hydroxyl group, or R.sup.3 and R.sup.4 together form a bond;each of R.sup.5 and R.sup.6 is a C.sub.1-4 alkyl group; andY is a cyano group, a halogen atom, a nitro group, a C.sub.1-6 alkyl group, a C.sub.2-6 alkynyl group, a C.sub.1-6 alkylcarbonyl group, a C.sub.1-6 alkoxy group, a di-C.sub.1-6 alkylaminocarbonyl group, an aryl group, a C.sub.1-6 alkoxycarbonyl group, a carboxyl group or a morpholinocarbonyl group.

公开(公告)号：US20070293443A1

公开(公告)日：2007-12-20

申请号：US11659227

申请日：2005-08-04

申请人： Kazuko Sanai ,  Yuko Tanaka ,  Shigenori Negishi ,  Kenji Seri ,  Hironori Sasaki

发明人： Kazuko Sanai ,  Yuko Tanaka ,  Shigenori Negishi ,  Kenji Seri ,  Hironori Sasaki

IPC分类号： A61K31/7012 ,  A23C9/152 ,  C07H17/04 ,  C12P17/06 ,  A23L1/30

CPC分类号： A61K31/191 ,  A23L33/10 ,  A23L33/16 ,  A61K31/365

摘要： The present invention relates to a composition for accelerating calcium absorption containing a poorly absorbable L-form aldonic acid, a salt thereof, or a poorly absorbable L-form aldonolactone. The invention also relates to a food or beverage containing L-arabonic acid, a salt thereof, or L-arabonolactone. The invention also relates to a process for preparing L-arabono-γ-lactone crystals, characterized by dissolving L-arabonic acid in an organic solvent and crystallizing L-arabono-γ-lactone from the solution. According to the invention, a food or pharmaceutical product effective in the prevention or treatment of osteoporosis can be provided.

摘要翻译： 本发明涉及一种加速钙吸收的组合物，其中含有吸收不良的L型醛糖酸，其盐或吸收不良的L型醛糖内酯。 本发明还涉及含有L-阿拉伯糖，其盐或L-阿拉糖内酯的食品或饮料。 本发明还涉及制备L-阿拉伯糖-γ-内酯晶体的方法，其特征在于将L-阿拉伯糖溶解在有机溶剂中并从该溶液中结晶L-阿拉伯糖-γ-内酯。 根据本发明，可以提供有效预防或治疗骨质疏松症的食品或药物产品。

公开(公告)号：US5468734A

公开(公告)日：1995-11-21

申请号：US368755

申请日：1995-01-04

申请人： Kenji Seri ,  Kazuko Sanai ,  Shigenori Negishi ,  Toshiro Akino

发明人： Kenji Seri ,  Kazuko Sanai ,  Shigenori Negishi ,  Toshiro Akino

IPC分类号： A23L1/307 ,  A23L1/09 ,  A61K31/70 ,  A61K31/7004 ,  A61K31/7016 ,  A61K31/715 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  C07H3/02 ,  C07H3/04

CPC分类号： A61K31/7004 ,  Y10S514/824 ,  Y10S514/866 ,  Y10S514/909

摘要： A prophylactic and remedial preparation for a disease attendant on hyperglycemia, a preparation for depressing the rise in blood sugar, and a wholesome food separately include, as an active ingredient, at least one component selected from the group consisting of L-arabinose, L-fucose, 2-deoxy-D-galactose, D-xylose, L-xylose, D-ribose, D-tagatose, D-ribulose, D-lyxose and D-xylulose.

摘要翻译： 作为有效成分，含有高血糖的疾病的预防和补救制剂，分别抑制血糖升高的制剂和健康食品包括至少一种选自L-阿拉伯糖，L-赖氨酸， 岩藻糖，2-脱氧-D-半乳糖，D-木糖，L-木糖，D-核糖，D-塔格糖，D-核酮糖，D-赖索糖和D-木酮糖。