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公开(公告)号：US07384928B2
公开(公告)日：2008-06-10
申请号：US10507502
申请日：2003-03-18
IPC分类号： C07D501/46 , A61K31/546 , A61P31/04 , C07D277/593
CPC分类号： C07D501/56 , A61K31/546 , C07D501/00
摘要： A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 下式的化合物：其中T是S，SO或O; X是卤素，CN，任选被低级烷基，低级烷基，低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基（其中取代基是 任选取代的单低级烷基，任选取代的低级亚烷基或任选取代的低级亚烷基）; Z +是任选取代的阳离子和含N原子的杂环基），酯，氨基保护的化合物 其中氨基与7-位的噻唑环或其药学上可接受的盐或溶剂化物的键合。
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公开(公告)号：US20090131655A1
公开(公告)日：2009-05-21
申请号：US12100307
申请日：2008-04-09
IPC分类号： C07D501/60
CPC分类号： C07D501/56 , A61K31/546 , C07D501/00
摘要： A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene) Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 下式的化合物：其中T是S，SO或O; X是卤素，CN，任选被低级烷基，低级烷基，低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基（其中取代基是 任选取代的单低级烷基，任选取代的低级亚烷基或任选取代的低级亚烷基）Z +是任选取代的阳离子和含N原子的杂环基），酯，氨基保护的化合物，其中氨基与噻唑环上的氨基键连接 7-位或其药学上可接受的盐或溶剂化物。
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公开(公告)号：US07696354B2
公开(公告)日：2010-04-13
申请号：US12100307
申请日：2008-04-09
IPC分类号： C07D277/38
CPC分类号： C07D501/56 , A61K31/546 , C07D501/00
摘要： A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 下式的化合物：其中T是S，SO或O; X是卤素，CN，任选被低级烷基，低级烷基，低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基（其中取代基是 任选取代的单低级烷基，任选取代的低级亚烷基或任选取代的低级亚烷基）; Z +是任选取代的，阳离子和含N原子的杂环基团），酯，氨基保护的化合物，其中氨基与噻唑环 在7-位，或其药学上可接受的盐或溶剂化物。
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公开(公告)号：US20050153950A1
公开(公告)日：2005-07-14
申请号：US10507502
申请日：2003-03-18
IPC分类号： A61K31/546 , A61P31/04 , C07D277/40 , C07D277/46 , C07D277/56 , C07D501/00 , C07D501/50 , C07D519/06 , A61K31/545 , A61K31/5383 , C07D501/14
CPC分类号： C07D501/56 , A61K31/546 , C07D501/00
摘要： A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 下式的化合物：其中T是S，SO或O; X是卤素，CN，任选被低级烷基，低级烷基，低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基（其中取代基是 任选取代的单低级烷基，任选取代的低级亚烷基或任选取代的低级亚烷基）; Z +是任选取代的阳离子和含N原子的杂环基），酯，氨基保护的化合物 其中氨基与7-位的噻唑环或其药学上可接受的盐或溶剂化物的键合。
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公开(公告)号：US08501179B2
公开(公告)日：2013-08-06
申请号：US12863983
申请日：2009-01-08
IPC分类号： A61K39/40
CPC分类号： C07K16/1214 , C07K2317/76 , C07K2317/92
摘要： Provided is an effective means for therapy of infection, particularly infection with Pseudomonas aeruginosa. Provided are a monoclonal antibody against PcrV or a part thereof, and a pharmaceutical composition containing the same as an active ingredient. Concretely, monoclonal antibody of the present invention has excellent inhibiting activity on cytotoxicity with respect to a target cell of Pseudomonas aeruginosa. Also, the monoclonal antibody of the present invention has high affinity with PcrV.
摘要翻译： 提供治疗感染，特别是铜绿假单胞菌感染的有效手段。 提供了针对PcrV或其一部分的单克隆抗体，以及含有其作为活性成分的药物组合物。 具体地，本发明的单克隆抗体相对于铜绿假单胞菌的靶细胞的细胞毒性具有优异的抑制活性。 此外，本发明的单克隆抗体与PcrV具有高亲和力。
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公开(公告)号：US5217833A
公开(公告)日：1993-06-08
申请号：US836731
申请日：1992-02-19
IPC分类号： H01J9/227
CPC分类号： H01J9/2278
摘要： A method of producing a fluorescent screen of a cathode-ray tube inclusive of a process to form carbon stripes by coating an inner surface of a panel with a carbon film and then drying, exposing and developing such a carbon film. The method comprises the steps of perceiving the carbon stripes on the inner surface of the panel as video information by optical means, then inputting the video information to an image processor to calculate the line widths of the carbon stripes, and controlling the exposure during the carbon stripe exposure process on the basis of the line widths thus calculated. According to this method, the line widths of the carbon stripes can be maintained constant to enhance the quality stability, and the measuring operation is remarkably simplified by a completely automated mechanical system.
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公开(公告)号：US20110150896A1
公开(公告)日：2011-06-23
申请号：US12863983
申请日：2009-01-08
CPC分类号： C07K16/1214 , C07K2317/76 , C07K2317/92
摘要： Provided is an effective means for therapy of infection, particularly infection with Pseudomonas aeruginosa. Provided are a monoclonal antibody against PcrV or a part thereof, and a pharmaceutical composition containing the same as an active ingredient. Concretely, monoclonal antibody of the present invention has excellent inhibiting activity on cytotoxicity with respect to a target cell of Pseudomonas aeruginosa. Also, the monoclonal antibody of the present invention has high affinity with PcrV.
摘要翻译： 提供治疗感染，特别是铜绿假单胞菌感染的有效手段。 提供了针对PcrV或其一部分的单克隆抗体，以及含有其作为活性成分的药物组合物。 具体地，本发明的单克隆抗体相对于铜绿假单胞菌的靶细胞的细胞毒性具有优异的抑制活性。 此外，本发明的单克隆抗体与PcrV具有高亲和力。
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公开(公告)号：US20080097078A1
公开(公告)日：2008-04-24
申请号：US11791446
申请日：2005-11-24
申请人： Hirokazu Arimoto , Jun Lu , Yoshinori Yamano , Tatsuro Yasukata , Osamu Yoshida , Tsutomu Iwaki , Yutaka Yoshida , Issei Kato , Kenji Morimoto , Kayo Yasoshima
发明人： Hirokazu Arimoto , Jun Lu , Yoshinori Yamano , Tatsuro Yasukata , Osamu Yoshida , Tsutomu Iwaki , Yutaka Yoshida , Issei Kato , Kenji Morimoto , Kayo Yasoshima
摘要： Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—RA [wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain part containing an amino sugar; and RA represents, e.g., the formula —X1—Ar1—X2—Y—X3—Ar2 (wherein X1, X2, and X3 each represents 1) a single bond or 2) a heteroatom or heteroatom-containing group selected from the group consisting of —N═, ═N—, —NR1—, —O—, etc.; Y represents —NR2CO— or —CONR2— (wherein R2 represents hydrogen or lower alkyl), etc.)]. These derivatives have antibacterial activity against vancomycin-resistant bacteria.
摘要翻译： 新型糖肽抗生素衍生物。 这些衍生物由式（糖肽抗生素衍生物的糖苷配基部分） - （Sac-NH）-R A表示[其中（糖肽抗生素衍生物的糖苷配基部分）是通过除去糖部分而形成的部分 从已知的糖肽抗生素衍生物; （Sac-NH）部分是含有氨基糖的氨基糖部分或糖链部分; 并且R A表示例如式-X 1 -Ar 1 -x 2 -YX SUP >其中X 1，X 2和X 3各自表示 1）单键或2）选自-N-，-N-，-NR 1 - ， - O - 等的杂原子或含杂原子的基团; Y表示-NR 2 CO-或-CONR 2 - （其中R 2表示氢或低级烷基）等）。 这些衍生物对万古霉素抗性细菌具有抗菌活性。
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公开(公告)号：US4883439A
公开(公告)日：1989-11-28
申请号：US129142
申请日：1987-12-07
IPC分类号： H01J9/26
CPC分类号： H01J9/263 , Y10S269/908
摘要： A cathode ray tube fixturing device for position a face panel and a funnel during a frit sealing process. The device includes a cone holder for positioning a constricted portion of the funnel, and a movable abutting block which is adapted to abut against the panel and the funnel. A pivoting arm connects the cone holder with the movable abutting block, and at least one fixed abutting block is adapted to abut against the panel and the funnel and is located in opposed relationship with respect to the movable abutting block. When the funnel and the panel are mounted in the cone holder in assembled relation, their common centerline is vertical. In this assembled relation, the panel and funnel are urged against the fixed abutting block by the movable abutting block so that the seal from the panel to the funnel can be effectively produced and the fixturing device is reduced in weight.
摘要翻译： 一种用于在玻璃料密封过程中定位面板和漏斗的阴极射线管夹持装置。 该装置包括用于定位漏斗的收缩部分的锥形保持器，以及适于抵靠面板和漏斗的可动邻接块。 枢转臂将锥形夹持器与可移动的邻接块连接，并且至少一个固定的邻接块适于抵靠面板和漏斗并且相对于可移动邻接块相对置。 当漏斗和面板以组装的关系安装在锥形支架中时，它们的共同中心线是垂直的。 在这种组装关系中，面板和漏斗通过可移动的抵接块被推靠在固定的邻接块上，使得可以有效地产生从面板到漏斗的密封，并且固定装置的重量减轻。
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公开(公告)号：US08778874B2
公开(公告)日：2014-07-15
申请号：US11791446
申请日：2005-11-24
申请人： Hirokazu Arimoto , Jun Lu , Yoshinori Yamano , Tatsuro Yasukata , Osamu Yoshida , Tsutomu Iwaki , Yutaka Yoshida , Issei Kato , Kenji Morimoto , Kayo Yasoshima
发明人： Hirokazu Arimoto , Jun Lu , Yoshinori Yamano , Tatsuro Yasukata , Osamu Yoshida , Tsutomu Iwaki , Yutaka Yoshida , Issei Kato , Kenji Morimoto , Kayo Yasoshima
摘要： Novel glycopeptide antibiotic derivatives. These derivatives are represented by the formula (aglycon part of glycopeptide antibiotic derivative)-(Sac-NH)—RA [wherein (aglycon part of glycopeptide antibiotic derivative) is the part formed by removing the sugar part from a known glycopeptide antibiotic derivative; (Sac-NH) part is an amino sugar part or a sugar chain part containing an amino sugar; and RA represents, e.g., the formula —X1—Ar1—X2—Y—X3—Ar2 (wherein X1, X2, and X3 each represents 1) a single bond or 2) a heteroatom or heteroatom-containing group selected from the group consisting of —N═, ═N—, —NR1—, —O—, etc.; Y represents —NR2CO— or —CONR2— (wherein R2 represents hydrogen or lower alkyl), etc.)]. These derivatives have antibacterial activity against vancomycin-resistant bacteria.
摘要翻译： 新型糖肽抗生素衍生物。 这些衍生物由式（糖肽抗生素衍生物的糖苷配基） - （Sac-NH）-RA [其中（糖肽抗生素衍生物的糖苷配基部分）是通过从已知的糖肽抗生素衍生物中除去糖部分而形成的部分） （Sac-NH）部分是含有氨基糖的氨基糖部分或糖链部分; RA表示例如式-X1-Ar1-X2-Y-X3-Ar2（其中X1，X2和X3各自表示1）单键或2）选自以下的杂原子或含杂原子的基团： 的-N =，-N =，-NR1-，-O-等; Y表示-NR2CO-或-CONR2-（其中R2表示氢或低级烷基）等）。 这些衍生物对万古霉素抗性细菌具有抗菌活性。
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