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公开(公告)号：US20090131655A1
公开(公告)日：2009-05-21
申请号：US12100307
申请日：2008-04-09
IPC分类号： C07D501/60
CPC分类号： C07D501/56 , A61K31/546 , C07D501/00
摘要： A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene) Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 下式的化合物：其中T是S，SO或O; X是卤素，CN，任选被低级烷基，低级烷基，低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基（其中取代基是 任选取代的单低级烷基，任选取代的低级亚烷基或任选取代的低级亚烷基）Z +是任选取代的阳离子和含N原子的杂环基），酯，氨基保护的化合物，其中氨基与噻唑环上的氨基键连接 7-位或其药学上可接受的盐或溶剂化物。
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公开(公告)号：US07384928B2
公开(公告)日：2008-06-10
申请号：US10507502
申请日：2003-03-18
IPC分类号： C07D501/46 , A61K31/546 , A61P31/04 , C07D277/593
CPC分类号： C07D501/56 , A61K31/546 , C07D501/00
摘要： A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 下式的化合物：其中T是S，SO或O; X是卤素，CN，任选被低级烷基，低级烷基，低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基（其中取代基是 任选取代的单低级烷基，任选取代的低级亚烷基或任选取代的低级亚烷基）; Z +是任选取代的阳离子和含N原子的杂环基），酯，氨基保护的化合物 其中氨基与7-位的噻唑环或其药学上可接受的盐或溶剂化物的键合。
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公开(公告)号：US07696354B2
公开(公告)日：2010-04-13
申请号：US12100307
申请日：2008-04-09
IPC分类号： C07D277/38
CPC分类号： C07D501/56 , A61K31/546 , C07D501/00
摘要： A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 下式的化合物：其中T是S，SO或O; X是卤素，CN，任选被低级烷基，低级烷基，低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基（其中取代基是 任选取代的单低级烷基，任选取代的低级亚烷基或任选取代的低级亚烷基）; Z +是任选取代的，阳离子和含N原子的杂环基团），酯，氨基保护的化合物，其中氨基与噻唑环 在7-位，或其药学上可接受的盐或溶剂化物。
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公开(公告)号：US20050153950A1
公开(公告)日：2005-07-14
申请号：US10507502
申请日：2003-03-18
IPC分类号： A61K31/546 , A61P31/04 , C07D277/40 , C07D277/46 , C07D277/56 , C07D501/00 , C07D501/50 , C07D519/06 , A61K31/545 , A61K31/5383 , C07D501/14
CPC分类号： C07D501/56 , A61K31/546 , C07D501/00
摘要： A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substituted lower alkylene (wherein the substituent is optionally substituted mono lower alkyl, optionally substituted lower alkylidene, or optionally substituted lower alkylene); Z+ is an optionally substituted, a cation and an N atom-containing heterocyclic group), ester, amino-protected compound wherein the amino bonds to a thiazole ring at the 7-position, or pharmaceutically acceptable salt or solvate thereof.
摘要翻译： 下式的化合物：其中T是S，SO或O; X是卤素，CN，任选被低级烷基，低级烷基，低级烷氧基或低级烷硫基取代的氨基甲酰基; A是取代的低级亚烷基（其中取代基是 任选取代的单低级烷基，任选取代的低级亚烷基或任选取代的低级亚烷基）; Z +是任选取代的阳离子和含N原子的杂环基），酯，氨基保护的化合物 其中氨基与7-位的噻唑环或其药学上可接受的盐或溶剂化物的键合。
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5.发明申请NOVEL CEPHEM COMPOUND HAVING CATECHOL OR PSEUDO-CATECHOL STRUCTURE 有权具有CATECHOL或PSEUDO-CATECHOL结构的新型CEPHEM化合物公开(公告)号：US20140088302A1
公开(公告)日：2014-03-27
申请号：US14113459
申请日：2012-04-25
申请人： Yasuhiro Nishitani , Toshiaki Aoki , Jun Sato , Kenji Yamawaki , Katsuki Yokoo , Masayuki SANO
发明人： Yasuhiro Nishitani , Toshiaki Aoki , Jun Sato , Kenji Yamawaki , Katsuki Yokoo , Masayuki SANO
IPC分类号： C07D501/60 , C07D519/00
CPC分类号： C07D501/60 , C07D501/18 , C07D501/46 , C07D519/00 , C07D519/06
摘要： The present invention provides a novel compound which has a wide antimicrobial spectrum, and in particular exhibits potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. Specifically, the present invention provides a compound of the formula (I): wherein each symbol is as defined in the specification, or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same.
摘要翻译： 本发明提供了具有广谱抗菌谱的新型化合物，并且特别表现出对产生β-内酰胺酶的革兰氏阴性菌具有强效的抗微生物活性。 具体而言，本发明提供了式（I）化合物：其中各符号如说明书中所定义，或氨基保护的化合物，当氨基存在于7-侧链的环上时，或药学上 可接受的盐，以及包含其的药物组合物。
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公开(公告)号：US06421504B1
公开(公告)日：2002-07-16
申请号：US09583923
申请日：2000-05-31
申请人： Tatsuo Saito , Yasuhiro Nishitani
发明人： Tatsuo Saito , Yasuhiro Nishitani
IPC分类号： G03B1748
CPC分类号： H04N1/2116 , H04N1/2112 , H04N5/225 , H04N5/2352 , H04N5/2354 , H04N2101/00
摘要： To record images by a film recording system and an electronic recording system with one light-emission of a flashing device, the flashing device is controlled according to set values of photo film recording conditions since the sensitivity of a silver halide film is different from that of an imaging device. Information about exposure control of the electronic recording system is transmitted from a CPU that is equivalent to a controlling device of the film recording system to a CPU of the electronic recording system, and the electronic recording system sets a CCD aperture, a CCD gain and so on according to the information.
摘要翻译： 为了通过具有闪光装置的一次发光的胶卷记录系统和电子记录系统记录图像，根据摄影胶片记录条件的设定值来控制闪光装置，因为卤化银膜的灵敏度不同于 成像装置。 关于电子记录系统的曝光控制的信息从等同于胶片记录系统的控制装置的CPU传送到电子记录系统的CPU，并且电子记录系统设置CCD孔径，CCD增益等 根据信息。
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公开(公告)号：US5933662A
公开(公告)日：1999-08-03
申请号：US746780
申请日：1996-11-15
申请人： Yasuhiro Nishitani
发明人： Yasuhiro Nishitani
CPC分类号： G03B17/425 , G03B17/36 , G03B2217/244 , G03B2217/263
摘要： The time after film is rewound up to a first frame until a film cartridge holding the film is allowed to be taken out is divided with the time required for rewinding the film by the currently-exposed frames. A delayed frame number is displayed at the time which is delayed from a time when the actual frame corresponding to the delayed frame number has been rewound for a delay time which is found based upon a number of the currently-exposed frames. Thus, a time in which a displayed number "1" changes to such a mark as "E" can be decreased, thereby preventing the user from opening a film cartridge chamber before the film is completely rewound.
摘要翻译： 将胶卷重新卷绕到第一框架之后的时间直到允许取出胶片的胶片暗盒被用当前曝光的框架重新卷绕胶片所需的时间来分割。 在从与对应于延迟帧号的实际帧已经被倒回延迟时间延迟的时间显示延迟帧号，延迟时间是基于当前曝光帧的数量而找到的。 因此，可以减少显示的数字“1”变为这样的标记为“E”的时间，从而防止用户在胶卷完全倒带之前打开暗盒。
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公开(公告)号：US4592865A
公开(公告)日：1986-06-03
申请号：US589670
申请日：1984-03-13
申请人： Masayuki Narisada , Hiroshi Onoue , Teruji Tsuji , Yasuhiro Nishitani , Mitsuru Yoshioka , Yoshio Hamashima , Wataru Nagata
发明人： Masayuki Narisada , Hiroshi Onoue , Teruji Tsuji , Yasuhiro Nishitani , Mitsuru Yoshioka , Yoshio Hamashima , Wataru Nagata
IPC分类号： C07D205/08 , C07D205/085 , C07D403/12 , C07D405/12 , C07D417/12 , C07D505/00 , C07F9/568 , C07D498/04
CPC分类号： C07F9/5683 , C07D205/085 , C07D505/00
摘要： Intermediates of the following formula are useful for the synthesis of 1-oxacephalosporins. Their preparation from penicillins and the transformation process to make 1-oxacephalosporins are disclosed. The compounds are of the formula: ##STR1## wherein A is amino or a selected acylamino;COB is carboxy or a selected protected-carboxy;X is halogen or the group ORin which R is a group represented by following formulas: ##STR2## wherein Nu is a selected nucleophilic group; R.sup.1 is a group of the following formula: ##STR3## in which Hal is halogen or alkylsulfonyloxy and R.sup.2 is alkyl or aryl; andY is hydrogen or methoxy; with the proviso that when R is propargyl or 2-oxopropyl andR.sup.1 is ##STR4## A is in the 3.alpha.-configuration and Y is 3.beta.-hydrogen or A is in the 3.beta.-configuration and Y is 3.alpha.-methoxy.
摘要翻译： 下列配方的中间体可用于合成1-氧杂七环素。 公开了它们从青霉素的制备和制备1-氧杂七环素的转化过程。 化合物具有下式：其中A是氨基或选择的酰氨基; COB是羧基或选择的保护羧基; X是卤素或基团OR，其中R是由下式表示的基团：CH2CCH，CH2CCNu，CH2CHCH2，＆lt; IMAGE＆gt;＆gt;其中Nu是选择的亲核基团; R1是下式的基团：其中Hal是卤素或烷基磺酰氧基，R2是烷基或芳基的
Y为氢或甲氧基; 条件是当R为炔丙基或2-氧代丙基且R 1为A 3构型时，Y为3个β-氢，或A为3个β-构型，Y为3个α-甲氧基。 -
9.发明授权
公开(公告)号：US4508909A
公开(公告)日：1985-04-02
申请号：US475410
申请日：1983-03-15
申请人： Wataru Nagata , Yasuhiro Nishitani , Hisao Sato
发明人： Wataru Nagata , Yasuhiro Nishitani , Hisao Sato
IPC分类号： C07C67/00 , C07C325/00 , C07C333/20 , C07D257/04
CPC分类号： C07D257/04 , Y02P20/55
摘要： By heating an N-(2-hydroxyethyl)dithiocarbamate ester protected at its hydroxy group as an ether in the presence of an azide, the corresponding 1-(protected hydroxyethyl)-1H-tetrazole-5-thiol is obtained, and then, if required, deprotecting the etheric protection to give an industrially useful chemical, 1-(2-hydroxyethyl)-1H-tetrazole-5-thiol.
摘要翻译： 通过在叠氮化物存在下加热其羟基作为醚保护的N-（2-羟乙基）二硫代氨基甲酸酯酯，得到相应的1-（保护的羟乙基）-1H-四唑-5-硫醇，然后如果 需要，脱保护以上的保护，得到工业上有用的化学品1-（2-羟乙基）-1H-四唑-5-硫醇。
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公开(公告)号：US20070219191A1
公开(公告)日：2007-09-20
申请号：US10591398
申请日：2005-03-03
IPC分类号： C07D501/56
CPC分类号： C07D501/00
摘要： A compound of Formula 1: (wherein A is optionally substituted lower alkylene (substituent: mono- or di-lower alkyl, lower alkylidene, or lower alkylene having two or more carbons); Z+ is either of the groups shown below: (wherein R1 and R2 are each independently hydrogen, optionally substituted amino lower alkyl, optionally substituted aminocycloalkyl, optionally substituted cyclic amino, or optionally substituted cyclic amino lower alkyl; R9 is hydrogen or lower alkyl, or R1 and R9 taken together with an adjacent N atom may form optionally substituted cyclic amino; R3 is hydrogen or amino; X is N or CR4 (R4 is hydrogen or optionally substituted lower alkyl)), a pharmaceutically acceptable salt or a solvate thereof.
摘要翻译： 式1的化合物：（其中A是任选取代的低级亚烷基（取代基：一或二低级烷基，低级亚烷基或具有两个或更多个碳的低级亚烷基）; Z + 下列基团：（其中R 1和R 2各自独立地为氢，任选取代的氨基低级烷基，任选取代的氨基环烷基，任选取代的环状氨基或任选取代的环状氨基 氨基低级烷基; R 9是氢或低级烷基，或者R 1和R 9与相邻的N原子一起可以形成任选取代的 环状氨基; R 3是氢或氨基; X是N或CR 4（R 4是氢或任选取代的低级烷基））， 其药学上可接受的盐或其溶剂合物。
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