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    Method for producing nucleoside derivatives
    5.
    发明授权
    Method for producing nucleoside derivatives 失效
    核苷衍生物的制备方法

    公开(公告)号：US08362244B2

    公开(公告)日：2013-01-29

    申请号：US11782695

    申请日：2007-07-25

    申请人： Satoji Takahashi ,  Mitsuhiko Kojima ,  Shouichi Kondou ,  Tatsuya Ishikawa ,  Yoshinori Ogawa

    发明人： Satoji Takahashi ,  Mitsuhiko Kojima ,  Shouichi Kondou ,  Tatsuya Ishikawa ,  Yoshinori Ogawa

    IPC分类号： C07D473/34 ,  C07D473/30

    CPC分类号： C12P17/182 ,  C07D473/30 ,  C07D473/34 ,  Y02P20/55

    摘要： The present invention relates to a method for producing a nucleoside derivative represented by formula (2), comprising the step of reducing a nucleoside of formula (1) in the presence of a noble metal catalyst comprising a carrier and a noble metal supported thereby, selected from the group consisting of (A) a homogeneously supported catalyst where the specific surface area of the noble metal is 95.0 m2/g or more and the particle size of the noble metal is 4.3 nm or less, and (B) a surface-loaded catalyst where the specific surface area of the noble metal is 56.0 m2/g or more and the particle size of the noble metal is 8.0 nm or less, wherein R1 is hydrogen or a protective group, R2 is NH2 or OH, R3 is an acyl group, and X is a chlorine or bromine atom. According to the present invention, the yield can be made equal even when the amount of catalyst is smaller than that used for the conventional products.

    摘要翻译： 本发明涉及一种制备由式（2）表示的核苷衍生物的方法，包括在贵金属催化剂存在下还原式（1）的核苷的步骤，所述贵金属催化剂包含载体和由其所支持的贵金属，所选择的贵金属被选择 由（A）贵金属的比表面积为95.0m 2 / g以上，贵金属的粒径为4.3nm以下的均匀负载的催化剂组成的组，（B）表面负载型 贵金属的比表面积为56.0m 2 / g以上，贵金属的粒径为8.0nm以下的催化剂，其中，R1为氢或保护基，R2为NH2或OH，R3为酰基 基团，X是氯或溴原子。 根据本发明，即使当催化剂的用量小于常规产品所用量时，产率也可以相等。

    METHOD FOR PRODUCING NUCLEOSIDE DERIVATIVES
    6.
    发明申请
    METHOD FOR PRODUCING NUCLEOSIDE DERIVATIVES 失效
    生产核苷衍生物的方法

    公开(公告)号：US20070282104A1

    公开(公告)日：2007-12-06

    申请号：US11782695

    申请日：2007-07-25

    申请人： Satoji TAKAHASHI ,  Mitsuhiko Kojima ,  Shouichi Kondou ,  Tatsuya Ishikawa ,  Yoshinori Ogawa

    发明人： Satoji TAKAHASHI ,  Mitsuhiko Kojima ,  Shouichi Kondou ,  Tatsuya Ishikawa ,  Yoshinori Ogawa

    IPC分类号： C07D473/02 ,  C07D473/10

    CPC分类号： C12P17/182 ,  C07D473/30 ,  C07D473/34 ,  Y02P20/55

    摘要： The present invention relates to a method for producing a nucleoside derivative represented by formula (2), comprising the step of reducing a nucleoside of formula (1) in the presence of a noble metal catalyst comprising a carrier and a noble metal supported thereby, selected from the group consisting of (A) a homogeneously supported catalyst where the specific surface area of the noble metal is 95.0 m2/g or more and the particle size of the noble metal is 4.3 nm or less, and (B) a surface-loaded catalyst where the specific surface area of the noble metal is 56.0 m2/g or more and the particle size of the noble metal is 8.0 nm or less, wherein R1 is hydrogen or a protective group, R2 is NH2 or OH, R3 is an acyl group, and X is a chlorine or bromine atom. According to the present invention, the yield can be made equal even when the amount of catalyst is smaller than that used for the conventional products.

    摘要翻译： 本发明涉及一种制备由式（2）表示的核苷衍生物的方法，包括在贵金属催化剂存在下还原式（1）的核苷的步骤，所述贵金属催化剂包含载体和由其所支持的贵金属，所选择的贵金属被选择 来自由（A）贵金属的比表面积为95.0m 2 / g以上的均匀负载的催化剂组成的组，贵金属的粒径为4.3nm以下， 和（B）贵金属的比表面积为56.0m 2 / g以上，贵金属的粒径为8.0nm以下的表面负载型催化剂，其中，R' R 1是氢或保护基，R 2是NH 2或OH，R 3是酰基， X是氯或溴原子。 根据本发明，即使当催化剂的用量小于常规产品所用量时，产率也可以相等。