公开(公告)号：US20050096520A1

公开(公告)日：2005-05-05

申请号：US10982101

申请日：2004-11-04

申请人： Yasunori Maekawa ,  Kennichi Sawa ,  Toshiyuki Sato ,  Seiki Okada ,  Kanako Nagaoka ,  Kaoru Asano

发明人： Yasunori Maekawa ,  Kennichi Sawa ,  Toshiyuki Sato ,  Seiki Okada ,  Kanako Nagaoka ,  Kaoru Asano

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1468 ,  A61B10/00

CPC分类号： A61B5/14546 ,  A61B5/14514 ,  A61B5/14532 ,  A61B2010/008

摘要： Extraction devices for extracting analyte through the skin of a living body are disclosed that includes first and second extraction units which are placed on the skin and in which analyte is extracted; electrode unit placed on the skin; and a power source unit for outputting a first current flowing through the electrode unit, the living body, and the first extraction unit, and a second current flowing through the electrode unit, the living body, and the second extraction unit.

摘要翻译： 公开了通过生物体的皮肤提取分析物的提取装置，其包括放置在皮肤上并且分析物被提取的第一和第二提取单元; 放置在皮肤上的电极单元; 以及电源单元，用于输出流过电极单元，生物体和第一提取单元的第一电流和流过电极单元，生物体和第二提取单元的第二电流。

公开(公告)号：US20110040166A1

公开(公告)日：2011-02-17

申请号：US12909577

申请日：2010-10-21

申请人： Seiki Okada ,  Yasunori Maekawa ,  Kennichi Sawa ,  Toshiyuki Sato ,  Kanako Nagaoka ,  Kei Hagino

发明人： Seiki Okada ,  Yasunori Maekawa ,  Kennichi Sawa ,  Toshiyuki Sato ,  Kanako Nagaoka ,  Kei Hagino

IPC分类号： A61B5/145

CPC分类号： A61B5/681 ,  A61B5/14514 ,  A61B5/14532 ,  A61M2037/0007 ,  A61N1/30 ,  A61N1/306

摘要： An extracting kits for extracting analyte through the skin of a living body are disclosed that comprises an inserting device comprising needles for forming a plurality of extraction holes in the skin through the stratum corneum but not reaching the subcutaneous tissue and an extracting device for extracting the analyte into a liquid supplied into the extraction holes by supplying the liquid into the plurality of extraction holes. An extracting device and extracting method are also described.

摘要翻译： 公开了一种用于通过生物体的皮肤提取分析物的提取试剂盒，其包括插入装置，所述插入装置包括用于通过角质层在皮肤中形成多个提取孔但不到达皮下组织的针，以及用于提取分析物的提取装置 通过将液体供给到多个提取孔中而供入到提取孔中的液体。 还描述了提取装置和提取方法。

公开(公告)号：US20050169799A1

公开(公告)日：2005-08-04

申请号：US11049599

申请日：2005-02-02

申请人： Kennichi Sawa ,  Yasunori Maekawa ,  Toshiyuki Sato ,  Kanako Nagaoka ,  Seiki Okada ,  Kei Hagino

发明人： Kennichi Sawa ,  Yasunori Maekawa ,  Toshiyuki Sato ,  Kanako Nagaoka ,  Seiki Okada ,  Kei Hagino

IPC分类号： A61B5/00 ,  G01N31/00 ,  C12M3/00

CPC分类号： A61B5/14532 ,  A61B5/14514 ,  A61B5/1459

摘要： An analyzer for extracting and analyzing an analyte from a subject is disclosed that comprises a reservoir capable of holding a liquid for holding the analyte extracted from the subject; and a liquid supplying mechanism for holding a liquid to be supplied to the reservoir and supplying the liquid to the reservoir. A cartridge, cartridge kit, and analyzing method are also described.

摘要翻译： 公开了一种用于提取和分析来自受试者的分析物的分析器，其包括能够容纳用于保持从被检体提取的分析物的液体的储存器; 以及液体供给机构，用于保持要供应到储存器的液体并将液体供应到储存器。 还描述了墨盒，墨盒套件和分析方法。

公开(公告)号：US20050177037A1

公开(公告)日：2005-08-11

申请号：US11031722

申请日：2005-01-07

申请人： Seiki Okada ,  Yasunori Maekawa ,  Kennichi Sawa ,  Toshiyuki Sato ,  Kanako Nagaoka ,  Kei Hagino

发明人： Seiki Okada ,  Yasunori Maekawa ,  Kennichi Sawa ,  Toshiyuki Sato ,  Kanako Nagaoka ,  Kei Hagino

IPC分类号： A61B5/00 ,  A61N1/30 ,  A61B5/05

CPC分类号： A61B5/681 ,  A61B5/14514 ,  A61B5/14532 ,  A61M2037/0007 ,  A61N1/30 ,  A61N1/306

摘要： An extracting kits for extracting analyte through the skin of a living body are disclosed that comprises an inserting device comprising needles for forming a plurality of extraction holes in the skin through the stratum corneum but not reaching the subcutaneous tissue and an extracting device for extracting the analyte into a liquid supplied into the extraction holes by supplying the liquid into the plurality of extraction holes. An extracting device and extracting method are also described.

摘要翻译： 公开了一种用于通过生物体的皮肤提取分析物的提取试剂盒，其包括插入装置，所述插入装置包括用于通过角质层在皮肤中形成多个提取孔但不到达皮下组织的针，以及用于提取分析物的提取装置 通过将液体供给到多个提取孔中而供入到提取孔中的液体。 还描述了提取装置和提取方法。

公开(公告)号：US07857759B2

公开(公告)日：2010-12-28

申请号：US10810412

申请日：2004-03-25

申请人： Kaoru Asano ,  Yasunori Maekawa ,  Kennichi Sawa ,  Toshiyuki Sato ,  Seiki Okada

发明人： Kaoru Asano ,  Yasunori Maekawa ,  Kennichi Sawa ,  Toshiyuki Sato ,  Seiki Okada

IPC分类号： A61B5/00

CPC分类号： A61B5/1486 ,  A61B5/14514 ,  A61B5/14532 ,  A61N1/30 ,  A61N1/325

摘要： Extraction device for extracting an analyte from living tissue through skin are described that include: (a) a first electrode part having a contact area with the skin of less than about 50 mm2; (b) a through-current electrode part; and (c) a power supply part for supplying electrical energy to the first electrode part and the through-current electrode part, and for extracting an analyte in the first electrode part. Analyzers, extraction methods, and analysis methods are also described.

摘要翻译： 描述了通过皮肤从活组织提取分析物的提取装置，其包括：（a）具有小于约50mm 2的与皮肤接触面积的第一电极部分; （b）直通电极部分; 以及（c）用于向第一电极部分和贯通电极部分提供电能并用于提取第一电极部分中的分析物的电源部分。 还描述了分析仪，提取方法和分析方法。

公开(公告)号：US20060029991A1

公开(公告)日：2006-02-09

申请号：US11194462

申请日：2005-08-02

申请人： Kei Hagino ,  Yasunori Maekawa ,  Kennichi Sawa ,  Seiki Okada ,  Toshiyuki Sato ,  Yoshihiro Asakura

发明人： Kei Hagino ,  Yasunori Maekawa ,  Kennichi Sawa ,  Seiki Okada ,  Toshiyuki Sato ,  Yoshihiro Asakura

IPC分类号： C12Q1/54 ,  C12M1/34 ,  A61B5/05

CPC分类号： A61B5/681 ,  A61B5/0531 ,  A61B5/14514 ,  A61B5/14532 ,  A61N1/30

摘要： An analyzer including an electrical information acquiring section for acquiring an electrical information by supplying an electricity to a skin of a subject; and a controller for acquiring a component value relating to an amount of a predetermined component included in a tissue fluid extracted via the skin of the subject and converting the component value into a concentration of the predetermined component included in the tissue fluid in a body of the subject based on the electrical information acquired by the electrical information acquiring section is disclosed. An analyzing method and a blood-sugar level measuring device are also disclosed.

摘要翻译： 一种分析器，包括：电信息获取部分，用于通过向对象的皮肤供电来获取电信息; 以及控制器，用于获取与经由经皮肤提取的组织液中包含的预定成分的量相关的成分值，并将成分值转换成包含在组织液中的预定成分的浓度 公开了基于由电信息获取部获取的电信息的主体。 还公开了分析方法和血糖水平测量装置。

公开(公告)号：US20070232875A1

公开(公告)日：2007-10-04

申请号：US11731441

申请日：2007-03-30

申请人： Yasunori Maekawa ,  Toshiyuki Sato ,  Kenichi Sawa ,  Seiki Okada ,  Kei Hagino ,  Yoshihiro Asakura ,  Yasuhito Ohnishi

发明人： Yasunori Maekawa ,  Toshiyuki Sato ,  Kenichi Sawa ,  Seiki Okada ,  Kei Hagino ,  Yoshihiro Asakura ,  Yasuhito Ohnishi

IPC分类号： A61B5/05

CPC分类号： A61B5/14532 ,  A61B5/14514

摘要： The present invention is to present an analyzer for analyzing a concentration of a predetermined component contained in tissue fluid of a subject, the analyzer being capable of mitigating the pain of the subject. The analyzer comprises: an extraction medium retainer for retaining an extraction medium for holding tissue fluid extracted through a skin of a subject; a component amount information obtainer for obtaining component amount information regarding amount of a predetermined component contained in the tissue fluid held in the extraction medium; an electrical information obtainer for obtaining electrical information related to amount of the extracted tissue fluid by supplying electrical power to the extraction medium which is holding the extracted tissue fluid; and a component concentration obtainer for obtaining a concentration of the predetermined component contained in body fluid of the subject based on the component amount information and the electrical information.

摘要翻译： 本发明提供一种用于分析被检体的组织液中所含有的预定成分的浓度的分析装置，该分析装置能够减轻受试者的疼痛。 分析仪包括：提取介质保持器，用于保持用于保持通过受试者皮肤提取的组织液的提取介质; 组分量信息获取器，用于获得关于包含在所述提取介质中保持的组织液中的预定成分的量的成分量信息; 电信息获取器，用于通过向正在保存所提取的组织液的提取介质提供电力来获得与所提取的组织液的量相关的电信息; 以及组分浓度获取器，用于基于组分量信息和电信息获得包含在对象体液中的预定成分的浓度。

公开(公告)号：US08916109B2

公开(公告)日：2014-12-23

申请号：US13072076

申请日：2011-03-25

申请人： Seiki Okada ,  Toshiyuki Sato

发明人： Seiki Okada ,  Toshiyuki Sato

IPC分类号： G01N33/00 ,  A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/14514 ,  G06F19/00

摘要： A diagnosis support method comprising: obtaining first blood glucose level information at a first time point and/or second blood glucose level information at a second time point which is later, by a predetermined period, than the first time point; placing a collection member, which is configured to collect a tissue fluid, on the skin of the subject for the predetermined period from the first time point to the second time point; obtaining glucose information about an amount of glucose contained in the tissue fluid collected by the collection member; and generating diagnosis support information for supporting a diagnosis of presence or absence of hypoglycemia in the subject, based on the first blood glucose level information and/or the second blood glucose level information and the glucose information. A diagnosis support system and a diagnosis support apparatus are also disclosed.

摘要翻译： 一种诊断支持方法，包括：在比所述第一时间点晚的预定时间段的第二时间点获取第一时间点的第一血糖值信息和/或第二血糖值信息; 将从所述第一时间点到所述第二时间点的所述规定期间内的被检体的皮肤上收集组织液的收集构件， 获取关于由收集构件收集的组织液中所含的葡萄糖量的葡萄糖信息; 以及基于第一血糖值信息和/或第二血糖值信息和葡萄糖信息生成用于支持对象中存在或不存在低血糖的诊断支持信息。 还公开了诊断支持系统和诊断支持装置。

公开(公告)号：US20110070565A1

公开(公告)日：2011-03-24

申请号：US12885035

申请日：2010-09-17

申请人： Seiki OKADA ,  Toshiyuki Sato ,  Kaya Yamada ,  Akinobu Seko ,  Teiji Nakamura ,  Sachi Totsuka

发明人： Seiki OKADA ,  Toshiyuki Sato ,  Kaya Yamada ,  Akinobu Seko ,  Teiji Nakamura ,  Sachi Totsuka

IPC分类号： G09B19/00

CPC分类号： G06F19/3475 ,  G06F19/3456 ,  G16H15/00

摘要： A postprandial blood glucose estimating apparatus for estimating a value related to a postprandial blood glucose of a subject, comprising: an input receiving part for receiving information relating to the amount of energy in a food; an estimating part for estimating a value related to a postprandial glucose level when the subject consums the food based on the information relating to the amount of energy in the food received by the input receiving part; and an outputting part for outputting a value related to the postprandial glucose level estimated by the estimating part, is disclosed.A postprandial blood glucose estimating method that is executable by a postprandial blood glucose estimating apparatus for estimating a value related to a postprandial blood glucose of a subject, and a computer program product are also disclosed.

摘要翻译： 一种餐后血糖估计装置，用于估计与受试者的餐后血糖相关的值，包括：输入接收部，用于接收与食物中的能量量有关的信息; 估计部，用于基于与所述输入接收部接收到的所述食物中的能量量有关的信息，估计所述被摄体消耗食物时与餐后血糖水平相关的值; 公开了一种用于输出由该估计部估计出的餐后葡萄糖水平的值的输出部。 还公开了一种餐后血糖估计方法，其可由餐后血糖估计装置执行，用于估计与受检者的餐后血糖相关的值，以及计算机程序产品。

公开(公告)号：US20110237919A1

公开(公告)日：2011-09-29

申请号：US13072076

申请日：2011-03-25

申请人： Seiki OKADA ,  Toshiyuki Sato

发明人： Seiki OKADA ,  Toshiyuki Sato

IPC分类号： A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/14514 ,  G06F19/00

摘要： A diagnosis support method comprising: obtaining first blood glucose level information at a first time point and/or second blood glucose level information at a second time point which is later, by a predetermined period, than the first time point; placing a collection member, which is configured to collect a tissue fluid, on the skin of the subject for the predetermined period from the first time point to the second time point; obtaining glucose information about an amount of glucose contained in the tissue fluid collected by the collection member; and generating diagnosis support information for supporting a diagnosis of presence or absence of hypoglycemia in the subject, based on the first blood glucose level information and/or the second blood glucose level information and the glucose information. A diagnosis support system and a diagnosis support apparatus are also disclosed.

摘要翻译： 一种诊断支持方法，包括：在比所述第一时间点晚的预定时间段的第二时间点获取第一时间点的第一血糖值信息和/或第二血糖值信息; 将从所述第一时间点到所述第二时间点的所述规定期间内的被检体的皮肤上收集组织液的收集构件， 获取关于由收集构件收集的组织液中所含的葡萄糖量的葡萄糖信息; 以及基于第一血糖值信息和/或第二血糖值信息和葡萄糖信息生成用于支持对象中存在或不存在低血糖的诊断支持信息。 还公开了诊断支持系统和诊断支持装置。