公开(公告)号：US5254545A

公开(公告)日：1993-10-19

申请号：US589922

申请日：1990-09-28

申请人： Yasuo Ishibashi ,  Isamu Hasegawa ,  Masanori Kayano ,  Ryoichi Machida ,  Masahiro Kawahara ,  Sumio Watanabe

发明人： Yasuo Ishibashi ,  Isamu Hasegawa ,  Masanori Kayano ,  Ryoichi Machida ,  Masahiro Kawahara ,  Sumio Watanabe

IPC分类号： A61K9/08 ,  A61K9/00 ,  A61K31/545 ,  A61K31/546 ,  A61K47/00 ,  A61K47/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26

CPC分类号： A61K9/0019 ,  A61K31/545

摘要： A preparation containing a cephalosporin medicament is disclosed. The preparation comprises a cephalosporin derivative represented by the following formula: ##STR1## namely, 7.beta.-{2-(5-amino-1,2,4-thiadiazol-3-yl)-(Z)-2-fluoromethoxyiminoacetamido}-3-{(E)-3-(carbamoylmethylethylmethylammonio) -1-propen-1-yl}-3-cephem-4-carboxylate or a pharmaceutically acceptable salt thereof salt, lactose, citric acid or a sodium salt thereof, and arginine or a hydrochloride thereof; or the cephalosporin derivative represented by the formula (I) or a pharmaceutically acceptable salt thereof, lactose, citric acid or a sodium salt thereof, and sodium chloride.

公开(公告)号：US4127622A

公开(公告)日：1978-11-28

申请号：US615086

申请日：1975-09-19

申请人： Sumio Watanabe ,  Yasuhiko Mizuno ,  Masanori Kayano ,  Yoshio Ishino

发明人： Sumio Watanabe ,  Yasuhiko Mizuno ,  Masanori Kayano ,  Yoshio Ishino

IPC分类号： A61K9/00 ,  A61K9/50 ,  B01J13/02 ,  B01J2/02

CPC分类号： A61K9/0065 ,  A61K9/5047 ,  A61K9/5089

摘要： A hollow particulate for gastric medicines and other durable medicines suspendable in the gastric juice and remainable in the stomach for a long period of time is provided which has been prepared by dissolving ethylcellulose in a lower chlorinated hydrocarbon, or a mixed solution of the lower chlorinated hydrocarbon and a lower chlorofluorinated hydrocarbon and/or water, so that the concentration of ethylcellulose is 0.5 - 4% by weight on the basis of the total weight of the resulting solution, and then spray-drying the solution at an inlet temperature of higher than 50.degree. C.

摘要翻译： 提供了一种用于胃药和其它耐用药物的中空颗粒，其可在胃液中悬浮并长时间保留在胃中，其通过将乙基纤维素溶解在较低氯化烃或下氯化烃的混合溶液中而制备 和较低的氯氟化烃和/或水，使得基于所得溶液的总重量，乙基纤维素的浓度为0.5-4重量％，然后在高于50℃的入口温度下将溶液喷雾干燥 DEG C.

公开(公告)号：US3976764A

公开(公告)日：1976-08-24

申请号：US557408

申请日：1975-03-11

申请人： Sumio Watanabe ,  Masanori Kayano ,  Yoshio Ishino ,  Kohei Miyao

发明人： Sumio Watanabe ,  Masanori Kayano ,  Yoshio Ishino ,  Kohei Miyao

IPC分类号： A61K9/00 ,  A61K9/22

CPC分类号： A61K9/0065

摘要： A solid therapeutic preparation for gastric diseases, remaining in stomach for a long period of time and gradually releasing pharmacologically active ingredient contained therein into gastric juice while remaining in stomach, is provided which has been prepared by impregnation of the active ingredient together with other suitable additives into a body of empty globular shell or a granular lump in small size of the material having high buoyancy. The persisting effect of the active ingredient in stomach is thus attained.

摘要翻译： 本发明提供了一种用于胃病的固体治疗制剂，其长期保留在胃中并逐渐释放其中保存在胃中的胃液中的药理活性成分，其通过将活性成分与其它合适的添加剂一起浸渍而制备 进入空的球状壳体或具有高浮力的材料的小尺寸的颗粒块。 从而达到活性成分在胃中的持续作用。

公开(公告)号：US5980947A

公开(公告)日：1999-11-09

申请号：US352188

申请日：1994-12-01

申请人： Ichiro Yamakawa ,  Ryoichi Machida ,  Sumio Watanabe

发明人： Ichiro Yamakawa ,  Ryoichi Machida ,  Sumio Watanabe

IPC分类号： A61K9/16 ,  A61K9/50 ,  B01J13/12 ,  A61K9/14

CPC分类号： A61K9/1694 ,  A61K9/1617 ,  A61K9/1647

摘要： Formation of a drug into microspheres by an oil-on-water solvent evaporation process in which a mixed solvent of at least one water-insoluble solvent and at least one water-miscible solvent is used as a solvent of an oil phase. A fatty acid or a salt thereof or at least one glycerin fatty acid ester and/or at least one propylene glycol fatty acid ester are added to the mixed solvent. The oil phase may also comprise the mixed solvent; a fatty acid or a salt thereof; and at least one glycerin fatty acid ester and/or at least one propylene glycol fatty acid ester. This oil phase is mixed and emulsified with an aqueous phase to form an oil-in-water emulsion. The emulsion with a drug contained therein is then subjected to an oil-in water solvent evaporation to produce the microspheres. The resulting drug-containing microspheres contain the drug at a high concentration and slowly release from the initial stage after administration.

摘要翻译： 通过油包水溶剂蒸发方法将药物形成为微球，其中使用至少一种水不溶性溶剂和至少一种与水相混溶的溶剂的混合溶剂作为油相的溶剂。 向混合溶剂中加入脂肪酸或其盐或至少一种甘油脂肪酸酯和/或至少一种丙二醇脂肪酸酯。 油相也可以包含混合溶剂; 脂肪酸或其盐; 和至少一种甘油脂肪酸酯和/或至少一种丙二醇脂肪酸酯。 将该油相与水相混合并乳化以形成水包油乳液。 然后将其中含有药物的乳液进行油包水溶剂蒸发以产生微球体。 所得含药微球含有高浓度的药物，并在给药后从初始阶段缓慢释放。

公开(公告)号：US5120719A

公开(公告)日：1992-06-09

申请号：US437463

申请日：1989-11-15

申请人： Kiyoshi Iwamoto ,  Masahiro Kawahara ,  Sumio Watanabe ,  Yasuo Miyake ,  Fumio Sagami

发明人： Kiyoshi Iwamoto ,  Masahiro Kawahara ,  Sumio Watanabe ,  Yasuo Miyake ,  Fumio Sagami

IPC分类号： C08B31/04 ,  A61K31/557 ,  A61K31/715 ,  A61K47/48 ,  A61P43/00 ,  C07C405/00 ,  C08B37/00

CPC分类号： A61K47/4823 ,  A61K31/557

摘要： A conjugate formed by the covalent bonding of a prostaglandin or a similar compound thereto and a polysaccharide. The prostaglandin is selected from prostaglandin E1, prostaglandin E2, prostaglandin F2.alpha., prostaglandin I2, carbacycline and iloprost and the polysaccharide is selected from pluran, amylose, amylopectin, cellulose, dextran and hydroxyethylated starch.

公开(公告)号：US06235724B1

公开(公告)日：2001-05-22

申请号：US09194704

申请日：1998-12-18

申请人： Yasuyuki Asai ,  Katsumi Onai ,  Kazuhide Ashizawa ,  Kiyoshi Iwamoto ,  Yasuo Ishibashi ,  Sumio Watanabe

发明人： Yasuyuki Asai ,  Katsumi Onai ,  Kazuhide Ashizawa ,  Kiyoshi Iwamoto ,  Yasuo Ishibashi ,  Sumio Watanabe

IPC分类号： A61K3170

CPC分类号： A61K31/7024 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/7032 ,  A61K47/02 ,  Y10S514/951

摘要： The present invention provides a preparation for injection containing a lipid A analog and a process for preparing the same. A preparation for injection prepared by dissolving a lipid A analog or a pharmacologically acceptable salt thereof in an alkaline aqueous solution, at an elevated temperature if necessary, and then adding a buffer thereto, and a process for preparing the same.

摘要翻译： 本发明提供了含有脂质A类似物的注射剂及其制备方法。 根据需要，在升高的温度下将脂质A类似物或其药理学可接受的盐溶解在碱性水溶液中，然后向其中加入缓冲剂制备的注射剂及其制备方法。

公开(公告)号：US5425943A

公开(公告)日：1995-06-20

申请号：US900796

申请日：1992-06-22

申请人： Masahiro Kawahara ,  Yuichiro Hayashi ,  Naoki Asakawa ,  Sumio Watanabe ,  Yasuo Miyake

发明人： Masahiro Kawahara ,  Yuichiro Hayashi ,  Naoki Asakawa ,  Sumio Watanabe ,  Yasuo Miyake

IPC分类号： A61K38/46 ,  A61K9/08 ,  A61K38/49 ,  A61K47/00 ,  A61K47/18 ,  A61K38/48 ,  C12N9/50 ,  C12N9/64

CPC分类号： A61K9/0019 ,  A61K38/49 ,  A61K47/183

摘要： An injection composition comprises a pharmacologically effective amount of a modified tPA, 47.5 mM or more of an amino acid or a salt thereof and is improved in view of stability and solubility.

摘要翻译： 注射组合物包含药理学上有效量的修饰的tPA，47.5mM或更多的氨基酸或其盐，并且从稳定性和溶解性的观点来看是有改进的。

公开(公告)号：US08827581B2

公开(公告)日：2014-09-09

申请号：US13477695

申请日：2012-05-22

申请人： Masahiro Tsuchiya ,  Tetsuhiro Ishikawa ,  Sumio Watanabe ,  Masaru Kihara ,  Yukihiro Mori

发明人： Masahiro Tsuchiya ,  Tetsuhiro Ishikawa ,  Sumio Watanabe ,  Masaru Kihara ,  Yukihiro Mori

IPC分类号： B65H35/04 ,  B41J15/04 ,  B41J11/70 ,  B41J2/32 ,  B41J13/10

CPC分类号： B41J15/04 ,  B41J2/32 ,  B41J11/70 ,  B41J13/106 ,  B65H35/006 ,  B65H2301/51256 ,  B65H2301/5151 ,  B65H2301/51532 ,  B65H2402/41 ,  B65H2801/12

摘要： A printer includes a printing part configured to perform printing on rolled recording paper, a presenter unit configured to convey the recording paper for up to a predetermined length, and a cutter part configured to cut the recording paper subjected to the printing and conveyed for up to the predetermined length, wherein the presenter unit is removably attached to a printer body part including the printing part and the presenter unit.

摘要翻译： 打印机包括被配置为在卷纸上执行打印的打印部件，被配置为将记录纸传送达预定长度的演示单元和被配置为将经过打印的记录纸切割直到 所述预定长度，其中所述演示单元可移除地附接到包括所述打印部分和所述演示者单元的打印机主体部分。

公开(公告)号：US08550733B2

公开(公告)日：2013-10-08

申请号：US12068127

申请日：2008-02-01

申请人： Yukihiro Mori ,  Sumio Watanabe

发明人： Yukihiro Mori ,  Sumio Watanabe

IPC分类号： B41J11/04 ,  B41J11/70 ,  B41J29/02

CPC分类号： B41J15/042 ,  B26D1/385 ,  B41J11/70

摘要： A printing apparatus having shorter length in the longitudinal direction and a dust-protecting feature is disclosed. The printer includes a main frame, a subframe assembly, first and second pulse motors each have a reduction gear drive mechanism, a thermal head, a platen roller, a rotary blade, and a stationary blade. The first motor for driving the platen roller and the second motor for driving the rotary blade are disposed between two side plates provided one on each end of the main frame. The reduction gear drive mechanisms are substantially sealed and disposed inside the corresponding side plates. Two pulleys and a timing belt are provided outside each of the side plates.

摘要翻译： 公开了一种在纵向具有较短长度和防尘特征的打印设备。 打印机包括主框架，子框架组件，第一和第二脉冲电机，每个具有减速齿轮驱动机构，热头，压纸辊，旋转刀片和固定刀片。 用于驱动压纸辊的第一电动机和用于驱动旋转刀片的第二电动机设置在设置在主框架的每个端部上的两个侧板之间。 减速齿轮驱动机构基本上被密封并设置在相应的侧板内。 在每个侧板的外侧设置有两个滑轮和同步皮带。

公开(公告)号：US07362346B2

公开(公告)日：2008-04-22

申请号：US11299627

申请日：2005-12-13

申请人： Sumio Watanabe ,  Fumio Sakurai ,  Yukihiro Mori ,  Masahiro Tsuchiya

发明人： Sumio Watanabe ,  Fumio Sakurai ,  Yukihiro Mori ,  Masahiro Tsuchiya

IPC分类号： B41J29/00

CPC分类号： B41J2/32 ,  B41J3/4075 ,  B41J15/042 ,  B41J29/02 ,  B41J29/13 ,  B41J29/38

摘要： A printer apparatus is disclosed that includes a printer unit, a first chassis, and a second chassis that is arranged to open/close through rotation. The printer unit includes a thermal head, a first module having a motor, and a second module having a platen roller and a rotating body. The first chassis includes a heat sensitive paper roll accommodating portion and a mount portion to which the first module is mounted. The second chassis includes mount portions to which the second module and a printed paper roll shaft are mounted, a printed paper roll accommodating portion, and a rotation transmitting mechanism. When the second chassis is closed, the heat sensitive paper roll accommodating portion is closed, the second module is coupled to the first module, the rotating body is rotated by the motor, and the shaft is rotated by the motor via the rotating body and the rotation transmitting mechanism.

摘要翻译： 公开了一种打印机装置，其包括打印机单元，第一机箱和布置成通过旋转打开/关闭的第二机箱。 打印机单元包括热敏头，具有电动机的第一模块和具有压纸辊和旋转体的第二模块。 第一底架包括热敏纸卷容纳部分和安装第一模块的安装部分。 第二底盘包括安装第二模块和打印纸辊轴的安装部分，打印纸卷容纳部分和旋转传递机构。 当第二底盘关闭时，热敏纸卷容纳部分关闭，第二模块联接到第一模块，旋转体由电动机旋转，并且轴通过旋转体由电动机旋转，并且 旋转传递机构。