利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

24 条记录 (耗时 0.026 秒)

    Piperidine derivatives and pharmaceutical compositions comprising the same
    4.
    发明授权
    Piperidine derivatives and pharmaceutical compositions comprising the same 失效
    哌啶衍生物和包含其的药物组合物

    公开(公告)号：US5095022A

    公开(公告)日：1992-03-10

    申请号：US538085

    申请日：1990-06-13

    申请人： Yasuo Ito ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

    发明人： Yasuo Ito ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

    IPC分类号： C07D211/70 ,  C07D405/04

    CPC分类号： C07D405/04 ,  C07D211/70

    摘要： A piperidine derivative represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or a lower alkyl group; X represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, or --CH.sub.2 O--; Y represents an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represented an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

    Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same
    6.
    发明授权
    Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same 失效
    哌啶衍生物，其制备方法和包含其的药物组合物

    公开(公告)号：US5153207A

    公开(公告)日：1992-10-06

    申请号：US520064

    申请日：1990-05-03

    申请人： Yasuo Ito ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

    发明人： Yasuo Ito ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Hiroyuki Nishino ,  Jun Sakaguchi

    IPC分类号： C07D211/46 ,  C07D211/54

    CPC分类号： C07D211/54 ,  C07D211/46

    摘要： A piperidine derivative represented by the following general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

    N-substituted flavone-8-carboxamides
    8.
    发明授权
    N-substituted flavone-8-carboxamides 失效
    N-取代的黄酮-8-甲酰胺

    公开(公告)号：US4525356A

    公开(公告)日：1985-06-25

    申请号：US546481

    申请日：1983-10-28

    申请人： Yasuo Itho ,  Hideo Kato ,  Nobuo Ogawa ,  Kagari Yamagishi ,  Eiichi Koshinaka ,  Kazuya Mitani

    发明人： Yasuo Itho ,  Hideo Kato ,  Nobuo Ogawa ,  Kagari Yamagishi ,  Eiichi Koshinaka ,  Kazuya Mitani

    IPC分类号： C07D311/30 ,  C07D405/12 ,  A61K31/35 ,  C07D405/10

    CPC分类号： C07D405/12 ,  C07D311/30

    摘要： Derivatives of N-substituted flavone-8-carboxamides represented by general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group or an ethyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a halogen atom or a nitro group, R.sub.3 represents a hydrogen atom or a lower alkyl group, k represents 0, 1, 2, or 3, m represents 0 or 1; X and Y, which must be different, represent a hydrogen atom or methyl group. A represents an amino group having the formula ##STR2## wherein, R.sub.4 and R.sub.5, which may be the same or different, represent a lower alkyl group or a cyclic amino group together with the nitrogen atom and with or without an oxygen atom, R.sub.6 represents a lower alkyl group and n represents 2 or 3, are disclosed, as well as pharmaceutical compositions thereof and method of treating therewith.The N-substituted flavone-8-carboxamides derivatives are useful as agents for treatment of dysurea.

    摘要翻译： 由通式（I）表示的N-取代的黄酮-8-甲酰胺的衍生物其中R1表示氢原子，甲基或乙基，R2表示氢原子，低级烷基，低级烷氧基 卤素原子或硝基，R3表示氢原子或低级烷基，k表示0,1,2或3，m表示0或1; X和Y必须不同，表示氢原子或甲基。 A表示具有式“IMAGE”的氨基，其中可以相同或不同的R 4和R 5与氮原子一起表示低级烷基或环状氨基，并且具有或不具有氧原子，R6表示 低级烷基和n代表2或3，以及其药物组合物和其处理方法。 N-取代的黄酮-8-甲酰胺衍生物可用作治疗尿素的药剂。