公开(公告)号：US5547962A

公开(公告)日：1996-08-20

申请号：US261446

申请日：1994-06-17

申请人： Yasuo Ito ,  Hideo Kato ,  Singo Yasuda ,  Noriyuki Kado ,  Toshihiko Yoshida ,  Yoichi Yamamoto

发明人： Yasuo Ito ,  Hideo Kato ,  Singo Yasuda ,  Noriyuki Kado ,  Toshihiko Yoshida ,  Yoichi Yamamoto

IPC分类号： C07D401/04 ,  A61K31/47 ,  A61K31/4725 ,  A61P31/04 ,  C07D215/56 ,  C07D215/233

CPC分类号： C07D215/56 ,  C07D401/04

摘要： A 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative represented by the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a halogenated lower alkanoyl group or a residue of carboxylic acid ester; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 or R.sup.6 are each independently a hydrogen atom or a lower alkyl group; or two of R.sup.4, R.sup.5 and R.sup.6 may be taken together to form a --(CH.sub.2).sub.n -group wherein n is 1 or 2, a stereoisomer thereof, or a pharmacologically acceptable salt thereof, the process for preparing these compounds, a pharmaceutical composition comprising an effective amount of these compounds and methods for the treatment of infectious diseases through the administration to patients of an effective amount of these compounds, and intermediates of these compounds are disclosed. These compounds are effective as antibacterial agents.

摘要翻译： 由以下通式表示的5-氨基-8-甲基-7-吡咯烷基喹啉-3-羧酸衍生物：其中R1是氢原子或低级烷基; R2是氢原子，低级烷基，低级烷酰基，卤代低级烷酰基或羧酸酯的残基; R3是氢原子或低级烷基; R4，R5或R6各自独立地为氢原子或低级烷基; 或R 2，R 5和R 6中的两个可以一起形成其中n为1或2的 - （CH 2）n - 基团，其立体异构体或其药理学上可接受的盐，制备这些化合物的方法，药物组合物 包括有效量的这些化合物和通过向患者施用有效量的这些化合物来治疗感染性疾病的方法，以及这些化合物的中间体。 这些化合物作为抗菌剂是有效的。

公开(公告)号：US5859026A

公开(公告)日：1999-01-12

申请号：US860469

申请日：1997-07-09

申请人： Yasuo Ito ,  Hideo Kato ,  Shingo Yasuda ,  Noriyuki Kada ,  Toshihiko Yoshida ,  Yoichi Yamamoto

发明人： Yasuo Ito ,  Hideo Kato ,  Shingo Yasuda ,  Noriyuki Kada ,  Toshihiko Yoshida ,  Yoichi Yamamoto

IPC分类号： C07D401/04 ,  A61K31/47 ,  C07D215/233

CPC分类号： C07D401/04

摘要： 5-Amino-7-((3S,4S)-3-amino-4-methyl (or ethyl)-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid or a pharmacologically acceptable salt thereof represented by the following formula wherein asymmetric carbon atoms marked with asterisks are in the S-configurations and R.sup.1 represents methyl group or ethyl group; and an antibacterial agent comprising said compound as an active ingredient. ##STR1##

摘要翻译： PCT No.PCT / JP95 / 02614 Sec。 371日期1997年7月9日第 102（e）日期1997年7月9日PCT 1995年12月20日PCT PCT。 公开号WO96 / 22988 日期：19965年9月1日 - 氨基-7 - （（3S，4S）-3-氨基-4-甲基（或乙基）-1-吡咯烷基）-1-环丙基-6-氟-1,4-二氢-8 - 甲基-4-氧代喹啉-3-羧酸或其药理学上可接受的盐，其中标有星号的不对称碳原子为S-构型，R1表示甲基或乙基; 以及包含所述化合物作为活性成分的抗菌剂。

公开(公告)号：US5126337A

公开(公告)日：1992-06-30

申请号：US505138

申请日：1990-04-05

申请人： Yasuo Ito ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Noriyuki Yagi ,  Toshihiko Yoshida ,  Tomio Suzuki

发明人： Yasuo Ito ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Noriyuki Yagi ,  Toshihiko Yoshida ,  Tomio Suzuki

IPC分类号： C07D513/04

CPC分类号： C07D513/04

摘要： A thiazetoquinoline-3-carboxylic acid derivative represented by the general formula (I) ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group; R.sub.2 is a fluorine atom or a chlorine atom; R.sub.3 is a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a halogenated lower alkanoyl, or alkoxycarbonyl group; and R.sub.4 is a hydrogen atom or a lower alkyl group, and a pharmacologically acceptable salt thereof, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for the treatment of an infectious disease by administering the same, are disclosed.

公开(公告)号：US4612329A

公开(公告)日：1986-09-16

申请号：US786742

申请日：1985-10-11

申请人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Sakae Kurata ,  Hiroyuki Nishino ,  Toshihiko Yoshida

发明人： Yasuo Itoh ,  Hideo Kato ,  Eiichi Koshinaka ,  Nobuo Ogawa ,  Sakae Kurata ,  Hiroyuki Nishino ,  Toshihiko Yoshida

IPC分类号： A61K31/275 ,  A61K31/445 ,  C07C20060101 ,  C07C255/58 ,  C07D20060101 ,  C07D211/08 ,  C07D295/08 ,  C07C121/78

CPC分类号： C07C255/00

摘要： Novel alpha-aminoalkyl-alpha-alkylphenylacetonitrile derivatives useful for treatment of cartino vaso diseases, a peripheral circulatory insufficiency and cerebral circulation failure are disclosed.

摘要翻译： 公开了用于治疗纸浆血管疾病，外周循环功能不全和脑循环衰竭的新型α-氨基烷基-α-烷基苯基乙腈衍生物。

公开(公告)号：US20130252134A1

公开(公告)日：2013-09-26

申请号：US13991437

申请日：2011-12-20

申请人： Masayoshi Takami ,  Toshihiko Yoshida ,  Masanori Aimu ,  Randal Lewis Perry ,  Mark Gerrit Roelofs ,  Robert Clayton Wheland ,  Ralph Munson Aten

发明人： Masayoshi Takami ,  Toshihiko Yoshida ,  Masanori Aimu ,  Randal Lewis Perry ,  Mark Gerrit Roelofs ,  Robert Clayton Wheland ,  Ralph Munson Aten

IPC分类号： H01M8/10

CPC分类号： H01M8/1039 ,  H01M4/8663 ,  H01M4/8828 ,  H01M6/183 ,  H01M8/1004 ,  H01M8/1027 ,  H01M10/0565 ,  H01M2300/0082

摘要： This invention relates to solid polymer electrolyte materials for use in one or more electrode of a fuel cell. The solid polymer electrolyte materials comprise one or more ionomer which comprises polymerized units of monomers A and monomers B, wherein monomers A are perfluoro dioxole or perfluoro dioxolane monomers, and the monomers B are functionalized perfluoro olefins having fluoroalkyl sulfonyl, fluoroalkyl sulfonate or fluoroalkyl sulfonic acid pendant groups, CF2═CF(O)[CF2]nSO2X. The ionomer of the solid polymer electrolyte material has a number average molecular weight, Mn, of greater than 140,000. Specifically, the ionomers of the invention may find use in the catalyst layer of an electrode because the high molecular weight ionomers mitigate the formation of cracks in the catalyst layer.

摘要翻译： 本发明涉及用于燃料电池的一个或多个电极的固体聚合物电解质材料。 固体聚合物电解质材料包含一种或多种离聚物，其包含单体A和单体B的聚合单元，其中单体A是全氟二氧杂环戊烯单体或全氟二氧戊环单体，单体B是具有氟代烷基磺酰基，氟烷基磺酸酯或氟烷基磺酸的全氟烯烃的官能化 侧链基团，CF 2 = CF（O）[CF 2] n SO 2 X。 固体高分子电解质材料的离聚物的数均分子量Mn大于14万。 具体地，本发明的离聚物可用于电极的催化剂层，因为高分子量离聚物可以减轻催化剂层中的裂纹的形成。

公开(公告)号：US08168349B2

公开(公告)日：2012-05-01

申请号：US12085303

申请日：2007-02-22

申请人： Masayoshi Takami ,  Toshihiko Yoshida ,  Masahiro Ueda ,  Yuri Tomisaka

发明人： Masayoshi Takami ,  Toshihiko Yoshida ,  Masahiro Ueda ,  Yuri Tomisaka

IPC分类号： H01M8/10

CPC分类号： H01M8/1023 ,  Y02P70/56

摘要： A fuel cell-purpose electrolyte material having a structural unit represented by a general formula (1): where n is 0 or a positive integer, and R1 represents H or CH3, and R2 represents (CH2)mSO3H (m is 0 or a positive integer).

摘要翻译： 一种具有由通式（1）表示的结构单元的燃料电池用电解质材料：其中n为0或正整数，并且R 1表示H或CH 3，并且R 2表示（CH 2）m SO 3 H（m为0或正 整数）。

公开(公告)号：US5863303A

公开(公告)日：1999-01-26

申请号：US004881

申请日：1998-01-09

申请人： Masaharu Yamamoto ,  Naoki Kono ,  Naomi Murakami ,  Toshihiko Yoshida

发明人： Masaharu Yamamoto ,  Naoki Kono ,  Naomi Murakami ,  Toshihiko Yoshida

IPC分类号： C10L1/02 ,  C10L1/18 ,  C10L1/182 ,  C10L1/185 ,  C10L1/19 ,  C10L10/02 ,  C10L10/12

CPC分类号： C10L1/19 ,  C10L1/026 ,  C10L1/18 ,  C10L10/02 ,  C10L10/12

摘要： The present invention is directed to a fuel oil for diesel engines, which is reduced in the discharges of particulate matters (PM) and carbon dioxide (CO) in exhaust gas upon combustion while retaining a high cetane number, characterized in that the fuel oil composition comprises a mineral oil as a principal component; and(a) 2-13 wt % of one or more dialkyl phthalate compounds represented by the chemical formula (1), and(b) 2-13 wt % of one or more glycol ether compounds represented by the chemical formula (2); andthe total content of said components (a) and (b) is from 4 to 15 wt %.

摘要翻译： 本发明涉及一种用于柴油发动机的燃料油，其在保持高十六烷值时减少了燃烧中废气中的颗粒物质（PM）和二氧化碳（CO）的排放，其特征在于，燃料油组合物 以矿物油为主要成分; 和（a）2-13重量％的由化学式（1）表示的一种或多种邻苯二甲酸二烷基酯化合物和（b）2-13重量％的由化学式（2）表示的一种或多种二醇醚化合物; 所述成分（a）和（b）的总含量为4〜15重量％。

公开(公告)号：US5109462A

公开(公告)日：1992-04-28

申请号：US577651

申请日：1990-09-05

申请人： Masanori Watanabe ,  Osamu Yamamoto ,  Toshihiko Yoshida

发明人： Masanori Watanabe ,  Osamu Yamamoto ,  Toshihiko Yoshida

IPC分类号： G02F1/37 ,  G02F1/377

CPC分类号： G02F1/377 ,  G02F2001/374

摘要： A light wavelength converter which includes a light source for emitting fundamental waves having a desired wavelength, a first loop-shaped optical waveguide for converting the fundemental waves into harmonics, and a second optical waveguide for receiving the light from the source, wherein the two waveguides are coupled by an optical directional coupler.

公开(公告)号：US5046802A

公开(公告)日：1991-09-10

申请号：US498573

申请日：1990-03-26

申请人： Osamu Yamamoto ,  Toshihiko Yoshida

发明人： Osamu Yamamoto ,  Toshihiko Yoshida

IPC分类号： G02B6/12 ,  G02F1/35 ,  G02F1/37 ,  G02F1/377 ,  G02F1/39

CPC分类号： G02F1/377 ,  G02F1/3534 ,  G02F2001/374

摘要： A light wavelength converter comprising a substrate that is made of a material with a non-linear optical effect, and a loop-shaped optical waveguide that is formed on the substrate, whereby a second harmonic wave or a sum wave emanates from a fundamental wave that has been propagated in a specific area of the optical waveguide and part of the fundamental wave that has not been converted to the second harmonic wave or the sum wave is returned to the specific area of the optical waveguide, so that a fundamental wave with a relatively low output can be efficiently converted to a second harmonic wave and a high-output second harmonic wave can be obtained.

公开(公告)号：US4941148A

公开(公告)日：1990-07-10

申请号：US119780

申请日：1987-11-12

申请人： Toshihiko Yoshida ,  Haruhisa Takiguchi ,  Shinji Kaneiwa ,  Hiroaki Kudo

发明人： Toshihiko Yoshida ,  Haruhisa Takiguchi ,  Shinji Kaneiwa ,  Hiroaki Kudo

IPC分类号： H01S5/00 ,  H01S5/12 ,  H01S5/20

CPC分类号： H01S5/20 ,  H01S5/12 ,  H01S5/2059

摘要： A semiconductor laser element of the present invention provides a double hetero junction structure having two clad layers and an active layer formed between the two clad layers. High resistance regions are formed vertically to the light propagating direction at almost the same interval as the light wavelength in at least one of the two clad layers. The high resistance regions form a periodic current blocking structure so the semiconductor laser element may oscillate in a single longitudinal mode even in a non-steady state operation.

摘要翻译： 本发明的半导体激光元件提供了具有两个包覆层和形成在两个包层之间的有源层的双异质结结构。 高电阻区域以与两个包覆层中的至少一个中的光波长几乎相同的间隔垂直于光传播方向形成。 高电阻区域形成周期性电流阻挡结构，因此即使在非稳态操作中，半导体激光元件也可以以单一纵向模式振荡。