公开(公告)号：USRE42327E1

公开(公告)日：2011-05-03

申请号：US12683813

申请日：2003-04-03

申请人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

发明人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

IPC分类号： A61K31/38

CPC分类号： A61K45/06 ,  A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K2300/00

摘要： An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

摘要翻译： 由下式表示的烷基醚衍生物：其中R 1，R 2，R 3，R 4，m和n如说明书中所定义，或其盐与具有乙酰胆碱酯酶抑制活性的化合物组合时，表现出协同改善的抗缺氧活性。 因此，本发明的组合作为改善脑功能的方法是有用的。 此外，含有本发明组合物的化合物的药物组合物可用于治疗和预防脑血管性痴呆，老年痴呆，老年痴呆症和缺血性脑损伤后遗症中脑乙酰胆碱神经元的功能障碍和脑中风 或由选择性神经元死亡引起的记忆障碍。

公开(公告)号：US07342043B2

公开(公告)日：2008-03-11

申请号：US10516320

申请日：2003-04-03

申请人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

发明人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

IPC分类号： A61K31/38

CPC分类号： A61K45/06 ,  A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K2300/00

摘要： An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

摘要翻译： 由下式表示的烷基醚衍生物其中R 1，R 2，R 3，R 4， m和n如说明书中所定义，或当其与具有乙酰胆碱酯酶抑制活性的化合物组合时，其表现出协同改善的抗缺氧活性。 因此，本发明的组合作为改善脑功能的方法是有用的。 此外，含有本发明组合物的化合物的药物组合物可用于治疗和预防脑血管性痴呆，老年痴呆，老年痴呆症和缺血性脑损伤后遗症中脑乙酰胆碱神经元的功能障碍和脑中风 或由选择性神经元死亡引起的记忆障碍。

公开(公告)号：US20050250843A1

公开(公告)日：2005-11-10

申请号：US10516320

申请日：2003-04-03

申请人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

发明人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

IPC分类号： A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K45/06 ,  A61P25/28 ,  A61P43/00 ,  A61K31/343 ,  C07D333/72

CPC分类号： A61K45/06 ,  A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K2300/00

摘要： An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

摘要翻译： 由下式表示的烷基醚衍生物：其中R 1，R 2，R 3，R 4， m和n如说明书中所定义，或当其与具有乙酰胆碱酯酶抑制活性的化合物组合时，其表现出协同改善的抗缺氧活性。 因此，本发明的组合作为改善脑功能的方法是有用的。 此外，含有本发明组合物的化合物的药物组合物可用于治疗和预防脑血管性痴呆，老年痴呆，老年痴呆症和缺血性脑损伤后遗症中脑乙酰胆碱神经元的功能障碍和脑中风 或由选择性神经元死亡引起的记忆障碍。

公开(公告)号：US07834053B2

公开(公告)日：2010-11-16

申请号：US11957832

申请日：2007-12-17

申请人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

发明人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

IPC分类号： A61K31/38

CPC分类号： A61K45/06 ,  A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K2300/00

摘要： An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

摘要翻译： 由下式表示的烷基醚衍生物：其中R 1，R 2，R 3，R 4，m和n如说明书中所定义，或其盐与具有乙酰胆碱酯酶抑制活性的化合物组合时，表现出协同改善的抗缺氧活性。 因此，本发明的组合作为改善脑功能的方法是有用的。 此外，含有本发明组合物的化合物的药物组合物可用于治疗和预防脑血管性痴呆，老年痴呆，老年痴呆症和缺血性脑损伤后遗症中脑乙酰胆碱神经元的功能障碍和脑中风 或由选择性神经元死亡引起的记忆障碍。

公开(公告)号：US20080103126A1

公开(公告)日：2008-05-01

申请号：US11957832

申请日：2007-12-17

申请人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

发明人： Yasushi Nakada ,  Masaya Nakagawa ,  Satoshi Ono

IPC分类号： A61K31/381 ,  A61K31/397 ,  A61K31/435 ,  A61K31/445 ,  A61K31/55 ,  A61P25/28

CPC分类号： A61K45/06 ,  A61K31/122 ,  A61K31/21 ,  A61K31/381 ,  A61K31/397 ,  A61K31/445 ,  A61K31/473 ,  A61K31/55 ,  A61K2300/00

摘要： An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.

摘要翻译： 由下式表示的烷基醚衍生物：其中R 1，R 2，R 3，R 4， m和n如说明书中所定义，或当其与具有乙酰胆碱酯酶抑制活性的化合物组合时，其表现出协同改善的抗缺氧活性。 因此，本发明的组合作为改善脑功能的方法是有用的。 此外，含有本发明组合物的化合物的药物组合物可用于治疗和预防脑血管性痴呆，老年痴呆，老年痴呆症和缺血性脑损伤后遗症中脑乙酰胆碱神经元的功能障碍和脑中风 或由选择性神经元死亡引起的记忆障碍。

公开(公告)号：US06797726B1

公开(公告)日：2004-09-28

申请号：US09926739

申请日：2001-12-11

申请人： Satoshi Ono ,  Akihito Saitoh ,  Noboru Iwakami ,  Masaya Nakagawa ,  Sumie Yamaguchi

发明人： Satoshi Ono ,  Akihito Saitoh ,  Noboru Iwakami ,  Masaya Nakagawa ,  Sumie Yamaguchi

IPC分类号： A61K3138

CPC分类号： C07D235/06 ,  C07C217/10 ,  C07C2602/08 ,  C07D215/14 ,  C07D241/42 ,  C07D277/64 ,  C07D307/79 ,  C07D311/22 ,  C07D317/54 ,  C07D319/18 ,  C07D333/54 ,  C07D333/56 ,  C07D333/62 ,  C07D333/68

摘要： An N-alkoxyalkyl-N,N-dialkylamine derivative represented by the following general formula [1]: wherein the ring D represents a 5- or 6-membered heterocyclic ring or hydrocarbon ring; R3 and R4, which are the same or different, represent an unsubstituted or substituted alkyl, cycloalkyl or aralkyl group; and R1, R2, R5, R6, R7, R8, m and n are as defined in the specification, or a salt thereof has an anti-hypoxic activity, a nerve-protecting activity and a nerve regeneration promoting activity and is useful for the treatment of neurodegenerative diseases.

摘要翻译： 由以下通式[1]表示的N-烷氧基烷基-N，N-二烷基胺衍生物：其中环D表示5或6元杂环或烃环; R 3和R 4相同或不同，表示未取代或取代的烷基，环烷基或芳烷基; 和R 1，R 2，R 5，R 6，R 7，R 8，m和n如说明书中所定义，或其盐具有抗缺氧性 活性，神经保护活性和神经再生促进活性，可用于治疗神经变性疾病。

公开(公告)号：US07661887B2

公开(公告)日：2010-02-16

申请号：US12143336

申请日：2008-06-20

申请人： Masaya Nakagawa

发明人： Masaya Nakagawa

IPC分类号： G02B6/38 ,  G02B6/36

CPC分类号： G02B6/4296 ,  G02B6/4246 ,  G02B6/4292 ,  G02B2006/4297

摘要： According to the shutter assembly of the present invention, since the guide groove for facilitating the insertion of the pivot shaft into the bearing hole of the second bearing part of the shutter member is formed at the opposing end surface of the second bearing part that faces to the first bearing part of the shutter member so that the guide groove is opened to the opposing end surface and is along the direction orthogonal to the axial-line direction of the pivot shaft, it is possible to easily and accurately form the guide groove.

摘要翻译： 根据本发明的闸门组件，由于用于便于将枢轴插入活门构件的第二轴承部分的轴承孔中的导槽形成在第二轴承部分的相对端面上， 活门构件的第一承载部分，使得导向槽朝向相对的端面开口并且沿着与枢转轴的轴线方向正交的方向，可以容易且精确地形成导向槽。

公开(公告)号：US07648286B2

公开(公告)日：2010-01-19

申请号：US12143277

申请日：2008-06-20

申请人： Masaya Nakagawa

发明人： Masaya Nakagawa

IPC分类号： G02B6/38 ,  G02B6/36

CPC分类号： G02B6/4296 ,  G02B6/4201 ,  G02B6/424 ,  G02B6/4246 ,  G02B6/4255 ,  G02B6/4256 ,  G02B6/4261 ,  G02B6/4292 ,  G02B2006/4297

摘要： According to the shutter assembly of the present invention, since the shutter member is connected in a swingable manner with the shutter housing that could be mounted on the optical adapter so as to surround the optical adapter, it is possible to easily provide the shutter member in either of the SC or LC optical adapter only by mounting the shutter housing on the SC or LC type optical adapter.

摘要翻译： 根据本发明的活门组件，由于活门构件与可安装在光学适配器上的遮光罩外壳以可摆动的方式连接，以便围绕光学适配器，因此可以容易地将遮光构件 只有通过将快门外壳安装在SC或LC型光学适配器上，才能使用SC或LC光纤适配器。

公开(公告)号：US08506174B2

公开(公告)日：2013-08-13

申请号：US13150567

申请日：2011-06-01

申请人： Masaya Nakagawa

发明人： Masaya Nakagawa

IPC分类号： G02B6/36

CPC分类号： G02B6/3897 ,  G02B6/3825 ,  G02B6/3893

摘要： An optical connector includes a second operation lever extending rearward from a first operation lever. By pressing a rear end portion of the second operation lever up, or pressing the second operation lever forward, the first operation lever can be inclined forward. In this way, a front end portion of the first operation lever presses a rear end portion of a locking lever down, and disengages the locking lever and an optical adapter from each other. Thus, the optical connector can be detached from the optical adapter.

摘要翻译： 光学连接器包括从第一操作杆向后延伸的第二操作杆。 通过向上按压第二操作杆的后端部或向前按压第二操作杆，第一操作杆可以向前倾斜。 以这种方式，第一操作杆的前端部向下按压锁定杆的后端部，并且使锁定杆和光学适配器彼此脱离。 因此，光学连接器可以从光学适配器拆下。

公开(公告)号：US20070165984A1

公开(公告)日：2007-07-19

申请号：US11643083

申请日：2006-12-21

申请人： Masaya Nakagawa

发明人： Masaya Nakagawa

IPC分类号： G02B6/38

CPC分类号： G02B6/3825 ,  G02B6/3897

摘要： There is provided optical adaptor mounting metal fittings for mounting an optical adaptor on a panel through it without wobbling and an optical adaptor with the mounting metal fittings attached thereto. An optical adaptor mounting metal fittings to be attached to the outer surface of an optical adaptor comprises a joining plate and a pair of facing side plates extending from either side of the joining plate nearly at a right angle, the side plates each comprise an elastic click engagement formed by cutting out and raising the middle part of the side plate so that the front end thereof closely faces the panel. A first side plate piece that is on the joining plate side of the elastic click engagement, and a second side plate piece that is on the opposite side of the elastic click engagement to the first side plate piece, and first elastic engagements each obliquely extending from the front end of the second side plate piece toward the joining plate and the optical adaptor are provided.

摘要翻译： 提供了光学适配器安装金属配件，用于通过其将光学适配器安装在面板上而不产生摆动，并且光学适配器具有附接到其上的安装金属配件。 要安装在光学适配器的外表面上的光学适配器安装金属配件包括接合板和一对相对的侧板，几乎以直角从接合板的任一侧延伸，侧板各自包括弹性单击 通过切割和提升侧板的中间部分使得其前端紧密面对面板而形成接合。 第一侧板件，其位于弹性止动卡合的接合板侧，以及第二侧板件，其位于与第一侧板件的弹性止动接合的相对侧上，以及第一弹性接合部， 第二侧板件的前端朝向接合板和光适配器。