公开(公告)号：US08481565B2

公开(公告)日：2013-07-09

申请号：US11793722

申请日：2005-12-27

申请人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

发明人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

IPC分类号： A01N43/42 ,  A61K9/14

CPC分类号： A61K9/2054 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K31/445

摘要： The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.

公开(公告)号：US20070208016A1

公开(公告)日：2007-09-06

申请号：US10590976

申请日：2005-03-04

申请人： Yasuyuki Suzuki ,  Satoshi Fujioka

发明人： Yasuyuki Suzuki ,  Satoshi Fujioka

IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4035

CPC分类号： A61K47/02 ,  A61K9/1611 ,  A61K9/19 ,  A61K9/2077 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/5377 ,  A61K33/00 ,  A61K2300/00 ,  C07D209/44

摘要： The present invention provides a composition containing a benzamidine derivative that does not decompose even when placed under humidification conditions and a method for stabilizing a benzamidine derivative. According to the present invention, decomposition reaction of a benzamidine derivative can be suppressed by adding to a benzamidine derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, at least one type of electrolyte selected from the group consisting of halide salts of alkaline metal or alkaline earth metal and alkaline metal salts or alkaline earth metal salts of perchloric acid.

摘要翻译： 本发明提供含有即使在加湿条件下也不分解的苯甲脒衍生物的组合物和稳定苯甲脒衍生物的方法。 根据本发明，通过加入由通式（I）表示的苯甲脒衍生物或其药理学上可接受的盐，可以抑制苄脒衍生物的分解反应，至少一种选自以下的电解质： 碱金属或碱土金属和高氯酸的碱金属盐或碱土金属盐。

公开(公告)号：US20050042285A1

公开(公告)日：2005-02-24

申请号：US10938554

申请日：2004-09-13

申请人： Koji Ukai ,  Masaki Ichikawa ,  Takashi Kato ,  Yukiko Sugaya ,  Yasuyuki Suzuki ,  Shigeru Aoki ,  Akira Kato ,  Masao Kawamura ,  Satoshi Fujioka

发明人： Koji Ukai ,  Masaki Ichikawa ,  Takashi Kato ,  Yukiko Sugaya ,  Yasuyuki Suzuki ,  Shigeru Aoki ,  Akira Kato ,  Masao Kawamura ,  Satoshi Fujioka

IPC分类号： A61K9/20 ,  A61K31/4184 ,  A61K31/4439

CPC分类号： A61K31/4439 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K31/4184

摘要： The present invention provides a chemically stable pharmaceutical preparation of a benzimidazole type compound. That is, the present invention relates to a composition comprising at least one substance selected from sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, aminoalkyl methaacrylate copolymer E, arginine aspartate, hydroxypropyl cellulose and crospovidone incorporated into a benzimidazole type compound or an alkali metal salt thereof.

摘要翻译： 本发明提供苯并咪唑型化合物的化学稳定的药物制剂。 也就是说，本发明涉及包含至少一种选自碳酸钠，碳酸钾，氢氧化钠，氢氧化钾，氨基烷基甲基丙烯酸酯共聚物E，精氨酸天冬氨酸盐，羟丙基纤维素和交聚维酮中的物质的组合物，其结合到苯并咪唑型化合物或碱 金属盐。

公开(公告)号：US08507527B2

公开(公告)日：2013-08-13

申请号：US12712959

申请日：2010-02-25

申请人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

发明人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

IPC分类号： A01N43/42 ,  A61K9/14

CPC分类号： A61K9/2054 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K31/445

摘要： The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.

摘要翻译： 本发明提供了通过向所述药物组合物中加入高分子量酸性物质，在含有抗痴呆药物和高分子量碱性物质的药物组合物中稳定抗痴呆药物的方法。 此外，本发明提供含有抗痴呆药物和高分子碱性物质的药物组合物，其中含有高分子量酸性物质以稳定抗痴呆药物。 此外，本发明提供了一种制备药物组合物的方法，其包括以下步骤：将含有高分子量酸性物质的溶液或悬浮液加入到抗痴呆药物和高分子量碱性物质的混合物中， 稳定抗痴呆药物。

公开(公告)号：US20080213368A1

公开(公告)日：2008-09-04

申请号：US11793722

申请日：2005-12-27

申请人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

发明人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

IPC分类号： A61K9/10 ,  A61K31/445

CPC分类号： A61K9/2054 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K31/445

摘要： The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.

摘要翻译： 本发明提供了通过向所述药物组合物中加入高分子量酸性物质，在含有抗痴呆药物和高分子量碱性物质的药物组合物中稳定抗痴呆药物的方法。 此外，本发明提供含有抗痴呆药物和高分子碱性物质的药物组合物，其中含有高分子量酸性物质以稳定抗痴呆药物。 此外，本发明提供了一种制备药物组合物的方法，其包括以下步骤：将含有高分子量酸性物质的溶液或悬浮液加入到抗痴呆药物和高分子量碱性物质的混合物中， 稳定抗痴呆药物。

公开(公告)号：US20100152164A1

公开(公告)日：2010-06-17

申请号：US12712959

申请日：2010-02-25

申请人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

发明人： Yosuke Ueki ,  Yasuyuki Suzuki ,  Satoshi Fujioka

IPC分类号： A61K31/445 ,  A61K31/27 ,  A61K31/55 ,  A61K31/454 ,  A61P25/28

CPC分类号： A61K9/2054 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2027 ,  A61K31/445

摘要： The present invention provides a method for stabilizing an anti-dementia drug in a pharmaceutical composition containing the anti-dementia drug and a high molecular weight basic substance by adding a high molecular weight acidic substance to said pharmaceutical composition. Further, the present invention provides a pharmaceutical composition containing an anti-dementia drug and a high molecular basic substance in which a high molecular weight acidic substance is contained for stabilizing the anti-dementia drug. Furthermore, the present invention provides a method for manufacturing a pharmaceutical composition which comprises steps wherein a solution or suspension containing a high molecular weight acidic substance is added to a mixture of an anti-dementia drug and a high molecular weight basic substance for the sake of stabilizing the anti-dementia drug.

摘要翻译： 本发明提供了通过向所述药物组合物中加入高分子量酸性物质，在含有抗痴呆药物和高分子量碱性物质的药物组合物中稳定抗痴呆药物的方法。 此外，本发明提供含有抗痴呆药物和高分子碱性物质的药物组合物，其中含有高分子量酸性物质以稳定抗痴呆药物。 此外，本发明提供了一种制备药物组合物的方法，其包括以下步骤：将含有高分子量酸性物质的溶液或悬浮液加入到抗痴呆药物和高分子量碱性物质的混合物中， 稳定抗痴呆药物。

公开(公告)号：US07612066B2

公开(公告)日：2009-11-03

申请号：US10590976

申请日：2005-03-04

申请人： Yasuyuki Suzuki ,  Satoshi Fujioka

发明人： Yasuyuki Suzuki ,  Satoshi Fujioka

IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4035

CPC分类号： A61K47/02 ,  A61K9/1611 ,  A61K9/19 ,  A61K9/2077 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/5377 ,  A61K33/00 ,  A61K2300/00 ,  C07D209/44

摘要： The present invention provides a composition containing a benzamidine derivative that does not decompose even when placed under humidification conditions and a method for stabilizing a benzamidine derivative. According to the present invention, decomposition reaction of a benzamidine derivative can be suppressed by adding to a benzamidine derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, at least one type of electrolyte selected from the group consisting of halide salts of alkaline metal or alkaline earth metal and alkaline metal salts or alkaline earth metal salts of perchloric acid.

摘要翻译： 本发明提供含有即使在加湿条件下也不分解的苯甲脒衍生物的组合物和稳定苯甲脒衍生物的方法。 根据本发明，通过加入由通式（I）表示的苯甲脒衍生物或其药理学上可接受的盐，可以抑制苄脒衍生物的分解反应，至少一种选自以下的电解质： 碱金属或碱土金属和高氯酸的碱金属盐或碱土金属盐。

公开(公告)号：US20150109646A1

公开(公告)日：2015-04-23

申请号：US14584837

申请日：2014-12-29

申请人： Suguru YOKOZAWA ,  Nobuyuki Satoh ,  Yasuyuki Suzuki ,  Masato Kobayashi ,  Yuichi Sakurada ,  Mamoru Yorimoto ,  Tatsuhiko Okada ,  Daisaku Horikawa ,  Masahiro Shigemoto ,  Kazushi Takei ,  Hideaki Suzuki ,  Satoshi Iwanami

发明人： Suguru YOKOZAWA ,  Nobuyuki Satoh ,  Yasuyuki Suzuki ,  Masato Kobayashi ,  Yuichi Sakurada ,  Mamoru Yorimoto ,  Tatsuhiko Okada ,  Daisaku Horikawa ,  Masahiro Shigemoto ,  Kazushi Takei ,  Hideaki Suzuki ,  Satoshi Iwanami

IPC分类号： G06K15/14

CPC分类号： G06K15/14 ,  G06K15/102 ,  G06K2215/0094 ,  G06K2215/101 ,  H04N1/00023 ,  H04N1/00045 ,  H04N1/00087 ,  H04N1/0009 ,  H04N1/0087 ,  H04N1/0282 ,  H04N1/034 ,  H04N1/50 ,  H04N1/6033

摘要： An image capturing unit includes a sensor section that images a predetermined range including a subject; a reference chart section that is imaged by the sensor section with the subject; and an illumination light source that illuminates the subject and the reference chart section. The illumination light source is arranged at a position where a mirror reflection region that mirror reflects light entering from the illumination light source to the sensor section is outside a region of the subject and the reference chart section.

摘要翻译： 图像拍摄单元包括对包括被摄体的预定范围成像的传感器部分; 通过传感器部分与对象成像的参考图部分; 以及照明被摄体和参考图部分的照明光源。 照明光源配置在将从照明光源进入的传感器部的反射光的镜面反射区域设置在被检体的区域和基准图部的外侧的位置。

公开(公告)号：US20130230185A1

公开(公告)日：2013-09-05

申请号：US13883614

申请日：2012-04-16

申请人： Hideki Osawa ,  Heiji Maruyama ,  Yasuyuki Suzuki ,  Yosuke Kuno ,  Hirofumi Onitsuka ,  Yoshikazu Honji

发明人： Hideki Osawa ,  Heiji Maruyama ,  Yasuyuki Suzuki ,  Yosuke Kuno ,  Hirofumi Onitsuka ,  Yoshikazu Honji

IPC分类号： B60Q5/00

CPC分类号： B60Q5/00 ,  B60R11/0217 ,  F01N1/065 ,  F02M35/021 ,  F02M35/1038 ,  F02M35/1294 ,  G10K15/02

摘要： Provided is a sound generating device (20) for a vehicle, including: a plurality of pressure sensors (21a to 21d) for detecting air pressures of an air intake sound of an engine (12) and outputting the air pressures as sound pressure signals; a signal processing unit (24) for performing processing of changing the sound pressure signals in accordance with a driving condition of a vehicle (10); and loudspeakers (28a and 28b) for outputting the sound pressure signals as the air intake sound of the engine (12). Then, the plurality of pressure sensors (21a to 21d) are provided at an interval in a circumferential direction of an outer periphery of an air intake duct (15) at positions in a vicinity of an air flow meter (18) on an air cleaner (16) side with respect to a center of the air intake duct (15), the air intake duct (15) connecting the air cleaner (16) to a throttle body (17).

摘要翻译： 本发明提供一种用于车辆的发声装置（20），包括：多个用于检测发动机（12）的吸气声的空气压力并将空气压力作为声压信号输出的压力传感器（21a〜21d） 信号处理单元（24），用于根据车辆（10）的驾驶状况执行改变声压信号的处理; 以及用于输出作为发动机（12）的进气声音的声压信号的扬声器（28a和28b）。 然后，多个压力传感器（21a〜21d）在空气净化器（18）的空气流量计（18）附近的位置处，在进气管道（15）的外周的周向上隔开间隔设置 （16）相对于进气管道（15）的中心的空气吸入管道（15），将空气滤清器（16）连接到节气门体（17）的进气管道（15）。

公开(公告)号：US20120316977A1

公开(公告)日：2012-12-13

申请号：US13486271

申请日：2012-06-01

申请人： Yasuyuki Suzuki

发明人： Yasuyuki Suzuki

IPC分类号： G06Q20/20

CPC分类号： G06Q20/20

摘要： A commodity sales data processing apparatus receives input of a comprehension degree which indicates the comprehension degree of a customer purchasing the commodity whose explanation is required by a salesperson if the sales data of the commodity whose explained is required by the salesperson is input through an input unit, and stores an information indicating the comprehension degree received in association with an identification information of at least one of the commodity and the salesperson.

摘要翻译： 商品销售数据处理装置接收输入的理解度，其指示如果销售人员所要求的商品的销售数据通过输入单元输入的，则销售人员需要解释的商品的购买商品的理解度的输入 并且存储指示与商品和销售员中的至少一个的识别信息相关联的表示理解度的信息。