公开(公告)号：US20230223147A1

公开(公告)日：2023-07-13

申请号：US18123435

申请日：2023-03-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: G16H20/60 ,  G16H50/70 ,  G16H10/60

CPC classification number: G16H20/60 ,  G16H50/70 ,  G16H10/60

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

公开(公告)号：US20210142905A1

公开(公告)日：2021-05-13

申请号：US17151232

申请日：2021-01-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: G16H50/20 ,  G06N20/00 ,  G16H10/60 ,  G16H50/70 ,  G16H20/60

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

公开(公告)号：US20190022152A1

公开(公告)日：2019-01-24

申请号：US16151455

申请日：2018-10-04

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Eran ELINAV ,  Eran SEGAL

IPC: A61K35/741 ,  C12Q1/6883 ,  C12Q1/04 ,  C12Q1/02

Abstract: A method of determining tolerance to an agent in a healthy subject is disclosed. The method comprises: (a) determining a signature of a microbiome in a sample of the healthy subject who has been subjected to the agent or condition; and (b) comparing the signature of the microbiome of the healthy subject to at least one reference signature of a pathological microbiome, wherein when the signature of the microbiome of the healthy subject is statistically significantly similar to the reference signature of the pathological microbiome, it is indicative that the healthy subject is intolerant to the agent.

公开(公告)号：US20180140648A1

公开(公告)日：2018-05-24

申请号：US15575827

申请日：2016-05-17

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: A61K35/747 ,  A61K35/745 ,  A61P3/08

CPC classification number: A61K35/747 ,  A61K35/741 ,  A61K35/744 ,  A61K35/745 ,  A61K2300/00 ,  A61P3/08 ,  Y02A50/47 ,  Y02A50/473 ,  Y02A50/475

Abstract: A method of improving the glucose response in glucose tolerant and intolerant subjects is provided. The method comprises providing to the subject probiotic compositions, or agents which specifically reduce bacterial species.

公开(公告)号：US20210353611A1

公开(公告)日：2021-11-18

申请号：US17277441

申请日：2019-09-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Eran SEGAL

IPC: A61K31/455 ,  A61K35/74 ,  A61P25/28

Abstract: A method of treating ALS in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount at least two metabolites.

公开(公告)号：US20200206283A1

公开(公告)日：2020-07-02

申请号：US16683332

申请日：2019-11-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: A61K35/747 ,  A61K35/745 ,  A61K35/744 ,  A61K35/741 ,  A61P3/08

Abstract: A method of improving the glucose response in glucose tolerant and intolerant subjects is provided. The method comprises providing to the subject probiotic compositions, or agents which specifically reduce bacterial species.

公开(公告)号：US20190142875A1

公开(公告)日：2019-05-16

申请号：US16077751

申请日：2017-02-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eran ELINAV ,  Eran SEGAL

IPC: A61K35/741 ,  A23L33/135 ,  A23L33/105 ,  A23L33/00 ,  A61K31/352 ,  C12Q1/689 ,  A61P3/04

Abstract: A method of analyzing the likelihood of weight regain in a subject who has reached a target weight by practicing a weight loss program is disclosed. The method comprises determining an amount or presence of at least one microbe and/or product thereof in the gut microbiome of the subject, wherein the amount of the at least one microbe is altered during a prior weight gain period of the subject to reach a level representative of an obese subject and further wherein the amount of the at least one microbe is retained at the level following the weight loss program, wherein the amount or presence of the at least one microbe or product thereof is predictive of weight regain.

公开(公告)号：US20160232311A1

公开(公告)日：2016-08-11

申请号：US15022643

申请日：2015-04-28

Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: G06F19/00 ,  G06N99/00

CPC classification number: G16H50/20 ,  G06F19/3475 ,  G06N20/00 ,  G16H50/70 ,  Y02A90/26

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

Abstract translation: 公开了预测受试者对食物的反应的方法。 该方法包括：选择对象的反应未知的食物; 访问具有描述所述对象的数据的第一数据库，而不是所述对象对所选食物的响应; 访问具有与其他受试者对食物有关的数据的第二数据库，其他对象的反应包括至少一个其他受试者对所选食物的反应或与所述选定食物相似的食物; 以及基于所选择的食物分析数据库以估计受试者对所选食物的反应。

公开(公告)号：US20230076246A1

公开(公告)日：2023-03-09

申请号：US17800245

申请日：2020-02-17

Applicant: Yeda Research and Development Co. Ltd. ,  Mor Research Applications Ltd.

Inventor： Eran SEGAL ,  Smadar SHILO ,  Yotam AMAR

IPC: A61B5/00 ,  G06N3/08 ,  A61B5/145

Abstract: A method of predicting an analyte level comprises receiving a time-ordered series of levels of the analyte, monitored over a time-period; feeding a trained neural network procedure with the monitored levels; and displaying, based on an output received from the procedure, a predicted level of the analyte in a future time. The procedure can comprise a plurality of layers, wherein for at least one pair of layers, a number of inter-layer connections within the pair is higher for later monitored levels than for earlier monitored levels.

公开(公告)号：US20220328185A1

公开(公告)日：2022-10-13

申请号：US17614024

申请日：2020-05-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Smadar SHILO ,  Nitzan ARTZI

IPC: G16H50/20 ,  G16H50/30 ,  G16H10/60 ,  G16H50/70 ,  G16H10/20

Abstract: A method of predicting likelihood for gestational diabetes, comprises: obtaining a plurality of parameters characterizing a female subject, accessing a computer readable medium storing a machine learning procedure trained for predicting likelihoods for gestational diabetes, feeding the procedure with the plurality of parameters, and receiving from the procedure an output indicative of a likelihood that the subject has, or expected to develop, gestational diabetes, wherein the output indicative is related non-linearly to the parameters.