公开(公告)号：US20160152991A1

公开(公告)日：2016-06-02

申请号：US15040018

申请日：2016-02-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yitzhak PILPEL ,  Tamir TULLER ,  Sivan NAVON ,  Menachem RUBINSTEIN

IPC: C12N15/67 ,  C12P21/02

CPC classification number: C12N15/67 ,  C07K14/505 ,  C07K14/555 ,  C07K14/59 ,  C07K14/61 ,  C07K14/62 ,  C07K14/705 ,  C07K14/755 ,  C12N9/2402 ,  C12N9/2465 ,  C12P21/02

Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.

Abstract translation: 公开了分离的多核苷酸，其提高异源细胞中基因表达的效率。 改编编码多肽的多核苷酸序列使得第一至少约30个氨基酸的平均翻译速率比多肽的剩余氨基酸的平均翻译速度慢至少两倍。