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公开(公告)号：US20110256127A1
公开(公告)日：2011-10-20
申请号：US13069582
申请日：2011-03-23
申请人： Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
发明人： Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/526 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
摘要翻译： 本发明提供抗LRP6抗体及其使用方法。 本发明的一个特定方面提供了抑制多种Wnt同种型的信号通路的双特异性抗LRP6抗体。
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公开(公告)号：US08846041B2
公开(公告)日：2014-09-30
申请号：US13069582
申请日：2011-03-23
申请人： Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
发明人： Eric Bourhis , Tim Cao , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
IPC分类号： A61K39/395 , C07K16/28 , C12P21/08 , A61K39/00
CPC分类号： C07K16/28 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/526 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
摘要翻译： 本发明提供抗LRP6抗体及其使用方法。 本发明的一个特定方面提供了抑制多种Wnt同种型的信号通路的双特异性抗LRP6抗体。
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公开(公告)号：US08535675B2
公开(公告)日：2013-09-17
申请号：US12956282
申请日：2010-11-30
申请人： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
发明人： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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4.发明申请WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS 审中-公开WNT拮抗剂及其在诊断和治疗WNT介导性疾病中的应用公开(公告)号：US20120141481A1
公开(公告)日：2012-06-07
申请号：US13367760
申请日：2012-02-07
IPC分类号： A61K39/395 , A61M37/00 , A61P35/00 , C07K16/18 , C07K14/705
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/71 , G01N2333/71 , Y02A50/473
摘要： The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
摘要翻译： 本发明提供了包含衍生自卷曲蛋白的Frz结构域组分，分泌的卷曲相关蛋白或Ror蛋白和Fc免疫球蛋白组分的嵌合Wnt拮抗剂，以及它们在细胞Wnt信号传导和Wnt介导的治疗和诊断检测中的用途 疾病，包括癌症。
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5.发明申请WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS 审中-公开WNT拮抗剂及其在诊断和治疗WNT介导性疾病中的应用公开(公告)号：US20110311534A1
公开(公告)日：2011-12-22
申请号：US13113211
申请日：2011-05-23
IPC分类号： A61K39/395 , A61P35/00 , C07K19/00 , C12N5/071 , C12N5/09
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/71 , G01N2333/71 , Y02A50/473
摘要： The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
摘要翻译： 本发明提供了包含衍生自卷曲蛋白的Frz结构域组分，分泌的卷曲相关蛋白或Ror蛋白和Fc免疫球蛋白组分的嵌合Wnt拮抗剂，以及它们在细胞Wnt信号传导和Wnt介导的治疗和诊断检测中的用途 疾病，包括癌症。
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公开(公告)号：US20110137016A1
公开(公告)日：2011-06-09
申请号：US12956282
申请日：2010-11-30
申请人： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
发明人： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
CPC分类号： C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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7.发明授权Wnt antagonists and their use in the diagnosis and treatment of Wnt-mediated disorders 有权Wnt拮抗剂及其在诊断和治疗Wnt介导的疾病中的应用公开(公告)号：US07947277B2
公开(公告)日：2011-05-24
申请号：US11851596
申请日：2007-09-07
IPC分类号： A61K38/01 , A61K38/00 , C07K19/00 , A61K39/385
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/71 , G01N2333/71 , Y02A50/473
摘要： The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
摘要翻译： 本发明提供了包含衍生自卷曲蛋白的Frz结构域组分，分泌的卷曲相关蛋白或Ror蛋白和Fc免疫球蛋白组分的嵌合Wnt拮抗剂，以及它们在细胞Wnt信号传导和Wnt介导的治疗和诊断检测中的用途 疾病，包括癌症。
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8.发明申请WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS 审中-公开WNT拮抗剂及其在诊断和治疗WNT介导性疾病中的应用公开(公告)号：US20100266593A1
公开(公告)日：2010-10-21
申请号：US12826194
申请日：2010-06-29
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , C12N5/07
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/71 , G01N2333/71 , Y02A50/473
摘要： The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
摘要翻译： 本发明提供了包含衍生自卷曲蛋白的Frz结构域组分，分泌的卷曲相关蛋白或Ror蛋白和Fc免疫球蛋白组分的嵌合Wnt拮抗剂，以及它们在细胞Wnt信号传导和Wnt介导的治疗和诊断检测中的用途 疾病，包括癌症。
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公开(公告)号：US20090280056A1
公开(公告)日：2009-11-12
申请号：US11978122
申请日：2007-10-26
申请人： Mark S. Dennis , Bonnee Rubinfeld , Paul Polakis , Aya Jakobovits
发明人： Mark S. Dennis , Bonnee Rubinfeld , Paul Polakis , Aya Jakobovits
IPC分类号： A61K51/10 , C07K16/30 , C07H21/00 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/06 , C12N5/00 , C12P21/00 , G01N33/53 , A61K39/395 , G01N33/68 , A61K51/00 , G01N33/574 , C07K1/107
CPC分类号： G01N33/57434 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6869 , A61K47/6871 , A61K49/0002 , A61K49/0058 , A61K51/1045 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K17/00 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
摘要翻译： 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。
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公开(公告)号：US08436147B2
公开(公告)日：2013-05-07
申请号：US11978122
申请日：2007-10-26
申请人： Mark S. Dennis , Bonnee Rubinfeld , Paul Polakis , Aya Jakobovits
发明人： Mark S. Dennis , Bonnee Rubinfeld , Paul Polakis , Aya Jakobovits
IPC分类号： C12P21/08
CPC分类号： G01N33/57434 , A61K38/05 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6869 , A61K47/6871 , A61K49/0002 , A61K49/0058 , A61K51/1045 , A61K51/1072 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K17/00 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.
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