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    Skin Lightening Compositions
    3.
    发明申请
    Skin Lightening Compositions 审中-公开

    公开(公告)号：US20140154190A1

    公开(公告)日：2014-06-05

    申请号：US14175360

    申请日：2014-02-07

    申请人： Yoko Niki ,  Masaki Yoshida ,  Masamitsu Ichihashi ,  Hideya Ando ,  Daniel B. Yarosh ,  Mary S. Matsui

    发明人： Yoko Niki ,  Masaki Yoshida ,  Masamitsu Ichihashi ,  Hideya Ando ,  Daniel B. Yarosh ,  Mary S. Matsui

    IPC分类号： A61K8/49 ,  A61Q17/04 ,  A61Q19/02

    CPC分类号： A61K8/4946 ,  A61K8/49 ,  A61K2800/782 ,  A61Q17/04 ,  A61Q19/02

    摘要： Compositions and methods for lightening and/or depigmenting skin are provided, the compositions comprising compounds having the structure: wherein: R1 and R2 are same or different and are each selected from the group consisting of hydrogen, alkyl, carbomethoxy, carboethoxy, alkoxy, and alkanoyl, any of which may be halogen-substituted, and halogen; R6 is selected from the group consisting of hydrogen, methyl, and ethyl; and R3, R4 and R5 are the same or different and are each selected from the group consisting of hydrogen, methyl, methoxy, ethoxy, methoxyethoxy, ethoxyethoxy, propoxy, propoxymethoxy, and the like, any of which may be halogen-substituted; or having the structure: wherein: R2 is hydrogen, lower alkyl or hydroxy lower alkyl; R3 is lower alkyl, —CH2CN, hydroxy lower alkyl, —NO, —CH2N═C or (wherein R6 and R7 are independently selected from the group consisting of hydrogen and lower alkyl) or hydrogen provided R2 is not hydrogen; R4 is Z-T-W wherein Z represents —O—, —NH— or a single bond; T represents a straight- or branched-chain lower-alkylene group; when Z is a single bond, T also represents an ethenylene or a propenylene group wherein the unsaturated carbon is at the single bond; when Z is —O—, T also represents an allylene group wherein the saturated carbon is at the oxygen; and W represents hydrogen, when T is allylene and Z is —O—, and Ar, wherein Ar is selected from thienyl, pyridinyl, furanyl, phenyl and substituted phenyl wherein there are one or more substituents on the phenyl independently selected from halogen or lower alkyl; and R5 is hydrogen, halogen or lower alkyl; or pharmaceutically-, cosmetically- and dermatologically-acceptable salts, solvates, and bioprecursors, and stereoisomers and enantiomers of these compounds, free from or mixed with other enantiomers or stereoisomers; and such compounds in compositions with a pharmaceutically-, cosmetically- or dermatologically-acceptable carrier thereof comprising a safe and effective amount of the skin lightening or depigmenting compound.

    Skin-whitening cosmetic
    6.
    发明授权
    Skin-whitening cosmetic 有权
    美白化妆品

    公开(公告)号：US06669932B2

    公开(公告)日：2003-12-30

    申请号：US09445562

    申请日：2000-03-14

    申请人： Hiromichi Imanaka ,  Hideya Ando ,  Taketoshi Makino

    发明人： Hiromichi Imanaka ,  Hideya Ando ,  Taketoshi Makino

    IPC分类号： A61K9127

    CPC分类号： A61K8/361 ,  A61K8/0212 ,  A61K8/14 ,  A61K8/37 ,  A61K8/375 ,  A61K8/553 ,  A61K8/64 ,  A61K8/65 ,  A61K8/67 ,  A61K8/676 ,  A61K8/678 ,  A61K8/735 ,  A61Q19/02 ,  A61Q19/10

    摘要： A skin-whitening cosmetic material which contains an unsaturated fatty acid or a derivative thereof as the active ingredient, is highly effective in making the color of pigmentation on the skin lighter at a lower concentration, and is highly safe. The skin-whitening cosmetic material comprises (A) at least one member selected from unsaturated fatty acids having from 18 to 22 carbon atoms and having from 2 to 6 double bonds in the molecular structure, and derivatives thereof, (B) a phospholipid, (C) an antioxidant, (D) at least one member selected from proteins and hydrolyzates thereof, and (E) at least one member selected from muco-polysaccharides and salts thereof.

    摘要翻译： 含有不饱和脂肪酸或其衍生物作为活性成分的皮肤美白化妆品，能够以更低的浓度使皮肤上色素沉着的颜色变得更亮，并且是高度安全的。 皮肤美白化妆品包含（A）选自具有18-22个碳原子的不饱和脂肪酸和分子结构中具有2至6个双键的至少一种，及其衍生物，（B）磷脂， C）抗氧化剂，（D）选自蛋白质及其水解产物中的至少一种，和（E）选自粘多糖及其盐中的至少一种。