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    Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
    4.
    发明授权
    Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol 失效
    来自2-苯基-1,2-乙二醇的卤素取代的氨基甲酸酯化合物

    公开(公告)号：US5698588A

    公开(公告)日：1997-12-16

    申请号：US586497

    申请日：1996-01-16

    申请人： Yong Moon Choi ,  Min Woo Kim

    发明人： Yong Moon Choi ,  Min Woo Kim

    IPC分类号： A61P25/00 ,  A61K31/27 ,  A61P25/08 ,  C07C271/10 ,  C07C271/12 ,  C07C271/28

    CPC分类号： A61K31/27 ,  C07C271/12 ,  C07B2200/07

    摘要： The pure enantiomeric forms, as well as enantiomeric mixtures excluding the racemic mixture of monocarbamates of 2-phenyl-1,2-ethanediol substituted with more than one halogen atom on the phenyl ring and dicarbamates of 2-phenyl-1,2-ethanediol substituted with more than one halogen atom on the phenyl ring have been found to be effective in the treatment of disorders of the central nervous system.

    摘要翻译： 纯对映异构体形式，以及除苯基环上被一个以上卤素原子取代的2-苯基-1,2-乙二醇的单体氨基甲酸酯的外消旋混合物和2-苯基-1,2-乙二醇取代的二异氰酸酯的对映体混合物 已经发现苯环上多于一个的卤素原子在治疗中枢神经系统紊乱中是有效的。

    Phenylcarbamate compound and muscle relaxant containing the same
    5.
    发明授权
    Phenylcarbamate compound and muscle relaxant containing the same 有权
    苯基氨基甲酸酯化合物和含有相同的肌肉松弛剂

    公开(公告)号：US09018253B2

    公开(公告)日：2015-04-28

    申请号：US13175025

    申请日：2011-07-01

    申请人： Yong Moon Choi

    发明人： Yong Moon Choi

    IPC分类号： C07C261/00 ,  A61K31/27 ,  C07C271/12 ,  C07C271/24

    CPC分类号： C07C271/12 ,  A61K31/27 ,  C07C271/24 ,  C07C2601/02 ,  C07C2601/14

    摘要： A novel phenylcarbamate compound and a pharmaceutical composition containing the same are provided. More specifically, a novel phenylcarbamate compound, a composition for muscle relaxation containing the phenylcarbamate compound as an active ingredient, and a method of muscle relaxation comprising administering a therapeutically effective amount of the phenylcarbamate compound, are provided.

    摘要翻译： 提供了新的苯基氨基甲酸酯化合物和含有它们的药物组合物。 更具体地，提供新的苯基氨基甲酸酯化合物，包含苯基氨基甲酸酯化合物作为活性成分的肌肉松弛组合物和包括施用治疗有效量的苯基氨基甲酸酯化合物的肌肉松弛方法。

    PHENYLCARBAMATE COMPOUND AND MUSCLE RELAXANT CONTAINING THE SAME
    6.
    发明申请
    PHENYLCARBAMATE COMPOUND AND MUSCLE RELAXANT CONTAINING THE SAME 有权
    苯并噻唑类化合物和包含它的肌松弛剂

    公开(公告)号：US20140051753A9

    公开(公告)日：2014-02-20

    申请号：US13175025

    申请日：2011-07-01

    申请人： Yong Moon Choi

    发明人： Yong Moon Choi

    IPC分类号： A61K31/27 ,  A61P25/00 ,  A61P21/02 ,  A61P21/00 ,  C07C271/12 ,  C07C271/24

    CPC分类号： C07C271/12 ,  A61K31/27 ,  C07C271/24 ,  C07C2601/02 ,  C07C2601/14

    摘要： A novel phenylcarbamate compound and a pharmaceutical composition containing the same are provided. More specifically, a novel phenylcarbamate compound, a composition for muscle relaxation containing the phenylcarbamate compound as an active ingredient, and a method of muscle relaxation comprising administering a therapeutically effective amount of the phenylcarbamate compound, are provided.

    摘要翻译： 提供了新的苯基氨基甲酸酯化合物和含有它们的药物组合物。 更具体地，提供新的苯基氨基甲酸酯化合物，包含苯基氨基甲酸酯化合物作为活性成分的肌肉松弛组合物和包括施用治疗有效量的苯基氨基甲酸酯化合物的肌肉松弛方法。

    Methods for Treatment of Sexual Dysfunction
    7.
    发明申请
    Methods for Treatment of Sexual Dysfunction 有权
    治疗性功能障碍的方法

    公开(公告)号：US20090221553A1

    公开(公告)日：2009-09-03

    申请号：US11922128

    申请日：2006-06-13

    申请人： Joseph Palumbo ,  Jonathan Sporn ,  Thomas Steckler ,  Yong Moon Choi ,  James S. Lee

    发明人： Joseph Palumbo ,  Jonathan Sporn ,  Thomas Steckler ,  Yong Moon Choi ,  James S. Lee

    IPC分类号： A61K31/553 ,  A61K31/27 ,  A61K31/55 ,  A61P15/00

    CPC分类号： A61K31/165

    摘要： This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and O to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

    摘要翻译： 本发明涉及治疗受试者的性功能障碍的方法，其包括施用治疗有效量的式（I）化合物或其药学上可接受的盐或酯的步骤，其中Rx是选自下组的成员 由氢，1至8个碳原子的低级烷基，选自F，Cl，Br和I的卤素，含有1至3个碳原子的烷氧基，硝基，羟基，三氟甲基和含有1至3个碳原子的硫代烷氧基组成; x为1〜3的整数，条件是当x为2或3时R可以相同或不同; R 1和R 2可以相同或不同，并且独立地选自氢，1至8个碳原子的低级烷基，芳基，芳基烷基，3至7个碳原子的环烷基; R1和R2可以连接形成被选自氢，烷基和芳基的成员所取代的5至7元杂环，其中环状化合物可包含1至2个氮原子和0至1个氧原子 其中氮原子彼此不直接连接或与氧原子直接连接。

    Transnasal anticonvulsive compositions and modulated process
    8.
    发明授权
    Transnasal anticonvulsive compositions and modulated process 失效
    经鼻抗惊厥组合物和调节过程

    公开(公告)号：US06627211B1

    公开(公告)日：2003-09-30

    申请号：US09624305

    申请日：2000-07-24

    申请人： Yong Moon Choi ,  Lianli Li ,  Kwon H. Kim

    发明人： Yong Moon Choi ,  Lianli Li ,  Kwon H. Kim

    IPC分类号： A61F1300

    CPC分类号： A61K9/0043 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  Y10S514/975

    摘要： A method of vehicle modulated administration of an anticonvulsive agent to the nasal mucous membranes of humans and animals is disclosed. The vehicle system is an aqueous pharmaceutical carrier comprising an aliphatic alcohol, a glycol and a biological surfactant such as a bile salt or a lecithin. The pharmaceutical composition provides a means to control and promote the rate and extent of transmucosal permeation and absorption of the medicaments via a single and multiple administration. Nasal administration of the pharmaceutical preparation produces a high plasma concentration of the anticonvulsant nearly as fast as intravenous administration. Such compositions are particularly suitable for a prompt and timely medication of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.

    摘要翻译： 公开了一种向人和动物的鼻粘膜施用抗惊厥药的车辆调节方法。 载体系统是包含脂族醇，二醇和生物表面活性剂如胆汁盐或卵磷脂的水性药物载体。 药物组合物通过单次和多次施用提供控制和促进药物经粘膜渗透和吸收的速率和程度的手段。 药物制剂的鼻内给药几乎与静脉内施用一样快地产生抗惊厥药的高血浆浓度。 这种组合物特别适用于急性和/或紧急治疗癫痫持续状态和其他发热引起的发作的患者的及时和及时的药物。

    Sulfamate compound containing N-substituted carbamoyl group and method for preparing the same
    10.
    发明授权
    Sulfamate compound containing N-substituted carbamoyl group and method for preparing the same 失效
    含有N-取代氨基甲酰基的氨基磺酸酯化合物及其制备方法

    公开(公告)号：US5892088A

    公开(公告)日：1999-04-06

    申请号：US742929

    申请日：1996-11-01

    申请人： Yong Moon Choi ,  Dong Il Han ,  Hyung Cheol Kim

    发明人： Yong Moon Choi ,  Dong Il Han ,  Hyung Cheol Kim

    IPC分类号： C07C35/20 ,  C07C309/14 ,  C07C309/63 ,  C07C311/05

    CPC分类号： C07C35/20

    摘要： There are disclosed novel sulfamate compounds containing N-substituted carbomoyl group including their racemates and (R)- and (S)-optical isomers represented by Formulas I, II and III, pharmaceutically useful for the prophylaxis and treatment of the disorders of the central nervous system, especially for nervous myalgia, epilepsy and minimal brain dysfunction: ##STR1## (III).

    摘要翻译： 公开了含有N-取代的甲硅烷氧基的新型氨基磺酸酯化合物，包括它们的外消旋物和由式I，II和III表示的（R） - 和（S） - 光学异构体，可用于预防和治疗中枢神经疾病 系统，特别是对于紧张的肌肉酸痛，癫痫和极少的脑功能障碍：（I）（II）（III）（III）。