摘要:
The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.
摘要:
The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.
摘要:
An optically active N-(α-mercaptopropionyl)glycine, i.e., R-(−)-N-(α-mercaptopropionyl)glycine or S-(−)-N-(α-mercaptopropionyl)glycine, a preparation method thereof, a pharmaceutical preparation containing the compound or a pharmaceutically acceptable salt or ester thereof, and use of the same in preparation of detoxification medicament for improving metabolism, are provided.
摘要:
The use of levo-ornidazole in the preparation of medicine for preventing and treating the anti-anaerobic bacteria infection is provided. It is demonstrated that levo-ornidazole exhibits lower toxicity and less central inhibition effects than dextro-ornidazole or racemic ornidazole. L-ornidazole possesses pharmacokinetics characteristics, which are superior to that of the racemic ornidazole, and anti-anaerobic activities which are slightly better than or substantially the same as that of the racemic ornidazole. Also, this invention particularly relates to a preparation process, which comprises formulating L-ornidazole as anti-anaerobic infection pharmaceutical preparations, which are suitable for clinical uses.
摘要:
The use of levo-ornidazole in the preparation of anti-parasitic infection drug is provided. It is demonstrated that levo-ornidazole is superior to dextro-ornidazole and racemic ornidazole in the therapeutic action against parasitization (especially trichomonas vaginalis infection and cecal amoeba infection), and thus it is more practicable to formulate L-ornidazole as anti-parasitic infection drugs, and particularly as drug preparations which are suitable for clinical uses, including oral preparation, intravenous preparation and vaginal preparation.
摘要:
The use of levo-ornidazole in the preparation of medicine for preventing and treating the anti-anaerobic bacteria infection is provided. It is demonstrated that levo-ornidazole exhibits lower toxicity and less central inhibition effects than dextro-ornidazole or racemic ornidazole. L-ornidazole possesses pharmacokinetics characteristics, which are superior to that of the racemic ornidazole, and anti-anaerobic activities which are slightly better than or substantially the same as that of the racemic ornidazole. Also, this invention particularly relates to a preparation process, which comprises formulating L-ornidazole as anti-anaerobic infection pharmaceutical preparations, which are suitable for clinical uses.
摘要:
A computer system comprises a keyboard with a plurality of touchbands, each of which is a narrow multi-touch touchpad, a display device and a computer touchband device application program executable on the computer processor configured to manage a multi-level context-dependent cascading menu interface wherein each menu item includes a plurality of drag-control functions, a plurality of tap commands and a plurality of submenu items; specify a plurality of menu operations, a plurality of control-drag operations and a plurality of command-tap operations from the multi-touch gestures on the touchbands; move the highlight in the menu structure based on the menu operations and display highlighted menu item contents under the active menu layer; change the value of the specified drag-control function listed for the highlighted menu item when detected a control-drag operation; trigger the specified tap command listed for the highlighted menu item when detected a command-tap operation.
摘要:
The present invention discloses the Theory and Method of Unified Internet Integration (UII) which is characterized in followings: the foundation theory of internet map/platform iconology, a series of conceptual definitions, specifications, standards and methods including a complete theoretical system and methodology invented to integrate all the Internet and other local area networks such as GIS, IoT, Block Chain etc into a whole. Especially, the present invention proposed a new concept of Positioning Oriented Architecture (POA) first time in the world and in computer science, and proposed a data structure of POA to organize all different types of icon positioning resources with other IP Address resources and service resources in a uniformed data format to form an icon positioning object to be transferred and used in all network platforms. This is impossible by all current traditional internet and network's theories and technologies.
摘要:
A heat pipe based passive residual heat removal system for a spent fuel pool (3). Partitions (6) are arranged around an inside of the spent fuel pool. Evaporation-end heat pipes (4) are arranged between the outside of the partitions and an inner wail of the pool. The evaporation-end heat pipes have outlets that extend beyond the pool and are connected to an Inlet of an ascending pipe (10), and have inlets connected to an outlet of a descending pipe (5). Condensation-end heat pipes (7) have inlets connected to an outlet of the ascending pipe, and have outlets connected to an inlet of the descending pipe. The heat pipes cool the spent fuel pool. A heat exchange by phase change of working medium in the heat pipe leads to heat exchange of low temperature difference and high efficiency, relying on density difference for natural circulation drive.