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1.发明授权Bone graft and scaffolding materials immobilized with osteogenesis enhancing peptides on the surface 有权骨移植物和脚手架材料固定在骨形成增强肽表面公开(公告)号：US07897163B2
公开(公告)日：2011-03-01
申请号：US10593430
申请日：2005-03-18
CPC分类号： A61K38/10 , A61F2/2875 , A61F2002/2817 , A61F2002/2835 , A61F2002/30678 , A61F2002/4648 , A61F2310/00023 , A61F2310/00293 , A61K38/16 , A61K38/1875 , A61L27/22 , A61L2430/02
摘要： The present invention relates to a bone graft material and a scaffold for tissue engineering applications, which have an osteogenesis-promoting peptide immobilized on the surface. More particularly, the invention relates to a bone graft material and a scaffold for tissue engineering applications, which have a cell adhesion-inducing peptide and/or tissue growth factor-derived peptide immobilized on the surface. By the osteogenesis-promoting peptide immobilized on the surface, the inventive bone graft material and scaffold for tissue engineering applications can promote the transition, proliferation and differentiation of cells associated with regeneration, and eventually maximize the regeneration of tissue. Moreover, the peptide immobilized on the surface has low molecular weight, indicating a reduced risk of immune responses upon its application in the body, and can be present in a stable form within the body, thus showing lasting effects. Accordingly, the peptide makes it expedient to perform surgical operations for the regeneration of periodontal tissue, alveolar bone and other bone tissues, and will show high therapeutic effect.
摘要翻译： 本发明涉及用于组织工程应用的骨移植材料和支架，其具有固定在表面上的成骨促进肽。 更具体地，本发明涉及用于组织工程应用的骨移植材料和支架，其具有固定在表面上的细胞粘附诱导肽和/或组织生长因子衍生的肽。 通过固定在表面上的成骨促进肽，本发明的骨移植材料和用于组织工程应用的支架可以促进与再生有关的细胞的转化，增殖和分化，并且最终使组织的再生最大化。 此外，固定在表面上的肽具有低分子量，表明其在体内应用时免疫应答的风险降低，并且可以以体内的稳定形式存在，从而显示出持久的效果。 因此，肽对于进行牙周组织，牙槽骨等骨组织的再生的外科手术是有利的，并且将显示出高疗效。
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2.发明申请PEPTIDE HAVING THE ABILITY TO REGENERATE BONE TISSUE AND FOR BINDING TO APATITE 有权具有再生骨组织和绑定至APATITE的能力的肽公开(公告)号：US20130210736A1
公开(公告)日：2013-08-15
申请号：US13821811
申请日：2011-03-09
CPC分类号： C07K14/52 , A61L27/12 , A61L27/22 , A61L27/54 , A61L2300/25
摘要： The present invention relates to a peptide having bone tissue regeneration capacity and binding to surface of apatite, and more particularly, to a peptide having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral, and a composition for bone tissue regeneration, containing the peptide. The peptide having binding capacity to the apatite mineral and bone tissue regeneration capacity according to the present invention binds to the surface of apatite to thereby be present in a stable state, and thus can be used in a bone replacement material for dental or orthopedic application, and metal, natural polymers, or synthetic polymers, coated with apatite; promote transition, proliferation, and differentiation of cells associated with regeneration and eventually maximize bone tissue regeneration; and can be stably present while maintaining peptide activity when being grafted into the body and thus is useful in development of the bone tissue regeneration therapeutic technology using the peptide.
摘要翻译： 本发明涉及具有骨组织再生能力和与磷灰石表面结合的肽，更具体地，涉及具有骨组织再生能力并且特异性结合磷灰石矿物质表面的肽，能够稳定地固定在磷酸钙表面上 磷灰石矿物质通过将具有骨组织再生能力的氨基酸序列和具有磷灰石结合能力的氨基酸序列彼此连接，从而保持有效活性并长时间展现骨再生作用，从而提供具有骨形成 对磷灰石矿物表面的作用和结合能力，以及含有该肽的骨组织再生组合物。 根据本发明的具有磷灰石矿物和骨组织再生能力的结合能力的肽结合磷灰石的表面，从而以稳定的状态存在，因此可用于牙科或矫形应用的骨替代材料中， 和用磷灰石涂覆的金属，天然聚合物或合成聚合物; 促进与再生相关的细胞的转移，增殖和分化，并最终最大化骨组织再生; 并且可以在接枝入体内时保持肽活性而稳定地存在，因此可用于开发使用该肽的骨组织再生治疗技术。
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3.发明授权Peptide having the ability to regenerate bone tissue and for binding to apatite 有权具有再生骨组织和结合磷灰石的能力的肽公开(公告)号：US08853165B2
公开(公告)日：2014-10-07
申请号：US13821811
申请日：2011-03-09
IPC分类号： A61P19/08 , A61K38/16 , A61K38/10 , C07K17/02 , C07K17/14 , C07K14/00 , C07K7/08 , A61L27/12 , A61L27/22 , C07K14/52 , A61L27/54
CPC分类号： C07K14/52 , A61L27/12 , A61L27/22 , A61L27/54 , A61L2300/25
摘要： The present invention relates to a peptide having bone tissue regeneration capacity and binding to a surface of apatite. More particularly, a peptide is provided having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral. A composition for bone tissue regeneration containing the peptide is further provided.
摘要翻译： 本发明涉及具有骨组织再生能力并与磷灰石表面结合的肽。 更具体地，提供具有骨组织再生能力并且特异性结合磷灰石矿物表面的肽，其能够稳定地固定在磷灰石矿物的表面以保持有效活性并长时间显示出骨再生效果，通过将 具有骨组织再生能力的氨基酸序列和具有彼此磷灰石结合能力的氨基酸序列，从而提供具有磷灰石矿物表面的成骨作用和结合能力的肽。 还提供了含有该肽的骨组织再生用组合物。
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