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公开(公告)号：US20160242912A1
公开(公告)日：2016-08-25
申请号：US15141394
申请日：2016-04-28
IPC分类号： A61F2/30
CPC分类号： A61F2/30907 , A61B17/68 , A61B17/72 , A61B17/7233 , A61B17/7291 , A61B17/742 , A61B17/80 , A61B17/866 , A61F2/28 , A61F2/2846 , A61F2/30771 , A61F2/32 , A61F2/38 , A61F2/40 , A61F2/42 , A61F2/44 , A61F2002/2835 , A61F2002/3024 , A61F2002/30677 , A61F2002/30678 , A61F2002/30784 , A61F2002/3085 , A61F2002/3092 , A61F2310/00179 , A61F2310/00353 , A61F2310/00359 , A61F2310/00407 , A61F2310/00413 , A61F2310/00592 , A61F2310/00796
摘要： The present invention relates to orthopaedic implants having a fenestrated hollow shell and a biologic core. These design features provide an improved interface between the implant and the surrounding tissue aiding fixation, and provide a vehicle for applying new bone healing and enhancing modalities, such as gene therapy, tissue engineering, and growth factors.
摘要翻译： 本发明涉及具有开窗中空壳和生物核的矫形植入物。 这些设计特征提供了植入物和周围组织辅助固定之间的改进的界面，并且提供了用于施加新的骨愈合和增强模式的载体，例如基因治疗，组织工程和生长因子。
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2.发明申请BONE TISSUE ENGINEERING BY EX VIVO STEM CELLS ONGROWTH INTO THREE-DIMENSIONAL TRABECULAR METAL 审中-公开骨组织工程骨髓间充质干细胞生长成三维金刚石公开(公告)号：US20140288661A1
公开(公告)日：2014-09-25
申请号：US14218039
申请日：2014-03-18
申请人： Zou Xuenong , Haisheng Li , Cody Bunger
发明人： Zou Xuenong , Haisheng Li , Cody Bunger
IPC分类号： A61F2/34 , C12N5/0775 , C12N5/00
CPC分类号： A61L27/56 , A61F2/28 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/44 , A61F2/4644 , A61F2002/0086 , A61F2002/2817 , A61F2002/2867 , A61F2002/30199 , A61F2002/30225 , A61F2002/30677 , A61F2002/30678 , A61F2002/3093 , A61F2002/30981 , A61F2002/4648 , A61F2230/0063 , A61F2230/0069 , A61F2310/00161 , A61F2310/00293 , A61F2310/00341 , A61F2310/00491 , A61F2310/00544 , A61F2310/00976 , A61F2310/00982 , A61L27/00 , A61L27/20 , A61L27/22 , A61L27/3608 , A61L27/38 , A61L27/54 , A61L2300/222 , A61L2300/252 , A61L2300/606 , A61L2300/64 , A61L2400/18 , A61L2430/00 , C12N5/0068 , C12N5/0662
摘要： Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue.
摘要翻译： 通过使用透明质酸和/或地塞米松在多孔，三维组织支架植入物上培养的成年自体干细胞用于骨再生，以加速单独的骨愈合或与重组生长因子或转染的成骨基因组合。 脚手架植入物可以在单独或组合的透明质酸和/或地塞米松存在下加工成用于支持细胞生长，肽储存，重组生长因子，细胞因子和抗肿瘤药物的定制形状的三维细胞培养系统 其中生长因子或转染的成骨基因将在组织培养箱中离体组装以植入骨组织。
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3.发明申请公开(公告)号：US20140242044A1
公开(公告)日：2014-08-28
申请号：US14270723
申请日：2014-05-06
CPC分类号： A61F2/28 , A61B17/00491 , A61B17/06166 , A61B17/064 , A61B17/32 , A61B17/32053 , A61B17/3468 , A61B2017/0647 , A61B2034/108 , A61B2090/062 , A61F2/30756 , A61F2/3859 , A61F2/4601 , A61F2/4618 , A61F2002/2817 , A61F2002/2825 , A61F2002/2842 , A61F2002/2867 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30032 , A61F2002/30062 , A61F2002/30075 , A61F2002/3021 , A61F2002/30224 , A61F2002/30233 , A61F2002/3024 , A61F2002/30293 , A61F2002/30583 , A61F2002/30677 , A61F2002/30678 , A61F2002/30772 , A61F2002/30822 , A61F2002/30827 , A61F2002/30881 , A61F2002/30891 , A61F2002/4627 , A61F2002/4635 , A61F2002/4662 , A61F2002/4677 , A61F2002/4681 , A61F2210/0004 , A61F2210/0061 , A61F2210/0085 , A61F2230/0067 , A61F2230/0069 , A61F2230/0091 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/003 , A61F2310/00179 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61K33/06 , A61K33/42 , A61K38/39 , A61L27/12 , A61L27/24 , A61L27/38 , A61L27/44 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/042 , A61L31/044 , A61L31/146 , A61L31/16 , A61L2300/406 , A61L2300/414
摘要： An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass.
摘要翻译： 公开了用于部署在选择位置或选择组织用于组织再生的植入物。 植入物包括胶原和/或其他生物可吸收材料，其中植入物也可用于治疗递送。 另外，植入物可以包括或掺入添加剂，例如骨诱导因子，例如生物相容性陶瓷和玻璃。
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公开(公告)号：US08313743B2
公开(公告)日：2012-11-20
申请号：US12791537
申请日：2010-06-01
申请人： Jeffrey M. Gimble , Mandi Lopez
发明人： Jeffrey M. Gimble , Mandi Lopez
IPC分类号： A61K35/12
CPC分类号： A61K35/28 , A61F2/4455 , A61F2002/30678 , A61F2002/445 , A61L27/3608 , A61L27/3654 , A61L27/3658 , A61L27/3804 , A61L27/3852 , A61L27/3856 , A61L2430/38
摘要： The present invention encompasses methods and compositions for treating a bone condition. The isolated adipose tissue-derived stromal cell of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications such as in spinal fusion procedures.
摘要翻译： 本发明包括用于治疗骨骼状况的方法和组合物。 本发明的分离的脂肪组织衍生的基质细胞及其相关产品具有多种用途，包括但不限于研究，诊断和治疗应用，例如脊柱融合术。
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公开(公告)号：US08133421B2
公开(公告)日：2012-03-13
申请号：US10736799
申请日：2003-12-16
IPC分类号： A61B17/56
CPC分类号： A61B17/0401 , A61B17/72 , A61B17/742 , A61B17/80 , A61B17/86 , A61B2017/0409 , A61B2017/0414 , A61B2017/044 , A61C8/0012 , A61C8/0036 , A61F2/28 , A61F2/2803 , A61F2/2875 , A61F2/30965 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/442 , A61F2/446 , A61F2/4611 , A61F2/4644 , A61F2002/2817 , A61F2002/2825 , A61F2002/2835 , A61F2002/2871 , A61F2002/2892 , A61F2002/30004 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30143 , A61F2002/30146 , A61F2002/30148 , A61F2002/30153 , A61F2002/30154 , A61F2002/30158 , A61F2002/30225 , A61F2002/30237 , A61F2002/30238 , A61F2002/30261 , A61F2002/30266 , A61F2002/30433 , A61F2002/30535 , A61F2002/30561 , A61F2002/30622 , A61F2002/30678 , A61F2002/30785 , A61F2002/3085 , A61F2002/3092 , A61F2002/3095 , A61F2002/30952 , A61F2002/30957 , A61F2002/30962 , A61F2002/30968 , A61F2002/3611 , A61F2002/365 , A61F2002/3686 , A61F2210/0004 , A61F2220/0041 , A61F2230/0006 , A61F2230/0008 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0026 , A61F2230/0069 , A61F2230/0082 , A61F2250/0014 , A61F2250/0058 , A61F2250/0071 , A61F2310/00011 , A61F2310/00161 , A61F2310/00173 , A61F2310/00293 , A61F2310/00347 , A61F2310/00365 , A61L27/3608 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3691 , A61L27/3839 , A61L27/3847 , A61L31/005 , A61L2430/02 , B33Y80/00
摘要： A load-bearing osteoimplant which comprises a shaped, coherent aggregate of bone particles.
摘要翻译： 一种承重骨植入物，其包括骨形成的，相干的骨颗粒聚集体。
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公开(公告)号：US20120046758A1
公开(公告)日：2012-02-23
申请号：US12947822
申请日：2010-11-16
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61B17/00491 , A61B17/06166 , A61B17/064 , A61B17/32 , A61B17/32053 , A61B17/3468 , A61B2017/0647 , A61B2034/108 , A61B2090/062 , A61F2/30756 , A61F2/3859 , A61F2/4601 , A61F2/4618 , A61F2002/2817 , A61F2002/2825 , A61F2002/2842 , A61F2002/2867 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30032 , A61F2002/30062 , A61F2002/30075 , A61F2002/3021 , A61F2002/30224 , A61F2002/30233 , A61F2002/3024 , A61F2002/30293 , A61F2002/30583 , A61F2002/30677 , A61F2002/30678 , A61F2002/30772 , A61F2002/30822 , A61F2002/30827 , A61F2002/30881 , A61F2002/30891 , A61F2002/4627 , A61F2002/4635 , A61F2002/4662 , A61F2002/4677 , A61F2002/4681 , A61F2210/0004 , A61F2210/0061 , A61F2210/0085 , A61F2230/0067 , A61F2230/0069 , A61F2230/0091 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/003 , A61F2310/00179 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61K33/06 , A61K33/42 , A61K38/39 , A61L27/12 , A61L27/24 , A61L27/38 , A61L27/44 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/042 , A61L31/044 , A61L31/146 , A61L31/16 , A61L2300/406 , A61L2300/414
摘要： An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery.
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7.发明授权公开(公告)号：US07892291B2
公开(公告)日：2011-02-22
申请号：US12246980
申请日：2008-10-07
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61B17/00491 , A61B17/06166 , A61B17/064 , A61B17/32 , A61B17/32053 , A61B17/3468 , A61B2017/0647 , A61B2034/108 , A61B2090/062 , A61F2/30756 , A61F2/3859 , A61F2/4601 , A61F2/4618 , A61F2002/2817 , A61F2002/2825 , A61F2002/2842 , A61F2002/2867 , A61F2002/30004 , A61F2002/30011 , A61F2002/30014 , A61F2002/30032 , A61F2002/30062 , A61F2002/30075 , A61F2002/3021 , A61F2002/30224 , A61F2002/30233 , A61F2002/3024 , A61F2002/30293 , A61F2002/30583 , A61F2002/30677 , A61F2002/30678 , A61F2002/30772 , A61F2002/30822 , A61F2002/30827 , A61F2002/30881 , A61F2002/30891 , A61F2002/4627 , A61F2002/4635 , A61F2002/4662 , A61F2002/4677 , A61F2002/4681 , A61F2210/0004 , A61F2210/0061 , A61F2210/0085 , A61F2230/0067 , A61F2230/0069 , A61F2230/0091 , A61F2250/0014 , A61F2250/0018 , A61F2250/0023 , A61F2250/003 , A61F2310/00179 , A61F2310/00293 , A61F2310/00365 , A61F2310/00383 , A61K33/06 , A61K33/42 , A61K38/39 , A61L27/12 , A61L27/24 , A61L27/38 , A61L27/44 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/042 , A61L31/044 , A61L31/146 , A61L31/16 , A61L2300/406 , A61L2300/414
摘要： An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant includes collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may include, or have blended in, an additive, such as an osteoinductive factor, for example biocompatible ceramics and glass.
摘要翻译： 公开了用于部署在选择位置或选择组织用于组织再生的植入物。 植入物包括胶原和/或其他生物可吸收材料，其中植入物也可用于治疗递送。 另外，植入物可以包括或掺入添加剂，例如骨诱导因子，例如生物相容性陶瓷和玻璃。
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公开(公告)号：US07867232B2
公开(公告)日：2011-01-11
申请号：US12037653
申请日：2008-02-26
申请人： Bahaa Seedhom , Takashi Toyoda , Michael Pullen
发明人： Bahaa Seedhom , Takashi Toyoda , Michael Pullen
CPC分类号： A61B17/1675 , A61B17/1604 , A61B17/1637 , A61B17/1659 , A61B17/32053 , A61B2017/00464 , A61B2017/00469 , A61B2017/1602 , A61B2017/320004 , A61B2017/320008 , A61B2017/320012 , A61B2090/08021 , A61F2/0063 , A61F2/0095 , A61F2/28 , A61F2/2846 , A61F2/30756 , A61F2/38 , A61F2/4618 , A61F2002/0086 , A61F2002/286 , A61F2002/30062 , A61F2002/30064 , A61F2002/30113 , A61F2002/30118 , A61F2002/30125 , A61F2002/30131 , A61F2002/30143 , A61F2002/3024 , A61F2002/30556 , A61F2002/30599 , A61F2002/30611 , A61F2002/30678 , A61F2002/30716 , A61F2002/30761 , A61F2002/30762 , A61F2002/30764 , A61F2002/3093 , A61F2002/3097 , A61F2002/4635 , A61F2210/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0017 , A61F2230/0069 , A61F2250/0009 , A61F2250/0063 , A61F2250/009 , A61F2310/00341 , A61F2310/00359
摘要： The invention relates to a method for the repair of damaged tissue present at or on the surface of bone in an animal, the method comprising forming a narrow groove around at least part of said damaged tissue, which groove extends into the bone below the damaged tissue, replacing the tissue around which the groove extends by at least one layer of biocompatible replacement material, and anchoring the material to the bone by the use of retaining means extending from the material into the groove; instruments for use in the repair of damaged tissue and kits comprising said instruments.
摘要翻译： 本发明涉及一种用于修复存在于动物骨骼表面或其表面上的受损组织的方法，所述方法包括在所述受损组织的至少部分周围形成窄槽，所述凹槽延伸到损伤组织下方的骨中 用至少一层生物相容的替代材料替代凹槽所延伸的组织，并且通过使用从材料延伸到凹槽中的保持装置将材料固定到骨骼上; 用于修复受损组织的仪器和包括所述仪器的试剂盒。
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9.发明授权Integrated global layout and local microstructure topology optimization approach for spinal cage design and fabrication 有权脊柱笼设计和制造的综合全局布局和局部微结构拓扑优化方法公开(公告)号：US07509183B2
公开(公告)日：2009-03-24
申请号：US10553851
申请日：2004-04-22
申请人： Chia Ying Lin , Scott J. Hollister , Cheng-Yu Lin
发明人： Chia Ying Lin , Scott J. Hollister , Cheng-Yu Lin
IPC分类号： G06F19/00
CPC分类号： A61F2/30942 , A61F2/4455 , A61F2002/2817 , A61F2002/30006 , A61F2002/30011 , A61F2002/30062 , A61F2002/30153 , A61F2002/30154 , A61F2002/30261 , A61F2002/30263 , A61F2002/30303 , A61F2002/30678 , A61F2002/30785 , A61F2002/30838 , A61F2002/30943 , A61F2002/30955 , A61F2002/30958 , A61F2002/30962 , A61F2002/30971 , A61F2210/0004 , A61F2230/0019 , A61F2230/0021 , A61F2230/0063 , A61F2230/0082 , A61F2230/0084 , A61F2250/0015 , A61F2250/0018 , A61F2250/0023 , A61F2310/00023 , B33Y50/00 , B33Y80/00
摘要： A method of designing an interbody fusion cage is disclosed. The method uses topology optimization algorithms to define the structural layout and the inner microstructures of the cage. After the structural layout is defined, a density distribution process is performed. Based on the density distribution, the inner microstructures of the cage are defined.
摘要翻译： 公开了一种设计椎间融合器的方法。 该方法使用拓扑优化算法来定义笼的结构布局和内部微观结构。 在定义了结构布局之后，执行密度分布过程。 基于密度分布，定义了笼的内部微观结构。
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公开(公告)号：US20070233272A1
公开(公告)日：2007-10-04
申请号：US11758751
申请日：2007-06-06
申请人： Todd Boyce , Lawrence Shimp , Albert Manrique , John Winterbottom
发明人： Todd Boyce , Lawrence Shimp , Albert Manrique , John Winterbottom
CPC分类号： A61F2/28 , A61B17/0401 , A61B17/72 , A61B17/74 , A61B17/80 , A61B17/86 , A61B2017/0409 , A61B2017/0414 , A61B2017/044 , A61C8/0012 , A61C8/0036 , A61F2/2803 , A61F2/2875 , A61F2/30965 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/442 , A61F2/446 , A61F2/4611 , A61F2/4644 , A61F2002/2817 , A61F2002/2825 , A61F2002/2835 , A61F2002/2871 , A61F2002/2892 , A61F2002/30004 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30143 , A61F2002/30146 , A61F2002/30148 , A61F2002/30153 , A61F2002/30154 , A61F2002/30158 , A61F2002/30225 , A61F2002/30237 , A61F2002/30238 , A61F2002/30261 , A61F2002/30266 , A61F2002/30433 , A61F2002/30561 , A61F2002/30622 , A61F2002/30678 , A61F2002/30785 , A61F2002/3085 , A61F2002/3092 , A61F2002/3095 , A61F2002/30952 , A61F2002/30957 , A61F2002/30962 , A61F2002/30968 , A61F2002/3611 , A61F2002/365 , A61F2002/3686 , A61F2210/0004 , A61F2220/0041 , A61F2230/0006 , A61F2230/0008 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0026 , A61F2230/0069 , A61F2230/0082 , A61F2250/0014 , A61F2250/0071 , A61F2310/00011 , A61F2310/00161 , A61F2310/00173 , A61F2310/00293 , A61F2310/00347 , A61F2310/00365 , A61L27/3608 , A61L27/3641 , A61L27/3683 , A61L27/3691 , A61L27/3839 , A61L27/3847 , A61L31/005 , A61L2430/02
摘要： A load-bearing osteoimplant which comprises a shaped, coherent aggregate of bone particles.
摘要翻译： 一种承重骨植入物，其包括骨形成的，相干的骨颗粒聚集体。
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