-
1.发明授权Anti-XDR-TB drug, anti-MDR-TB drug, and combination anti-tuberculosis drug 有权抗XDR-TB药物，抗MDR-TB药物和抗结核药物组合公开(公告)号：US09040502B2
公开(公告)日：2015-05-26
申请号：US13075356
申请日：2011-03-30
IPC分类号： C07H19/067 , A61K31/4409 , A61K31/496 , A61K31/7072
CPC分类号： C07H19/067 , A61K31/4409 , A61K31/496 , A61K31/7072 , A61K2300/00
摘要： A method for treating an individual infected with XDR-TB, the method including administering to the individual an anti-XDR-TB drug which comprises a compound having a structure expressed by Structural Formula (1) below:
摘要翻译： 一种用于治疗感染XDR-TB的个体的方法，所述方法包括向个体施用包含具有由以下结构式（1）表示的结构的化合物的抗XDR-TB药物：
-
2.发明授权Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof 有权作为新化合物及其衍生物，并且作为新化合物及其衍生物的螯合物，公开(公告)号：US07482439B2
公开(公告)日：2009-01-27
申请号：US10543887
申请日：2004-01-30
IPC分类号： A61K31/7008 , A61K31/7016 , A61K31/551 , A61K31/51 , C07H17/02 , C07D243/08
CPC分类号： C07H19/067 , A61K31/7072 , C07D403/08 , C07D403/14 , C07D405/14 , C07H15/26 , C07H19/06 , Y02P20/55
摘要： Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1′″-amide derivative of the formula (II) and a caprazene-1′″-ester derivative of the formula (III) from caprazene. Further, there could be synthesized a caprazol-1′″-amide derivative of the formula (V) and a caprazol-1′″-amide-3′″-ester derivative and a caprazol-3′″-ester derivative, etc. from caprazol. Furthermore, an imidazolidinone derivative could be synthesized from the ring-opened product of the 1,4-diazepinone ring of caprazol. The novel caprazene derivative, novel caprazol derivative and novel imidazolidinone derivative now synthesized exhibit excellent antibacterial activities against a variety of bacteria, including acid-fast bacteria.
摘要翻译： Caprazene和caprazol可以通过caprazamycin的水解合成。 可以从癸腈合成式（II）的癸酰肼衍生物和式（III）的癸酰基-1“ - 酯衍生物。 此外，可以合成式（V）的十六唑-1“ - 酰胺衍生物和十六唑-1” - 酰胺-3“ - 酯衍生物和癸酰唑-3' - 酯衍生物 衍生物等。 此外，咪唑啉酮衍生物可以由四唑的1,4-二氮杂环酮环的开环产物合成。 现在合成的新型caprazene衍生物，新型吡唑衍生物和新型咪唑啉酮衍生物对各种细菌，包括耐酸细菌表现出优异的抗菌活性。
-
3.发明授权公开(公告)号：US08058247B2
公开(公告)日：2011-11-15
申请号：US12378172
申请日：2009-02-11
IPC分类号： A61K31/7016 , A61K31/7052 , C07G11/00 , C07H15/26
CPC分类号： A61K31/7072 , A01N43/62
摘要： An antibacterial agent having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is provided. Specifically, the antibacterial agent of the present invention having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is a caprazamycin derivative represented, for example, by the following general formula (II): wherein Me is a methyl group; and R1 is a straight or substantially straight chain alkyl group having 5 to 21 carbon atoms, a straight or substantially straight chain alkenyl group having 5 to 21 carbon atoms, a cycloalkyl group having 5 to 12 carbon atoms, or a phenyl group substituted at the para-position with a straight chain alkyl group having 1 to 14 carbon atoms, a straight chain alkoxy group having 1 to 9 carbon atoms or a cycloalkyl group having 5 to 12 carbon atoms.
摘要翻译： 对鸟分枝杆菌亚种具有高抗菌活性的抗菌剂 提供副结核病。 具体地说，本发明的抗菌剂对鸟分枝杆菌属 副结核病是由例如由以下通式（II）表示的卡拉霉素衍生物：其中Me是甲基; R1为碳原子数5〜21的直链或直链状的直链状的碳原子数为5〜21的直链或直链的烯基，碳原子数为5〜12的环烷基， 具有1至14个碳原子的直链烷基的对位位置，具有1至9个碳原子的直链烷氧基或具有5至12个碳原子的环烷基。
-
4.发明申请公开(公告)号：US20090209744A1
公开(公告)日：2009-08-20
申请号：US12378172
申请日：2009-02-11
IPC分类号： C07H19/06
CPC分类号： A61K31/7072 , A01N43/62
摘要： An antibacterial agent having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is provided. Specifically, the antibacterial agent of the present invention having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is a caprazamycin derivative represented, for example, by the following general formula (II): wherein Me is a methyl group; and R1 is a straight or substantially straight chain alkyl group having 5 to 21 carbon atoms, a straight or substantially straight chain alkenyl group having 5 to 21 carbon atoms, a cycloalkyl group having 5 to 12 carbon atoms, or a phenyl group substituted at the para-position with a straight chain alkyl group having 1 to 14 carbon atoms, a straight chain alkoxy group having 1 to 9 carbon atoms or a cycloalkyl group having 5 to 12 carbon atoms.
摘要翻译： 对鸟分枝杆菌亚种具有高抗菌活性的抗菌剂 提供副结核病。 具体地说，本发明的抗菌剂对鸟分枝杆菌属 副结核病是例如由以下通式（II）表示的卡拉霉素衍生物：其中Me是甲基; R1为碳原子数5〜21的直链或直链状的直链状烷基，碳原子数5〜21的直链或直链状的链烯基，碳原子数5〜12的环烷基， 具有1至14个碳原子的直链烷基的对位位置，具有1至9个碳原子的直链烷氧基或具有5至12个碳原子的环烷基。
-
5.发明授权Caprazene as a novel compound and derivatives thereof, and caprazol as a novel compound and derivatives thereof 有权Caprazene作为新化合物及其衍生物，以及作为新化合物及其衍生物的螯合物公开(公告)号：US08710198B2
公开(公告)日：2014-04-29
申请号：US12345190
申请日：2008-12-29
IPC分类号： C07H19/067 , C07D403/08 , C07D403/14 , C07D243/08 , C07D405/14
CPC分类号： C07H19/067 , A61K31/7072 , C07D403/08 , C07D403/14 , C07D405/14 , C07H15/26 , C07H19/06 , Y02P20/55
摘要： Caprazene is provided which is the compound represented by the following formula (I) wherein Me stands for methyl group, and a 5″-N-alkoxycarbonyl or 5″-N-aralkyloxycarbonyl derivative thereof, and wherein said compound has the 1H-NMR and 13C-NMR data as set forth in Table 15.
摘要翻译： 提供了作为Me表示甲基的下式（I）表示的化合物和5“-N-烷氧基羰基或5”-N-芳烷氧基羰基衍生物的化合物，其中所述化合物具有1H-NMR和 13C-NMR数据如表15所示。
-
6.发明申请Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof 有权作为新化合物及其衍生物，并且作为新化合物及其衍生物的螯合物，公开(公告)号：US20060178319A1
公开(公告)日：2006-08-10
申请号：US10543887
申请日：2004-01-30
IPC分类号： A61K31/7072 , C07H19/048
CPC分类号： C07H19/067 , A61K31/7072 , C07D403/08 , C07D403/14 , C07D405/14 , C07H15/26 , C07H19/06 , Y02P20/55
摘要： Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1′″- amide derivative of the formula (II) and a caprazene-1′″-ester derivative of the formula (III) from caprazene. Further, there could be synthesized a caprazol-1′″-amide derivative of the formula (V) and a caprazol-1′″-amide-3′″-ester derivative and a caprazol-3′″-ester derivative, etc. from caprazol. Furthermore, an imidazolidinone derivative could be synthesized from the ring-opened product of the 1,4-diazepinone ring of caprazol. The novel caprazene derivative, novel caprazol derivative and novel imidazolidinone derivative now synthesized exhibit excellent antibacterial activities against a variety of bacteria, including acid-fast bacteria.
摘要翻译： Caprazene和caprazol可以通过caprazamycin的水解合成。 可以从癸腈合成式（II）的癸酰肼衍生物和式（III）的癸酰基-1“ - 酯衍生物。 此外，可以合成式（V）的十六唑-1“ - 酰胺衍生物和十六唑-1” - 酰胺-3“ - 酯衍生物和癸酰唑-3' - 酯衍生物 衍生物等。 此外，咪唑啉酮衍生物可以由四唑的1,4-二氮杂环酮环的开环产物合成。 现在合成的新型caprazene衍生物，新型吡唑衍生物和新型咪唑啉酮衍生物对各种细菌，包括耐酸细菌表现出优异的抗菌活性。
-
公开(公告)号：US20130161664A1
公开(公告)日：2013-06-27
申请号：US13819895
申请日：2011-08-12
IPC分类号： H01L33/08
CPC分类号： H01L51/5215 , H01L51/5234 , H01L51/5275 , H01L2251/55 , H05B33/22 , H05B33/28
摘要： An electroluminescent element (10) is provided with: a lamination section in which a first conductive layer (12), a dielectric layer (13), a second conductive layer (14), a light-emitting layer (15) and a third conductive layer (16) are laminated in order; and contact holes (17) for at least penetrating through the dielectric layer (13) and electrically connecting the first conductive layer (12) and the second conductive layer (14). When viewed from the light-emitting surface side, the electroluminescent element (10) (i) has at least one continuous light-emitting region, and (ii) the number of contact holes (17) is 102 or more per one light-emitting region and such that the ratio of the area of the contact holes (17) to the area of the light-emitting region is 0.1 or less. Thus, it is possible to provide an electroluminescent element, etc., that is easily manufactured and has high light emission uniformity.
摘要翻译： 电致发光元件（10）具有：层叠部，其中第一导电层（12），电介质层（13），第二导电层（14），发光层（15）和第三导电层 层（16）依次层压; 和用于至少穿透介电层（13）并且电连接第一导电层（12）和第二导电层（14）的接触孔（17）。 当从发光面侧观察时，电致发光元件（10）（i）具有至少一个连续的发光区域，（ii）接触孔（17）的数量为每个发光 使得接触孔（17）的面积与发光区域的面积的比例为0.1以下。 因此，可以提供易于制造并且具有高发光均匀性的电致发光元件等。
-
公开(公告)号：US08011310B2
公开(公告)日：2011-09-06
申请号：US12922174
申请日：2009-04-01
申请人： Yoshiaki Takahashi
发明人： Yoshiaki Takahashi
CPC分类号： B63B1/38 , Y02T70/122
摘要： Micro-bubble generators attached to a ship hull below the waterline decrease frictional resistance during navigation and improve fuel efficiency. Each micro-bubble generator is supplied with air and has a wing positioned outside the hull for generating negative pressure. The negative pressure created by the wing increases with an increase in ship's speed, which pushes the air-liquid interface outwardly toward the wing. As the air and the water move at different speeds due to difference in their densities, micro-bubbles are generated in the micro-bubble generator according to the Kelvin-Helmholtz Instability mechanism and discharged downstream to move closely along the outside surface of the hull.
摘要翻译： 附着在船底下的微型气泡发生器在导线下降低摩擦阻力，提高燃油效率。 每个微气泡发生器都供应空气，并有一个位于船体外部的机翼产生负压。 机翼产生的负压随着船速的增加而增加，从而将空气 - 液体界面向外推向机翼。 由于空气和水由于其密度的差异而以不同的速度移动，所以微气泡发生器中根据开尔文 - 亥姆霍兹不稳定性机制产生微气泡，并在下游排出以沿着船体的外表面紧密地移动。
-
9.发明授权Organic electroluminescence device using a copolymer and a phosphorescent compound 有权使用共聚物和磷光化合物的有机电致发光元件公开(公告)号：US07872411B2
公开(公告)日：2011-01-18
申请号：US12063698
申请日：2006-08-04
IPC分类号： H01L51/50
CPC分类号： C09K11/06 , C09K2211/1425 , C09K2211/1466 , C09K2211/1475 , C09K2211/185 , H01L51/004 , H01L51/0043 , H01L51/0059 , H01L51/0062 , H01L51/007 , H01L51/0085 , H01L51/5016 , H01L51/5036 , H05B33/14
摘要： An organic electroluminescence device including one layer or two or more layers of organic layer sandwiched between an anode and a cathode. At least one of the organic layers includes a phosphorescent compound and a polymer. The polymer has a structural unit derived from a monomer represented by formula (1) as defined herein, and a structural unit derived from a monomer having heterocycle(s) containing two or more heteroatoms.
摘要翻译： 一种有机电致发光器件，包括夹在阳极和阴极之间的一层或两层或更多层有机层。 至少一个有机层包括磷光化合物和聚合物。 聚合物具有衍生自如本文定义的由式（1）表示的单体的结构单元和衍生自含有两个或更多个杂原子的杂环的单体的结构单元。
-
公开(公告)号：US20110000418A1
公开(公告)日：2011-01-06
申请号：US12922174
申请日：2009-04-01
申请人： Yoshiaki Takahashi
发明人： Yoshiaki Takahashi
IPC分类号： B63B1/38
CPC分类号： B63B1/38 , Y02T70/122
摘要： [Object] The present invention provides for a frictional resistance reduction ship able to decrease friction resistance and improve fuel efficiency.[Solution] When the navigation speed increases, and negative pressure which is created by the wing 33 increases, a result is that the air-liquid interface is pushed down further. Due to the air and the water (sea water) moving different speeds, density differs between air and water (as shown in FIG. 7), micro-bubbles are generated in the micro-bubble generator according to the Kelvin-Helmholtz Instability mechanism, and these micro-bubbles flow through onto the downstream side along the hull.
摘要翻译： 本发明提供能够降低摩擦阻力并提高燃料效率的摩擦阻力减小船。 [解决方案]当导航速度增加时，由翼33产生的负压增加，结果是空气 - 液体界面被进一步向下推。 由于空气和水（海水）移动速度不同，空气和水之间的密度不同（如图7所示），根据开尔文 - 亥姆霍兹不稳定机制在微气泡发生器中产生微气泡， 并且这些微气泡沿着船体流过下游侧。
-
-
-
-
-
-
-
-
-
搜索结果
130 条记录 (耗时 0.023 秒)
