Pharmaceutical composition for neurotrophic action
    3.
    发明授权
    Pharmaceutical composition for neurotrophic action 失效
    用于神经营养作用的药物组合物

    公开(公告)号:US06500820B1

    公开(公告)日:2002-12-31

    申请号:US09673057

    申请日:2000-10-10

    IPC分类号: A61K3155

    CPC分类号: A61K31/445 A61K31/55

    摘要: The present invention provides a composition for neurotrophic action which comprises a compound of the formula: wherein Ar is an optionally condensed phenyl group which may be substituted; n is an integer of 1 to 10; R is a hydrogen atom or a hydrocarbon group which may be substituted; and Y is an amino group which may be substituted or a nitrogen-containing saturated heterocyclic group which may be substituted; or a salt thereof, which compounds are useful for preventing and/or treating (1) neurodegenerative diseases (e.g. senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, Creutzfelt-Jakob disease, amyotrophic lateral sclerosis, diabetic neuropathy, etc.), (2) neuropathy in cerebrovascular diseases (e.g. impairment of cerebral blood flow based on cerebral infarction, cerebral hemorrhage, cerebral sclerosis, etc.), brain trauma, spinal cord injury, cerebritis sequela and cerebral palsy, (4) mental diseases (e.g. depression, panic disorder, schizophrenia, etc.), etc.

    摘要翻译: 本发明提供了用于神经营养作用的组合物,其包含下式化合物:其中Ar是可被取代的任选缩合的苯基; n是1至10的整数; R是氢原子或可以是 取代 Y为可被取代的氨基或可被取代的含氮饱和杂环基; 或其盐,所述化合物可用于预防和/或治疗(1)神经变性疾病(例如老年性痴呆,阿尔茨海默病,唐氏综合征,帕金森病,克雅氏病,肌萎缩性侧索硬化,糖尿病性神经病变等) (2)脑血管疾病中的神经病变(如基于脑梗死,脑出血,脑硬化等)脑损伤,脑外伤,脊髓损伤,脑炎后遗症和脑瘫等脑损伤,(4)精神疾病 ,恐慌症,精神分裂症等)等

    Alignment detecting apparatus
    4.
    发明授权
    Alignment detecting apparatus 失效
    对准检测装置

    公开(公告)号:US5909268A

    公开(公告)日:1999-06-01

    申请号:US958158

    申请日:1997-10-27

    CPC分类号: A61B3/152 A61B3/103 A61B3/107

    摘要: An alignment detecting apparatus for detecting an alignment condition between an eye to be examined having approximately spherical surface or approximately toric surface and a device having a standard axial lines the apparatus comprising a target projecting optical system which includes a first target projecting optical system for projecting a first target with a predetermined angle relative to the standard axial line, and a second target projecting optical system for projecting a second target with a different angle compared with the angle of the first target projecting optical system relative to the standard axial lines of which at least one between the first and second targets is a target of a finite distances a detecting optical system for detecting positions of images of the first and second targets which are projected onto the eye by the first and second target projecting optical systems, and a judging device for judging the alignment condition based on results detected by the detecting optical system.

    摘要翻译: 一种对准检测装置,用于检测具有大致球形表面或近似复曲面的待检查眼睛之间的对准状态和具有标准轴线的装置,该装置包括目标投影光学系统,该目标投影光学系统包括:第一目标投影光学系统, 第一目标相对于标准轴线具有预定角度;以及第二目标投影光学系统,用于与第一目标投影光学系统相对于至少在第一目标投影光学系统的标准轴线的角度具有不同的角度投影第二目标 第一和第二目标之间的一个是具有有限距离的目标,用于检测由第一和第二目标投影光学系统投射到眼睛上的第一和第二目标的图像的位置的检测光学系统,以及用于 根据de检测到的结果判断对准条件 光学系统。

    Quinoline compound
    5.
    发明授权
    Quinoline compound 失效
    喹啉化合物

    公开(公告)号:US07183415B2

    公开(公告)日:2007-02-27

    申请号:US10493427

    申请日:2002-10-24

    IPC分类号: C07D215/38 C07D215/14

    摘要: A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R1 and R2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s); Y is a divalent hydrocarbon group optionally having substituent(s) (except CO); R3 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); and ring A and ring B may further have substituents, and when ring B further has a substituent, the substituent may be linked to R1 to form a ring, or a salt thereof, or a prodrug thereof, is provided.

    摘要翻译: 一种化合物,其具有黑色素浓集激素拮抗作用并且可用作预防或治疗肥胖症的药剂,并且其由下式表示:其中Ar是任选具有取代基的环状基团; X是具有1至6个原子的主链的键或间隔基; R 1和R 2相同或不同,各自为氢原子或任选具有取代基的烃基,或R 1〜 >和R 2可以与相邻的氮原子一起形成任选具有取代基的含氮杂环; Y是任选具有取代基(CO除外)的二价烃基; R 3是氢原子或任选具有取代基的烃基; 并且环A和环B可以进一步具有取代基,并且当环B还具有取代基时,取代基可以与R 1连接形成环,或其盐或其前药, 被提供。

    Eye refractive power measurement apparatus
    7.
    发明授权
    Eye refractive power measurement apparatus 有权
    眼屈光力测量仪

    公开(公告)号:US6030081A

    公开(公告)日:2000-02-29

    申请号:US141347

    申请日:1998-08-27

    申请人: Koki Kato

    发明人: Koki Kato

    IPC分类号: A61B3/10 A61B3/103

    CPC分类号: A61B3/103

    摘要: An eye refractive power measurement apparatus for measuring a refractive power of an eye to be examined, the apparatus comprising a projecting optical system for scanning and projecting a slit light bundle onto a fundus of the eye to be examined, a photo-receiving optical system provided with a photo-detector arranged at a conjugate position with a cornea of the eye so as to have a predetermined position with respect to a scanning direction of the slit light bundle and an open diaphragm, can be arranged at different predetermined positions, for reducing the slit light bundle, a selecting device for selecting the position of the open diaphragm so as to change a range in which the photo-receiving optical system can detect an eye refractive power and an eye refractive power calculating device to calculate a refractive power of the eye based on an output signal from the photo-detector receiving the slit light bundle reflected from the fundus of the eye through the open diaphragm and the position of the open diaphragm.

    摘要翻译: 一种用于测量待检眼睛的屈光力的眼屈光力测量装置,该装置包括用于扫描并将狭缝光束投射到待检眼睛的眼底上的投影光学系统,设置的光接收光学系统 利用布置在与眼睛的角膜的共轭位置处的光检测器,以便相对于狭缝光束和开口膜片的扫描方向具有预定位置,可以布置在不同的预定位置,以减少 狭缝光束,选择装置,用于选择开放光阑的位置,以便改变光接收光学系统可以检测眼睛屈光度的范围和眼睛屈光度计算装置,以计算眼睛的屈光度 基于来自光电检测器的输出信号,其接收从眼睛的眼底通过开放的隔膜反射的狭缝光束和po 打开隔膜的位置。

    Multimedia data search system that searches for a portion of multimedia
data using objects corresponding to the portion of multimedia data
    8.
    发明授权
    Multimedia data search system that searches for a portion of multimedia data using objects corresponding to the portion of multimedia data 失效
    多媒体数据搜索系统,使用与该多媒体数据的一部分相对应的对象来搜索一部分多媒体数据

    公开(公告)号:US5713021A

    公开(公告)日:1998-01-27

    申请号:US528041

    申请日:1995-09-14

    IPC分类号: G06F12/00 G06F17/30

    摘要: A multimedia data search system, includes a storage unit for storing features of a portion of data and data identifying the portion of data, a search unit for searching view objects stored in the storage unit according to a feature of the portion of data, and a display/reproduction unit for displaying and reproducing a portion of data corresponding to a searched view object, or multimedia data including the portion of the data. The system implemented with this invention facilitates searching for a portion of sequential data, and displays neighboring data depending on a requirement when displaying the portion of data.

    摘要翻译: 一种多媒体数据搜索系统,包括:存储单元,用于存储识别数据部分的一部分数据和数据;搜索单元,用于根据数据部分的特征搜索存储在存储单元中的查看对象;以及 用于显示和再现与搜索到的查看对象相对应的数据的一部分的显示/再现单元,或包括该部分数据的多媒体数据。 利用本发明实现的系统有助于搜索一部分顺序数据,并且在显示数据部分时根据需要显示相邻数据。

    Cell differentiation inducing amide derivatives, their production and use
    10.
    发明授权
    Cell differentiation inducing amide derivatives, their production and use 失效
    细胞分化诱导酰胺衍生物,其生产和使用

    公开(公告)号:US06340704B1

    公开(公告)日:2002-01-22

    申请号:US09341803

    申请日:1999-07-19

    IPC分类号: A61K31357

    摘要: The present invention provides a compound represented by the formula: wherein R1 is an amino group which may be substituted; R2 is a hydrogen atom or a lower alkyl group which may be substituted; X is a methyne group which may be substituted or N(O)m (m is 0 or 1); a ring A is a homo- or hetero-cycle which is substituted by a halogen atom, lower alkyl, lower alkoxy or lower alkylenedioxy; and a ring B is a homo- or hetero-cycle which may be substituted; or a salt thereof, which exhibits excellent cell differentiation-inducing action and cell differentiation-inducing factor action-enhancing action, and is useful in the treatment and prevention of various nerve diseases or bone/joint diseases.

    摘要翻译: 本发明提供由下式表示的化合物:其中R1是可被取代的氨基; R2是氢原子或可被取代的低级烷基; X是可以被取代的甲炔基或N(O)m(m是0或1); 环A是被卤素原子,低级烷基,低级烷氧基或低级亚烷基二氧基取代的同 - 或异 - 循环; 并且环B是可被取代的同 - 或异 - 循环; 或其盐,其表现出优异的细胞分化诱导作用和细胞分化诱导因子作用增强作用,并且可用于治疗和预防各种神经疾病或骨/关节疾病。