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公开(公告)号：US08033395B2
公开(公告)日：2011-10-11
申请号：US12314564
申请日：2008-12-12
摘要： The main object of the present invention is to provide a patch package structure including a patch containing a physiologically active ingredient and a package housing the patch, which is capable of stably retaining the physiologically active ingredient in the patch during preservation. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 having an adhesive layer containing an organic liquid component, and a packaging member 51 housing the patch, wherein the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译： 本发明的主要目的是提供一种贴片包装结构，其包括含有生理活性成分的贴剂和容纳该贴剂的包装，其能够在保存期间稳定地保留贴剂中的生理活性成分。 该目的可以通过采用以下结构来实现。 具体而言，本发明是一种贴片包装结构，其包括具有含有有机液体成分的粘合剂层的贴片1和容纳该贴片的包装部件51，其中，包装部件51包括第一包装体11，第一包装体11 包括丙烯腈树脂层12，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14和丙烯腈树脂层12设置在 补丁1。
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公开(公告)号：US08096417B2
公开(公告)日：2012-01-17
申请号：US12314563
申请日：2008-12-12
CPC分类号： A61F15/001 , A61L15/24 , C08L33/20
摘要： The main object of the present invention is to provide a patch package structure capable of stably retaining the physiologically active ingredient in a patch during preservation of the patch. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 and a packaging member 51 holding the patch, wherein the patch 1 includes a support 2 and an adhesive layer 3 formed on at least one surface of the support 2, the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译： 本发明的主要目的是提供一种贴片包装结构，其能够在贴片保存期间将贴片的生理活性成分稳定地保持。 该目的可以通过采用以下结构来实现。 具体而言，本发明是一种贴片包装结构，其包括贴片1和保持贴片的包装部件51，其中贴片1包括形成在支撑体2的至少一个表面上的支撑体2和粘合剂层3， 包装部件51包括第一包装11，包含丙烯腈树脂层12的第一包装11，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14，以及 丙烯腈树脂层12设置在贴剂1的近侧。
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公开(公告)号：US20090166236A1
公开(公告)日：2009-07-02
申请号：US12314563
申请日：2008-12-12
CPC分类号： A61F15/001 , A61L15/24 , C08L33/20
摘要： The main object of the present invention is to provide a patch package structure capable of stably retaining the physiologically active ingredient in a patch during preservation of the patch. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 and a packaging member 51 holding the patch, wherein the patch 1 includes a support 2 and an adhesive layer 3 formed on at least one surface of the support 2, the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译： 本发明的主要目的是提供一种贴片包装结构，其能够在贴片保存期间将贴片的生理活性成分稳定地保持。 该目的可以通过采用以下结构来实现。 具体而言，本发明是一种贴片包装结构，其包括贴片1和保持贴片的包装部件51，其中贴片1包括形成在支撑体2的至少一个表面上的支撑体2和粘合剂层3， 包装部件51包括第一包装11，包含丙烯腈树脂层12的第一包装11，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14，以及 丙烯腈树脂层12设置在贴剂1的近侧。
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公开(公告)号：US20090166229A1
公开(公告)日：2009-07-02
申请号：US12314564
申请日：2008-12-12
摘要： The main object of the present invention is to provide a patch package structure including a patch containing a physiologically active ingredient and a package housing the patch, which is capable of stably retaining the physiologically active ingredient in the patch during preservation. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 having an adhesive layer containing an organic liquid component, and a packaging member 51 housing the patch, wherein the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译： 本发明的主要目的是提供一种贴片包装结构，其包括含有生理活性成分的贴剂和容纳该贴剂的包装，其能够在保存期间稳定地保留贴剂中的生理活性成分。 该目的可以通过采用以下结构来实现。 具体而言，本发明是一种贴片包装结构，其包括具有含有有机液体成分的粘合剂层的贴片1和容纳该贴片的包装部件51，其中，包装部件51包括第一包装体11，第一包装体11 包括丙烯腈树脂层12，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14和丙烯腈树脂层12设置在 补丁1。
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公开(公告)号：US09040077B2
公开(公告)日：2015-05-26
申请号：US12656700
申请日：2010-02-12
CPC分类号： A61K9/703 , A61F2013/00651 , A61K9/7061
摘要： The present invention provides to a patch and a patch preparation having low stretchability, which can be continuously adhered to the skin for a long time without undesirable detachment and marked falling off from the skin due to various factors during adhesion, and specifically provides a low stretchable patch and a patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein a ratio P of the total length W (mm) of curved sections of a planar outer shape of the patch to the total length S (mm) of straight-line sections of the planar outer shape of the patch (W/S) is not more than 1.22, and, when the curved sections are approximated by a circular arc, the radius R (mm) of the circular arc is not less than 0.5 mm.
摘要翻译： 本发明提供一种具有低拉伸性的贴剂和贴片制剂，其可以在粘合期间由于各种因素而长时间连续地粘附到皮肤上而没有不希望的分离并且从皮肤上显着脱落，并且具体地提供了低伸缩性 贴片和贴片制剂，其包含支撑体和形成在支撑体的一个表面上的粘合剂层，其中贴片平面外形的弯曲部分的总长度W（mm）与总长度S（mm）之比P （W / S）的平面外形的直线部分的面积不大于1.22，并且当弯曲部分被圆弧近似时，圆弧的半径R（mm）不是 小于0.5毫米。
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公开(公告)号：US20100203108A1
公开(公告)日：2010-08-12
申请号：US12656700
申请日：2010-02-12
CPC分类号： A61K9/703 , A61F2013/00651 , A61K9/7061
摘要： The present invention provides to a patch and a patch preparation having low stretchability, which can be continuously adhered to the skin for a long time without undesirable detachment and marked falling off from the skin due to various factors during adhesion, and specifically provides a low stretchable patch and a patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein a ratio P of the total length W (mm) of curved sections of a planar outer shape of the patch to the total length S (mm) of straight-line sections of the planar outer shape of the patch (W/S) is not more than 1.22, and, when the curved sections are approximated by a circular arc, the radius R (mm) of the circular arc is not less than 0.5 mm.
摘要翻译： 本发明提供一种具有低拉伸性的贴剂和贴片制剂，其可以在粘合期间由于各种因素而长时间连续地粘附到皮肤上而没有不希望的分离并且从皮肤上显着脱落，并且具体地提供了低伸缩性 贴片和贴片制剂，其包含支撑体和形成在支撑体的一个表面上的粘合剂层，其中贴片平面外形的弯曲部分的总长度W（mm）与总长度S（mm）之比P （W / S）的平面外形的直线部分的面积不大于1.22，并且当弯曲部分被圆弧近似时，圆弧的半径R（mm）不是 小于0.5毫米。
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公开(公告)号：US20110243998A1
公开(公告)日：2011-10-06
申请号：US13074911
申请日：2011-03-29
申请人： Sachiko SAKAMOTO , Akinori Hanatani , Arimichi Okazaki , Hitoshi Akemi , Yoshihiro Iwao , Kensuke Matsuoka
发明人： Sachiko SAKAMOTO , Akinori Hanatani , Arimichi Okazaki , Hitoshi Akemi , Yoshihiro Iwao , Kensuke Matsuoka
IPC分类号： A61K9/00 , A61K31/445 , A61K31/4174 , A61K31/34 , A61K31/192 , A61K31/195 , A61K31/4152 , A61K31/46
CPC分类号： A61K9/7061 , A61K9/7053
摘要： The invention provides a patch preparation containing (a) a support and (b) an adhesive layer containing a drug on the surface of the support, wherein a crystal of the drug is formed in the adhesive layer immediately after application of a physical stimulation to the adhesive layer, while a crystal of the drug is formed during preservation after the physical stimulation. The patch preparation which does not require an increase in the area and thickness of an adhesive layer, achieves a sufficiently high skin permeation amount of the drug, shows good adhesiveness to skin, and permits a long-term adhesion to skin. The invention also provides a method of producing the patch preparation.
摘要翻译： 本发明提供了一种补片制剂，其包含（a）支持物和（b）在载体表面上含有药物的粘合剂层，其中在施加物理刺激之后立即在粘合剂层中形成药物的晶体 而在物理刺激后的保存期间形成药物的晶体。 不需要增加粘合剂层的面积和厚度的贴片制剂能够获得足够高的皮肤渗透量的药物，对皮肤具有良好的粘附性，并且可以长期粘附到皮肤上。 本发明还提供一种制备贴剂的方法。
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公开(公告)号：US20060292210A1
公开(公告)日：2006-12-28
申请号：US11447046
申请日：2006-06-06
申请人： Keigo Inosaka , Takateru Muraoka , Yoshihiro Iwao , Akio Takada , Toshinobu Tsuda , Junichi Sekiya
发明人： Keigo Inosaka , Takateru Muraoka , Yoshihiro Iwao , Akio Takada , Toshinobu Tsuda , Junichi Sekiya
IPC分类号： A61K9/70 , A61K31/137
CPC分类号： A61K31/135 , A61K9/7061 , A61K47/02
摘要： A stable percutaneous absorption-type pharmaceutical preparation for percutaneous administration of selegiline or selegiline hydrochloride, which does not suffer a decrease in the cohesive force of the adhesive layer therein even in the presence of sweat components due to perspiration during wear and which is free from cohesive failure and resultant adhesive remaining when stripped off, is provided. A percutaneous absorption-type pharmaceutical preparation which comprises: a support; and an adhesive layer containing a metal chloride, an adhesive and at least one of (−)-(R)—N,α-dimethyl-N-2-propynylphenethylamine and its hydrochloride, wherein the adhesive layer is subjected to a crosslinking treatment.
摘要翻译： 一种用于经皮给药司来吉兰或司来吉兰盐酸盐的稳定的经皮吸收型药物制剂，其即使在汗液组分由于汗液在磨损期间也不会降低粘合剂层的内聚力，并且不含内聚 提供了剥离时残留的失效和残留的粘合剂。 一种经皮吸收型药物制剂，其包含：载体; 以及含有金属氯化物，粘合剂和（ - ） - （R）-N，α-二甲基-N-二丙炔基苯乙胺及其盐酸盐中的至少一种的粘合剂层，其中对粘合剂层进行交联处理。
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公开(公告)号：US09005174B2
公开(公告)日：2015-04-14
申请号：US13581079
申请日：2011-02-23
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
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公开(公告)号：US20120323191A1
公开(公告)日：2012-12-20
申请号：US13581079
申请日：2011-02-23
IPC分类号： A61M35/00
CPC分类号： A61K9/7061 , A61F2013/00651 , A61K9/7023 , A61K9/703 , A61K9/7053
摘要： The invention is intended to provide an adhesive patch which contains a drug except bisoprolol and which effectively inhibits the occurrence of oozing out or sticking out of the adhesive layer components from the exposed area of the adhesive layer of the adhesive patch during storage as well as the occurrence of oozing out of the drug from the adhesive layer thereby preventing the reduction in drug content. The support, the release liner and the adhesive layer constituting the adhesive patch each are formed to have a rectangular planar shape and the entire adhesive patch are formed to have a rectangular planar shape, and a protrudent part is formed on the support-side surface of the adhesive patch at a corner thereof. In addition, the adhesive patch may be formed to have a middle part and a peripheral part, and the protrudent part may be formed at a corner of the rectangular middle part. Further, between the adjacent at least two protrudent parts, a connecting built-up part may be provided in which the thickness of the adhesive patch is smaller than the thickness of the adhesive patch in the protrudent part. In case where the release liner has a split part, the split part is made so as not to traverse the protrudent part.
摘要翻译： 本发明旨在提供一种粘合贴片，其包含除比索洛尔以外的药物，并且其有效地抑制在保存期间从粘合剂贴剂的粘合剂层的暴露区域渗出或渗出粘合剂层组分的发生以及 从粘合剂层渗出药物的发生，从而防止药物含量的降低。 构成粘合片的支持体，剥离衬垫和粘合剂层各自形成为矩形平面形状，并且整个粘合贴片形成为矩形平面形状，并且在支撑体的支撑侧表面上形成突起部 在其角落处的粘合剂贴剂。 此外，粘合贴片可以形成为具有中间部分和周边部分，并且凸起部分可以形成在矩形中间部分的角部。 此外，在相邻的至少两个突出部之间，可以提供连接组装部分，其中粘合贴片的厚度小于突出部分中的粘合贴片的厚度。 在剥离衬垫具有分割部分的情况下，分割部分被制成不穿过突出部分。
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