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    Nucleic acid molecule capable of binding to rabbit-derived IgG antibody
    1.
    发明授权
    Nucleic acid molecule capable of binding to rabbit-derived IgG antibody 有权
    能够结合兔衍生的IgG抗体的核酸分子

    公开(公告)号：US08283457B2

    公开(公告)日：2012-10-09

    申请号：US12516293

    申请日：2007-11-22

    申请人： Yoshihito Yoshida ,  Makio Furuichi ,  Iwao Waga ,  Hiroshi Mizuno

    发明人： Yoshihito Yoshida ,  Makio Furuichi ,  Iwao Waga ,  Hiroshi Mizuno

    IPC分类号： C07H21/02

    CPC分类号： C12Q1/6883 ,  C12N15/115 ,  C12N2310/16

    摘要： The present invention provides a nucleic acid molecule having an ability to bind to a rabbit anti-mouse IgG antibody, which can be prepared more easily than an antibody and has a binding ability equal to or higher than that of an antibody. The nucleic acid molecule according to the present invention may have the sequences set forth in SEQ ID NOS: 1 to 5. The nucleic acid molecule according to the present invention may be a nucleic acid having an ability to bind to a rabbit IgG antibody, which substantially has homology to its sequence. The nucleic acid molecule according to the present invention may have a binding constant (KD) of 1.18×10−7 (M) or less to the rabbit IgG antibody.

    摘要翻译： 本发明提供具有与兔抗小鼠IgG抗体结合的能力的核酸分子，其可以比抗体更容易制备并且具有等于或高于抗体的结合能力。 根据本发明的核酸分子可以具有SEQ ID NO：1至5所示的序列。根据本发明的核酸分子可以是具有结合兔IgG抗体的能力的核酸，其中 与其序列基本上具有同源性。 本发明的核酸分子与兔IgG抗体的结合常数（KD）可以为1.18×10 -7（M）以下。

    NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO RABBIT-DERIVED lgG ANTIBODY
    2.
    发明申请
    NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO RABBIT-DERIVED lgG ANTIBODY 有权
    能够结合RABBI衍生的IgG抗体的核酸分子

    公开(公告)号：US20100222559A1

    公开(公告)日：2010-09-02

    申请号：US12516293

    申请日：2007-11-22

    申请人： Yoshihito Yoshida ,  Makio Furuichi ,  Iwao Waga ,  Hiroshi Mizuno

    发明人： Yoshihito Yoshida ,  Makio Furuichi ,  Iwao Waga ,  Hiroshi Mizuno

    IPC分类号： C07H21/02

    CPC分类号： C12Q1/6883 ,  C12N15/115 ,  C12N2310/16

    摘要： The present invention provides a nucleic acid molecule having an ability to bind to a rabbit anti-mouse IgG antibody, which can be prepared more easily than an antibody and has a binding ability equal to or higher than that of an antibody. The nucleic acid molecule according to the present invention may have the sequences set forth in SEQ ID NOS: 1 to 5. The nucleic acid molecule according to the present invention may be a nucleic acid having an ability to bind to a rabbit IgG antibody, which substantially has homology to its sequence. The nucleic acid molecule according to the present invention may have a binding constant (KD) of 1.18×10−7 (M) or less to the rabbit IgG antibody.

    摘要翻译： 本发明提供具有与兔抗小鼠IgG抗体结合的能力的核酸分子，其可以比抗体更容易制备并且具有等于或高于抗体的结合能力。 根据本发明的核酸分子可以具有SEQ ID NO：1至5所示的序列。根据本发明的核酸分子可以是具有结合兔IgG抗体的能力的核酸，其中 与其序列基本上具有同源性。 本发明的核酸分子与兔IgG抗体的结合常数（KD）可以为1.18×10 -7（M）以下。

    METHOD FOR OBTAINING OLIGONUCLEOTIDE
    7.
    发明申请
    METHOD FOR OBTAINING OLIGONUCLEOTIDE 审中-公开
    获得寡核苷酸的方法

    公开(公告)号：US20100129870A1

    公开(公告)日：2010-05-27

    申请号：US12376182

    申请日：2007-07-10

    申请人： Fumiko Nishikawa ,  Satoshi Nishikawa ,  Makio Furuichi ,  Hiroshi Mizuno ,  Iwao Waga

    发明人： Fumiko Nishikawa ,  Satoshi Nishikawa ,  Makio Furuichi ,  Hiroshi Mizuno ,  Iwao Waga

    IPC分类号： C12P19/34 ,  B01D57/02

    CPC分类号： C12N15/115 ,  C12N2310/16 ,  C12N2330/30

    摘要： The present invention is to provide a method for obtaining an oligonucleotide such as RNA aptamer having high binding capacity to a target substance with easy-to-use and high purity. The method for obtaining oligonucleotide according to the present invention is as follows:A method for obtaining oligonucleotide comprising the steps of: performing an electrophoresis of a nucleic acid molecule/target substance complex comprising a nucleic acid molecule and a target substance; recovering said nucleic acid molecule/target substance complex; extracting the nucleic acid molecule from said nucleic acid molecule/target substance complex; gene amplifying said nucleic acid molecule.

    摘要翻译： 本发明提供一种获得对具有易于使用和高纯度的目标物质具有高结合能力的RNA适体的寡核苷酸的方法。 根据本发明的获得寡核苷酸的方法如下：一种获得寡核苷酸的方法，包括以下步骤：进行包含核酸分子和靶物质的核酸分子/靶物质复合物的电泳; 回收所述核酸分子/靶物质复合物; 从所述核酸分子/靶物质复合物提取核酸分子; 基因扩增所述核酸分子。

    NUCLEIC ACID ELEMENT FOR USE IN ANALYSIS, AND ANALYTICAL METHOD, ANALYTICAL REAGENT, AND ANALYTICAL INSTRUMENT USING SAME
    9.
    发明申请
    NUCLEIC ACID ELEMENT FOR USE IN ANALYSIS, AND ANALYTICAL METHOD, ANALYTICAL REAGENT, AND ANALYTICAL INSTRUMENT USING SAME 有权
    用于分析的核酸元件，分析方法，分析试剂和使用分析试剂的分析仪器

    公开(公告)号：US20120202195A1

    公开(公告)日：2012-08-09

    申请号：US13389222

    申请日：2010-08-06

    申请人： Iwao Waga ,  Jou Akitomi ,  Makio Furuichi

    发明人： Iwao Waga ,  Jou Akitomi ,  Makio Furuichi

    IPC分类号： G01N33/53 ,  G01N27/26 ,  C12N9/96 ,  G01N21/75 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6825 ,  C12N15/115 ,  C12N2310/3519 ,  C12N2320/10 ,  C12Q2565/101 ,  C12Q2525/301 ,  C12Q2525/205 ,  C12Q1/6823 ,  C12Q2563/125

    摘要： The technique by which simple analysis of an intended subject to be analyzed can be carried out is provided. In this technique, a nucleic acid element 16 for use in analysis including: a first nucleic acid part 12; and a second nucleic acid part 13 is used. In the nucleic acid element 16, the first nucleic acid part 12 is a binding part that can bind to a subject 11 to be analyzed, and the second nucleic acid part 13 is a labeling part that can distinguish between binding and non-binding of the first nucleic acid part 12 to the subject 11. It is preferred that the first nucleic acid part 12 is an aptamer against the subject 11. The subject 11 can be analyzed easily by using the nucleic acid element 16, binding the subject 11 to the first nucleic acid part 12, and then analyzing the binding with the second nucleic acid part 13.

    摘要翻译： 提供了可以进行要分析的目标对象的简单分析的技术。 在该技术中，用于分析的核酸元件16包括：第一核酸部分12; 并且使用第二核酸部分13。 在核酸元件16中，第一核酸部分12是可以结合待分析对象11的结合部分，第二核酸部分13是可以区分结合部分和非结合的标记部分 优选的是，第一核酸部分12是针对受试者11的适体。可以通过使用核酸元件16容易地分析受试者11，将受试者11结合到第一核酸部分 核酸部分12，然后分析与第二核酸部分13的结合。