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    Benzodiazepine derivatives
    1.
    发明授权
    Benzodiazepine derivatives 失效
    苯并二氮杂衍生物

    公开(公告)号：US5763437A

    公开(公告)日：1998-06-09

    申请号：US776196

    申请日：1997-01-29

    申请人： Yoshinari Sato ,  Kazuo Sakane ,  Seiichiro Tabuchi ,  Hitoshi Mitsui ,  Ikuyo Katsumi ,  Yuichi Satoh

    发明人： Yoshinari Sato ,  Kazuo Sakane ,  Seiichiro Tabuchi ,  Hitoshi Mitsui ,  Ikuyo Katsumi ,  Yuichi Satoh

    IPC分类号： C07D243/14 ,  A61K31/55 ,  A61K31/551 ,  A61P1/00 ,  A61P25/04 ,  A61P25/18 ,  C07D243/24 ,  C07D243/26 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D487/08

    CPC分类号： C07D243/24

    摘要： Benzodiazepine derivatives of formula (I) wherein R.sup.1 is aryl which may have one or more suitable substituent(s), R.sup.2 is C.sub.3 -C.sub.8 cycloalkyl which may have one or more suitable substituent(s), A is lower alkylene, R.sup.3 is a heterocyclic group selected from the group consisting of tetrahydrofuryl, dioxolanyl, filryl, thienyl, isoxazolyl, pyridyl, benzimidazolyl, benzotiazolyl, benzoxazolyl, benzopyrany, quinolyl, isoquinolyl, tetrahydroisoquinolyl, benzothienyl and benzofuryl, each of which may have one or more suitable substituent(s), or a pharmaceutically acceptable salt thereof, which are useful as a medicament.

    摘要翻译： PCT No.PCT / JP95 / 01497 Sec。 371日期1997年1月29日 102（e）1997年1月29日PCT PCT 1995年7月27日PCT公布。 公开号WO96 / 04254 日期：1996年2月15日，式（I）的苯并二氮杂衍生物，其中R 1为可具有一个或多个合适取代基的芳基，R 2为可具有一个或多个合适取代基的C 3 -C 8环烷基，A为低级亚烷基 R3是选自四氢呋喃基，二氧戊环基，二烯丙基，噻吩基，异恶唑基，吡啶基，苯并咪唑基，苯并噻唑基，苯并恶唑基，苯并吡喃基，喹啉基，异喹啉基，四氢异喹啉基，苯并噻吩基和苯并呋喃基的杂环基，其各自可以具有一个或多个 合适的取代基或其药学上可接受的盐，其可用作药物。

    Process for preparing fluoroaryl magnesium derivative and process for preparing (fluoroaryl) borane compound
    3.
    发明授权
    Process for preparing fluoroaryl magnesium derivative and process for preparing (fluoroaryl) borane compound 失效
    制备氟芳基镁衍生物的方法和制备（氟化芳基）硼烷化合物的方法

    公开(公告)号：US6057480A

    公开(公告)日：2000-05-02

    申请号：US930708

    申请日：1997-10-16

    申请人： Tsunemasa Ueno ,  Ikuyo Katsumi ,  Naoko Yamamoto ,  Hitoshi Mitsui

    发明人： Tsunemasa Ueno ,  Ikuyo Katsumi ,  Naoko Yamamoto ,  Hitoshi Mitsui

    IPC分类号： C07F3/02 ,  C07F5/02

    CPC分类号： C07F3/02 ,  C07F5/027

    摘要： A fluoroaryl magnesium derivative is produced by reacting aryl fluoride, hydrocarbon halide, and magnesium with one another in an ether solvent or a mixed solvent of the ether solvent and a hydrocarbon solvent. Also, a (fluoroaryl)borane compound is produced by mixing both a solution prepared by dissolving the fluoroaryl magnesium derivative into the ether solvent and another solvent prepared by dissolving the boron halide in the ether solvent with a hydrocarbon solvent having a higher boiling point than the ether solvent, so that the fluoroaryl magnesium derivative and boron halide react with each other while the ether solvent is being distilled out.

    摘要翻译： PCT No.PCT / JP97 / 00391 Sec。 371日期：1997年10月16日 102（e）日期1997年10月16日PCT 1997年2月12日提交PCT公布。 公开号WO97 / 31924 PCT 日期1997年9月4日氟芳基镁衍生物通过芳基氟化物，烃卤化物和镁在醚溶剂或醚溶剂和烃溶剂的混合溶剂中彼此反应来制备。 此外，（氟化芳基）硼烷化合物是通过将通过将氟化芳基镁衍生物溶解在醚溶剂中制备的溶液和通过将卤化硼溶解在醚溶剂中制备的另一种溶剂与沸点高于 醚溶剂，使得氟化芳基镁衍生物和卤化硼在蒸出醚溶剂的同时彼此反应。

    Process for preparing a tetrakis(fluoroaryl) borate derivative
    4.
    发明授权
    Process for preparing a tetrakis(fluoroaryl) borate derivative 失效
    制备四（氟化芳基）硼酸盐衍生物的方法

    公开(公告)号：US06683218B1

    公开(公告)日：2004-01-27

    申请号：US08955854

    申请日：1997-10-21

    申请人： Hitoshi Mitsui ,  Ikuyo Katsumi ,  Naoko Yamamoto

    发明人： Hitoshi Mitsui ,  Ikuyo Katsumi ,  Naoko Yamamoto

    IPC分类号： C07F502

    CPC分类号： C07F5/02

    摘要： A fluoroaryl magnesium derivative expressed by General Formula (1): where each of R1-R5 represents a hydrogen atom, a fluorine atom, a hydrocarbon group, or an alkoxy group while at least one of R1-R5 representing a fluorine atom, and Xa represents a chlorine atom, a bromine atom, or an iodine atom; and boron halide expressed by General Formula (2): BXb3  (2)  where Xb represents a fluorine atom, a chlorine atom, a bromine atom, or an iodine atom, are reacted with each other in a solvent (a) containing diethyl ether and/or tetrahydrofuran, after which the resulting reaction solution is added to a solvent (b) having a higher boiling point than diethyl ether and/or tetrahydrofuran while diethyl ether and/or tetrahydrofuran are distilled out. Consequently, it has become possible to obtain a (fluoroaryl)borane compound expressed by General Formula (3):  where each of R1-R5, and Xb, represents the same as above, and n represents 2 or 3, from which magnesium halide produced as a by-product is separated and removed, selectively in a simple manner at a low cost.

    摘要翻译： 由通式（1）表示的氟化芳基镁衍生物：其中R1-R5各自表示氢原子，氟原子，烃基或烷氧基，而R1-R5中至少一个表示氟原子，Xa 表示氯原子，溴原子或碘原子; 由通式（2）表示的卤代硼：其中Xb表示氟原子，氯原子，溴原子或碘原子，在含有二乙醚和/或四氢呋喃的溶剂（a）中彼此反应，之后 将所得反应溶液加入到沸点比二乙醚和/或四氢呋喃高的溶剂（b）中，同时蒸馏出乙醚和/或四氢呋喃。 因此，可以获得由通式（3）表示的（氟化芳基）硼烷化合物：其中R1-R5和Xb各自表示与上述相同的含义，n表示2或3，由此产生卤化镁 作为副产物以低成本以简单的方式选择性地分离和除去。

    Diaryliodonium salt mixture and process for production thereof, and process for production of diaryliodonium compound
    5.
    发明授权
    Diaryliodonium salt mixture and process for production thereof, and process for production of diaryliodonium compound 有权
    二芳基碘盐混合物及其制备方法以及二芳基碘化合物的制备方法

    公开(公告)号：US08975203B2

    公开(公告)日：2015-03-10

    申请号：US13138975

    申请日：2010-04-30

    申请人： Tomoaki Tanaka ,  Ikuyo Katsumi

    发明人： Tomoaki Tanaka ,  Ikuyo Katsumi

    IPC分类号： C08F4/00 ,  C07C17/26 ,  C07C25/18

    CPC分类号： C07C25/18 ,  C07C17/26

    摘要： Disclosed are: a diaryliodonium salt mixture which is a precursor of a BF4 salt or the like of a diaryliodonium compound, can be produced in the form of crystals at ambient temperature, can be purified in a simple manner, can be produced with high efficiency, and can be induced into a BF4 salt or the like salt that has excellent solubility in a monomer or the like; and a process for producing the diaryliodonium salt mixture. Also disclosed is a production process which can achieve good yield and can produce reduced amounts of byproducts, and is therefore applicable to the industrial mass production of a diaryliodonium compound. The diaryliodonium salt mixture is characterized by containing at least two specific diaryliodonium salts.

    摘要翻译： 公开了：作为二芳基碘化合物的BF 4盐等的前体的二芳基碘盐混合物可以在环境温度下以晶体的形式生产，可以以简单的方式纯化，可以高效率地制备， 并且可以诱导成在单体等中具有优异溶解性的BF 4盐等盐; 和二芳基碘盐混合物的制备方法。 还公开了可以获得良好产率并且可以产生减少量的副产物的生产方法，因此适用于二芳基碘化合物的工业量产。 二芳基碘盐混合物的特征在于含有至少两种特定的二芳基碘鎓盐。

    Method of producing naphthalenedicarboxylic acids and diaryldicarboxylic acids
    7.
    发明授权
    Method of producing naphthalenedicarboxylic acids and diaryldicarboxylic acids 失效
    生产萘二羧酸和二芳基二羧酸的方法

    公开(公告)号：US5523473A

    公开(公告)日：1996-06-04

    申请号：US450934

    申请日：1995-05-25

    申请人： Noboru Saitou ,  Koichi Hirota ,  Ren Hasebe ,  Norimasa Okuda ,  Ikuyo Katsumi

    发明人： Noboru Saitou ,  Koichi Hirota ,  Ren Hasebe ,  Norimasa Okuda ,  Ikuyo Katsumi

    IPC分类号： C07C51/265

    CPC分类号： C07C51/265

    摘要： A method of producing naphthalenedicarboxylic acids by the oxidation of dialkyl-substituted naphthalene with a gas containing molecular oxygen in an organic solvent and in the presence of a catalyst comprising copper and bromine, or a catalyst comprising copper, bromine and at least one kind of element/compound selected from the group of consisting of amine compounds and heavy metallic elements which are vanadium, manganese, iron, nickel, palladium and cerium. And a method of producing diaryldicarboxylic acids by the oxidation of dialkyl-substituted diaryl compounds with a gas containing molecular oxygen in an organic solvent and in the presence of the same catalyst. These methods permit high yields of naphthalenedicarboxylic acids of high purity and of diaryldicarboxylic acids of high purity with the use of small amounts of catalyst.

    摘要翻译： 通过在有机溶剂中和在包含铜和溴的催化剂存在下，在含有分子氧的气体下二烷基取代的萘氧化制备萘二甲酸的方法，或包含铜，溴和至少一种元素的催化剂 /选自由胺化合物和钒，锰，铁，镍，钯和铈的重金属元素组成的组的化合物。 以及通过在有机溶剂中和在相同催化剂存在下，用含有分子氧的气体氧化二烷基取代的二芳基化合物来生产二芳基二羧酸的方法。 这些方法允许使用少量催化剂高纯度的萘二甲酸和高纯度的二芳基二羧酸的高产率。

    Diaryliodonium salt mixture and process for production thereof, and process for production of diaryliodonium compound
    8.
    发明申请
    Diaryliodonium salt mixture and process for production thereof, and process for production of diaryliodonium compound 有权
    二芳基碘盐混合物及其制备方法以及二芳基碘化合物的制备方法

    公开(公告)号：US20120053048A1

    公开(公告)日：2012-03-01

    申请号：US13138975

    申请日：2010-04-30

    申请人： Tomoaki Tanaka ,  Ikuyo Katsumi

    发明人： Tomoaki Tanaka ,  Ikuyo Katsumi

    IPC分类号： C08F4/00 ,  C07C17/26

    CPC分类号： C07C25/18 ,  C07C17/26

    摘要： Disclosed are: a diaryliodonium salt mixture which is a precursor of a BF4 salt or the like of a diaryliodonium compound, can be produced in the form of crystals at ambient temperature, can be purified in a simple manner, can be produced with high efficiency, and can be induced into a BF4 salt or the like salt that has excellent solubility in a monomer or the like; and a process for producing the diaryliodonium salt mixture. Also disclosed is a production process which can achieve good yield and can produce reduced amounts of byproducts, and is therefore applicable to the industrial mass production of a diaryliodonium compound. The diaryliodonium salt mixture is characterized by containing at least two specific diaryliodonium salts.

    摘要翻译： 公开了：作为二芳基碘化合物的BF 4盐等的前体的二芳基碘盐混合物可以在环境温度下以晶体的形式生产，可以以简单的方式纯化，可以高效率地制备， 并且可以诱导成在单体等中具有优异溶解性的BF 4盐等盐; 和二芳基碘盐混合物的制备方法。 还公开了可以获得良好产率并且可以产生减少量的副产物的生产方法，因此适用于二芳基碘化合物的工业量产。 二芳基碘盐混合物的特征在于含有至少两种特定的二芳基碘鎓盐。

    Stabilizing Method and Stabilized Composition for Aryl Boron Compounds
    9.
    发明申请
    Stabilizing Method and Stabilized Composition for Aryl Boron Compounds 审中-公开
    芳基硼化合物的稳定化方法和稳定组合物

    公开(公告)号：US20080154065A1

    公开(公告)日：2008-06-26

    申请号：US11883164

    申请日：2006-01-25

    申请人： Ikuyo Katsumi

    发明人： Ikuyo Katsumi

    IPC分类号： C07F5/02

    CPC分类号： C07F5/027

    摘要： A method for stabilizing an aryl boron compound of formula (1): wherein Ar1, Ar2, and Ar3 are aryl groups, including mixing a compound which has higher affinity for the aryl boron compound than water, as a stabilizer, in a solution or slurry containing the aryl boron compound in a hydrocarbon solvent; and a stabilized composition obtained thereby. The stabilizing method and the stabilized composition of the present invention make it possible to store aryl boron compounds stably over a long term, while keeping their high purity, in the form of forming a substantially homogeneous system in the case of a solution or in the form of forming a substantially homogeneous system by heating in the case of slurry.

    摘要翻译： 稳定式（1）的芳基硼化合物的方法：其中Ar 1，Ar 2和Ar 3是芳基，包括 在烃溶剂中将含有芳基硼化合物的亲水性高于水的化合物作为稳定剂混合在含有芳基硼化合物的溶液或浆料中; 和由此得到的稳定化组合物。 本发明的稳定化方法和稳定化的组合物使得可以在保持高纯度的同时长期稳定地储存芳基硼化合物，形成在溶液或形式中形成基本均匀的体系 在浆料的情况下通过加热形成基本均匀的体系。