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公开(公告)号：US4141291A
公开(公告)日：1979-02-27
申请号：US793304
申请日：1977-05-03
申请人： Yoshio Hata , Hiroyuki Harada
发明人： Yoshio Hata , Hiroyuki Harada
CPC分类号： B41J11/18
摘要： A mechanism for actuating a platen of a printer in which a cooperating pin and lever are provided to permit a plurality of printing rings with the desired characters thereon to be printed to be placed into a printing position, to move a platen into abutting engagement with the printing rings and hold them engaged for printing, all during a first period of time, and to remove the platen from the printing rings during a second period of time, and in which the first time period is about two to three times longer than the second time period so that the speed of the printer for each printing operation is increased.
摘要翻译： 一种用于致动打印机的压板的机构，其中设置有配合的销和杆以允许将要打印的所需字符的多个打印环放置在打印位置，以使压板移动到与所述打印机 打印环并且在第一时间期间保持它们被接合以进行打印，并且在第二时间段期间从打印环移除压板，并且其中第一时间段比第二时间段长约两到三倍 使得打印机的每个打印操作的速度增加。
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公开(公告)号：US08649892B2
公开(公告)日：2014-02-11
申请号：US11910762
申请日：2006-04-03
IPC分类号： G06F19/00
CPC分类号： B25J9/1674 , G05B2219/40197 , G05B2219/40224 , Y02P90/14 , Y02P90/20
摘要： There is provided a production management system that requires no backup step for performing a backup operation when trouble occurs in a robot, and can increase workability of a repair operation of the robot. The production management system for a production line mixedly including robot operation steps and manual operation steps, including: a monitor that displays the cause of abnormality that occurs in the robot operation step; a warning device that warns of occurrence of abnormality in the robot operation step; and a robot reversing device that reverses the orientation of a robot when abnormality occurs in the robot, wherein production is continued by changing the robot operation step where the abnormality occurs to the manual operation step. Also, a repair operation is performed for the robot reversed by the robot reversing device.
摘要翻译： 提供了一种生产管理系统，当机器人发生故障时，不需要执行备份操作的备份步骤，并且可以提高机器人的修复操作的可操作性。 混合生产线的生产管理系统，包括机器人操作步骤和手动操作步骤，包括：显示机器人操作步骤中出现的异常原因的监视器; 警告装置，其在所述机器人动作步骤中发生异常发生; 以及机器人逆转装置，其在机器人发生异常时使机器人的姿势反转，其中通过将进行异常的机器人操作步骤改变为手动操作步骤来继续生产。 此外，对由机器人反转装置反转的机器人执行修理操作。
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公开(公告)号：US20060128938A1
公开(公告)日：2006-06-15
申请号：US11348464
申请日：2006-02-07
申请人： Kohei Yamamoto , Tsutomu Tani , Takashi Aoki , Yoshio Hata
发明人： Kohei Yamamoto , Tsutomu Tani , Takashi Aoki , Yoshio Hata
IPC分类号： C08G63/08
CPC分类号： A61K38/09 , A61K9/1647 , A61K9/5031 , A61K47/34 , C08G63/08 , C08G63/88 , C08G63/912 , Y10S514/963 , Y10S514/965
摘要： A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physiologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time.
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公开(公告)号：US5901129A
公开(公告)日：1999-05-04
申请号：US727732
申请日：1996-10-08
IPC分类号： G11B17/04 , G11B17/047 , G11B23/03 , G11B33/02
CPC分类号： G11B17/047 , G11B17/056 , G11B17/057 , G11B23/0307 , G11B23/0308 , G11B23/0311 , G11B23/0316
摘要： A flat tray (1) for receiving a disk cartridge (21) for a disk loading apparatus, wherein positioning holes (28) are provided at the rear end (27a), on a peripheral side, of the disk cartridge, and protrusions (18) are formed on the tray providing for a rigid positioning of the cartridge in order to fix the cartridge at the specified position on the tray. The protrusions (18) may be made of leaf springs that are formed with one end curved. When the disk cartridge (21) is pushed into the tray (1), the curved portions of the protrusions match the positioning holes (28) on the disk cartridge.
摘要翻译： 一个平板托盘（1），用于容纳用于盘装载装置的盘盒（21），其中定位孔（28）设置在盘盒的周边的后端（27a）处，以及突起（18 ）形成在托盘上，用于盒的刚性定位，以便将盒固定在托盘上的指定位置。 突起（18）可以由形成有一端弯曲的板簧制成。 当盘盒（21）被推入托盘（1）时，突起的弯曲部分与盘盒上的定位孔（28）相匹配。
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公开(公告)号：US20120283187A1
公开(公告)日：2012-11-08
申请号：US13548463
申请日：2012-07-13
申请人： Kazumichi Yamamoto , Akiko Yamada , Yoshio Hata
发明人： Kazumichi Yamamoto , Akiko Yamada , Yoshio Hata
CPC分类号： A61K38/09 , A61K9/1617 , A61K9/1647 , A61K38/24 , A61K2300/00
摘要： A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.
摘要翻译： 提供含有高含量的生理活性物质，抑制初始过量释放并长时间达到稳定释放速度的控释组合物。 控释组合物，其包含（1）基于总组合物重量的约14％（w / w）至约24％（w / w）的生理活性物质或其盐，（2）羟基萘甲酸 由3-羟基-2-萘甲酸和1-羟基-2-萘甲酸或其盐组成的组，和（3）重均分子量为15000〜50000的乳酸聚合物或其盐，其中 分子量为5000以下的聚合物的含量为约5重量％以下，其中所述羟基萘甲酸或其盐与所述生理活性物质或其盐的摩尔比为3:4至4:3。
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公开(公告)号：US08092830B2
公开(公告)日：2012-01-10
申请号：US11822128
申请日：2007-07-02
申请人： Kohei Yamamoto , Tsutomu Tani , Takashi Aoki , Yoshio Hata
发明人： Kohei Yamamoto , Tsutomu Tani , Takashi Aoki , Yoshio Hata
IPC分类号： A61K9/50 , A61K9/52 , C08G63/44 , C08F283/06
CPC分类号： A61K38/09 , A61K9/1647 , A61K9/5031 , A61K47/34 , C08G63/08 , C08G63/88 , C08G63/912 , Y10S514/963 , Y10S514/965
摘要： A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physiologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time.
摘要翻译： 一种生产重均分子量为15,000至50,000的乳酸聚合物的方法，其中重均分子量不超过约5,000的聚合物材料的含量不超过约5重量％，其特征在于水解 高分子量乳酸聚合物，将包含水解产物的所得溶液置于能够沉淀目标乳酸聚合物的条件下，分离沉淀的乳酸聚合物并收集它们。 乳酸聚合物可用作缓释制剂的基质。 包封生理活性物质的缓释微胶囊制剂可以充分地防止生物活性物质从微胶囊的初始过度释放，并在长时间内保持稳定的释放速率。
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公开(公告)号：US07429559B2
公开(公告)日：2008-09-30
申请号：US10182731
申请日：2002-06-28
申请人： Kazumichi Yamamoto , Akiko Yamada , Yoshio Hata
发明人： Kazumichi Yamamoto , Akiko Yamada , Yoshio Hata
IPC分类号： A61K38/00
CPC分类号： A61K38/09 , A61K9/1617 , A61K9/1647 , A61K38/24 , A61K2300/00
摘要： A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided.A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.
摘要翻译： 提供含有高含量的生理活性物质，抑制初始过量释放并长时间达到稳定释放速度的控释组合物。 控释组合物，其包含（1）基于总组合物重量的约14％（w / w）至约24％（w / w）的生理活性物质或其盐，（2）羟基萘甲酸 由3-羟基-2-萘甲酸和1-羟基-2-萘甲酸或其盐组成的组，和（3）重均分子量为15000〜50000的乳酸聚合物或其盐，其中 分子量为5000以下的聚合物的含量为约5重量％以下，其中所述羟基萘甲酸或其盐与所述生理活性物质或其盐的摩尔比为3:4至4:3。
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公开(公告)号：US20070259036A1
公开(公告)日：2007-11-08
申请号：US11822128
申请日：2007-07-02
申请人： Kohei Yamamoto , Tsutomu Tani , Takashi Aoki , Yoshio Hata
发明人： Kohei Yamamoto , Tsutomu Tani , Takashi Aoki , Yoshio Hata
CPC分类号： A61K38/09 , A61K9/1647 , A61K9/5031 , A61K47/34 , C08G63/08 , C08G63/88 , C08G63/912 , Y10S514/963 , Y10S514/965
摘要： A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physiologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time.
摘要翻译： 一种生产重均分子量为15,000至50,000的乳酸聚合物的方法，其中重均分子量不超过约5,000的聚合物材料的含量不超过约5重量％，其特征在于水解 高分子量乳酸聚合物，将包含水解产物的所得溶液置于能够沉淀目标乳酸聚合物的条件下，分离沉淀的乳酸聚合物并收集它们。 乳酸聚合物可用作缓释制剂的基质。 包封生理活性物质的缓释微胶囊制剂可以充分地防止生物活性物质从微胶囊的初始过度释放，并在长时间内保持稳定的释放速率。
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公开(公告)号：US08258252B2
公开(公告)日：2012-09-04
申请号：US11960114
申请日：2007-12-19
申请人： Kazumichi Yamatomo , Akiko Yamada , Yoshio Hata
发明人： Kazumichi Yamatomo , Akiko Yamada , Yoshio Hata
IPC分类号： C08G67/00
CPC分类号： A61K38/09 , A61K9/1647
摘要： Present invention is to provide a sustained-release composition which contains a physiologically active substance in high content even when gelatin is not included, and suppresses its initial excessive release and, thus, can achieve a stable release rate over about one month. A sustained-release composition containing a lactic acid-glycolic acid polymer having a ratio or weight average molecular weight and number average molecular weight of about 1.90 or lower, or a salt thereof, and a physiologically active substance.
摘要翻译： 本发明提供即使在不含明胶时也含有高含量的生理活性物质的缓释组合物，抑制其初始过度释放，从而能够在约1个月内达到稳定的释放速度。 一种缓释组合物，其含有比例或重均分子量和数均分子量为约1.90以下的乳酸 - 乙醇酸聚合物或其盐和生理活性物质。
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公开(公告)号：US20110166084A1
公开(公告)日：2011-07-07
申请号：US13064282
申请日：2011-03-16
申请人： Kazumichi Yamamoto , Akiko Yamada , Yoshio Hata
发明人： Kazumichi Yamamoto , Akiko Yamada , Yoshio Hata
CPC分类号： A61K38/09 , A61K9/1617 , A61K9/1647 , A61K38/24 , A61K2300/00
摘要： A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided.A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.
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