公开(公告)号：US6153266A

公开(公告)日：2000-11-28

申请号：US206265

申请日：1998-12-07

申请人： Yoshiyuki Yokogawa ,  Tetsuya Kameyama ,  Yukari Kawamoto ,  Kaori Nishizawa ,  Fukue Nagata ,  Kohji Okada ,  Hiroshi Sumi

发明人： Yoshiyuki Yokogawa ,  Tetsuya Kameyama ,  Yukari Kawamoto ,  Kaori Nishizawa ,  Fukue Nagata ,  Kohji Okada ,  Hiroshi Sumi

IPC分类号： A61L27/00 ,  A61K6/033 ,  C01B25/32 ,  D06M11/71 ,  D06M11/72 ,  B05D1/38 ,  B05D1/18 ,  B05D3/02

CPC分类号： D06M11/71 ,  D06M11/72

摘要： The present invention provides a method for producing a calcium phosphate coating film on the surface of a substrate, even a substrate which has poor heat resistance. The method comprises the steps of soaking a substrate in a first solution containing phosphate ions, inter alia, aqueous solutions of a basic phosphate salt such as Na.sub.3 PO.sub.4 or Na.sub.2 HPO.sub.4 ; removing the substrate and drying it; and soaking the substrate in a second solution (aqueous solution) containing calcium ions, to thereby obtain a coating film comprising hydroxyapatite or a mixture containing hydroxyapatite and a hydroxyapatite precursor. The substrate removed from the second solution may be soaked in a third solution (aqueous solution) containing an apatite component at a substantially saturated or supersaturated concentration, to thereby form a hydroxyapatite coating film. There may be used substrates formed of metals, ceramics, organic polymer materials, etc. The method is applicable to a substrate having poor heat resistance, such as synthetic resin fabric, due to omission of high-temperature treatment.

摘要翻译： 本发明提供一种在基材表面即使是耐热性差的基材上生产磷酸钙涂膜的方法。 该方法包括以下步骤：将底物浸泡在含有磷酸根离子的第一溶液中，特别是碱性磷酸盐如Na 3 PO 4或Na 2 HPO 4的水溶液; 去除基底并干燥; 并将基材浸渍在含有钙离子的第二溶液（水溶液）中，从而得到包含羟基磷灰石或含羟基磷灰石和羟基磷灰石前体的混合物的涂膜。 从第二溶液中除去的基材可以浸渍在含有基本上饱和或过饱和浓度的磷灰石组分的第三溶液（水溶液）中，从而形成羟基磷灰石涂膜。 可以使用由金属，陶瓷，有机聚合物材料等形成的基材。由于省略了高温处理，该方法可应用于耐热性差的基材如合成树脂织物。

公开(公告)号：US5698265A

公开(公告)日：1997-12-16

申请号：US607885

申请日：1996-02-27

申请人： Michael Roger Mucalo ,  Yoshiyuki Yokogawa ,  Motohiro Toriyama ,  Yukari Kawamoto ,  Takahiro Suzuki ,  Kaori Nishizawa ,  Fukue Nagata ,  Hajime Nagae

发明人： Michael Roger Mucalo ,  Yoshiyuki Yokogawa ,  Motohiro Toriyama ,  Yukari Kawamoto ,  Takahiro Suzuki ,  Kaori Nishizawa ,  Fukue Nagata ,  Hajime Nagae

IPC分类号： B01J20/281 ,  C01B25/32 ,  D06M11/00 ,  D06M11/71 ,  D06M101/00 ,  D06M101/02 ,  D06M101/06 ,  D21C9/00 ,  D21H17/67 ,  G01N30/88 ,  B05D3/04

CPC分类号： D21C9/002 ,  D06M11/71

摘要： A method for the production of a composite consisting of cellulose fibers coated with a calcium phosphate compound consists essentially of phosphorylating the surface of cellulose fibers, immersing the surface-phosphorylated cellulose fibers in an aqueous solution containing calcium ions and hydroxyl ions, removing the cellulose fibers from the aqueous solution and subsequently immersing them in an aqueous solution containing calcium ions and phosphoric acid ions, and then removing the cellulose fibers from the aqueous solution. Also disclosed is a composite produced by the method.

摘要翻译： 制备由磷酸钙化合物涂覆的纤维素纤维组成的复合材料的方法主要包括磷酸化纤维素纤维的表面，将表面磷酸化的纤维素纤维浸入含有钙离子和羟基离子的水溶液中，除去纤维素纤维 然后将其浸入含有钙离子和磷酸离子的水溶液中，然后从水溶液中除去纤维素纤维。 还公开了通过该方法制备的复合材料。

公开(公告)号：US5427754A

公开(公告)日：1995-06-27

申请号：US174264

申请日：1993-12-28

申请人： Fukue Nagata ,  Yoshiyuki Yokogawa ,  Motohiro Toriyama ,  Yukari Kawamoto ,  Takahiro Suzuki ,  Kaori Nishizawa ,  Hajime Nagae

发明人： Fukue Nagata ,  Yoshiyuki Yokogawa ,  Motohiro Toriyama ,  Yukari Kawamoto ,  Takahiro Suzuki ,  Kaori Nishizawa ,  Hajime Nagae

IPC分类号： B01J20/281 ,  C01B25/32 ,  C30B29/14 ,  C30B29/64 ,  G01N30/88

CPC分类号： C01B25/327

摘要： A platelike hydroxyapatite is produced by preparing from a phosphate and a calcium salt an aqueous slurry of amorphous calcium phosphate having an atomic ratio of calcium atoms to phosphorus atoms in the range of 1.3:1 to 2.0:1, adding to the aqueous slurry not less than 10% by weight of alcohol based on the amount of the aqueous slurry, and subjecting the resultant mixture to a hydrothermal treatment.

摘要翻译： 通过从磷酸盐和钙盐制备具有1.3:1至2.0:1的钙原子与磷原子之比的无定形磷酸钙的水性浆料制备板状羟基磷灰石，不少于 相对于含水浆料的量为10重量％以上的醇，并对所得混合物进行水热处理。

公开(公告)号：US06402517B1

公开(公告)日：2002-06-11

申请号：US09513200

申请日：2000-02-25

申请人： Atsushi Hozumi ,  Masahiko Inagaki ,  Kaori Nishizawa ,  Fukue Nagata ,  Yoshiyuki Yokogawa ,  Tetsuya Kameyama

发明人： Atsushi Hozumi ,  Masahiko Inagaki ,  Kaori Nishizawa ,  Fukue Nagata ,  Yoshiyuki Yokogawa ,  Tetsuya Kameyama

IPC分类号： A61C800

CPC分类号： A61C8/0012 ,  A61C8/0013 ,  A61K6/0008 ,  A61K6/0017 ,  A61K6/0044 ,  A61K6/0205 ,  A61K6/033 ,  A61K6/04 ,  A61K6/0643 ,  A61K6/08

摘要： The invention provides an artificial tooth root having acid resistance and anti-adherence of sordes and various germs, consisting of a substrate and a coating of calcium phosphate based ceramic having bioaffinity formed on the surface of this substrate, the substrate is composed of a polymer, ceramic, metal, or other material, the surface of the ceramic coating on the substrate surface is endowed with a protrusion-and-recession configuration, and is, chemically modified, and to a method for producing the artificial tooth root, by forming a coating of calcium phosphate based ceramic having bioaffinity over a substrate while imparting protrusions and recessions thereto, masking an area of the ceramic coating surface of which bioaffinity is required, and fixing a silane coupling agent exclusively over a predetermined area of the ceramic coating surface.

摘要翻译： 本发明提供了一种具有耐酸性和抗粘附性的人造牙根和各种细菌，由基材和在该基材的表面上形成的具有生物亲和性的磷酸钙基陶瓷涂层组成，基材由聚合物， 陶瓷，金属或其他材料，基板表面上的陶瓷涂层的表面具有突起 - 退回构型，并被化学改性，并且通过形成涂层来形成人造牙根的制造方法 的具有生物亲和力的磷酸钙基陶瓷，同时赋予其突起和凹陷，掩蔽需要生物亲和性的陶瓷涂层表面的区域，并将硅烷偶联剂固定在陶瓷涂层表面的预定区域上。

公开(公告)号：US06841143B2

公开(公告)日：2005-01-11

申请号：US09946327

申请日：2001-09-06

申请人： Masahiko Inagaki ,  Atsushi Hozumi ,  Kei Teraoka ,  Kaori Nishizawa ,  Fukue Nagata ,  Yoshiyuki Yokogawa ,  Tetsuya Kameyama

发明人： Masahiko Inagaki ,  Atsushi Hozumi ,  Kei Teraoka ,  Kaori Nishizawa ,  Fukue Nagata ,  Yoshiyuki Yokogawa ,  Tetsuya Kameyama

IPC分类号： B01J23/10 ,  C01B13/36 ,  C01B37/00 ,  C01F17/00 ,  C01G9/02 ,  C01G25/02 ,  C04B38/00 ,  C09K3/00

CPC分类号： C04B38/009 ,  B01J23/10 ,  B01J35/1061 ,  C01B13/36 ,  C01B37/00 ,  C01P2006/16

摘要： This invention provides mesostructured oxide ceramics and a synthesizing method thereof, the synthesizing method employs a water-based solvent containing a metallic salt or metal complex as the ceramics precursor, template formed from an organic compound or the association thereof, and a precipitant, wherein mesostructured oxide ceramics are obtained from self-assembled oxide ceramics and organic substance by directly extracting oxide ceramics at a low temperature of 200° C. or less by utilizing a homogenous precipitation reaction from said ceramics precursor under the coexistence of a nanometer-sized template in the solvent, and separating and collecting the obtained precipitation, and mesostructured oxide ceramics is prepared by employing the synthesizing method described above.

摘要翻译： 本发明提供介观结构氧化物陶瓷及其合成方法，该合成方法采用含有金属盐或金属络合物作为陶瓷前体的水溶剂，由有机化合物形成的模板或其缔合物，以及沉淀剂，其中介孔结构 氧化物陶瓷由自组装的氧化物陶瓷和有机物质通过在200℃或更低的低温下直接提取氧化物陶瓷而获得，通过在纳米尺寸模板共存的情况下利用来自所述陶瓷前体的均匀沉淀反应 溶剂，并分离和收集所得沉淀，并通过使用上述合成方法制备介孔结构氧化物陶瓷。