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公开(公告)号：US08575089B2
公开(公告)日：2013-11-05
申请号：US13390888
申请日：2010-08-17
申请人： Young Sook Son , Hyun Sook Hong , Do Yeon Kim , Eun Kyung Lee
发明人： Young Sook Son , Hyun Sook Hong , Do Yeon Kim , Eun Kyung Lee
CPC分类号： A61K38/08
摘要： The present invention relates to a composition containing Substance P for preventing or treating an inflammation. The composition containing Substance P according to the present invention exhibits the effect of decreasing leukocytes, neutrophils and hematopoietic stem cells in a blood, which are associated with the inflammation, and of increasing anti-inflammatory cytokines, regulatory T-lymphocytes, anti-inflammatory macrophages and the like, thereby terminating inflammatory response at an early stage, and is thus highly effective in preventing and treating the inflammation caused by a non-traumatic, traumatic, infectious or ischemic retinal injury.
摘要翻译： 本发明涉及含有用于预防或治疗炎症的物质P的组合物。 含有根据本发明的物质P的组合物具有降低血液中与炎症相关的白细胞，嗜中性粒细胞和造血干细胞以及增加抗炎细胞因子，调节性T淋巴细胞，抗炎巨噬细胞的作用 从而在早期终止炎症反应，因此在预防和治疗由非创伤性，创伤性，感染性或缺血性视网膜损伤引起的炎症方面非常有效。
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2.发明授权Method for inhibiting or treating intestinal damage caused by radiotherapy or chemotherapy comprising administering substance-P 有权用于抑制或治疗由放射治疗或化学疗法引起的肠损伤的方法，包括施用物质-P公开(公告)号：US07846901B2
公开(公告)日：2010-12-07
申请号：US12245969
申请日：2008-10-06
申请人： Young Sook Son , Do Yeon Kim , Hyun Sook Hong
发明人： Young Sook Son , Do Yeon Kim , Hyun Sook Hong
CPC分类号： A61K38/046
摘要： Disclosed herein are a composition for prevention or treatment of gastrointestinal damage comprising Substance-P as an active ingredient, a use of Substance-P for the preparation of a medicament for prevention or treatment of gastrointestinal damage, and a method for prevention or treatment of gastrointestinal damage comprising administering a therapeutically effective amount of Substance-P to a mammal.
摘要翻译： 本文公开了一种用于预防或治疗消化道损伤的组合物，其包含物质-P作为活性成分，使用物质-P用于制备用于预防或治疗胃肠道损伤的药物，以及预防或治疗胃肠道损伤的方法 损伤包括向哺乳动物施用治疗有效量的物质-P。
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公开(公告)号：US20120252040A1
公开(公告)日：2012-10-04
申请号：US13516460
申请日：2010-11-29
申请人： Kang Jun Yoon , Young Sook Son , Hyun Sook Hong , Hyeongwon Choi
发明人： Kang Jun Yoon , Young Sook Son , Hyun Sook Hong , Hyeongwon Choi
IPC分类号： G01N33/574 , C07K16/40
CPC分类号： G01N33/57434
摘要： The present invention relates to a kit and method for diagnosing prostate cancer, which use an antibody to prostate-specific antigen (PSA) to detect PSA in human urine. More specifically, the invention relates to a kit for diagnosing prostate cancer, which comprises an antibody to PSA and uses human urine as a sample, and to a method for diagnosing prostate cancer, which comprises brining a human urine sample into contact with an antibody to PSA in order to detect PSA in the sample.
摘要翻译： 本发明涉及一种用于诊断前列腺癌的试剂盒和方法，其使用前列腺特异性抗原（PSA）的抗体来检测人尿中的PSA。 更具体地，本发明涉及用于诊断前列腺癌的试剂盒，其包含PSA的抗体并使用人尿作为样品，以及用于诊断前列腺癌的方法，其包括使人尿样品与抗体接触 PSA以检测样品中的PSA。
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4.发明申请AGENT FOR OSTEOGENESIS USING SUBSTANCE-P AND PREPARATION PROCESS THEREOF 审中-公开使用物质P及其制备方法进行骨质疏松症的药剂公开(公告)号：US20130089529A1
公开(公告)日：2013-04-11
申请号：US13703299
申请日：2010-06-11
申请人： Young Sook Son , Eun Ah Lee , Hyun Sook Hong
发明人： Young Sook Son , Eun Ah Lee , Hyun Sook Hong
IPC分类号： A61K35/28
CPC分类号： A61K35/28
摘要： The present invention relates to an agent for osteogenesis containing as an active ingredient mesenchymal stem cells (MSCs) that have been mobilized from bone marrow into blood by administration of Substance-P; and a process of preparing the agent.
摘要翻译： 本发明涉及含有作为活性成分的间质干细胞（MSC）的成骨剂，其通过给予物质-P从骨髓移入血液; 以及制备该试剂的方法。
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公开(公告)号：US20120142596A1
公开(公告)日：2012-06-07
申请号：US13389954
申请日：2010-08-12
申请人： Young Sook Son , Hyun Sook Hong
发明人： Young Sook Son , Hyun Sook Hong
CPC分类号： A61K38/046
摘要： The present invention provides a composition for stimulating the mobilization of endothelial precursor cells, which comprises substance-P (SP). Substance-P according to the invention exhibits an activity of stimulating the mobilization of endothelial precursor cells from the bone marrow, thereby stimulating vasculogenesis. Thus, substance-P exhibits excellent effects on the prevention or treatment of diseases, including myocardial infarction, angina, ischemic stroke, cerebrovascular dementia, cerebral infarction, sequelae of cerebral injury, spinal cord injury, sequelae of spinal nerve injury, degenerative diseases, sequelae of cerebral infarction, peripheral nerve disorders, presbyopia, degenerative hearing loss, sequelae of brain surgery, and diabetic ulcer, which are accompanied by ischemic vascular injury or traumatic vascular injury.
摘要翻译： 本发明提供了一种用于刺激内皮前体细胞动员的组合物，其包括物质-P（SP）。 根据本发明的物质-P表现出刺激内皮前体细胞从骨髓的动员，从而刺激血管发生的活性。 因此，物质-P对预防或治疗包括心肌梗死，心绞痛，缺血性中风，脑血管性痴呆，脑梗塞，脑损伤后遗症，脊髓损伤，脊髓神经损伤后遗症，退行性疾病，后遗症等疾病的预防或治疗具有优异的效果 的脑梗塞，周围神经障碍，老花眼，退行性听力损失，脑外科后遗症和糖尿病性溃疡，伴有缺血性血管损伤或创伤性血管损伤。
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6.发明申请USE OF SUBSTANCE P FOR MOBILIZATION OF MESENCHYMAL STEM CELLS OR PROLIFERATION OF MESENCHYMAL STEM CELLS AND FOR WOUND HEALING OR FACILITATING WOUND HEALING 有权使用物质P用于移植细胞干细胞或增殖细胞干细胞，并用于治疗或促进创伤愈合公开(公告)号：US20140065109A1
公开(公告)日：2014-03-06
申请号：US14018772
申请日：2013-09-05
申请人： Young Sook Son , Hyun Sook Hong , Jae Chan Kim
发明人： Young Sook Son , Hyun Sook Hong , Jae Chan Kim
IPC分类号： A61K38/04
CPC分类号： A61K38/046 , A61K35/28 , A61K2300/00
摘要： The present invention relates to a use of Substance-P for the manufacture of a medicament for mobilization or proliferation of Mesenchymal stem cells (MSCs) from the bone marrow, or facilitating said mobilization or proliferation, and use of Substance-P for the manufacture of a medicament for wound-healing or facilitating wound-healing.
摘要翻译： 本发明涉及物质-P在制备用于从骨髓中移动或增殖间充质干细胞（MSC）或促进所述动员或增殖的药物的用途，以及使用物质-P来制造 用于伤口愈合或促进伤口愈合的药物。
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7.发明授权Use of substance P for mobilization of Mesenchymal stem cells or proliferation of Mesenchymal stem cells and for wound healing or facilitating wound healing 有权使用物质P用于间充质干细胞的移动或间充质干细胞的增殖和伤口愈合或促进伤口愈合公开(公告)号：US08551470B2
公开(公告)日：2013-10-08
申请号：US11259550
申请日：2005-10-25
申请人： Young Sook Son , Hyun Sook Hong , Jae Chan Kim
发明人： Young Sook Son , Hyun Sook Hong , Jae Chan Kim
CPC分类号： A61K38/046 , A61K35/28 , A61K2300/00
摘要： The present invention relates to a use of Substance-P for the manufacture of a medicament for mobilization or proliferation of Mesenchymal stem cells (MSCs) from the bone marrow, or facilitating said mobilization or proliferation, and use of Substance-P for the manufacture of a medicament for wound-healing or facilitating wound-healing.
摘要翻译： 本发明涉及物质-P在制备用于骨髓间充质干细胞（MSC）的移动或增殖或促进所述动员或增殖的药物中的用途，以及使用物质-P来制造 用于伤口愈合或促进伤口愈合的药物。
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公开(公告)号：US20120214729A1
公开(公告)日：2012-08-23
申请号：US13390888
申请日：2010-08-17
申请人： Young Sook Son , Hyung Sook Hong , Do Yeon Kim , Eun Kyung Lee
发明人： Young Sook Son , Hyung Sook Hong , Do Yeon Kim , Eun Kyung Lee
IPC分类号： A61K38/08 , A61P11/06 , A61P19/02 , A61P11/00 , A61P31/14 , A61P1/04 , A61P1/00 , A61P17/02 , A61P25/00 , A61P25/28 , A61P27/02 , A61P17/00 , A61P9/00 , A61P37/00 , A61P37/06 , A61P3/10 , A61P17/14 , A61P17/06 , A61P7/06 , A61P1/16 , A61P13/12 , A61P29/00
CPC分类号： A61K38/08
摘要： The present invention relates to a composition containing Substance P for preventing or treating an inflammation. The composition containing Substance P according to the present invention exhibits the effect of decreasing leukocytes, neutrophils and hematopoietic stem cells in a blood, which are associated with the inflammation, and of increasing anti-inflammatory cytokines, regulatory T-lymphocytes, anti-inflammatory macrophages and the like, thereby terminating inflammatory response at an early stage, and is thus highly effective in preventing and treating the inflammation caused by a non-traumatic, traumatic, infectious or ischemic retinal injury.
摘要翻译： 本发明涉及含有用于预防或治疗炎症的物质P的组合物。 含有根据本发明的物质P的组合物具有降低血液中与炎症相关的白细胞，嗜中性粒细胞和造血干细胞以及增加抗炎细胞因子，调节性T淋巴细胞，抗炎巨噬细胞的作用 从而在早期终止炎症反应，因此在预防和治疗由非创伤性，创伤性，感染性或缺血性视网膜损伤引起的炎症方面非常有效。
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公开(公告)号：US09078851B2
公开(公告)日：2015-07-14
申请号：US13390892
申请日：2010-08-17
申请人： Young Sook Son , Mei Hua Jiang
发明人： Young Sook Son , Mei Hua Jiang
CPC分类号： A61K38/10
摘要： The present invention relates to a novel use of substance P. The substance P of the present invention exhibits effects of decreasing microglia activity, decreasing proinflammatory cytokines, inhibiting apoptosis, etc. The substance P of the present invention effectively treats degenerative central nervous system diseases or disorders such as a spinal cord injury caused by a traumatic injury (flexion injury, vertical compression injury, hyperextension injury, flexion-rotation injury) and by a non-traumatic injury (vascular dysfunction, arthritis, or degenerative arthritis), Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, depressive disorder, epilepsy, etc.
摘要翻译： 本发明涉及物质P的新用途。本发明的物质P具有降低小胶质细胞活性，降低促炎细胞因子，抑制凋亡等作用。本发明的物质P有效治疗退行性中枢神经系统疾病或 由创伤性损伤（屈曲损伤，垂直压迫性损伤，过度伸张损伤，屈曲旋转损伤）和非创伤性损伤（血管功能障碍，关节炎或退行性关节炎）引起的脊髓损伤，帕金森氏病，阿尔茨海默病 疾病，肌萎缩性侧索硬化，亨廷顿病，抑郁障碍，癫痫等。
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公开(公告)号：US20120225821A1
公开(公告)日：2012-09-06
申请号：US13390892
申请日：2010-08-17
申请人： Young Sook Son , Mei Hua Jiang
发明人： Young Sook Son , Mei Hua Jiang
IPC分类号： A61K38/08 , A61P25/28 , C07K7/06 , A61P25/14 , A61P25/24 , A61P25/08 , A61P25/16 , A61P25/00
CPC分类号： A61K38/10
摘要： The present invention relates to a novel use of substance P. The substance P of the present invention exhibits effects of decreasing microglia activity, decreasing proinflammatory cytokines, inhibiting apoptosis, etc. The substance P of the present invention effectively treats degenerative central nervous system diseases or disorders such as a spinal cord injury caused by a traumatic injury (flexion injury, vertical compression injury, hyperextension injury, flexion-rotation injury) and by a non-traumatic injury (vascular dysfunction, arthritis, or degenerative arthritis), Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, depressive disorder, epilepsy, etc.
摘要翻译： 本发明涉及物质P的新用途。本发明的物质P具有降低小胶质细胞活性，降低促炎细胞因子，抑制凋亡等作用。本发明的物质P有效治疗退行性中枢神经系统疾病或 由创伤性损伤（屈曲损伤，垂直压迫性损伤，过度伸张损伤，屈曲旋转损伤）和非创伤性损伤（血管功能障碍，关节炎或退行性关节炎）引起的脊髓损伤，帕金森氏病，阿尔茨海默病 疾病，肌萎缩性侧索硬化，亨廷顿病，抑郁障碍，癫痫等。
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