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公开(公告)号：US20090002699A1
公开(公告)日：2009-01-01
申请号：US11769920
申请日：2007-06-28
CPC分类号： G01J3/02 , B82Y15/00 , G01J3/0264 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01N21/658 , G01N33/54326 , G01N33/588 , G01N2333/32
摘要： A device for identifying an unknown substance includes an optical source configured to direct a laser excitation beam at the unknown substance. A detector is configured to detect scattered light from the unknown substance and generate at least one signal representative of a scattering spectrum corresponding to at least one chemical within the unknown substance. A microprocessor is in signal communication with the detector and configured to generate a pattern representative of the at least one chemical in response to the at least one signal received from the detector to identify the chemical composition of the unknown substance. The device is configured to complete a bioassay to identify a biological nature of the unknown substance.
摘要翻译： 用于识别未知物质的装置包括被配置为将激光激发光束引导到未知物质的光源。 检测器被配置为检测来自未知物质的散射光，并产生代表对应于未知物质内的至少一种化学物质的散射光谱的至少一个信号。 微处理器与检测器进行信号通信，并被配置为响应于从检测器接收的至少一个信号产生表示至少一种化学品的图案，以识别未知物质的化学成分。 该装置被配置成完成生物测定以鉴定未知物质的生物学性质。
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公开(公告)号：US07502105B2
公开(公告)日：2009-03-10
申请号：US10941565
申请日：2004-09-15
IPC分类号： G01J3/44
CPC分类号： G01N21/274 , G01J3/0232 , G01J3/44 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： An apparatus for generating a Raman signal of a test sample is disclosed. The apparatus includes a first optical path, a second optical path, a first station, and a second station. The first optical path is adapted for coupling with a radiation source that produces a test beam at the first optical path. The first station is responsive to the test beam and is adapted to house a test standard. The second station is responsive to the test beam and is adapted to house the test sample. In response to the test beam, Raman radiation from the test standard and the test sample are combined and directed to the second optical path, which is adapted for coupling with a spectrometer and a detector for producing a Raman spectrum of the test sample.
摘要翻译： 公开了一种用于产生测试样品的拉曼信号的装置。 该装置包括第一光路，第二光路，第一台和第二台。 第一光路适于与在第一光路处产生测试光束的辐射源耦合。 第一个工作站响应测试梁并适应测试标准。 第二站响应于测试梁并适于容纳测试样品。 响应于测试光束，来自测试标准的拉曼辐射和测试样品被组合并引导到第二光路，其适于与用于产生测试样品的拉曼光谱的光谱仪和检测器耦合。
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公开(公告)号：US07133129B2
公开(公告)日：2006-11-07
申请号：US10901823
申请日：2004-07-29
CPC分类号： G01N1/2214 , B82Y30/00 , G01N1/405 , G01N21/658 , G01N2001/022
摘要： A cargo inspection apparatus for the inspection of an analyte carried by a medium is disclosed. The apparatus includes a housing having an inlet allowing for entry of the medium and an outlet allowing for exit of the medium, and an adsorber disposed within the housing in fluid communication with the medium flow from the inlet to the outlet, the adsorber includes a substrate having disposed thereon a nanoparticle film. The nanoparticle film has nanoparticles having an average particle size of equal to or less than about 500 nanometers.
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公开(公告)号：US20060055919A1
公开(公告)日：2006-03-16
申请号：US10941565
申请日：2004-09-15
IPC分类号： G01J3/44
CPC分类号： G01N21/274 , G01J3/0232 , G01J3/44 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： An apparatus for generating a Raman signal of a test sample is disclosed. The apparatus includes a first optical path, a second optical path, a first station, and a second station. The first optical path is adapted for coupling with a radiation source that produces a test beam at the first optical path. The first station is responsive to the test beam and is adapted to house a test standard. The second station is responsive to the test beam and is adapted to house the test sample. In response to the test beam, Raman radiation from the test standard and the test sample are combined and directed to the second optical path, which is adapted for coupling with a spectrometer and a detector for producing a Raman spectrum of the test sample.
摘要翻译： 公开了一种用于产生测试样品的拉曼信号的装置。 该装置包括第一光路，第二光路，第一台和第二台。 第一光路适于与在第一光路处产生测试光束的辐射源耦合。 第一个工作站响应测试梁并适应测试标准。 第二站响应于测试梁并适于容纳测试样品。 响应于测试光束，来自测试标准的拉曼辐射和测试样品被组合并引导到第二光路，其适于与用于产生测试样品的拉曼光谱的光谱仪和检测器耦合。
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5.发明申请Cargo inspection apparatus having a nanoparticle film and method of use thereof 失效具有纳米颗粒膜的货物检验装置及其使用方法公开(公告)号：US20060023209A1
公开(公告)日：2006-02-02
申请号：US10901823
申请日：2004-07-29
申请人： Yuan-Hsiang Lee , William McGann , Kenneth Ribeiro , Tao Deng
发明人： Yuan-Hsiang Lee , William McGann , Kenneth Ribeiro , Tao Deng
CPC分类号： G01N1/2214 , B82Y30/00 , G01N1/405 , G01N21/658 , G01N2001/022
摘要： A cargo inspection apparatus for the inspection of an analyte carried by a medium is disclosed. The apparatus includes a housing having an inlet allowing for entry of the medium and an outlet allowing for exit of the medium, and an adsorber disposed within the housing in fluid communication with the medium flow from the inlet to the outlet, the adsorber includes a substrate having disposed thereon a nanoparticle film. The nanoparticle film has nanoparticles having an average particle size of equal to or less than about 500 nanometers.
摘要翻译： 公开了一种用于检查由介质携带的分析物的货物检验装置。 该装置包括具有允许介质进入的入口和允许介质的出口的入口以及设置在壳体内的吸入器，其与从入口到出口的介质流体流体连通，吸附器包括基板 在其上设置有纳米颗粒膜。 纳米颗粒膜具有平均粒度等于或小于约500纳米的纳米颗粒。
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公开(公告)号：US20090201497A1
公开(公告)日：2009-08-13
申请号：US11400947
申请日：2006-04-10
申请人： Anis Zribi , Wei-Cheng Tian , Yuan-Hsiang Lee , Min-Yi Shih
发明人： Anis Zribi , Wei-Cheng Tian , Yuan-Hsiang Lee , Min-Yi Shih
CPC分类号： G01N21/0303 , G01N21/658 , G01N30/74 , G01N2021/651 , G02B6/10 , G02B2006/1213
摘要： An optofluidic device is provided. The device includes a cladding region having a first refractive index, and a channel defined by the cladding region such that the cladding region forms an inner surface or an interface of the channel. The channel is configured to house one or more of a liquid, a solid, a gas, a colloidal, or a suspension sample, wherein the sample has a second refractive index, where the channel is configured to guide radiation, and where the first refractive index is lower than the second refractive index.
摘要翻译： 提供了一种光流体装置。 该器件包括具有第一折射率的包层区域和由包层区域限定的沟道，使得包层区域形成沟道的内表面或界面。 通道被配置成容纳液体，固体，气体，胶体或悬浮样品中的一种或多种，其中样品具有第二折射率，其中通道被构造成引导辐射，并且其中第一折射 指数低于第二折射率。
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公开(公告)号：US08440469B2
公开(公告)日：2013-05-14
申请号：US11764537
申请日：2007-06-18
IPC分类号： G01N33/553 , G01N33/543
CPC分类号： G01N21/6428 , G01N33/54333
摘要： A method for increasing a spectroscopic signal in a biological assay is provided. The method includes forming a suspension of magnetically attractable particles. The method also includes introducing a first magnetic field at a first location to draw the magnetically attractable particles towards the first location and form a first agglomeration. The method also includes removing the first magnetic field. The method further includes introducing a second magnetic field at a second location to draw the first agglomeration towards the second location and form a second agglomeration. The method further includes focusing an excitation source on the second agglomeration formed at the second location.
摘要翻译： 提供了用于增加生物测定中的光谱信号的方法。 该方法包括形成磁吸引颗粒的悬浮液。 该方法还包括在第一位置引入第一磁场以将磁性可吸引颗粒吸引到第一位置并形成第一附聚。 该方法还包括去除第一磁场。 该方法还包括在第二位置引入第二磁场以将第一附聚物吸引到第二位置并形成第二聚集。 该方法还包括将激发源聚焦在形成在第二位置处的第二聚集体上。
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公开(公告)号：US07574089B1
公开(公告)日：2009-08-11
申请号：US11400947
申请日：2006-04-10
申请人： Anis Zribi , Wei-Cheng Tian , Yuan-Hsiang Lee , Min-Yi Shih
发明人： Anis Zribi , Wei-Cheng Tian , Yuan-Hsiang Lee , Min-Yi Shih
CPC分类号： G01N21/0303 , G01N21/658 , G01N30/74 , G01N2021/651 , G02B6/10 , G02B2006/1213
摘要： An optofluidic device is provided. The device includes a cladding region having a first refractive index, and a channel defined by the cladding region such that the cladding region forms an inner surface or an interface of the channel. The channel is configured to house one or more of a liquid, a solid, a gas, a colloidal, or a suspension sample, wherein the sample has a second refractive index, where the channel is configured to guide radiation, and where the first refractive index is lower than the second refractive index.
摘要翻译： 提供了一种光流体装置。 该器件包括具有第一折射率的包层区域和由包层区域限定的沟道，使得包层区域形成沟道的内表面或界面。 通道被配置成容纳液体，固体，气体，胶体或悬浮样品中的一种或多种，其中样品具有第二折射率，其中通道被构造成引导辐射，并且其中第一折射 指数低于第二折射率。
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公开(公告)号：US20080309335A1
公开(公告)日：2008-12-18
申请号：US11764537
申请日：2007-06-18
IPC分类号： G01R33/465
CPC分类号： G01N21/6428 , G01N33/54333
摘要： A method for increasing a spectroscopic signal in a biological assay is provided. The method includes forming a suspension of magnetically attractable particles. The method also includes introducing a first magnetic field at a first location to draw the magnetically attractable particles towards the first location and form a first agglomeration. The method also includes removing the first magnetic field. The method further includes introducing a second magnetic field at a second location to draw the first agglomeration towards the second location and form a second agglomeration. The method further includes focusing an excitation source on the second agglomeration formed at the second location.
摘要翻译： 提供了用于增加生物测定中的光谱信号的方法。 该方法包括形成磁吸引颗粒的悬浮液。 该方法还包括在第一位置引入第一磁场以将磁性可吸引颗粒吸引到第一位置并形成第一附聚。 该方法还包括去除第一磁场。 该方法还包括在第二位置引入第二磁场以将第一附聚物吸引到第二位置并形成第二聚集。 该方法还包括将激发源聚焦在形成在第二位置处的第二聚集体上。
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公开(公告)号：US20070059203A1
公开(公告)日：2007-03-15
申请号：US11223353
申请日：2005-09-09
申请人： Michael Burrell , Frank Mondello , Yuan-Hsiang Lee , Patrick Engel , Andrew Pris
发明人： Michael Burrell , Frank Mondello , Yuan-Hsiang Lee , Patrick Engel , Andrew Pris
IPC分类号： G01N21/00
CPC分类号： G01N21/65 , G01N21/658
摘要： A lateral flow device is disclosed. The lateral flow device includes a substrate having a flow path and a detection zone disposed along the flow path. The detection zone includes an immobilized target-binding moiety directed against a target of a Raman-active complex. Also disclosed is a method of conducting a lateral flow assay and detection system. The method includes i) defining a flow path having a detection zone; ii) flowing a sample down the flow path; and iii) immobilizing a Raman-active complex if present, at the detection zone. The sample includes a Raman-active complex or a Raman-active tag.
摘要翻译： 公开了一种侧流装置。 横向流动装置包括具有沿着流动路径设置的流路和检测区域的基板。 检测区包括针对拉曼活性复合物的靶的固定的靶结合部分。 还公开了进行侧流测定和检测系统的方法。 该方法包括：i）定义具有检测区域的流路; ii）将样品沿着流动路径流动; 和iii）在检测区域固定拉曼活性复合物（如果存在）。 样品包括拉曼活性复合物或拉曼活性标签。
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