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8 条记录 (耗时 0.015 秒)

    Cell-based platform for high throughput screening
    1.
    发明授权
    Cell-based platform for high throughput screening 有权
    基于细胞的高通量筛选平台

    公开(公告)号：US07629115B2

    公开(公告)日：2009-12-08

    申请号：US11129074

    申请日：2005-05-13

    申请人： Yuandong Gu ,  Leon Xu ,  Jicang Zhou

    发明人： Yuandong Gu ,  Leon Xu ,  Jicang Zhou

    IPC分类号： C12Q1/00

    CPC分类号： B01L3/5085 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/165

    摘要： The present invention relates to an apparatus for testing multiple sample compounds for their biological effect comprising a porous block having substantially planar top and bottom surfaces. The top surface comprises a plurality of cell adhesive regions and cell dis-adhesive regions and the bottom surface provides multiple sites to load the sample compounds. These sites are located opposite from the cell adhesive regions on the top surface of the porous block. In certain embodiments, the invention further comprises at least one dissolvable layer which provides multiple sites to load the sample compounds.

    摘要翻译： 本发明涉及一种用于测试多种样品化合物的生物效应的装置，包括具有基本平坦的顶表面和底表面的多孔块。 顶表面包括多个细胞粘附区域和细胞分离区域，并且底表面提供多个位点以加载样品化合物。 这些位置与多孔块的顶表面上的细胞粘合剂区域相对。 在某些实施方案中，本发明还包括至少一个可溶性层，其提供多个位点以加载样品化合物。

    Cell-based platform for high throughput screening
    2.
    发明申请
    Cell-based platform for high throughput screening 有权

    公开(公告)号：US20060286661A1

    公开(公告)日：2006-12-21

    申请号：US11129074

    申请日：2005-05-13

    申请人： Yuandong Gu ,  Leon Xu ,  Jicang Zhou

    发明人： Yuandong Gu ,  Leon Xu ,  Jicang Zhou

    IPC分类号： C12M1/34

    CPC分类号： B01L3/5085 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/165

    摘要： The present invention relates to an apparatus for testing multiple sample compounds for their biological effect comprising a porous block having substantially planar top and bottom surfaces. The top surface comprises a plurality of cell adhesive regions and cell dis-adhesive regions and the bottom surface provides multiple sites to load the sample compounds. These sites are located opposite from the cell adhesive regions on the top surface of the porous block. In certain embodiments, the invention further comprises at least one dissolvable layer which provides multiple sites to load the sample compounds.

    Core-shell nanoparticles for detection based on SERS
    3.
    发明授权
    Core-shell nanoparticles for detection based on SERS 失效
    用于基于SERS检测的核壳纳米颗粒

    公开(公告)号：US07727776B2

    公开(公告)日：2010-06-01

    申请号：US11552383

    申请日：2006-10-24

    申请人： Jicang Zhou ,  Yuandong Gu ,  Allen A. Cox ,  Aravind Padmanabhan

    发明人： Jicang Zhou ,  Yuandong Gu ,  Allen A. Cox ,  Aravind Padmanabhan

    IPC分类号： G01N33/551

    CPC分类号： G01N33/587 ,  G01N33/54346 ,  G01N33/54373

    摘要： A nanoparticle having a self assembly monolayer of molecules as a shell on the nanoparticle. The monolayer may include organic molecules working as surface enhanced Raman spectroscopy (SERS) reporters. Also, the core shell may include at least a receptor, and/or the like, to ensure that a target analyte can be bound for measurement with SERS. The target analyte may be organic, chemical, biological, inorganic, gas, liquid, solid, and so forth.

    摘要翻译： 具有在纳米颗粒上作为壳的自组装单分子层的纳米颗粒。 单层可以包括作为表面增强拉曼光谱（SERS）记者工作的有机分子。 此外，核心壳可以包括至少一种受体和/或类似物，以确保靶分析物能够与SERS结合以进行测量。 目标分析物可以是有机的，化学的，生物的，无机的，气体的，液体的，固体的等等。

    CORE-SHELL NANOPARTICLES FOR DETECTION BASED ON SERS
    4.
    发明申请
    CORE-SHELL NANOPARTICLES FOR DETECTION BASED ON SERS 失效
    用于基于SERS检测的核壳纳米粒子

    公开(公告)号：US20080096289A1

    公开(公告)日：2008-04-24

    申请号：US11552383

    申请日：2006-10-24

    申请人： Jicang Zhou ,  Yuandong Gu ,  Allen A. Cox ,  Aravind Padmanabhan

    发明人： Jicang Zhou ,  Yuandong Gu ,  Allen A. Cox ,  Aravind Padmanabhan

    IPC分类号： G01N33/549

    CPC分类号： G01N33/587 ,  G01N33/54346 ,  G01N33/54373

    摘要： A nanoparticle having a self assembly monolayer of molecules as a shell on the nanoparticle. The monolayer may include organic molecules working as surface enhanced Raman spectroscopy (SERS) reporters. Also, the core shell may include at least a receptor, and/or the like, to ensure that a target analyte can be bound for measurement with SERS. The target analyte may be organic, chemical, biological, inorganic, gas, liquid, solid, and so forth.

    摘要翻译： 具有在纳米颗粒上作为壳的自组装单分子层的纳米颗粒。 单层可以包括作为表面增强拉曼光谱（SERS）记者工作的有机分子。 此外，核心壳可以包括至少一种受体和/或类似物，以确保靶分析物能够与SERS结合以进行测量。 目标分析物可以是有机的，化学的，生物的，无机的，气体的，液体的，固体的等等。

    Polymeric self-assembly multiplayer membranes for ion screening: design, fabrication and application in sensors
    8.
    发明申请
    Polymeric self-assembly multiplayer membranes for ion screening: design, fabrication and application in sensors 审中-公开
    用于离子筛选的聚合自组装多层膜：传感器的设计，制造和应用

    公开(公告)号：US20080096271A1

    公开(公告)日：2008-04-24

    申请号：US11713794

    申请日：2007-03-05

    申请人： Jicang Zhou ,  Qing Li

    发明人： Jicang Zhou ,  Qing Li

    IPC分类号： C08J5/20 ,  B05D1/36 ,  C12M1/34

    CPC分类号： B32B27/08 ,  B32B7/02

    摘要： The embodiments of the invention are related to an extrinsically compensated multilayer membrane comprising at least a first layer comprising charged polymers and a second layer comprising neutral polymers, wherein the first layer is characteristic of extrinsic compensation and the charges on the polymer are balanced by mobile counter ions. The embodiments of the invention relate to: i) extrinsically compensated membrane for ion screening; ii) two types of polymers for fabricating the extrinsically compensated membrane; iii) driving force for self-assembly and approaches to create such a driving force between the two polymers, which involve the functionalization of the two types of polymers via functional moieties: donors and acceptors; iv) one or more approaches of synthesis of the two types of polymers; v) the fabrications of extrinsically compensated membrane with the two types of polymers; and vi) the fabrication of functional sensing membranes and the sensors thereof.

    摘要翻译： 本发明的实施方案涉及包含至少包含带电聚合物的第一层和包含中性聚合物的第二层的外部补偿的多层膜，其中第一层是外在补偿的特征，聚合物上的电荷由移动计数器 离子。 本发明的实施例涉及：i）用于离子筛选的外在补偿膜; ii）两种用于制造外补膜的聚合物; iii）用于自组装的驱动力和在两种聚合物之间产生这种驱动力的方法，其涉及通过功能部分的两种类型的聚合物的官能化：供体和受体; iv）合成两种类型的聚合物的一种或多种方法; v）使用两种类型的聚合物制成外置补偿膜; 和vi）制造功能感测膜及其传感器。