公开(公告)号：US07491735B2

公开(公告)日：2009-02-17

申请号：US11012002

申请日：2004-12-13

申请人： Yuanxi Zhou ,  Gary J. Bridger ,  Renato T. Skerlj ,  David Bogucki ,  Wen Yang ,  Elyse Bourque ,  Jonathan Langille ,  Tong-Shuang Li ,  Markus Metz ,  Maria R. Di Fluri ,  Siqiao Nan

发明人： Yuanxi Zhou ,  Gary J. Bridger ,  Renato T. Skerlj ,  David Bogucki ,  Wen Yang ,  Elyse Bourque ,  Jonathan Langille ,  Tong-Shuang Li ,  Markus Metz ,  Maria R. Di Fluri ,  Siqiao Nan

IPC分类号： A61K31/4468

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

公开(公告)号：US07354934B2

公开(公告)日：2008-04-08

申请号：US11301725

申请日：2005-12-13

申请人： Gary J. Bridger ,  Al Kaller ,  Curtis Harwig ,  Renato T. Skerlj ,  David Bogucki ,  Trevor R. Wilson ,  Jason B. Crawford ,  Ernest J. McEachern ,  Bem Atsma ,  Siqiao Nan ,  Yuanxi Zhou ,  Dominique Schols ,  Christopher Dennis Smith ,  Maria R. Di Fluri

发明人： Gary J. Bridger ,  Al Kaller ,  Curtis Harwig ,  Renato T. Skerlj ,  David Bogucki ,  Trevor R. Wilson ,  Jason B. Crawford ,  Ernest J. McEachern ,  Bem Atsma ,  Siqiao Nan ,  Yuanxi Zhou ,  Dominique Schols ,  Christopher Dennis Smith ,  Maria R. Di Fluri

IPC分类号： A61K31/4709 ,  C07D403/12

CPC分类号： C07D401/14 ,  C07D235/14 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  C07D471/06 ,  C07D491/04

摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

公开(公告)号：US20080167341A1

公开(公告)日：2008-07-10

申请号：US12036187

申请日：2008-02-22

申请人： Gary BRIDGER ,  Renato T. Skerlj ,  Al Kaller ,  Curtis Harwig ,  David Bogucki ,  Trevor R. Wilson ,  Jason B. Crawford ,  Ernest J. Mceachern ,  Bem Atsma ,  Siqiao Nan ,  Yuanxi Zhou ,  Dominique Schols ,  Christopher Dennis Smith ,  Maria R. Di Fluri

发明人： Gary BRIDGER ,  Renato T. Skerlj ,  Al Kaller ,  Curtis Harwig ,  David Bogucki ,  Trevor R. Wilson ,  Jason B. Crawford ,  Ernest J. Mceachern ,  Bem Atsma ,  Siqiao Nan ,  Yuanxi Zhou ,  Dominique Schols ,  Christopher Dennis Smith ,  Maria R. Di Fluri

IPC分类号： A61K31/4709 ,  A61P7/00

CPC分类号： A61K31/4184 ,  A61K31/415 ,  A61K31/436 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/495 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/50 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  C07D235/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D471/06 ,  C07D491/04 ,  C07D491/052 ,  Y02A50/411

摘要： The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

摘要翻译： 本发明涉及由三个侧基包围的核心氮原子组成的杂环化合物，其中三个侧基中的两个优选为苯并咪唑基甲基和四氢喹啉基，第三侧基含有N并且任选地含有另外的环。 这些化合物与趋化因子受体结合，包括CXCR4和CCR5，并表现出针对人类免疫缺陷病毒（HIV）感染靶细胞的保护作用。