-
公开(公告)号：US5719291A
公开(公告)日：1998-02-17
申请号：US433007
申请日：1995-05-03
申请人： Yuhko Aoki , Hiromichi Kotaki , Kazunao Masubuchi , Toru Okuda , Nobuo Shimma , Takuo Tsukuda , Isao Umeda
发明人： Yuhko Aoki , Hiromichi Kotaki , Kazunao Masubuchi , Toru Okuda , Nobuo Shimma , Takuo Tsukuda , Isao Umeda
IPC分类号： A01N37/44 , A01N43/16 , A01N43/50 , A01N43/653 , A01N43/90 , A01N49/00 , C07C43/188 , C07C43/196 , C07C45/30 , C07C45/40 , C07C45/51 , C07C217/52 , C07C225/20 , C07C237/04 , C07D309/04 , C07D309/10 , C07D309/14 , C07D405/04 , C07D493/10 , C07D495/10 , C07D521/00 , C07F9/6558
CPC分类号： C07D231/12 , A01N37/44 , A01N43/16 , A01N43/50 , A01N43/653 , A01N43/90 , A01N49/00 , C07C217/52 , C07C225/20 , C07C237/04 , C07C43/188 , C07C43/196 , C07C45/30 , C07C45/40 , C07C45/513 , C07D233/56 , C07D249/08 , C07D309/10 , C07D309/14 , C07D493/10 , C07D495/10 , C07F9/6558 , C07C2101/14
摘要： Compounds of the formula ##STR1## which have antifungal activity.
-
公开(公告)号：US5449785A
公开(公告)日：1995-09-12
申请号：US911853
申请日：1992-07-10
申请人： Yuhko Aoki , Hiromichi Kotaki , Kazunao Masubuchi , Toru Okuda , Nobuo Shimma , Takuo Tsukuda , Isao Umeda
发明人： Yuhko Aoki , Hiromichi Kotaki , Kazunao Masubuchi , Toru Okuda , Nobuo Shimma , Takuo Tsukuda , Isao Umeda
IPC分类号： A01N37/44 , A01N43/16 , A01N43/50 , A01N43/653 , A01N43/90 , A01N49/00 , C07C43/188 , C07C43/196 , C07C45/30 , C07C45/40 , C07C45/51 , C07C217/52 , C07C225/20 , C07C237/04 , C07D309/04 , C07D309/10 , C07D309/14 , C07D405/04 , C07D493/10 , C07D495/10 , C07D521/00 , C07F9/6558 , C07D255/02 , A61K31/425 , A61K31/535 , C07D401/08
CPC分类号： C07D231/12 , A01N37/44 , A01N43/16 , A01N43/50 , A01N43/653 , A01N43/90 , A01N49/00 , C07C217/52 , C07C225/20 , C07C237/04 , C07C43/188 , C07C43/196 , C07C45/30 , C07C45/40 , C07C45/513 , C07D233/56 , C07D249/08 , C07D309/10 , C07D309/14 , C07D493/10 , C07D495/10 , C07F9/6558 , C07C2101/14
摘要： Compounds of the formula ##STR1## which have antifungal activity.
摘要翻译： 具有抗真菌活性的式（Ⅰ）化合物。
-
公开(公告)号：US06849709B2
公开(公告)日：2005-02-01
申请号：US09760949
申请日：2001-01-16
IPC分类号： A61K38/00 , A61K38/10 , A61P31/00 , A61P31/10 , C07K7/02 , C07K7/08 , C07K7/50 , A61K38/12 , C07K7/06
CPC分类号： C07K7/08 , A61K38/00 , Y10S435/911
摘要： The present invention relates to novel Aerothricins represented by the Formula (I), and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition comprising an Aerothricin of the Formula (I) and a pharmaceutically acceptable carrier. Furthermore, the present invention relates to the use of such Aerothricins for the preparation of medicaments, as well as to processes for the preparation of the Aerothricins of the Formula (I).
摘要翻译： 本发明涉及由式（I）表示的新型气丝菌素及其药学上可接受的盐。本发明还涉及包含式（I）的气丝菌素和药学上可接受的载体的药物组合物。 此外，本发明涉及这种气丝菌素用于制备药物的用途，以及制备式（I）的气丝菌素的方法。
-
公开(公告)号：US06489440B1
公开(公告)日：2002-12-03
申请号：US09360476
申请日：1999-07-23
申请人： Masahiro Aoki , Masami Kohchi , Kazunao Masubuchi , Eisaku Mizuguchi , Takeshi Murata , Hiroaki Ohkuma , Takehiro Okada , Masahiro Sakaitani , Nobuo Shimma , Takahide Watanabe , Mieko Yanagisawa , Yuri Yasuda
发明人： Masahiro Aoki , Masami Kohchi , Kazunao Masubuchi , Eisaku Mizuguchi , Takeshi Murata , Hiroaki Ohkuma , Takehiro Okada , Masahiro Sakaitani , Nobuo Shimma , Takahide Watanabe , Mieko Yanagisawa , Yuri Yasuda
IPC分类号： C07K750
摘要： The present invention relates to novel Aerothricins represented by the Formula (I), wherein R1, R2, R3, R4, R5, X, Y, Z, and m are as defined in Claim 1; and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition comprising an Aerothricin of the Formula (I) and a pharmaceutically acceptable carrier. Furthermore, the present invention relates to the use of such Aerothricins for the preparation of medicaments, as well as to processes and intermediates for the preparation of the Aerothricins of the Formula (I).
摘要翻译： 本发明涉及由式（I）表示的新型气丝菌素，其中R1，R2，R3，R4，R5，X，Y，Z和m如权利要求1所定义; 本发明还涉及包含式（I）的气丝菌素和药学上可接受的载体的药物组合物。 此外，本发明涉及这种气丝菌素用于制备药物的用途，以及制备式（I）的气丝菌素的方法和中间体。
-
5.发明申请4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US20100003213A1
公开(公告)日：2010-01-07
申请号：US12561097
申请日：2009-09-16
申请人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
发明人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/7068 , A61K31/7072 , A61K31/7076 , A61P31/12 , A61K38/20 , A61K38/21
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式Ia核苷衍生物的用途，其中符号如说明书中所定义，及其药学上可接受的盐以及含有这些化合物的药物组合物。
-
6.发明授权4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication. 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂。公开(公告)号：US06784166B2
公开(公告)日：2004-08-31
申请号：US10167106
申请日：2002-06-11
申请人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
发明人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31776
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof; for the treatment of diseases mediated by the Hepatitis C Virus (HCV), for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式I的核苷衍生物的用途，其中B表示式I的9-嘌呤基残基B1或式I的1-嘧啶基残基B2，符号如说明书中所定义;及其药学上可接受的盐; 用于治疗由丙型肝炎病毒（HCV）介导的疾病，用于制备用于这种治疗的药物和含有这些化合物的药物组合物。
-
7.发明申请4'-Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US20100004192A1
公开(公告)日：2010-01-07
申请号：US12559186
申请日：2009-09-14
申请人： Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Nobuo Shimma , Takuo Tsukuda
发明人： Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/7076 , C07H19/20 , C07H19/16
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式Ia核苷衍生物的用途，其中符号如说明书中所定义，及其药学上可接受的盐以及含有这些化合物的药物组合物。
-
8.发明申请4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION 审中-公开4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US20120034184A1
公开(公告)日：2012-02-09
申请号：US13274743
申请日：2011-10-17
申请人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
发明人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/7068 , A61K31/708 , A61K31/7076 , A61P29/00 , A61K38/21 , A61K38/19 , A61P37/02 , A61P31/14 , A61K31/7072 , A61K38/20
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof; for the treatment of diseases mediated by the Hepatitis C Virus (HCV), for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式I的核苷衍生物的用途，其中B表示式的9-嘌呤基残基B1或式的1-嘧啶基残基B2，其中符号如说明书中所定义，及其药学上可接受的盐; 用于治疗由丙型肝炎病毒（HCV）介导的疾病，用于制备用于这种治疗的药物和含有这些化合物的药物组合物。
-
9.发明授权4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US08071567B2
公开(公告)日：2011-12-06
申请号：US12561097
申请日：2009-09-16
申请人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
发明人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/715 , A61K38/00
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式Ia核苷衍生物的用途，其中符号如说明书中所定义，及其药学上可接受的盐以及含有这些化合物的药物组合物。
-
10.发明授权4′-Substituted nucleoside derivatives as inhibitors of HCV RNA replication 有权4'-取代的核苷衍生物作为HCV RNA复制的抑制剂公开(公告)号：US07608601B2
公开(公告)日：2009-10-27
申请号：US10891967
申请日：2004-07-15
申请人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
发明人： Rene Robert Devos , Christopher John Hobbs , Wen Rong Jiang , Joseph Armstrong Martin , John Herbert Merrett , Isabel Najera , Nobuo Shimma , Takuo Tsukuda
IPC分类号： A61K31/675 , A61K31/522 , A61K31/52
CPC分类号： A61K31/7076 , A61K31/52 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , C07H19/04 , Y02P20/582 , Y10S514/934 , A61K2300/00
摘要： The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof; for the treatment of diseases mediated by the Hepatitis C Virus (HCV), for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式I的核苷衍生物的用途，其中B表示式的9-嘌呤基残基B1或式的1-嘧啶基残基B2，其中符号如说明书中所定义，及其药学上可接受的盐; 用于治疗由丙型肝炎病毒（HCV）介导的疾病，用于制备用于这种治疗的药物和含有这些化合物的药物组合物。
-
-
-
-
-
-
-
-
-
搜索结果
47 条记录 (耗时 0.039 秒)
