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    Horizontal type blind
    1.
    发明授权
    Horizontal type blind 失效
    卧式盲

    公开(公告)号：US4327797A

    公开(公告)日：1982-05-04

    申请号：US77414

    申请日：1979-09-20

    申请人： Yukihiko Nakajima ,  Mitsuru Ohkubo ,  Tadakatsu Hashimoto ,  Shigeki Nakamura

    发明人： Yukihiko Nakajima ,  Mitsuru Ohkubo ,  Tadakatsu Hashimoto ,  Shigeki Nakamura

    IPC分类号： E06B9/32 ,  E06B9/324 ,  E06B9/322

    CPC分类号： E06B9/32 ,  E06B9/324

    摘要： A horizontal type blind having a novel mechanism for opening and closing slats which includes a pair of drive shafts juxtaposed in a housing fixed to a head box and adapted to be rotated in the same direction by pulling a slats-opening and closing cord and a pair of rollers connected to the drive shafts respectively and having two straps for holding the slats wound therearound respectively so as to feed either one of the straps while taking up the other according to the rotation of the rollers.

    摘要翻译： 一种具有用于打开和关闭板条的新型机构的水平式百叶窗，其包括一对驱动轴，该驱动轴并置在固定到头箱的壳体中，并且适于通过拉动板条开闭帘线和一对而沿相同方向旋转 的辊分别连接到驱动轴上，并具有两个带，用于分别缠绕在其上的板条，以便根据辊的旋转而进给另一个带。

    Aminopyridine derivatives having Aurora A selective inhibitory action
    3.
    发明授权
    Aminopyridine derivatives having Aurora A selective inhibitory action 有权
    具有极光A的氨基吡啶衍生物选择性抑制作用

    公开(公告)号：US07491720B2

    公开(公告)日：2009-02-17

    申请号：US11258447

    申请日：2005-10-25

    申请人： Mitsuru Ohkubo ,  Tetsuya Kato ,  Nobuhiko Kawanishi ,  Takashi Mita ,  Toshiyasu Shimomura

    发明人： Mitsuru Ohkubo ,  Tetsuya Kato ,  Nobuhiko Kawanishi ,  Takashi Mita ,  Toshiyasu Shimomura

    IPC分类号： C07D241/00 ,  C07D241/02 ,  A01N43/58 ,  A61K31/50

    CPC分类号： C07D417/12 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/14

    摘要： The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1; j is an integer of 1 to m2; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rai and Rai′ is hydrogen atom, etc. and Rbj and Rbj′ is hydrogen atom, etc.; Rc, Rd, and Re are hydrogen atom, etc; X1 is CH, CX1a, or N; X2 is CH, N, etc.; X3 is CH, N, etc.; X4 is CH or N; Y1, Y2, and Y3 are each independently CH or N; Z1 and Z2 are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).

    摘要翻译： 本发明涉及由通式（I）表示的化合物：其中m1和m2为1,2或3; n1和n2为0或1; 我是1到m1中任何一个的整数; j为1〜m2的整数， R是芳基，杂芳基或环烷基，其中任一个可以被取代; Rai和Rai'是氢原子等，Rbj和Rbj'是氢原子等; Rc，Rd和Re为氢原子等; X1是CH，CX1a或N; X2是CH，N等; X3是CH，N等; X4是CH或N; Y1，Y2和Y3各自独立地为CH或N; Z1和Z2各自独立地为CH或N; W是5元芳族杂环基，例如吡唑基，噻唑基等，或其药学上可接受的盐或酯; 含有它们的药物组合物或抗肿瘤剂; 以及抗肿瘤剂与其它抗肿瘤剂的组合。

    Isoxazolopyridone derivatives and their use
    5.
    发明授权
    Isoxazolopyridone derivatives and their use 失效
    异恶唑吡啶酮衍生物及其用途

    公开(公告)号：US07053219B2

    公开(公告)日：2006-05-30

    申请号：US10732988

    申请日：2003-12-10

    申请人： Masayuki Nakamura ,  Hideki Kurihara ,  Mitsuru Ohkubo ,  Naohiro Tsukamoto

    发明人： Masayuki Nakamura ,  Hideki Kurihara ,  Mitsuru Ohkubo ,  Naohiro Tsukamoto

    IPC分类号： C07D471/22 ,  A61K31/44

    CPC分类号： C07D498/04

    摘要： The invention relates to isoxazolopyridone derivatives of a formula (I-a): wherein R1a represents an optionally-substituted heteroaryl or phenyl group, R2a represents an optionally-substituted phenyl or heteroaryl group, and R3a represents a methyl group, provided that, (1) when R1a is an unsubstituted phenyl group, then R2a must not be a para-substituted phenyl group of which the substituent is any of a methoxy group, a chloro group, a methyl group, a trifluoromethyl group, a fluoro group, a bromomethyl group or a dimethylaminomethyl group, and R2a must not be an unsubstituted heteroaryl group, and (2) when R1a is a 4-tolyl group or a 4-fluorophenyl group, then R2a must not be an unsubstituted phenyl group, a 4-methoxyphenyl group or a 4-fluorophenyl group, or their pharmaceutically-acceptable salts. The isoxazolopyridone derivatives or their pharmaceutically-acceptable salts of the invention have a metabotropic glutamic acid receptor-antagonistic effect, and are useful for remedy of, for example, anxiety disorders, psychosomatic disorders, obsessive-compulsive neurosis, bipolar disorders, melancholia, eating disorders, schizophrenia, multi-infarct dementia, Alzheimer disease, epilepsy, Parkinson disease, Huntington's chorea, pain or retrograde neurosis.

    摘要翻译： 本发明涉及式（Ia）的异恶唑吡啶酮衍生物：其中R 1a表示任选取代的杂芳基或苯基，R 2a表示任选取代的苯基或杂芳基 基团，且R 3a表示甲基，条件是（1）当R 1a为未取代的苯基时，R 2a必须 不是取代基是甲氧基，氯基，甲基，三氟甲基，氟基，溴甲基或二甲基氨基甲基中的任何一个的对位取代的苯基，R 2a， / SUP>不能是未取代的杂芳基，和（2）当R 1a是4-甲苯基或4-氟苯基时，R 2a不能 为未取代的苯基，4-甲氧基苯基或4-氟苯基，或其药学上可接受的盐。 本发明的异恶唑吡啶酮衍生物或其药学上可接受的盐具有代谢型谷氨酸受体拮抗作用，并且可用于治疗例如焦虑症，心理障碍，强迫性神经症，双相情感障碍，忧郁症，进食障碍 ，精神分裂症，多发性梗塞性痴呆，阿尔茨海默病，癫痫，帕金森病，亨廷顿舞蹈病，疼痛或逆行神经症。

    Aminopyridine derivatives having aurora a selective inhibitory action
    8.
    发明授权
    Aminopyridine derivatives having aurora a selective inhibitory action 有权
    具有极光选择性抑制作用的氨基吡啶衍生物

    公开(公告)号：US07834018B2

    公开(公告)日：2010-11-16

    申请号：US12315425

    申请日：2008-12-03

    申请人： Mitsuru Ohkubo ,  Tetsuya Kato ,  Nobuhiko Kawanishi ,  Takashi Mita ,  Toshiyasu Shimomura

    发明人： Mitsuru Ohkubo ,  Tetsuya Kato ,  Nobuhiko Kawanishi ,  Takashi Mita ,  Toshiyasu Shimomura

    IPC分类号： A61K31/497 ,  C07D241/04 ,  C07D295/00

    CPC分类号： C07D417/12 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/14

    摘要： The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1; j is an integer of 1 to m2; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rai and Rai′ is hydrogen atom, etc. and Rbj and Rbj′ is hydrogen atom, etc.; Rc, Rd, and Re are hydrogen atom, etc; X1 is CH, CX1a, or N; X2 is CH, N, etc.; X3 is CH, N, etc.; X4 is CH or N; Y1, Y2, and Y3 are each independently CH or N; Z1 and Z2 are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).

    摘要翻译： 本发明涉及由通式（I）表示的化合物：其中m1和m2为1,2或3; n1和n2为0或1; 我是1到m1中任何一个的整数; j为1〜m2的整数， R是芳基，杂芳基或环烷基，其中任一个可以被取代; Rai和Rai'是氢原子等，Rbj和Rbj'是氢原子等; Rc，Rd和Re为氢原子等; X1是CH，CX1a或N; X2是CH，N等; X3是CH，N等; X4是CH或N; Y1，Y2和Y3各自独立地为CH或N; Z1和Z2各自独立地为CH或N; W是5元芳族杂环基，例如吡唑基，噻唑基等，或其药学上可接受的盐或酯; 含有它们的药物组合物或抗肿瘤剂; 以及抗肿瘤剂与其它抗肿瘤剂的组合。

    Novel Aminopyridine Derivatives Having Aurora a Selective Inhibitory Action
    9.
    发明申请
    Novel Aminopyridine Derivatives Having Aurora a Selective Inhibitory Action 有权
    具有极光选择性抑制作用的新型氨基吡啶衍生物

    公开(公告)号：US20090192174A1

    公开(公告)日：2009-07-30

    申请号：US12226639

    申请日：2007-04-25

    申请人： Tetsuya Kato ,  Nobuhiko Kawanishi ,  Takashi Mita ,  Keita Nagai ,  Katsumasa Nonoshita ,  Mitsuru Ohkubo

    发明人： Tetsuya Kato ,  Nobuhiko Kawanishi ,  Takashi Mita ,  Keita Nagai ,  Katsumasa Nonoshita ,  Mitsuru Ohkubo

    IPC分类号： A61K31/506 ,  C07D487/04

    CPC分类号： C07D487/08

    摘要： The present invention relates to a compound of general formula I: wherein: n1 and n2 are the same or different, and are 0 or 1; R is aryl, heteroaryl, etc.; Re is hydrogen atom or lower alkyl; two groups selected from four groups consisting of (i) either one of Ra1 and Ra1′, (ii) either one of Ra2 and Ra2′, (iii) either one of Rb1 and Rb1′, and (iv) either one of Rb2 and Rb2′, are combined to form —(CH2)n— where n is 1, 2 or 3; and among Ra1, Ra1′, Ra2, Ra2′, Rb1, Rb1′, Rb2 and Rb2′, the groups which do not form —(CH2)n— are each independently hydrogen atom, etc.; X1, X2, X3 and X4 are each independently CH, N, etc.; Y1, Y2, Y3 and Y4 are the same or different and are CH or N, etc.; W is a 5-membered aromatic heterocyclic group, or a pharmaceutically acceptable salt or ester thereof.

    摘要翻译： 本发明涉及通式I的化合物：其中：n1和n2相同或不同，为0或1; R是芳基，杂芳基等; Re为氢原子或低级烷基; 选自由（i）Ra1和Ra1'中的任一个组成的四组中的两个基团，（ii）Ra2和Ra2'中的任一个，（iii）Rb1和Rb1'中的任一个，以及（iv）Rb2和 Rb2'组合形成 - （CH 2）n - ，其中n为1,2或3; 在Ra1，Ra1'，Ra2，Ra2'，Rb1，Rb1'，Rb2和Rb2'之间，不形成 - （CH2）n-的基团各自独立地为氢原子等; X1，X2，X3和X4各自独立地为CH，N等; Y1，Y2，Y3和Y4相同或不同，为CH或N等; W是5元芳杂环基或其药学上可接受的盐或酯。

    Novel 35 kd protein
    10.
    发明申请
    Novel 35 kd protein 失效
    新型35 kd蛋白

    公开(公告)号：US20050214858A1

    公开(公告)日：2005-09-29

    申请号：US10511270

    申请日：2003-04-28

    申请人： Hidenori Nakajima ,  Mitsuru Ohkubo ,  Seiji Yoshimura ,  Nobuya Nishio ,  Kaori Nishio

    发明人： Hidenori Nakajima ,  Mitsuru Ohkubo ,  Seiji Yoshimura ,  Nobuya Nishio ,  Kaori Nishio

    IPC分类号： C07K14/47 ,  C12N9/88 ,  C12N15/12 ,  G01N33/53 ,  C07H21/04 ,  C12N9/24 ,  C12N15/09

    CPC分类号： C12N9/88 ,  C07K14/4702 ,  G01N2500/00

    摘要： It is intended to provide a protein participating in the regulation of sugar production, a polynucleotide encoding the same, a method of screening a compound participating in the regulation of sugar production and a drug for treating or preventing diabetes which contains the compound participating in the regulation of sugar production. A polynucleotide encoding a protein specifically binding to a substance WF00144 is found out from rat liver cells and thus a protein participating in the regulation of sugar production and a polynucleotide encoding the same are provided. Moreover, a method and a substance relating to a method of treating and preventing diabetes are found out and thus a method of treating diabetes relating to the regulation of sugar production relating to the method of treating and preventing diabetes is provided.

    摘要翻译： 目的在于提供参与糖生产调节的蛋白质，编码糖蛋白的多核苷酸，筛选参与糖生产调节的化合物的方法和用于治疗或预防糖尿病的药物，其含有参与调节的化合物 的糖生产。 从大鼠肝细胞中发现编码与物质WF00144特异性结合的蛋白质的多核苷酸，因此提供了参与糖产​​生调节的蛋白质和编码该多核苷酸的多核苷酸。 此外，发现了与治疗和预防糖尿病的方法有关的方法和物质，因此提供了治疗和预防糖尿病的方法中关于糖生产调节的糖尿病的治疗方法。