公开(公告)号：US5554758A

公开(公告)日：1996-09-10

申请号：US474133

申请日：1995-06-07

申请人： Yukio Mizuno ,  Miichiro Arita

发明人： Yukio Mizuno ,  Miichiro Arita

IPC分类号： C07D213/30 ,  C07D417/12 ,  C07D213/28

CPC分类号： C07D213/30 ,  C07D417/12

摘要： A compound of the formula:A--CH.sub.2 CH.sub.2 --O--B[wherein A stands for an aromatic ring residue, a group shown by R.sup.1 --CO-- (wherein R.sup.1 stands for an aliphatic hydrocarbon residue, aromatic hydrocarbon residue, a heterocyclic residue, an aromatic alipahtic hydrocarbon residue or an alicyclic hydrocarbon residue) or R.sup.2 --CH.dbd.CH-- (wherein R.sup.2 stands for an aliphatic hydrocarbon residue an aromatic hydrocarbon residue a heterocyclic residue an aromatic aliphatic hydrocarbon residue or an alicyclic hydrocarbon residue), and B stands for an aromatic ring residue], can be obtained in high yield, at high purity level by short reaction time, by reacting a compound of the formula:A--CH.sub.2 CH.sub.2 --X(wherein A is of the same meaning as defined above, and X stands for a leaving group) with a compound represented by the general formula:MO--B(wherein M stands for an alkali metal atom or an alkaline earth metal atom and B is of the same meaning as defined above) in a non-aqueous solvent.

摘要翻译： 下式化合物：A-CH2CH2-OB [其中A表示芳香环残基，由R1-CO-表示的基团（其中R1表示脂肪族烃残基，芳香族烃残基，杂环残基，芳族脂肪酸 烃残基或脂环烃残基）或R2-CH = CH-（其中R2表示脂族烃残基，芳香烃残基，杂环残基，芳族脂族烃残基或脂环族烃残基），B表示芳环 残基]可以通过使下式化合物：A-CH 2 CH 2 -X（其中A与上述定义相同）表示的化合物，通过短反应时间以高纯度获得，高纯度水平，X表示离去 基团）与通式MO-B（其中M表示碱金属原子或碱土金属原子，B与上述定义相同）表示的化合物与非水溶剂反应。

公开(公告)号：US5210271A

公开(公告)日：1993-05-11

申请号：US748964

申请日：1991-08-23

申请人： Yukio Mizuno ,  Miichiro Arita

发明人： Yukio Mizuno ,  Miichiro Arita

IPC分类号： C07C255/25 ,  C07C269/02

CPC分类号： C07C255/25 ,  C07C269/02

摘要： A method of producing diethanolamine derivatives or acid salts thereof according to the reaction scheme: ##STR1## wherein X stands for a leaving group; and R.sup.1 stands for an alkylcarbamoyl group, which provides an industrially advantageous method of preparing the subject matter useful as an antiarrhythmic agent.

公开(公告)号：US6077943A

公开(公告)日：2000-06-20

申请号：US143365

申请日：1998-08-28

申请人： Satoshi Omura ,  Masayasu Kato ,  Miichiro Arita

发明人： Satoshi Omura ,  Masayasu Kato ,  Miichiro Arita

IPC分类号： C07H17/08 ,  A01N43/04 ,  C07H1/06

CPC分类号： C07H17/08

摘要： A method of producing an N-demethyl-N-isopropyl-8,9-anhydroerythromycin A-6,9-hemiacetal or a salt thereof, characterized in that an N-demethylerythromycin A or a salt thereof is reacted with an isopropylating agent and subsequently treated under acidic conditions, and a method of producing a substantially pure crystal of an 8,9-anhydroerythromycin A-6,9-hemiacetal derivative represented formula (VI): ##STR1## wherein R.sup.1 and R.sup.2, whether identical or not, represent an alkyl having 1 to 6 carbon atoms, an alkenyl having 2 to 6 carbon atoms or an alkynyl having 2 to 6 carbon atoms; R.sup.3 represents hydrogen or a hydroxyl group; one of R.sup.4 and R.sup.5 represents hydrogen and the other represents a hydroxyl group, or R.sup.4 and R.sup.5 bind together to represent O.dbd.; R.sup.6 represents hydrogen or a hydroxyl group that may be substituted for; R.sup.7 represents hydrogen or a hydroxyl group; or a salt thereof, characterized in that a crude crystal of said 8,9-anhydroerythromycin A-6,9-hemiacetal derivative or a salt thereof is recrystallized as a solvation product from hydrated isopropanol.

摘要翻译： 一种N-去甲基-N-异丙基-8,9-去水红霉素A-6,9-半缩醛或其盐的制备方法，其特征在于N-去甲基红霉素A或其盐与异丙基化试剂反应，随后 在酸性条件下处理的方法，以及制备基本上纯的由9,9-脱水红霉素A-6,9-半缩醛衍生物衍生的结晶的方法，其中R 1和R 2相同或不相同，表示具有1 至6个碳原子，具有2至6个碳原子的烯基或具有2至6个碳原子的炔基; R3表示氢或羟基; R4和R5之一表示氢，另一个表示羟基，或R4和R5结合在一起代表O =; R6表示氢或可以被取代的羟基; R 7表示氢或羟基; 或其盐，其特征在于所述8,9-脱水红霉素A-6,9-半缩醛衍生物或其盐的粗结晶作为溶剂合物从水合异丙醇中重结晶。