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6 条记录 (耗时 0.036 秒)

    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    1.
    发明授权
    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto 有权
    促性腺激素释放激素受体拮抗剂及其相关方法

    公开(公告)号：US06537998B1

    公开(公告)日：2003-03-25

    申请号：US09688774

    申请日：2000-10-16

    申请人： Yun-Fei Zhu ,  Timothy D. Gross ,  Yinghong Gao ,  Patrick J. Connors, Jr. ,  Zhiqiang Guo ,  Chen Chen

    发明人： Yun-Fei Zhu ,  Timothy D. Gross ,  Yinghong Gao ,  Patrick J. Connors, Jr. ,  Zhiqiang Guo ,  Chen Chen

    IPC分类号： C07D48704

    CPC分类号： C07D487/04

    摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein Ar, A, B, Q, R1, R2, R3a, R3b, R6, R7 and m are as defined herein, including stereoisomers, prodrugs and pharmaceutical acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

    摘要翻译： 公开了GnRH受体拮抗剂，其可用于治疗男性和女性中各种性激素相关病症。 本发明的化合物具有以下结构：其中Ar，A，B，Q，R 1，R 2，R 3a，R 3b，R 6，R 7和m如本文所定义，包括立体异构体，前药和其药学上可接受的盐。 还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及涉及其在有需要的受试者中拮抗促性腺激素释放激素的方法。

    Thermal control of concentric tube liquid source gas lines
    6.
    发明授权
    Thermal control of concentric tube liquid source gas lines 失效
    同心管液体源气体管线的热控制

    公开(公告)号：US5343937A

    公开(公告)日：1994-09-06

    申请号：US856816

    申请日：1992-03-24

    申请人： Timothy D. Gross

    发明人： Timothy D. Gross

    IPC分类号： F16L39/00 ,  F16L53/00

    CPC分类号： F16L39/00 ,  Y10T137/6416 ,  Y10T137/6579

    摘要： A double containment liquid source gas line uses an outer annular chamber which functions as a safety containment housing and a thermal control liner. The thermal control is accomplished by providing hot water and pumping the water in a closed loop configuration. The water serves to accurately and reliably control temperature of liquid source gas in the gas line. The water is in a closed loop system, so that, by providing leak detection equipment on the water line, faults in either chamber may be rapidly detected.

    摘要翻译： 双重密封液体源气体管线使用用作安全容纳壳体和热控制衬套的外部环形室。 热控制通过提供热水并以闭环配置泵送水来实现。 该水用于准确可靠地控制气体管线中的液体源气体的温度。 水处于闭环系统中，通过在水线上提供泄漏检测设备，可以快速检测任一室中的故障。