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公开(公告)号：US20080026473A1
公开(公告)日：2008-01-31
申请号：US11492273
申请日：2006-07-25
申请人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
发明人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/006 , Y10T29/49002
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.
摘要翻译： 本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。 在本发明的某些实施方案中，传感器包括具有中心链和耦合到中心链的多个侧链的亲水梳状共聚物，其中至少一个侧链包含硅氧烷部分。
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公开(公告)号：US09237865B2
公开(公告)日：2016-01-19
申请号：US11492273
申请日：2006-07-25
发明人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
IPC分类号： G01N33/48 , A61B5/05 , A61B5/1486 , A61B5/145 , C12Q1/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/006 , Y10T29/49002
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.
摘要翻译： 本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。 在本发明的某些实施方案中，传感器包括具有中心链和耦合到中心链的多个侧链的亲水梳状共聚物，其中至少一个侧链包含硅氧烷部分。
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公开(公告)号：US08352011B2
公开(公告)日：2013-01-08
申请号：US12264810
申请日：2008-11-04
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
IPC分类号： A61B5/05
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US08591416B2
公开(公告)日：2013-11-26
申请号：US12887451
申请日：2010-09-21
申请人： Rajiv Shah , Wayne A. Morgan , David Y. Choy , James L. Henke , Bahar Reghabi , Gopikrishnan Soundararajan , Peter Schultz , Udo Hoss
发明人： Rajiv Shah , Wayne A. Morgan , David Y. Choy , James L. Henke , Bahar Reghabi , Gopikrishnan Soundararajan , Peter Schultz , Udo Hoss
CPC分类号： G01N27/403 , A61B5/14532 , A61B5/1473 , A61B2560/0223 , A61B2562/02 , C12Q1/006 , G01N27/327 , G01N27/416
摘要： A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.
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公开(公告)号：US20110106480A1
公开(公告)日：2011-05-05
申请号：US13004631
申请日：2011-01-11
申请人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
发明人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
摘要翻译： 血糖感测系统包括传感器和传感器电子设备。 传感器包括多个电极。 传感器电子设备包括稳定电路。 稳定电路使得第一电压被施加到第一时间帧中的一个电极，并且使得第二电压被施加到第二时间范围中的一个电极。 稳定电路重复施加第一电压和第二电压以继续阳极 - 阴极循环。 传感器电子设备可以包括电源，调节器和电压施加装置，其中电压施加装置从调节器接收调节电压，在第一时间帧向电极施加第一电压，并施加第二电压 第二时间段的电极。
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公开(公告)号：US20110048938A1
公开(公告)日：2011-03-03
申请号：US12887465
申请日：2010-09-21
申请人： RAJIV SHAH , Wayne A. Morgan , David Y. Choy , James L. Henke , Bahar Reghabi , Gopikrishnan Soundararajan , Peter Schultz , Udo Hoss
发明人： RAJIV SHAH , Wayne A. Morgan , David Y. Choy , James L. Henke , Bahar Reghabi , Gopikrishnan Soundararajan , Peter Schultz , Udo Hoss
IPC分类号： G01N27/403
CPC分类号： G01N27/403 , A61B5/14532 , A61B5/1473 , A61B2560/0223 , A61B2562/02 , C12Q1/006 , G01N27/327 , G01N27/416
摘要： A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.
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公开(公告)号：US20110010105A1
公开(公告)日：2011-01-13
申请号：US12887460
申请日：2010-09-21
申请人： RAJIV SHAH , Wayne A. Morgan , David Y. Choy , James L. Henke , Bahar Reghabi , Gopikrishnan Soundararajan , Peter Schultz , Udo Hoss
发明人： RAJIV SHAH , Wayne A. Morgan , David Y. Choy , James L. Henke , Bahar Reghabi , Gopikrishnan Soundararajan , Peter Schultz , Udo Hoss
CPC分类号： G01N27/403 , A61B5/14532 , A61B5/1473 , A61B2560/0223 , A61B2562/02 , C12Q1/006 , G01N27/327 , G01N27/416
摘要： A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.
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公开(公告)号：US07468033B2
公开(公告)日：2008-12-23
申请号：US10935954
申请日：2004-09-08
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US20070173712A1
公开(公告)日：2007-07-26
申请号：US11322977
申请日：2005-12-30
申请人： Rajiv Shah , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
发明人： Rajiv Shah , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry cases a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulator voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
摘要翻译： 血糖感测系统包括传感器和传感器电子设备。 传感器包括多个电极。 传感器电子设备包括稳定电路。 稳定电路将第一时间帧施加到电极中的一个施加第一电压，并且将第二电压施加到第二时间框架中的一个电极。 稳定电路重复施加第一电压和第二电压以继续阳极 - 阴极循环。 传感器电子设备可以包括电源，调节器和电压施加装置，其中电压施加装置从调节器接收调节器电压，在第一时间帧向电极施加第一电压，并将第二电压施加到 第二时间段的电极。
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公开(公告)号：US20110101995A1
公开(公告)日：2011-05-05
申请号：US13004660
申请日：2011-01-11
申请人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
发明人： RAJIV SHAH , Bahar Reghabi , James L. Henke , Wayne A. Morgan , Gopikrishnan Soundararajan , David Y. Choy , Peter Schultz , Udo Hoss
摘要： A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.
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