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公开(公告)号：US08352011B2
公开(公告)日：2013-01-08
申请号：US12264810
申请日：2008-11-04
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Larry Wang , Kent L. Clark
IPC分类号： A61B5/05
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US07468033B2
公开(公告)日：2008-12-23
申请号：US10935954
申请日：2004-09-08
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US20090149728A1
公开(公告)日：2009-06-11
申请号：US12264810
申请日：2008-11-04
申请人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
发明人： Nannette M. Van Antwerp , Bradley J. Enegren , John J. Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent L. Clark
IPC分类号： A61B5/1468
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。
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公开(公告)号：US20080027287A1
公开(公告)日：2008-01-31
申请号：US11493054
申请日：2006-07-26
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6849
摘要： The disclosure provides a sensor including a sensor having an external surface and a cannula. The cannula comprises a substantially cylindrical wall encircling a lumen, at least one aperture and a distal end. The sensor is positioned within the lumen and the distal end of the cannula extends beyond the sensor. This configuration functions for example to stabilize chemical reactions associated with the sensor by creating a buffer zone between the sensor and the surrounding tissues at the site of implantation. In certain embodiments, the sensor can further comprise an accessory material in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the sensor. The sensor can also comprise anchors that keeps the sensor in contact with subcutaneous tissue of a subject upon insertion of the sensor into the body of the subject.
摘要翻译： 本公开提供了一种传感器，其包括具有外表面和插管的传感器。 套管包括围绕内腔，至少一个孔和远端的基本上圆柱形的壁。 传感器位于内腔内，套管的远端延伸超过传感器。 该配置用于例如通过在植入位置处在传感器和周围组织之间产生缓冲区来稳定与传感器相关的化学反应。 在某些实施例中，传感器还可包括靠近外表面的辅助材料，其中辅助材料改变与传感器接触的组织的生物反应。 传感器还可以包括锚固件，当将传感器插入到受试者的身体中时，保持传感器与受试者的皮下组织接触。
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公开(公告)号：US20080026473A1
公开(公告)日：2008-01-31
申请号：US11492273
申请日：2006-07-25
申请人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
发明人： Yunbing Wang , Udo Hoss , Rajiv Shah , Jenn-Hann Larry Wang , William P. Van Antwerp , Brooks B. Cochran
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/006 , Y10T29/49002
摘要： Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes a hydrophilic comb-copolymer having a central chain and a plurality of side chains coupled to the central chain, wherein at least one side chain comprises a silicone moiety.
摘要翻译： 本发明的实施例提供了分析物传感器，其具有被设计成调节其化学反应的元件以及用于制造和使用这些传感器的方法。 在本发明的某些实施方案中，传感器包括具有中心链和耦合到中心链的多个侧链的亲水梳状共聚物，其中至少一个侧链包含硅氧烷部分。
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公开(公告)号：US20120004524A1
公开(公告)日：2012-01-05
申请号：US13233338
申请日：2011-09-15
申请人： Nannette M. Van Antwerp , Udo Hoss
发明人： Nannette M. Van Antwerp , Udo Hoss
IPC分类号： A61B5/145
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The methods and apparatus for detecting an analyte in blood are useful for detecting an analyte in tissue of a subject. The apparatus comprises a sensor, which comprises an elongated conductive material having a protrudent end, the protrudent end comprising an electrode that detects the presence of an analyte; a substrate affixed to the conductive material; and a support having an external surface, a proximal end, and a distal end. The conductive material is positioned on the support and the protrudent end of the conductive material protrudes beyond the distal end of the support. Optionally, the sensor is suspended within the lumen of a venous flow device. Typically, only a portion of the sensor is suspended within the lumen of the venous flow device, said portion comprising the protrudent end of the conductive material. Alternatively, the conductive material is positioned on the external surface of the intravenous infusion catheter.
摘要翻译： 用于检测血液中分析物的方法和装置可用于检测受试者组织中的分析物。 该装置包括传感器，其包括具有突出端的细长导电材料，该突出端包括检测分析物的存在的电极; 固定在导电材料上的基板; 以及具有外表面，近端和远端的支撑件。 导电材料定位在支撑件上，并且导电材料的突出端突出超出支撑件的远端。 可选地，传感器悬挂在静脉流动装置的内腔内。 通常，只有一部分传感器悬挂在静脉流装置的内腔内，所述部分包括导电材料的突出端。 或者，导电材料定位在静脉输液导管的外表面上。
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公开(公告)号：US08032198B2
公开(公告)日：2011-10-04
申请号：US11348894
申请日：2006-02-07
申请人： Nannette M. Van Antwerp , Udo Hoss
发明人： Nannette M. Van Antwerp , Udo Hoss
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The methods and apparatus for detecting an analyte in blood are useful for detecting an analyte in tissue of a subject. The apparatus comprises a sensor, which comprises an elongated conductive material having a protrudent end, the protrudent end comprising an electrode that detects the presence of an analyte; a substrate affixed to the conductive material; and a support having an external surface, a proximal end, and a distal end. The conductive material is positioned on the support and the protrudent end of the conductive material protrudes beyond the distal end of the support. Optionally, the sensor is suspended within the lumen of a venous flow device. Typically, only a portion of the sensor is suspended within the lumen of the venous flow device, said portion comprising the protrudent end of the conductive material. Alternatively, the conductive material is positioned on the external surface of the intravenous infusion catheter.
摘要翻译： 用于检测血液中分析物的方法和装置可用于检测受试者组织中的分析物。 该装置包括传感器，其包括具有突出端的细长导电材料，该突出端包括检测分析物的存在的电极; 固定在导电材料上的基板; 以及具有外表面，近端和远端的支撑件。 导电材料定位在支撑件上，并且导电材料的突出端突出超出支撑件的远端。 可选地，传感器悬挂在静脉流动装置的内腔内。 通常，只有一部分传感器悬挂在静脉流装置的内腔内，所述部分包括导电材料的突出端。 或者，导电材料定位在静脉输液导管的外表面上。
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公开(公告)号：US20060052745A1
公开(公告)日：2006-03-09
申请号：US10935954
申请日：2004-09-08
申请人： Nannette Van Antwerp , Bradley Enegren , John Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent Clark
发明人： Nannette Van Antwerp , Bradley Enegren , John Mastrototaro , Rajiv Shah , Udo Hoss , Yanan Zhang , Jenn-Hann Wang , Kent Clark
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
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公开(公告)号：US08600470B2
公开(公告)日：2013-12-03
申请号：US13233338
申请日：2011-09-15
申请人： Nannette M. Van Antwerp , Udo Hoss
发明人： Nannette M. Van Antwerp , Udo Hoss
CPC分类号： A61B5/153 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150755 , A61B5/150862 , A61B5/150992
摘要： The methods and apparatus for detecting an analyte in blood are useful for detecting an analyte in tissue of a subject. The apparatus comprises a sensor, which comprises an elongated conductive material having a protrudent end, the protrudent end comprising an electrode that detects the presence of an analyte; a substrate affixed to the conductive material; and a support having an external surface, a proximal end, and a distal end. The conductive material is positioned on the support and the protrudent end of the conductive material protrudes beyond the distal end of the support. Optionally, the sensor is suspended within the lumen of a venous flow device. Typically, only a portion of the sensor is suspended within the lumen of the venous flow device, said portion comprising the protrudent end of the conductive material. Alternatively, the conductive material is positioned on the external surface of the intravenous infusion catheter.
摘要翻译： 用于检测血液中分析物的方法和装置可用于检测受试者组织中的分析物。 该装置包括传感器，其包括具有突出端的细长导电材料，该突出端包括检测分析物的存在的电极; 固定在导电材料上的基板; 以及具有外表面，近端和远端的支撑件。 导电材料定位在支撑件上，并且导电材料的突出端突出超出支撑件的远端。 可选地，传感器悬挂在静脉流动装置的内腔内。 通常，只有一部分传感器悬挂在静脉流装置的内腔内，所述部分包括导电材料的突出端。 或者，导电材料定位在静脉输液导管的外表面上。
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公开(公告)号：US09492111B2
公开(公告)日：2016-11-15
申请号：US11493054
申请日：2006-07-26
IPC分类号： A61B5/00 , A61B5/1486 , A61B5/145
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6849
摘要： The disclosure provides a sensor including a sensor having an external surface and a cannula. The cannula comprises a substantially cylindrical wall encircling a lumen, at least one aperture and a distal end. The sensor is positioned within the lumen and the distal end of the cannula extends beyond the sensor. This configuration functions for example to stabilize chemical reactions associated with the sensor by creating a buffer zone between the sensor and the surrounding tissues at the site of implantation. In certain embodiments, the sensor can further comprise an accessory material in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the sensor. The sensor can also comprise anchors that keeps the sensor in contact with subcutaneous tissue of a subject upon insertion of the sensor into the body of the subject.
摘要翻译： 本公开提供了一种传感器，其包括具有外表面和插管的传感器。 套管包括围绕内腔，至少一个孔和远端的基本上圆柱形的壁。 传感器位于内腔内，套管的远端延伸超过传感器。 该配置用于例如通过在植入位置处在传感器和周围组织之间产生缓冲区来稳定与传感器相关的化学反应。 在某些实施例中，传感器还可包括邻近外表面的辅助材料，其中辅助材料改变与传感器接触的组织的生物反应。 传感器还可以包括锚固件，当将传感器插入到受试者的身体中时，保持传感器与受试者的皮下组织接触。
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