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    ORAL COMPOSITION FOR ALLEVIATING ULTRAVIOLET IRRADIATION-INDUCED DAMAGE
    3.
    发明申请
    ORAL COMPOSITION FOR ALLEVIATING ULTRAVIOLET IRRADIATION-INDUCED DAMAGE 审中-公开
    用于治疗超紫外线辐射诱导性损伤的口腔组合物

    公开(公告)号：US20120189563A1

    公开(公告)日：2012-07-26

    申请号：US13261161

    申请日：2010-03-31

    申请人： Yutaka Ashida ,  Yosuke Tojo ,  Chieko Mizumoto ,  Masashi Mita ,  Shoichiro Shimada

    发明人： Yutaka Ashida ,  Yosuke Tojo ,  Chieko Mizumoto ,  Masashi Mita ,  Shoichiro Shimada

    IPC分类号： A61K31/197 ,  A61P17/12 ,  A61Q19/02 ,  A61Q19/08 ,  A61P27/12 ,  A61K8/44 ,  A61P17/00 ,  A61P35/00

    CPC分类号： A61K31/198 ,  A21D2/245 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/447 ,  A61K2800/92 ,  A61Q17/04 ,  A61Q19/08 ,  A23V2200/318 ,  A23V2250/06

    摘要： Disclosed are: an oral composition for alleviating ultraviolet irradiation-induced damage, which can be used on a daily basis and is stable and safe; and a medicinal agent; and anti-wrinkle agent and a food composition, each of which comprises the oral composition. Specifically disclosed is an oral composition for alleviating ultraviolet irradiation-induced damage, which comprises at least one compound selected from the group consisting of methionine and derivatives and/or salts thereof. The composition may be an anti-wrinkle agent, a pharmaceutical composition for treating and/or preventing skin diseases, a food composition, or a pharmaceutical composition for preventing or treating cataract. In the oral composition for alleviating ultraviolet irradiation-induced damage, methionine may be in the D-form.

    摘要翻译： 公开了一种用于减轻紫外线照射引起的损伤的口服组合物，其可以每天使用并且是稳定和安全的; 和药剂; 和抗皱剂和食品组合物，其各自包含口腔组合物。 具体公开了一种用于减轻紫外线照射诱发的损伤的口服组合物，其包含至少一种选自甲硫氨酸及其衍生物和/或盐的化合物。 组合物可以是抗皱剂，用于治疗和/或预防皮肤病的药物组合物，食品组合物或用于预防或治疗白内障的药物组合物。 在用于减轻紫外线照射诱发的损伤的口服组合物中，甲硫氨酸可以是D-型。

    ANTIOXIDANT COMPOSITION
    6.
    发明申请
    ANTIOXIDANT COMPOSITION 有权
    抗氧化剂组合物

    公开(公告)号：US20120184620A1

    公开(公告)日：2012-07-19

    申请号：US13261240

    申请日：2010-03-31

    申请人： Yosuke Tojo ,  Chieko Mizumoto ,  Yutaka Ashida ,  Masashi Mita

    发明人： Yosuke Tojo ,  Chieko Mizumoto ,  Yutaka Ashida ,  Masashi Mita

    IPC分类号： A61K31/198 ,  A61P35/00 ,  A61P27/12 ,  A61P17/00

    CPC分类号： A23L1/3051 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/44 ,  A61K31/198 ,  A61K45/06 ,  A61K2800/522 ,  A61Q19/007 ,  A61Q19/08 ,  A61K2300/00 ,  A23V2200/318 ,  A23V2250/06

    摘要： Disclosed is a stable and safe antioxidant composition which can be used routinely. Specifically disclosed is an antioxidant composition which contains one or more compounds selected from the group consisting of D-aspartic acid, derivatives and/or salts thereof. The composition may be used for the purpose of suppressing and/or improving skin conditions. The skin conditions may include, but is not limited to, fine wrinkles, a rough skin, a dry skin, a skin cancer, a skin allergy, an inflammation of the skin and a photosensitive dermatosis. The composition may be used for an external preparation for the skin, a food, and a pharmaceutical product for cataract.

    摘要翻译： 公开了可以常规使用的稳定且安全的抗氧化剂组合物。 具体公开的是含有一种或多种选自D-天冬氨酸，其衍生物和/或盐的化合物的抗氧化剂组合物。 该组合物可用于抑制和/或改善皮肤状况。 皮肤状况可以包括但不限于细皱纹，粗糙皮肤，干性皮肤，皮肤癌，皮肤过敏，皮肤炎症和感光性皮肤病。 该组合物可用于皮肤外用制剂，食品和白内障药用制品。

    COMPOSITION FOR ALLEVIATING ULTRAVIOLET IRRADIATION-INDUCED DAMAGE
    7.
    发明申请
    COMPOSITION FOR ALLEVIATING ULTRAVIOLET IRRADIATION-INDUCED DAMAGE 审中-公开
    用于治疗超紫外线辐射诱导的损伤的组合物

    公开(公告)号：US20120148509A1

    公开(公告)日：2012-06-14

    申请号：US13261182

    申请日：2010-09-14

    申请人： Yutaka Ashida ,  Yosuke Tojo ,  Chieko Mizumoto ,  Masashi Mita

    发明人： Yutaka Ashida ,  Yosuke Tojo ,  Chieko Mizumoto ,  Masashi Mita

    IPC分类号： A61K31/198 ,  A61K31/42 ,  A61P17/00 ,  A61K8/49 ,  A61Q19/00 ,  A61Q17/04 ,  A61P27/12 ,  A61K8/44 ,  A61P35/00

    CPC分类号： A61Q17/04 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/0208 ,  A61K8/44 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/12 ,  A61K9/2018 ,  A61K9/4858 ,  A61K9/7007 ,  A61K31/198 ,  A61Q19/004 ,  A61Q19/08 ,  A23V2200/318 ,  A23V2250/0632 ,  A23V2250/0642

    摘要： Disclosed are a composition for alleviating ultraviolet irradiation-induced damage, which is stable and safe and can be used on a daily basis, and a pharmaceutical composition, an external skin preparation, a food composition and a medicine for cataract, each comprising aforesaid composition for alleviating ultraviolet irradiation-induced damage. Specifically disclosed is a composition for alleviating ultraviolet irradiation-induced damage which contains one or more kinds of compounds selected from the group consisting of methionine, D-serine and derivatives and/or salts of the same. The aforesaid composition may be an external preparation for the skin, an anti-wrinkle agent, a sunscreen agent, a medicinal composition for treating and/or preventing skin diseases, a food composition or a pharmaceutical product for cataract. In the aforesaid composition for alleviating ultraviolet irradiation-induced damage, the aforesaid methionine may be D-methionine, and the aforesaid D-serine derivative may be D-cycloserine.

    摘要翻译： 公开了一种缓和紫外线照射诱发的损伤的组合物，其是稳定和安全的并且可以每天使用，以及药物组合物，外用皮肤制剂，食品组合物和白内障药物，其各自包含上述组合物 缓解紫外线照射引起的损伤。 具体公开了含有选自甲硫氨酸，D-丝氨酸及其衍生物和/或其盐的一种或多种化合物的减轻紫外线照射诱发的损伤的组合物。 上述组合物可以是用于皮肤的外用制剂，抗皱剂，防晒剂，用于治疗和/或预防皮肤病的药物组合物，食品组合物或白内障药物。 在上述减轻紫外线照射诱发损伤的组合物中，上述甲硫氨酸可以是D-甲硫氨酸，上述D-丝氨酸衍生物可以是D-环丝氨酸。

    SKIN-WHITENING AGENT AND COSMETIC METHOD FOR WHITENING SKIN
    9.
    发明申请
    SKIN-WHITENING AGENT AND COSMETIC METHOD FOR WHITENING SKIN 审中-公开
    用于白化皮肤的皮肤白化剂和化妆方法

    公开(公告)号：US20120122951A1

    公开(公告)日：2012-05-17

    申请号：US13138787

    申请日：2010-03-04

    申请人： Rikako Suzuki ,  Yosuke Tojo ,  Chieko Mizumoto ,  Kiyotaka Hasegawa ,  Yutaka Ashida ,  Jun-ichi Hosoi ,  Kiyoshi Sato

    发明人： Rikako Suzuki ,  Yosuke Tojo ,  Chieko Mizumoto ,  Kiyotaka Hasegawa ,  Yutaka Ashida ,  Jun-ichi Hosoi ,  Kiyoshi Sato

    IPC分类号： A61K31/40 ,  A61Q19/02 ,  C07D207/16

    CPC分类号： A61K31/401 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/0212 ,  A61K8/0216 ,  A61K8/4913 ,  A61K2800/92 ,  A61Q19/02 ,  A23V2200/318

    摘要： The development of a skin-whitening agent which has a lower molecular weight, can be synthesized through a fewer steps and can be produced at low cost has been demanded. Thus, it is provided by the present invention a skin-whitening agent including one or more compounds selected from the group consisting of 4-cis-hydroxyproline and its derivative and/or its salt, a skin-whitening composition for external formulation to the skin, a cosmetic composition and a pharmaceutical composition, each of which contains the skin-whitening agent of the invention, and a cosmetic method for whitening the skin, which includes a step of administering one or more compounds selected from the group consisting of 4-cis-hydroxyproline and its derivative and/or its salt. In the skin-whitening agent and the cosmetic method for whitening the skin of the invention, the 4-cis-hydroxyproline may be 4-cis-L-hydroxyproline and/or 4-cis-D-hydroxyproline.

    摘要翻译： 需要开发具有较低分子量的皮肤增白剂，可以通过较少的步骤合成并且可以以低成本生产。 因此，本发明提供一种皮肤增白剂，其包含一种或多种选自4-顺式 - 羟基脯氨酸及其衍生物和/或其盐的化合物，用于皮肤外用制剂的皮肤增白组合物 ，化妆品组合物和药物组合物，其含有本发明的皮肤增白剂和美白化妆品的方法，其包括给予一种或多种选自4-顺式 - 羟脯氨酸及其衍生物和/或其盐。 在本发明的皮肤美白剂和美白化妆品的美白方法中，4-顺式 - 羟基脯氨酸可以是4-顺式-L-羟基脯氨酸和/或4-顺式-D-羟基脯氨酸。

    Laminin-332 product on stimulating composition
    10.
    发明授权
    Laminin-332 product on stimulating composition 有权
    Laminin-332产品刺激组成

    公开(公告)号：US08586622B2

    公开(公告)日：2013-11-19

    申请号：US13261241

    申请日：2010-05-14

    申请人： Yosuke Tojo ,  Jun-ichi Hosoi ,  Kayo Matsumoto

    发明人： Yosuke Tojo ,  Jun-ichi Hosoi ,  Kayo Matsumoto

    IPC分类号： A01N43/36

    CPC分类号： A21D2/245 ,  A23C9/1322 ,  A23G3/34 ,  A23G3/44 ,  A23L7/20 ,  A23L11/09 ,  A23L27/50 ,  A23L27/60 ,  A23L33/175 ,  A23V2002/00 ,  A61K8/35 ,  A61K8/44 ,  A61K8/4913 ,  A61K31/198 ,  A61K31/401 ,  A61Q19/00 ,  A61Q19/08 ,  A23V2200/318 ,  A23V2250/0604

    摘要： Disclosed is a novel composition which has a function of stimulating production of laminin-332. The composition is stable and safe, and can be used routinely. Specifically disclosed is a laminin-332 production stimulating composition which contains one or more compounds selected from the group consisting of D-alanine, D-hydroxyproline, derivatives and/or salts thereof. The composition may be used for the purpose of suppressing and/or improving a skin condition. The skin condition may include, but is not limited to a photoaging, wrinkles, a rough skin, fine wrinkles and a dry skin. The composition may be used for an external preparation for the skin or a food.

    摘要翻译： 公开了具有刺激层粘连蛋白-33的产生的功能的新型组合物。 组合物稳定安全，可以常规使用。 具体公开的是含有一种或多种选自D-丙氨酸，D-羟脯氨酸，其衍生物和/或盐的化合物的层粘连蛋白-33生产刺激组合物。 该组合物可以用于抑制和/或改善皮肤状况。 皮肤状况可以包括但不限于光老化，皱纹，粗糙的皮肤，细小的皱纹和干燥的皮肤。 该组合物可用于皮肤或食物的外用制剂。