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公开(公告)号:US5187186A
公开(公告)日:1993-02-16
申请号:US755760
申请日:1991-09-06
申请人: Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
发明人: Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
IPC分类号: C07D487/04 , C07D487/10
CPC分类号: C07D487/04 , C07D487/10
摘要: DC-88A derivatives represented by the general formula: ##STR1## wherein X represents hydrogen or CO.sub.2 R.sup.1 (in which R.sup.1 represents hydrogen, a straight-chain or branched alkyl having 1 to 4 carbon atoms, allyl, or benzyl); and ##STR2## have an excellent anti-tumor activity and are useful as anti-tumor agents.
摘要翻译: 其中X表示氢或CO 2 R 1(其中R 1表示氢,具有1至4个碳原子的直链或支链烷基,烯丙基或苄基)表示的DC-88A衍生物。 和
具有优异的抗肿瘤活性,可用作抗肿瘤剂。 -
公开(公告)号:US5070092A
公开(公告)日:1991-12-03
申请号:US545579
申请日:1990-06-29
申请人: Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
发明人: Yutaka Kanda , Youichi Uosaki , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto , Satoru Nagamura
IPC分类号: A61K31/40 , A61K31/445 , A61K31/495 , A61P35/00 , C07D487/04 , C07D487/10
CPC分类号: C07D487/04 , C07D487/10
摘要: DC-88A derivatives represented by the general formula: ##STR1## wherein X represents hydrogen or CO.sub.2 R.sup.1 (in which R.sup.1 represents hydrogen, a straight-chain or branched alkyl having 1 to 4 carbon atoms, allyl, or benzyl); and ##STR2## have an excellent anti-tumor activity and are useful as anti-tumor agents.
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公开(公告)号:US5117006A
公开(公告)日:1992-05-26
申请号:US700507
申请日:1991-05-15
申请人: Hiromitsu Saito , Masaji Kasai , Makoto Morimoto , Eiji Kobayashi , Yoichi Uosaki , Yutaka Kanda , Hiroshi Sano
发明人: Hiromitsu Saito , Masaji Kasai , Makoto Morimoto , Eiji Kobayashi , Yoichi Uosaki , Yutaka Kanda , Hiroshi Sano
IPC分类号: C07D487/04 , C07D487/10
CPC分类号: C07D487/04 , C07D487/10
摘要: A DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an anti-tumor agent.
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公开(公告)号:US5084468A
公开(公告)日:1992-01-28
申请号:US392271
申请日:1989-08-10
申请人: Hiromitsu Saito , Masaji Kasai , Makoto Morimoto , Eiji Kobayashi , Yoichi Uosaki , Yutaka Kanda , Hiroshi Sano
发明人: Hiromitsu Saito , Masaji Kasai , Makoto Morimoto , Eiji Kobayashi , Yoichi Uosaki , Yutaka Kanda , Hiroshi Sano
IPC分类号: C07D487/04 , C07D487/10
CPC分类号: C07D487/04 , C07D487/10
摘要: A novel DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an antitumor agent.
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公开(公告)号:US5008271A
公开(公告)日:1991-04-16
申请号:US423788
申请日:1989-10-18
申请人: Yutaka Kanda , Tohru Yasuzawa , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto
发明人: Yutaka Kanda , Tohru Yasuzawa , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto
IPC分类号: C07D471/04 , C07D487/04 , C07D487/10
CPC分类号: C07D471/04 , C07D487/04 , C07D487/10
摘要: A novel DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an antitumor agent.
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公开(公告)号:US5138059A
公开(公告)日:1992-08-11
申请号:US380379
申请日:1989-07-17
申请人: Keiichi Takahashi , Michio Ichimura , Shigeo Katsumata , Tatsuhiro Ogawa , Makoto Morimoto , Tadashi Ashizawa , Masaji Kasai , Kenichi Muroi , Hiromitsu Saito , Hiroshi Sano , Toru Yasuzawa
发明人: Keiichi Takahashi , Michio Ichimura , Shigeo Katsumata , Tatsuhiro Ogawa , Makoto Morimoto , Tadashi Ashizawa , Masaji Kasai , Kenichi Muroi , Hiromitsu Saito , Hiroshi Sano , Toru Yasuzawa
IPC分类号: C12P17/18 , A61K31/40 , A61K31/435 , A61P31/04 , A61P35/00 , C07D471/04 , C07D487/04 , C12N1/20 , C12R1/465
CPC分类号: C07D471/04 , C07D487/04
摘要: Novel DC-89 compounds represented by the general formula: ##STR1## wherein X represents a single bond or --CH.sub.2 --; and when X represents a single bond, Y represents --CH.sub.2 Br or --CH.sub.2 Cl and when X represents --CH.sub.2 --, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.
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公开(公告)号:US5068349A
公开(公告)日:1991-11-26
申请号:US404353
申请日:1989-09-07
申请人: Yutaka Kanda , Masaji Kasai , Hitoshi Arai , Makoto Morimoto , Tadashi Ashizawa
发明人: Yutaka Kanda , Masaji Kasai , Hitoshi Arai , Makoto Morimoto , Tadashi Ashizawa
IPC分类号: A61K31/40 , A61P31/04 , A61P35/00 , C07D487/14 , C07D513/14
CPC分类号: C07D487/14
摘要: Novel mitomycin derivatives are characterized by a substituent on the C.sub.6 -methyl group. The mitomycin derivatives exhibit anti-tumor and antibacterial activity and have low toxicity.
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公开(公告)号:US4946957A
公开(公告)日:1990-08-07
申请号:US400883
申请日:1989-08-30
申请人: Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
发明人: Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
IPC分类号: A61K31/495 , A61P31/04 , C07D471/18 , C07D498/22
CPC分类号: C07D471/18 , C07D498/22
摘要: The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.
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公开(公告)号:US4822882A
公开(公告)日:1989-04-18
申请号:US102359
申请日:1987-09-29
申请人: Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
发明人: Hiromitsu Saito , Yoichi Uosaki , Akira Sato , Tadashi Hirata , Makoto Morimoto , Tadashi Ashizawa
IPC分类号: C07D471/18 , C07D498/22 , A61K31/495 , C07D487/18
CPC分类号: C07D471/18 , C07D498/22
摘要: Compounds represented by the following formula or by the corresponding hydroquinone type formula: ##STR1## in which R.sup.1 and R.sup.2 are independently hydrogen, lower alkoxy, azido, amino, lower alkylamino, di-lower alkylamino, cyclic amino, lower alkylthio or unsubstituted or substituted arylthio; and X represents hydroxyl and Y represents cyano or X and Y together represents --O-- in the form of --X--Y--, have an excellent antitumor activity.
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公开(公告)号:US4880825A
公开(公告)日:1989-11-14
申请号:US173219
申请日:1988-03-25
申请人: Masaji Kasai , Yutaka Kanda , Motomichi Kono , Yutaka Saito , Makoto Morimoto , Tadashi Ashizawa
发明人: Masaji Kasai , Yutaka Kanda , Motomichi Kono , Yutaka Saito , Makoto Morimoto , Tadashi Ashizawa
IPC分类号: C07D491/22
CPC分类号: C07D491/22
摘要: Mitomycin derivatives having potent anti-tumor activity having the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 represents carbamoyloxymethyl and the other represents hydrogen or R.sub.1 and R.sub.2 are bonded together to form methylene;X is hydrogen or halogen;Y is hydrogen or methyl;Z is hydrogen, methyl or acyl; andn is an integer of 2 or 3.
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