公开(公告)号：US5138059A

公开(公告)日：1992-08-11

申请号：US380379

申请日：1989-07-17

申请人： Keiichi Takahashi ,  Michio Ichimura ,  Shigeo Katsumata ,  Tatsuhiro Ogawa ,  Makoto Morimoto ,  Tadashi Ashizawa ,  Masaji Kasai ,  Kenichi Muroi ,  Hiromitsu Saito ,  Hiroshi Sano ,  Toru Yasuzawa

发明人： Keiichi Takahashi ,  Michio Ichimura ,  Shigeo Katsumata ,  Tatsuhiro Ogawa ,  Makoto Morimoto ,  Tadashi Ashizawa ,  Masaji Kasai ,  Kenichi Muroi ,  Hiromitsu Saito ,  Hiroshi Sano ,  Toru Yasuzawa

IPC分类号： C12P17/18 ,  A61K31/40 ,  A61K31/435 ,  A61P31/04 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C12N1/20 ,  C12R1/465

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Novel DC-89 compounds represented by the general formula: ##STR1## wherein X represents a single bond or --CH.sub.2 --; and when X represents a single bond, Y represents --CH.sub.2 Br or --CH.sub.2 Cl and when X represents --CH.sub.2 --, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.

公开(公告)号：US5071984A

公开(公告)日：1991-12-10

申请号：US612487

申请日：1990-11-14

申请人： Hiromitsu Saito ,  Akira Sato ,  Masaji Kasai ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Akira Sato ,  Masaji Kasai ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： Disclosed are DC-52 derivatives represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or hydroxyl, X represents hydroxyl and Y represents cyano and Z represents carboxyl or hydroxymethyl, or pharmacologically acceptable salts thereof. The DC-52 derivatives are useful as antitumor agents.

公开(公告)号：US4992551A

公开(公告)日：1991-02-12

申请号：US435246

申请日：1989-11-13

申请人： Hiromitsu Saito ,  Akira Sato ,  Masaji Kasai ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Akira Sato ,  Masaji Kasai ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： Disclosed are DC-52 derivatives represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or hydroxyl, X represents hydroxyl and Y represents cyano and Z represents carboxyl or hydroxymethyl, or pharmacologically acceptable salts thereof. The DC-52 derivatives are useful as antitumor agents.

公开(公告)号：US5084468A

公开(公告)日：1992-01-28

申请号：US392271

申请日：1989-08-10

申请人： Hiromitsu Saito ,  Masaji Kasai ,  Makoto Morimoto ,  Eiji Kobayashi ,  Yoichi Uosaki ,  Yutaka Kanda ,  Hiroshi Sano

发明人： Hiromitsu Saito ,  Masaji Kasai ,  Makoto Morimoto ,  Eiji Kobayashi ,  Yoichi Uosaki ,  Yutaka Kanda ,  Hiroshi Sano

IPC分类号： C07D487/04 ,  C07D487/10

CPC分类号： C07D487/04 ,  C07D487/10

摘要： A novel DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an antitumor agent.

公开(公告)号：US5117006A

公开(公告)日：1992-05-26

申请号：US700507

申请日：1991-05-15

申请人： Hiromitsu Saito ,  Masaji Kasai ,  Makoto Morimoto ,  Eiji Kobayashi ,  Yoichi Uosaki ,  Yutaka Kanda ,  Hiroshi Sano

发明人： Hiromitsu Saito ,  Masaji Kasai ,  Makoto Morimoto ,  Eiji Kobayashi ,  Yoichi Uosaki ,  Yutaka Kanda ,  Hiroshi Sano

IPC分类号： C07D487/04 ,  C07D487/10

CPC分类号： C07D487/04 ,  C07D487/10

摘要： A DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an anti-tumor agent.

公开(公告)号：US5952355A

公开(公告)日：1999-09-14

申请号：US757080

申请日：1996-11-26

申请人： Shun-Ichi Ikeda ,  Uichiro Kimura ,  Tadashi Ashizawa ,  Katsushige Gomi ,  Hiromitsu Saito ,  Masaji Kasai ,  Junji Kanazawa ,  Kimihito Sasaki ,  Etsuko Nukui ,  Masami Okabe ,  Soichiro Sato

发明人： Shun-Ichi Ikeda ,  Uichiro Kimura ,  Tadashi Ashizawa ,  Katsushige Gomi ,  Hiromitsu Saito ,  Masaji Kasai ,  Junji Kanazawa ,  Kimihito Sasaki ,  Etsuko Nukui ,  Masami Okabe ,  Soichiro Sato

IPC分类号： C07D209/12 ,  C07D209/30 ,  C07D401/06 ,  C07D405/06 ,  C07F7/08 ,  C07H15/24 ,  A61K31/40 ,  A61K31/44 ,  C07D209/32 ,  C07D209/40

CPC分类号： C07D401/06 ,  C07D209/12 ,  C07D209/30 ,  C07D405/06 ,  C07F7/0812 ,  C07H15/24

摘要： The present invention relates to propenone derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR.sup.5 (wherein Y represents S or O; and R.sup.5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue); R.sup.2 and R.sup.3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R.sup.2 and R.sup.3 are combined to form substituted or unsubstituted methylene or ethylene; R.sup.4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl; or pharmaceutically acceptable salts thereof.

摘要翻译： 本发明涉及由下式（I）表示的丙烯酮衍生物：其中R1表示氢，取代或未取代的低级烷基，取代或未取代的芳基或YR5（其中Y表示S或O; R5表示取代或未取代的低级烷基 取代或未取代的芳基，取代或未取代的杂芳基，或取代或未取代的环醚残基）; R2和R3独立地表示氢，低级烷基或取代或未取代的芳烷基，或者R2和R3组合形成取代或未取代的亚甲基或亚乙基; R4表示氢，羟基，低级烷基，取代或未取代的芳烷基，低级烷氧基，取代或未取代的芳烷氧基或卤素; X表示取代或未取代的吲哚基; 或其药学上可接受的盐。

公开(公告)号：US5011854A

公开(公告)日：1991-04-30

申请号：US281050

申请日：1989-12-07

申请人： Mitsuru Takahashi ,  Shigeto Kitamura ,  Hiroshi Kase ,  Masaji Kasai ,  Isao Kawamoto ,  Takao Iida ,  Hiroshi Sano ,  Hiromitsu Saito ,  Koji Yamada ,  Chikara Murakata

发明人： Mitsuru Takahashi ,  Shigeto Kitamura ,  Hiroshi Kase ,  Masaji Kasai ,  Isao Kawamoto ,  Takao Iida ,  Hiroshi Sano ,  Hiromitsu Saito ,  Koji Yamada ,  Chikara Murakata

IPC分类号： C07C239/16 ,  C07C259/06

CPC分类号： C07C239/16 ,  C07C259/06

摘要： A hydroxamic acid compound represented by the general formula (I) or a salt thereof; ##STR1## wherein R.sup.1 represents a hydrogen atom, or a substituted or unsubstituted alkanoyl group, R.sup.2 represents an unsubstituted alkanoyl, substituted lower alkanoyl or substituted lower alkyl group, and m represents an integer of 3 to 7, which are useful for the prevention and/or treatment of diseases caused by lipoxygenase-mediated metablites.

公开(公告)号：US4946957A

公开(公告)日：1990-08-07

申请号：US400883

申请日：1989-08-30

申请人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.

公开(公告)号：US4822882A

公开(公告)日：1989-04-18

申请号：US102359

申请日：1987-09-29

申请人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： C07D471/18 ,  C07D498/22 ,  A61K31/495 ,  C07D487/18

CPC分类号： C07D471/18 ,  C07D498/22

摘要： Compounds represented by the following formula or by the corresponding hydroquinone type formula: ##STR1## in which R.sup.1 and R.sup.2 are independently hydrogen, lower alkoxy, azido, amino, lower alkylamino, di-lower alkylamino, cyclic amino, lower alkylthio or unsubstituted or substituted arylthio; and X represents hydroxyl and Y represents cyano or X and Y together represents --O-- in the form of --X--Y--, have an excellent antitumor activity.

公开(公告)号：US4879386A

公开(公告)日：1989-11-07

申请号：US207639

申请日：1988-05-25

申请人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

发明人： Hiromitsu Saito ,  Yoichi Uosaki ,  Akira Sato ,  Tadashi Hirata ,  Makoto Morimoto ,  Tadashi Ashizawa

IPC分类号： A61K31/495 ,  A61P31/04 ,  C07D471/18 ,  C07D498/22

CPC分类号： C07D471/18 ,  C07D498/22

摘要： The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## ps [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.