PROCESS FOR PRODUCING MUSCARINE RECEPTOR ANTAGONIST AND INTERMEDIATE THEREFOR
    1.
    发明申请
    PROCESS FOR PRODUCING MUSCARINE RECEPTOR ANTAGONIST AND INTERMEDIATE THEREFOR 有权
    生产肌肉受体拮抗剂及其中间体的方法

    公开(公告)号:US20090299075A1

    公开(公告)日:2009-12-03

    申请号:US11721378

    申请日:2005-12-13

    IPC分类号: C07D233/64

    CPC分类号: C07D233/56

    摘要: The industrial production of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide, a urinary incontinence remedy, necessitates elimination of problems concerning the use of a synthetic adsorbent, e.g., HP-20, the efficiency of operation with the same, purification efficiency, etc. An acid salt, e.g., hydrochloride or phosphate, of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide or a hydrate of any of these salts is used as an intermediate. This intermediate is neutralized and then purified. Thus, high-purity 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide is easily obtained in satisfactory yield. The industrial-scale production process has been thus established.

    摘要翻译: 4-(2-甲基-1-咪唑基)-2,2-二苯基丁酰胺(尿失禁药物)的工业化生产需要消除使用合成吸附剂的问题,例如HP-20,操作效率 相同的,净化效率等。使用4-(2-甲基-1-咪唑基)-2,2-二苯基丁酰胺或任何这些盐的水合物的酸式盐,例如盐酸盐或磷酸盐作为中间体。 将该中间体中和,然后纯化。 因此,以良好的产率容易地获得高纯度的4-(2-甲基-1-咪唑基)-2,2-二苯基丁酰胺。 工业规模化生产过程已经形成。

    Process for producing muscarine receptor antagonist and intermediate therefor
    2.
    发明授权
    Process for producing muscarine receptor antagonist and intermediate therefor 有权
    生产毒蕈碱受体拮抗剂及其中间体的方法

    公开(公告)号:US07868183B2

    公开(公告)日:2011-01-11

    申请号:US11721378

    申请日:2005-12-13

    IPC分类号: C07D233/64

    CPC分类号: C07D233/56

    摘要: The industrial production of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide, a urinary incontinence remedy, necessitates elimination of problems concerning the use of a synthetic adsorbent, e.g., HP-20, the efficiency of operation with the same, purification efficiency, etc. An acid salt, e.g., hydrochloride or phosphate, of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide or a hydrate of any of these salts is used as an intermediate. This intermediate is neutralized and then purified. Thus, high-purity 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide is easily obtained in satisfactory yield. The industrial-scale production process has been thus established.

    摘要翻译: 4-(2-甲基-1-咪唑基)-2,2-二苯基丁酰胺(尿失禁药物)的工业化生产需要消除使用合成吸附剂的问题,例如HP-20,操作效率 相同的,净化效率等。使用4-(2-甲基-1-咪唑基)-2,2-二苯基丁酰胺或任何这些盐的水合物的酸式盐,例如盐酸盐或磷酸盐作为中间体。 将该中间体中和,然后纯化。 因此,以良好的产率容易地获得高纯度的4-(2-甲基-1-咪唑基)-2,2-二苯基丁酰胺。 工业规模化生产过程已经形成。

    Photoreactive agent containing photoreactive semiconductor for removing harmful materials
    3.
    发明授权
    Photoreactive agent containing photoreactive semiconductor for removing harmful materials 失效
    含光反应性半导体去除有害物质的光反应剂

    公开(公告)号:US06346253B2

    公开(公告)日:2002-02-12

    申请号:US08807701

    申请日:1997-02-28

    IPC分类号: A01N2500

    摘要: A photoreactive agent is provided for removing harmful materials which comprises a substrate and a layer containing a photoreactive semiconductor and organic fine particles coated with inorganic fine particles which is formed on at least one side of the substrate. A photoreactive agent is provided for removing harmful materials which comprises a substrate, a layer containing a photoreactive semiconductor and a layer containing organic fine particles coated with inorganic fine particles which layers are formed in that order on at least one side of the substrate. A photoreactive agent is provided for removing harmful materials which comprises a substrate, a layer containing a photoreactive semiconductor and a layer containing film-forming inorganic fine particles and a water repellent which layers are formed in that order on at least one side of the substrate. A photoreactive agent is provided for removing harmful materials which comprises a substrate, a layer containing a photoreactive semiconductor, a layer containing film-forming inorganic fine particles and a layer containing a water repellent which layers are formed in that order on at least one side of the substrate. The photoreactive agents for removing harmful materials are excellent in ability to remove harmful materials such as malodor, are water-resistant, are not changed in characteristics over a long period of time, and can easily be produced.

    摘要翻译: 提供了一种光反应剂,用于去除有害材料,该有害材料包括基材和含有光反应性半导体的层和涂覆有无机细颗粒的有机细颗粒,其形成在基材的至少一侧上。 提供了一种光反应剂,用于除去有害材料,其包括基材,含有光反应性半导体的层和包含无机细颗粒的有机细颗粒层,该层在基材的至少一侧依次形成。 提供了一种光反应剂,用于除去基材,含有光反应性半导体的层和含有成膜无机细颗粒的层以及防水剂,该有害物质在基材的至少一侧依次形成。 提供了一种光反应剂,用于除去有害材料,该有害物质包括基材,含有光反应性半导体的层,含有成膜无机细颗粒的层和含有防水剂的层,该层在至少一个 底物。 用于除去有害物质的光反应性试剂在除去有害物质如恶臭的能力方面具有优异的性能,耐水性,长时间不变化的特性,并且可以容易地生产。

    Fuel assembly
    5.
    发明授权
    Fuel assembly 有权
    燃油组件

    公开(公告)号:US06400788B1

    公开(公告)日:2002-06-04

    申请号:US09245899

    申请日:1999-02-08

    IPC分类号: G21C3326

    摘要: A fuel assembly, particularly, a fuel assembly including short-length fuel rods and fuel spacers, is used for a boiling water reactor, which is capable of sufficiently reducing the pressure loss of at least one of the fuel spacers positioned above the upper ends of the short-length fuel rods, irrespective of the arrangement of the short-length fuel rods, and also ensuring the structural strength of the fuel spacer. The fuel assembly includes fuel rods located in a square lattice array, two water rods arranged in a region in which seven of the fuel rods are arrangeable, two fuel spacers for holding the fuel rods and the water rods with mutual intervals kept immovable. Each of the fuel spacers includes cells which are connected to each other and in which the fuel rods are to be inserted, respectively, and a band for surrounding the outermost peripheries of the cells. The short-length fuel rods include four first short-length fuel rods arranged in the outermost peripheral region of the square lattice array. One of the fuel spacers, positioned upward from the upper ends of the short-length fuel rods, is configured such that the cells located at lattice positions associated with the first short-length fuel rods are removed and instead supporting members, each being adapted to connect two of the cells adjacently located on both sides of each of the lattice positions in the outermost peripheral region to the band, are provided at the lattice positions.

    摘要翻译: 一种燃料组件,特别是包括短长度燃料棒和燃料间隔件的燃料组件,用于沸水反应堆,其能够充分降低位于上游侧上方的燃料间隔物中至少一个的压力损失 短长度的燃料棒,不管短长度的燃料棒的布置,以及确保燃料间隔件的结构强度。 燃料组件包括位于正方形格子阵列中的燃料棒,布置在其中七个燃料棒可布置的区域中的两个水棒,用于保持燃料棒和水杆的相互间隔保持不动的两个燃料间隔件。 每个燃料间隔件包括彼此连接并且其中分别插入燃料棒的单元和用于围绕单元的最外周的带。 短长度燃料棒包括布置在正方形格子阵列的最外围区域中的四个第一短长度燃料棒。 燃料间隔件中的一个位于距短燃料棒的上端上方的位置,使得位于与第一短长度燃料棒相关联的格子位置处的电池被去除,并且代替支撑构件 将位于最外围区域中的每个格子位置的两侧相邻的两个单元连接到该格子位置。

    Sulfate salt of quinolonecarboxylic acid derivatives and the use thereof
    9.
    发明授权
    Sulfate salt of quinolonecarboxylic acid derivatives and the use thereof 失效
    喹诺酮羧酸衍生物的硫酸盐及其用途

    公开(公告)号:US06582609B2

    公开(公告)日:2003-06-24

    申请号:US10182445

    申请日:2002-07-29

    IPC分类号: C02F152

    CPC分类号: C07D215/56

    摘要: A method of treating an industrial waste liquor containing 1-cyclopropyl-7-(3-methyl-1-piperazinyl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (gatifloxacin), comprising adding aqueous sulfuric acid to said liquor to form a sulfate of said gatifloxacin, and/or a hydrate of said sulfate; and the sulfate, and/or hydrate of said sulfate, made by said method.

    摘要翻译: 一种处理含有1-环丙基-7-(3-甲基-1-哌嗪基)-6-氟-8-甲氧基-1,4-二氢-4-氧代-3-喹啉羧酸(加替沙星)的工业废液的方法, 包括向所述液体中加入硫酸以形成所述加替沙星的硫酸盐和/或所述硫酸盐的水合物; 和所述硫酸盐的硫酸盐和/或水合物。

    Fuel assembly
    10.
    发明授权
    Fuel assembly 失效
    燃油组件

    公开(公告)号:US5490192A

    公开(公告)日:1996-02-06

    申请号:US247854

    申请日:1994-05-23

    IPC分类号: G21C3/344 G21C3/34

    摘要: A fuel assembly comprises a plurality of fuel rods, tie plates for holding both ends of these fuel rods, and spacers which support these fuel rods. The spacer comprises a plurality of cells into which the fuel rods are inserted respectively, the adjacent cells being joined to each other at axial ends thereof, whereby a space between these cells being held or retained, and a plurality of loop springs held respectively on the cells. Each of the loop springs has a pair of resilient members which are located within the pair of adjacent cells and which urge the fuel rods in a radial direction, and a pair of connections which connect axial ends of the resilient members to each other. Each of the connections have a passage through which coolant flows axially and which is defined by a closed peripheral wall. The closed peripheral wall is not uniform in thickness. The pair of adjacent cells have at axial end portions of peripheral walls openings for accommodating or receiving the connections of the loop spring.

    摘要翻译: 燃料组件包括多个燃料棒,用于保持这些燃料棒的两端的连接板以及支撑这些燃料棒的间隔件。 间隔件包括分别插入燃料棒的多个单元,相邻的单元在其轴向端部彼此接合,由此保持或保持这些单元之间的空间,以及分别保持在该单元上的多个环形弹簧 细胞。 每个环形弹簧具有一对弹性构件,该弹性构件位于一对相邻的单元内并且沿径向推动燃料棒,以及将弹性构件的轴向端部彼此连接的一对连接件。 每个连接件都有一个通道,冷却剂通过该通道轴向流动,并由封闭的外围壁限定。 封闭的周边壁厚度不均匀。 一对相邻的单元具有用于容纳或接收环形弹簧的连接的外围壁开口的轴向端部。