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公开(公告)号：US09999616B2
公开(公告)日：2018-06-19
申请号：US15492838
申请日：2017-04-20
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , A61K45/06 , A61K31/422 , A61K31/5377 , A61K31/4439 , A61K31/497 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/4709 , A61K31/428 , A61K31/423
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US11026926B2
公开(公告)日：2021-06-08
申请号：US16251536
申请日：2019-01-18
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , C07D405/14 , C07D403/14 , C07D405/04 , C07D471/04 , C07D417/14 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , C07D409/14 , C07D487/04 , A61K31/454
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US10226451B2
公开(公告)日：2019-03-12
申请号：US15459886
申请日：2017-03-15
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4709 , A61K45/06 , A61K31/4439 , A61K31/422 , A61K31/423 , A61K31/4184 , C07D405/14 , C07D403/14 , C07D405/04 , C07D417/14 , C07D471/04 , A61K31/427 , C07D413/04 , C07D413/14 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , C07D409/14 , C07D487/04 , A61K31/454
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US20190216782A1
公开(公告)日：2019-07-18
申请号：US16251536
申请日：2019-01-18
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , C07D409/14 , A61K31/4709 , C07D413/14 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/4439 , A61K45/06 , C07D413/04 , C07D471/04 , C07D417/14 , C07D405/04 , C07D403/14 , C07D405/14 , C07D487/04 , A61K31/454 , A61K31/428 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/426 , A61K31/437
CPC分类号： A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , Y02A50/467
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US09662311B2
公开(公告)日：2017-05-30
申请号：US14900139
申请日：2014-06-20
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , C07D405/14 , C07D403/14 , C07D405/04 , C07D409/14 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , C07D417/14 , C07D471/04 , A61K31/4439 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , A61K31/437 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , C07D487/04
CPC分类号： A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , Y02A50/467
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US10166215B2
公开(公告)日：2019-01-01
申请号：US15492838
申请日：2017-04-20
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K45/06 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/454
CPC分类号： A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , Y02A50/467
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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