-
公开(公告)号：US09999616B2
公开(公告)日：2018-06-19
申请号：US15492838
申请日：2017-04-20
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , A61K45/06 , A61K31/422 , A61K31/5377 , A61K31/4439 , A61K31/497 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/4709 , A61K31/428 , A61K31/423
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
-
公开(公告)号：US20170143731A1
公开(公告)日：2017-05-25
申请号：US15424616
申请日：2017-02-03
发明人： Shuang Liu , Bryan Cordell Duffy , John Frederick Quinn , May Xiaowu Jiang , Ruifang Wang , Gregory Scott Martin , He Zhao , Bruce Francis Molino , Peter Ronald Young
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/4439 , A61K31/497 , A61K31/513 , A61K31/4545 , A61K31/50 , A61K31/498 , A61K31/4709 , A61K31/444 , A61K31/4412 , A61K31/496 , A61K31/472 , A61K31/502 , A61K31/4725 , A61K31/4375 , A61K31/501
CPC分类号： A61K31/5377 , A61K31/4375 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/513 , A61K45/06 , C07D213/64 , C07D213/74 , C07D237/04 , C07D237/14 , C07D237/22 , C07D237/32 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04 , Y02A50/467
摘要： The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
-
公开(公告)号：US11026926B2
公开(公告)日：2021-06-08
申请号：US16251536
申请日：2019-01-18
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , C07D405/14 , C07D403/14 , C07D405/04 , C07D471/04 , C07D417/14 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , C07D409/14 , C07D487/04 , A61K31/454
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
-
公开(公告)号：US10226451B2
公开(公告)日：2019-03-12
申请号：US15459886
申请日：2017-03-15
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4709 , A61K45/06 , A61K31/4439 , A61K31/422 , A61K31/423 , A61K31/4184 , C07D405/14 , C07D403/14 , C07D405/04 , C07D417/14 , C07D471/04 , A61K31/427 , C07D413/04 , C07D413/14 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , C07D409/14 , C07D487/04 , A61K31/454
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
-
公开(公告)号：US09765039B2
公开(公告)日：2017-09-19
申请号：US14085544
申请日：2013-11-20
发明人： David John Fairfax , Gregory Scott Martin , John Frederick Quinn , Bryan Cordell Duffy , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/5375 , C07D239/91 , A61K31/4725 , A61K31/517 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/04
CPC分类号： C07D239/91 , A61K31/4725 , A61K31/517 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , Y02A50/467 , A61K2300/00
摘要： The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
-
公开(公告)号：US10010556B2
公开(公告)日：2018-07-03
申请号：US15486256
申请日：2017-04-12
发明人： John Frederick Quinn , Bryan Cordell Duffy , Shuang Liu , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/5377 , A61K31/52 , A61K31/437 , A61K31/423 , A61K31/422 , A61K31/498 , A61K31/517 , A61K31/4985 , A61K31/496 , A61K31/4184 , A61K31/4545 , A61K45/06
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
-
公开(公告)号：US10231953B2
公开(公告)日：2019-03-19
申请号：US15534166
申请日：2015-12-16
发明人： Olesya Kharenko , Peter Ronald Young , Samuel David Brown , Bryan Cordell Duffy , Shuang Liu , Peter Guzzo
IPC分类号： A61K31/422 , C07D413/14 , A61K31/437 , A61K31/4439 , C07D471/04 , A61K45/06 , A61K31/4184 , A61K31/435 , A61K45/00 , C07D261/06 , C07D413/04 , A61P3/00 , A61P9/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00
摘要： The present disclosure relates to compounds capable of acting as covalent inhibitors of bromodomains and the therapeutic use of these inhibitors.
-
公开(公告)号：US10166215B2
公开(公告)日：2019-01-01
申请号：US15492838
申请日：2017-04-20
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K45/06 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/454
CPC分类号： A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , Y02A50/467
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
-
公开(公告)号：US11446306B2
公开(公告)日：2022-09-20
申请号：US16940785
申请日：2020-07-28
发明人： John Frederick Quinn , Bryan Cordell Duffy , Shuang Liu , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/5377 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/52 , A61K45/06 , C07D413/04 , C07D471/04 , C07D473/34 , A61P1/16 , A61P11/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P3/12 , A61P5/14 , A61P5/50 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/02 , A61P11/16 , A61P13/10 , A61P13/12 , A61P15/16 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/08 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/04 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
-
公开(公告)号：US10772892B2
公开(公告)日：2020-09-15
申请号：US16440350
申请日：2019-06-13
发明人： John Frederick Quinn , Bryan Cordell Duffy , Shuang Liu , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/5377 , A61K31/4184 , A61K31/4545 , A61K31/4985 , C07D413/04 , C07D471/04 , C07D473/34 , A61K45/06 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/517 , A61K31/52 , A61P3/10 , A61P9/14 , A61P9/10 , A61P9/04 , A61P9/00 , A61P7/06 , A61P7/04 , A61P7/02 , A61P5/50 , A61P5/14 , A61P43/00 , A61P37/08 , A61P37/06 , A61P37/02 , A61P37/00 , A61P3/06 , A61P35/02 , A61P35/00 , A61P31/20 , A61P31/18 , A61P31/14 , A61P31/12 , A61P31/04 , A61P3/12 , A61P3/04 , A61P3/00 , A61P29/00 , A61P27/16 , A61P27/04 , A61P27/02 , A61P25/28 , A61P25/24 , A61P25/18 , A61P25/16 , A61P25/14 , A61P25/00 , A61P21/04 , A61P21/00 , A61P19/06 , A61P19/02 , A61P17/06 , A61P17/02 , A61P17/00 , A61P15/16 , A61P13/12 , A61P11/16 , A61P11/02 , A61P11/00 , A61P1/18 , A61P1/16 , A61P1/04 , A61P1/02 , A61P1/00
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.03 秒)
