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公开(公告)号：US09999616B2
公开(公告)日：2018-06-19
申请号：US15492838
申请日：2017-04-20
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , A61K45/06 , A61K31/422 , A61K31/5377 , A61K31/4439 , A61K31/497 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/4709 , A61K31/428 , A61K31/423
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US20170320866A1
公开(公告)日：2017-11-09
申请号：US15531526
申请日：2015-12-01
发明人： May Xiaowu Jiang , Bruce Francis Molino , Shuang Liu , Ruifang Wang , Bryan Cordell Duffy , John Frederick Quinn , Gregory Steven Wagner
IPC分类号： C07D413/14 , C07D413/04 , A61K45/06 , A61K31/4439 , A61K31/4709 , A61K31/444 , C07D417/14 , C07D409/14
摘要： The present disclosure relates to substituted pyridinones, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
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公开(公告)号：US20170143731A1
公开(公告)日：2017-05-25
申请号：US15424616
申请日：2017-02-03
发明人： Shuang Liu , Bryan Cordell Duffy , John Frederick Quinn , May Xiaowu Jiang , Ruifang Wang , Gregory Scott Martin , He Zhao , Bruce Francis Molino , Peter Ronald Young
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/4439 , A61K31/497 , A61K31/513 , A61K31/4545 , A61K31/50 , A61K31/498 , A61K31/4709 , A61K31/444 , A61K31/4412 , A61K31/496 , A61K31/472 , A61K31/502 , A61K31/4725 , A61K31/4375 , A61K31/501
CPC分类号： A61K31/5377 , A61K31/4375 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/513 , A61K45/06 , C07D213/64 , C07D213/74 , C07D237/04 , C07D237/14 , C07D237/22 , C07D237/32 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04 , Y02A50/467
摘要： The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
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公开(公告)号：US11446306B2
公开(公告)日：2022-09-20
申请号：US16940785
申请日：2020-07-28
发明人： John Frederick Quinn , Bryan Cordell Duffy , Shuang Liu , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/5377 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/52 , A61K45/06 , C07D413/04 , C07D471/04 , C07D473/34 , A61P1/16 , A61P11/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P3/12 , A61P5/14 , A61P5/50 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/02 , A61P11/16 , A61P13/10 , A61P13/12 , A61P15/16 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/08 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/04 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US10772892B2
公开(公告)日：2020-09-15
申请号：US16440350
申请日：2019-06-13
发明人： John Frederick Quinn , Bryan Cordell Duffy , Shuang Liu , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/5377 , A61K31/4184 , A61K31/4545 , A61K31/4985 , C07D413/04 , C07D471/04 , C07D473/34 , A61K45/06 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/517 , A61K31/52 , A61P3/10 , A61P9/14 , A61P9/10 , A61P9/04 , A61P9/00 , A61P7/06 , A61P7/04 , A61P7/02 , A61P5/50 , A61P5/14 , A61P43/00 , A61P37/08 , A61P37/06 , A61P37/02 , A61P37/00 , A61P3/06 , A61P35/02 , A61P35/00 , A61P31/20 , A61P31/18 , A61P31/14 , A61P31/12 , A61P31/04 , A61P3/12 , A61P3/04 , A61P3/00 , A61P29/00 , A61P27/16 , A61P27/04 , A61P27/02 , A61P25/28 , A61P25/24 , A61P25/18 , A61P25/16 , A61P25/14 , A61P25/00 , A61P21/04 , A61P21/00 , A61P19/06 , A61P19/02 , A61P17/06 , A61P17/02 , A61P17/00 , A61P15/16 , A61P13/12 , A61P11/16 , A61P11/02 , A61P11/00 , A61P1/18 , A61P1/16 , A61P1/04 , A61P1/02 , A61P1/00
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US10363257B2
公开(公告)日：2019-07-30
申请号：US15875678
申请日：2018-01-19
发明人： John Frederick Quinn , Bryan Cordell Duffy , Shuang Liu , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , Gregory Steven Wagner , Peter Roland Young
IPC分类号： A61K31/5377 , A61K31/06 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/517 , A61K31/52 , A61K31/4184 , A61K31/4985 , A61K31/4545 , C07D413/04 , C07D471/04 , C07D473/34 , A61K45/06
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US20190216782A1
公开(公告)日：2019-07-18
申请号：US16251536
申请日：2019-01-18
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , C07D409/14 , A61K31/4709 , C07D413/14 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/4439 , A61K45/06 , C07D413/04 , C07D471/04 , C07D417/14 , C07D405/04 , C07D403/14 , C07D405/14 , C07D487/04 , A61K31/454 , A61K31/428 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K31/426 , A61K31/437
CPC分类号： A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , Y02A50/467
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US09861637B2
公开(公告)日：2018-01-09
申请号：US15424616
申请日：2017-02-03
发明人： Shuang Liu , Bryan Cordell Duffy , John Frederick Quinn , May Xiaowu Jiang , Ruifang Wang , Gregory Scott Martin , He Zhao , Bruce Francis Molino , Peter Ronald Young
IPC分类号： A61K31/5377 , A61K31/501 , A61K31/506 , A61K31/4439 , A61K31/497 , A61K31/513 , A61K31/4545 , A61K31/50 , A61K31/498 , A61K31/4709 , A61K31/444 , A61K31/4412 , A61K31/496 , A61K31/472 , A61K31/502 , A61K31/4725 , A61K31/4375
CPC分类号： A61K31/5377 , A61K31/4375 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/506 , A61K31/513 , A61K45/06 , C07D213/64 , C07D213/74 , C07D237/04 , C07D237/14 , C07D237/22 , C07D237/32 , C07D401/12 , C07D413/04 , C07D413/14 , C07D417/04 , Y02A50/467
摘要： The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
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公开(公告)号：US09662311B2
公开(公告)日：2017-05-30
申请号：US14900139
申请日：2014-06-20
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , C07D405/14 , C07D403/14 , C07D405/04 , C07D409/14 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , C07D417/14 , C07D471/04 , A61K31/4439 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , A61K31/437 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , C07D487/04
CPC分类号： A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , Y02A50/467
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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公开(公告)号：US11026926B2
公开(公告)日：2021-06-08
申请号：US16251536
申请日：2019-01-18
发明人： Shuang Liu , John Frederick Quinn , Bryan Cordell Duffy , Ruifang Wang , May Xiaowu Jiang , Gregory Scott Martin , He Zhao , Michael Ellis , Gregory Steven Wagner , Peter Ronald Young
IPC分类号： A61K31/4184 , C07D405/14 , C07D403/14 , C07D405/04 , C07D471/04 , C07D417/14 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K45/06 , C07D413/04 , C07D413/14 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , C07D409/14 , C07D487/04 , A61K31/454
摘要： The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.
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