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    DISACCHARIDE INTERMEDIATE AND SYNTHESIS METHOD THEREOF
    1.
    发明申请
    DISACCHARIDE INTERMEDIATE AND SYNTHESIS METHOD THEREOF 审中-公开
    不同的中间体及其合成方法

    公开(公告)号：US20160264609A1

    公开(公告)日：2016-09-15

    申请号：US15036390

    申请日：2014-04-28

    申请人： ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.

    发明人： Yanghui Guo ,  Junhui Zhou ,  Qingfeng Cai ,  Hegeng Wei ,  Hua Bai ,  Fei Long ,  Yue Zhang ,  Yingqiu Wu

    IPC分类号： C07H11/00 ,  C07H17/04

    CPC分类号： C07H11/00 ,  C07H1/00 ,  C07H3/10 ,  C07H13/04 ,  C07H13/08 ,  C07H17/04

    摘要： The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically relates to a method for preparing a disaccharide segment of a key intermediate for chemically synthesizing heparin and heparinoid compounds. Disclosed are a new disaccharide intermediate and three methods for synthesizing the disaccharide intermediate, that is, compounds of a formula (4) and glucopyranose protected by different anomeric carbon are made to react in the presence of an active agent, to obtain the disaccharide intermediate. According to the technical solutions of the present invention, synthetic raw materials are easy to obtain, have a mild reaction condition, and are suitable for industrialized production.

    摘要翻译： 本发明涉及二糖中间体及其合成方法，涉及化学药物领域，更具体地涉及制备化学合成肝素和类肝素化合物的关键中间体的二糖段的方法。 公开了一种新的二糖中间体和三种合成二糖中间体的方法，即式（4）的化合物和由不同端基异构体碳保护的吡喃葡萄糖在活性剂存在下反应，得到二糖中间体。 根据本发明的技术方案，合成原料易于获得，反应条件温和，适用于工业化生产。