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61 条记录 (耗时 0.039 秒)

    Regulable shock-absorption valve system for the dashpot in a motor vehicle
    1.
    发明授权
    Regulable shock-absorption valve system for the dashpot in a motor vehicle 失效
    用于机动车辆缓冲器的可调节减震阀系统

    公开(公告)号：US5624010A

    公开(公告)日：1997-04-29

    申请号：US351501

    申请日：1994-12-07

    申请人： Zhen Huang ,  Klaus Schmidt ,  Hans Scheerer ,  Andreas Opara

    发明人： Zhen Huang ,  Klaus Schmidt ,  Hans Scheerer ,  Andreas Opara

    IPC分类号： F16F9/46 ,  B60G17/08

    CPC分类号： F16F9/46

    摘要： The invention concerns a regulable shock-absorption valve system for the dashpot in a motor vehicle. It has two shock-absorption valves. Each valve consists of an electromagnetic bolt that slides back and forth and operates in conjunction with at least one port and of a pressure-sensitive valve for the suction stage and for the compression stage, mutually coaxially accommodated in an essentially cylindrical housing and capable of communicating by way of hydraulic-fluid channels. The pressure-sensitive valves (7 & 8) in accordance with the present invention rest on a simple or complex component (15) with its ends permanently or temporarily secured in a bore that extends through the center of the pole cores (17 & 18) of the electromagnets (11) that actuate the bolts (5 & 6). The advantages of the present invention are direct transmission of the shock-absorption forces and simpler assembly of the system.

    摘要翻译： 本发明涉及用于机动车辆中的缓冲器的可调节减震阀系统。 它有两个减震阀。 每个阀门由电磁螺栓组成，前后滑动并与至少一个端口和用于吸入级和压缩级的压敏阀一起工作，相互同轴地容纳在基本上圆柱形的壳体中并且能够连通 通过液压通道。 根据本发明的压敏阀（7和8）搁置在简单或复杂的部件（15）上，其端部永久地或临时固定在延伸穿过极芯（17和18）的中心的孔中， 的驱动螺栓（5和6）的电磁体（11）。 本发明的优点是直接传递减震力并简化了系统的组装。

    Controllable vibration damper for motor vehicles
    2.
    发明授权
    Controllable vibration damper for motor vehicles 失效
    机动车可控振动阻尼器

    公开(公告)号：US5375683A

    公开(公告)日：1994-12-27

    申请号：US164418

    申请日：1993-12-09

    申请人： Zhen Huang ,  Hans J. Betsch ,  Hans Scheerer ,  Andreas Opara ,  Walter Schulz ,  Klaus Schmidt

    发明人： Zhen Huang ,  Hans J. Betsch ,  Hans Scheerer ,  Andreas Opara ,  Walter Schulz ,  Klaus Schmidt

    IPC分类号： F16F9/096 ,  F16F9/46

    CPC分类号： F16F9/096 ,  F16F9/46 ,  B60G2202/154 ,  B60G2202/23 ,  B60G2500/102 ,  B60G2500/20

    摘要： A variable dashpot for motor vehicles. It comprises a vibration-suppressing piston-and-cylinder mechanism. The cylinder contains displacement fluid. The piston divides the cylinder into two displacement compartments. The piston has a piston rod attached to it. The piston is provided with pressure-dependent valves that vary the level of vibration suppression. The vibration-suppression valve system has two vibration-suppressing valves (2) accommodated in alignment in a cylindrical valve housing (1). Each vibration-suppressing valve consists of an axially displaced electromagnetic plunger (5 or 6) that operates in conjunction with at least one outlet (3 or 4) and of at least one pressure-sensitive valve (7 or 8) on stream parallel or in alignment with the plunger.

    摘要翻译： 机动车辆的可变缓冲器。 它包括一个振动抑制活塞和气缸机构。 气缸包含位移流体。 活塞将气缸分成两个位移隔间。 活塞具有连接到其上的活塞杆。 活塞设有压力相关阀，可改变振动抑制的水平。 减振阀系统具有在圆柱形阀壳体（1）中对准容纳的两个减振阀（2）。 每个减振阀由轴向移动的电磁柱塞（5或6）组成，其与至少一个出口（3或4）和至少一个压力敏感阀（7或8）并联或在 与柱塞对准。

    Hydraulic cylinder sealing structure
    3.
    发明授权
    Hydraulic cylinder sealing structure 失效
    液压缸密封结构

    公开(公告)号：US5540309A

    公开(公告)日：1996-07-30

    申请号：US355642

    申请日：1994-12-14

    申请人： Zhen Huang ,  Klaus Schmidt ,  Hans Scheerer ,  Andreas Opara

    发明人： Zhen Huang ,  Klaus Schmidt ,  Hans Scheerer ,  Andreas Opara

    IPC分类号： F16F9/32 ,  F16F9/36 ,  B60G17/08 ,  B60G13/08 ,  F16F9/46

    CPC分类号： F16F9/3235 ,  F16F9/369

    摘要： A regulable hydraulic dashpot for motor vehicles with a shock-absorption piston equipped with pressure-sensitive throttle valves traveling back and forth on the end of a piston rod inside a shock-absorption cylinder full of shock-absorbing fluid and dividing the cylinder into two displacement chambers. A gas-filled pressure-compensation chamber operates in conjunction with one displacement chamber. A shock-absorption performance-curve selection valve is positioned outside the cylinder and opens and closes a bypass. To create a hydraulic-fluid channel, the cylinder comprises two parts of different width between the two displacement chambers. One of the parts overlaps the other to the length of the stroke traveled by the piston and its open end is sealed tight to the outer part. The outer part is provided with two hydraulic-fluid conveying connections into the shock-absorption performance-curve selection valve. The parts of the cylinder between the connections are sealed off from each other by a sealing component.

    摘要翻译： 用于机动车辆的可调节液压缓冲器，其具有减震活塞，其配备有压力节流阀，在活塞杆的端部前后移动，该活塞杆内装有缓冲液体并且将气缸分成两个位移 房间。 气体充填压力补偿室与一个位移室联合操作。 减震性能曲线选择阀位于气缸外部并打开和关闭旁路。 为了产生液压流体通道，气缸在两个位移室之间包括两个不同宽度的部分。 其中一个部分与活塞的行程长度重叠，其开口端与外部部分密封。 外部设有两个液压流体输送连接到减震性能曲线选择阀中。 连接件之间的气缸部分通过密封部件彼此密封。

    Controllable hydraulic vibration dampener
    5.
    发明授权
    Controllable hydraulic vibration dampener 失效
    可控液压减振器

    公开(公告)号：US5392883A

    公开(公告)日：1995-02-28

    申请号：US154815

    申请日：1993-11-19

    申请人： Zhen Huang ,  Klaus Schmidt

    发明人： Zhen Huang ,  Klaus Schmidt

    IPC分类号： F16F9/46 ,  B60G17/08

    CPC分类号： F16F9/465

    摘要： A regulable hydraulic dashpot for motor vehicles. It features a shock-absorbing piston (1) and a shock-absorbing cylinder (2). The piston travels into and out of the cylinder on a rod (21). The piston divides the cylinder into two hydraulics compartments (3 & 4). The piston accommodates constrictions that incorporate pressure-sensitive valves (26 & 27). The piston has at least one bypass port. A system of (34) of electromagnetically operated valves reroutes the bypass ports in accordance with whether the dashpot is in the suction state or the compression phase. The object is continuous regulation of the level of shock absorption in a dashpot, rapid response to frequent actuation, an easy-to-establish base line, and a simple design. A slide-valve bolt (13) is associated with the routing (5, 9, 10, & 6) of the bypass during the suction phase. Another slide-valve bolt (14) is associated with its routing (6, 8, and 7) during the compression phase. Each slide-valve bolt is subject to a spring (11 & 12) that forces it to maintain the bore closed. The bolts accommodate pilot reservoirs (15 & 16) that are provided with hydraulic fluid through a port in the bolt from whichever hydraulics compartment is pressurized. The pilot reservoirs communicate through a hydraulic-fluid line (17). The line can be opened and closed to various extents by an electromagnetically controlled bolt (18). Fluid flows out of the pilot reservoir in whichever slide-valve bolt is subjected to pressure through the port in whichever slide-valve bolt is not subjected to pressure.

    摘要翻译： 用于机动车辆的可调节液压缓冲器。 它具有减震活塞（1）和减震缸（2）。 活塞在杆（21）上进出气缸。 活塞将气缸分成两个液压隔室（3和4）。 活塞容纳有压敏阀（26和27）的收缩部。 活塞至少有一个旁路口。 根据缓冲器是处于吸入状态还是压缩阶段，电磁阀的（34）系统重新路由旁路端口。 目的是持续调节缓冲器中的减震水平，快速响应频繁启动，易于建立的基线和简单的设计。 在抽吸阶段，滑阀螺栓（13）与旁路的路由（5,9,10和6）相关联。 在压缩阶段，另一个滑阀螺栓（14）与其路线（6,8和7）相关联。 每个滑阀螺栓受到弹簧（11和12）的作用，迫使其保持孔闭合。 螺栓容纳先导储存器（15和16），其通过来自螺栓中的端口的任何液压室被加压而设置有液压流体。 先导水库通过液压流体管线（17）进行通信。 线可以通过电磁控制的螺栓（18）以各种程度打开和关闭。 流体从先导储存器流出，无论哪个滑阀螺栓经受无压力的滑阀螺栓经过该端口的压力。

    Subunit-selective nucleic acid inhibitors of glutamate receptors
    8.
    发明授权
    Subunit-selective nucleic acid inhibitors of glutamate receptors 有权
    亚基选择性谷氨酸受体核酸抑制剂

    公开(公告)号：US09200286B2

    公开(公告)日：2015-12-01

    申请号：US13810572

    申请日：2011-07-15

    申请人： Li Niu ,  Zhen Huang ,  Jae Seon Park

    发明人： Li Niu ,  Zhen Huang ,  Jae Seon Park

    IPC分类号： C07H21/04 ,  C12N15/115 ,  C12N15/11 ,  C12N15/113

    CPC分类号： C12N15/115 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/16 ,  C12N2310/322 ,  C12N2310/3533 ,  C12N2320/13

    摘要： Inhibitors of AMPA-type glutamate ion channels are useful as biochemical probes for structure-function studies and as drug candidates for a number of neurological disorders and diseases. Disclosed herein is the identification of an RNA inhibitor or aptamer by an in vitro evolution approach and characterization of its mechanism of inhibition on the sites of interaction by equilibrium binding and on the receptor channel-opening rate by a laser-pulse photolysis technique. The aptamer of the invention is a noncompetitive inhibitor of AMPA-type glutamate ion channels, one that selectively inhibits the GluA2Qflip AMPA receptor subunit without any effect on other AMPA receptor subunits or on kainate or NMDA receptors. Furthermore, the aptamer preferentially inhibits the closed-channel state of GluA2Qflip with a KI=1.5 μM or by ˜15-fold over the open-channel state. The potency and selectivity of this aptamer rival those of small molecule inhibitors. Together, these properties make the aptamers of the present invention promising water-soluble, highly potent, GluA2 subunit-selective drugs.

    摘要翻译： AMPA型谷氨酸离子通道的抑制剂可用作结构功能研究的生物化学探针和许多神经障碍和疾病的候选药物。 本文公开了通过体外进化方法鉴定RNA抑制剂或适体，并通过激光脉冲光解技术通过平衡结合和受体通道开放速率表征其抑制作用位点的机制。 本发明的适体是AMPA型谷氨酸离子通道的非竞争性抑制剂，其选择性地抑制GluA2Qflip AMPA受体亚基而对其它AMPA受体亚基或红藻氨酸或NMDA受体没有任何作用。 此外，适体优先抑制GluA2Qflip的闭通道状态，KI =1.5μM或比开放通道状态约〜15倍。 该适配体的效力和选择性与小分子抑制剂的效力和选择性相当。 这些性质一起使得本发明的适体具有潜在的水溶性，高效的GluA2亚基选择性药物。

    Ultraviolet and High-Performance Liquid Chromatography Methods for the Evaluation of Sunscreen Efficacy
    9.
    发明申请
    Ultraviolet and High-Performance Liquid Chromatography Methods for the Evaluation of Sunscreen Efficacy 审中-公开
    紫外线和高效液相色谱法评估防晒功效

    公开(公告)号：US20130183765A1

    公开(公告)日：2013-07-18

    申请号：US13823028

    申请日：2011-09-13

    申请人： Zhen Huang

    发明人： Zhen Huang

    IPC分类号： G01N21/63

    CPC分类号： G01N21/631 ,  C12Q1/6883 ,  C12Q2523/313 ,  C12Q2525/313 ,  G01N21/33 ,  G01N30/06 ,  G01N2030/8827 ,  Y10T436/143333

    摘要： Disclosed are compositions which can mimic DNA and/or RNA in cells of a subject and methods of using them as a substrate in testing efficacy of one or more compositions in reducing and/or preventing radiation, such as ultraviolet (UV) radiation-caused DNA and/or RNA damage of said subject. Also disclosed are systems related to the disclosed methods.

    摘要翻译： 公开了可以模拟受试者细胞中的DNA和/或RNA的组合物以及在测试一种或多种组合物在减少和/或预防辐射中的功效（例如紫外线（UV）辐射引起的DNA）中使用它们作为底物的方法 和/或所述受试者的RNA损伤。 还公开了与所公开的方法相关的系统。