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27 条记录 (耗时 0.039 秒)

    Fully human anti-TNF-alpha monoclonal antibody, preparation method and use thereof
    4.
    发明授权
    Fully human anti-TNF-alpha monoclonal antibody, preparation method and use thereof 有权
    全人类抗TNF-α单克隆抗体，其制备方法和用途

    公开(公告)号：US08597648B2

    公开(公告)日：2013-12-03

    申请号：US13579208

    申请日：2010-04-16

    申请人： Huaizu Guo ,  Chuan Li ,  Xin Tong

    发明人： Huaizu Guo ,  Chuan Li ,  Xin Tong

    IPC分类号： A61K39/395 ,  C07K16/24 ,  C12N5/10 ,  C12N15/13 ,  C12N15/00

    CPC分类号： C07K16/241 ,  C07K2317/21 ,  C07K2317/76

    摘要： The present invention provides a full human anti-TNF-α monoclonal antibody, the preparation method and use thereof. The antibody in the present invention has an amino acid sequence of heavy chain variable region as shown in SEQ ID NO: 6 and an amino acid sequence of light chain variable region as shown in SEQ ID NO: 8. The antibody in the present invention can be used to prepare medicines for the treatment of autoimmune disorders.

    摘要翻译： 本发明提供了全人类抗TNF-α单克隆抗体，其制备方法和用途。 本发明的抗体具有如SEQ ID NO：6所示的重链可变区的氨基酸序列和如SEQ ID NO：8所示的轻链可变区的氨基酸序列。本发明中的抗体可以 用于制备治疗自身免疫性疾病的药物。

    Processes for directionally ligating double stranded nucleic acids
    6.
    发明授权
    Processes for directionally ligating double stranded nucleic acids 失效
    用于定向连接双链核酸的方法

    公开(公告)号：US07504238B2

    公开(公告)日：2009-03-17

    申请号：US11119869

    申请日：2005-05-02

    申请人： Brian Ward ,  Chuan Li ,  Keming Song ,  Kristen E. Bettinger ,  Stephanie Uder

    发明人： Brian Ward ,  Chuan Li ,  Keming Song ,  Kristen E. Bettinger ,  Stephanie Uder

    IPC分类号： C12P19/34

    CPC分类号： C12N15/66 ,  C12Q1/6846 ,  C12Q2525/125 ,  C12Q2521/319

    摘要： Amplification mixtures, kits, amplicons, kits and processes are provided for amplifying a nucleic acid. In particular, provided are processes which utilize an amplification mixture comprising a polymerase, a deoxynucleotidetriphosphate (dNTP) mixture which contains modified dNTPs, a first primer and a second primer. Further provided are dNTP mixtures which contain modified dNTPs for at least two of the four nucleotide triphosphates, which when incorporated into a polynucelotide, impart resistance to enzymatic degradation by an exonuclease at the sites of incorporation of the modified dNTPs. Also provided are the amplicons and vectors which incorporate the modified nucleotides.

    摘要翻译： 提供扩增混合物，试剂盒，扩增子，试剂盒和方法用于扩增核酸。 特别地，提供了利用包含聚合酶，含有修饰的dNTP的脱氧核苷三磷酸（dNTP）混合物，第一引物和第二引物的扩增混合物的方法。 还提供了dNTP混合物，其含有用于四种核苷酸三磷酸中的至少两种的修饰的dNTP，当掺入多聚苷中时，其在掺入修饰的dNTP的位点赋予外切核酸酶对酶降解的抗性。 还提供了掺入修饰的核苷酸的扩增子和载体。

    REMOVAL OF NEEDLE SHIELDS FROM SYRINGES AND AUTOMATIC INJECTION DEVICES
    8.
    发明申请
    REMOVAL OF NEEDLE SHIELDS FROM SYRINGES AND AUTOMATIC INJECTION DEVICES 有权
    从注射器和自动注射装置中去除针孔

    公开(公告)号：US20120238961A1

    公开(公告)日：2012-09-20

    申请号：US13357508

    申请日：2012-01-24

    申请人： Joseph F. Julian ,  Chuan Li ,  Philip D. Anderson ,  Linas P. Laurusonis ,  Lior Raday ,  Ehud Carmel ,  Lior Marli ,  David Daily ,  Guy Keenan

    发明人： Joseph F. Julian ,  Chuan Li ,  Philip D. Anderson ,  Linas P. Laurusonis ,  Lior Raday ,  Ehud Carmel ,  Lior Marli ,  David Daily ,  Guy Keenan

    IPC分类号： A61M5/32

    CPC分类号： A61M5/3204 ,  A61M5/20 ,  A61M5/32 ,  A61M5/321 ,  A61M2205/581 ,  A61M2207/00 ,  Y10T29/49826 ,  Y10T29/53

    摘要： Exemplary embodiments provide a needle shield remover that reliably engages with a distal cap of an automatic injection device and with one or more needle shields coupled to a syringe of the device. When a user removes the distal cap, the needle shield remover reliably removes the needle shields (e.g., a soft needle shield and a rigid needle shield) from the syringe, thereby exposing the injection needle for performing an injection. In an exemplary assembly method, a needle shield remover is engaged to a needle shield coupled to a syringe, prior to insertion of the syringe and needle shield remover assembly into a housing of the device. This exemplary assembly method allows visual inspection, outside the housing of the device, to ensure that the needle shield remover is correctly and reliably engaged to the needle shield before the syringe and needle shield remover assembly is inserted into the housing.

    摘要翻译： 示例性实施例提供了一种针头护罩去除器，其可靠地与自动注射装置的远侧帽接合并且与一个或多个针罩连接到装置的注射器。 当用户移除远端帽时，针头护罩移除器可靠地从注射器移除针罩（例如，软针护罩和刚性针罩），从而暴露注射针以进行注射。 在示例性组装方法中，在将注射器和针护罩移除器组件插入设备的壳体之前，针护罩去除器接合到联接到注射器的针护罩。 该示例性组装方法允许在装置的外壳之外的目视检查，以确保在将注射器和针护罩移除器组件插入壳体之前将针罩去除器正确可靠地接合到针护罩。

    De novo synthesized plasmid, methods of making and use thereof
    9.
    发明申请
    De novo synthesized plasmid, methods of making and use thereof 审中-公开
    从头合成质粒，制备和使用方法

    公开(公告)号：US20090130741A1

    公开(公告)日：2009-05-21

    申请号：US12157047

    申请日：2008-06-06

    申请人： Chuan Li

    发明人： Chuan Li

    IPC分类号： C12N1/21 ,  C12N15/00

    CPC分类号： C12N15/70

    摘要： The invention relates to a de novo synthesized plasmid. The plasmid comprises relevant sequences for plasmid replication and plasmid selection. The methods of making and use of the plasmid are disclosed. The plasmid can be used to make other plasmids. These plasmids and their host cells can be used for biomedical applications.

    摘要翻译： 本发明涉及一种从头合成的质粒。 质粒包含用于质粒复制和质粒选择的相关序列。 公开了制备和使用质粒的方法。 质粒可用于制备其他质粒。 这些质粒及其宿主细胞可用于生物医学应用。