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公开(公告)号:US20100113335A1
公开(公告)日:2010-05-06
申请号:US12580722
申请日:2009-10-16
申请人: Zichria Zakay-Rones , Amos Panet , Evgeniya Greenbaum , Eithan Galun , Arnold I. Freeman , Linda Rasooly , Charles S. Irving
发明人: Zichria Zakay-Rones , Amos Panet , Evgeniya Greenbaum , Eithan Galun , Arnold I. Freeman , Linda Rasooly , Charles S. Irving
CPC分类号: C07K14/005 , A61K35/768 , A61K48/00 , C12N7/00 , C12N2760/18122 , C12N2760/18132 , C12N2760/18164
摘要: The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment of cancer by application of a clonal NDV strain to tumors. According to an alternative preferred embodiment the use of at least one isolated viral protein or subunit or analog thereof, or an isolated polynucleotide encoding same, is used in the treatment of cancer.
摘要翻译: 本发明公开了用于治疗癌症的易感基因病毒株。 新城疫病毒(NDV)的优选病毒株特异性地表现在生物活性方面。 本发明还公开了通过将NDV菌株应用于肿瘤来治疗癌症。 根据另一优选实施方案,使用至少一种分离的病毒蛋白或其亚单位或其类似物或其编码的分离的多核苷酸用于治疗癌症。
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2.
公开(公告)号:US07615209B2
公开(公告)日:2009-11-10
申请号:US11561510
申请日:2006-11-20
申请人: Zichria Zakay-Rones , Amos Panet , Evgeniya Greenbaum , Eithan Galun , Arnold I. Freeman , Linda Rasooly , Charles S. Irving
发明人: Zichria Zakay-Rones , Amos Panet , Evgeniya Greenbaum , Eithan Galun , Arnold I. Freeman , Linda Rasooly , Charles S. Irving
CPC分类号: A61K35/768 , C12N2760/18132
摘要: The present invention discloses methods for inducing regression of a tumor in a subject by administering a pharmaceutical composition comprising a lentogenic strain of Newcastle disease virus (NDV). A preferred viral strain of NDV for inducing regression of a tumor in a subject is a clonal strain of NDV, the NDV HUJ. The methods of the present invention are particularly useful for inducing regression of tumors in patients unresponsive to conventional anti-cancer therapies.
摘要翻译: 本发明公开了通过施用包含新城疫病毒(NDV)的微生物菌株的药物组合物来诱导受试者的肿瘤消退的方法。 用于诱导受试者肿瘤消退的NDV的优选病毒株是NDV(NDV HUJ)的克隆菌株。 本发明的方法特别可用于诱导对常规抗癌疗法无反应的患者的肿瘤消退。
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3.
公开(公告)号:US20070128170A1
公开(公告)日:2007-06-07
申请号:US11561510
申请日:2006-11-20
申请人: Zichria Zakay-Rones , Amos Panet , Evgeniya Greenbaum , Eithan Galun , Arnold Freeman , Linda Rasooly , Charles Irving
发明人: Zichria Zakay-Rones , Amos Panet , Evgeniya Greenbaum , Eithan Galun , Arnold Freeman , Linda Rasooly , Charles Irving
IPC分类号: A61K35/76
CPC分类号: A61K35/768 , C12N2760/18132
摘要: The present invention discloses methods for inducing regression of a tumor in a subject by administering a pharmaceutical composition comprising a lentogenic strain of Newcastle disease virus (NDV). A preferred viral strain of NDV for inducing regression of a tumor in a subject is a clonal strain of NDV, the NDV HUJ. The methods of the present invention are particularly useful for inducing regression of tumors in patients unresponsive to conventional anti-cancer therapies.
摘要翻译: 本发明公开了通过施用包含新城疫病毒(NDV)的微生物菌株的药物组合物来诱导受试者的肿瘤消退的方法。 用于诱导受试者肿瘤消退的NDV的优选病毒株是NDV(NDV HUJ)的克隆菌株。 本发明的方法特别可用于诱导对常规抗癌疗法无反应的患者的肿瘤消退。
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公开(公告)号:US07223389B2
公开(公告)日:2007-05-29
申请号:US10800256
申请日:2004-03-11
申请人: Zichria Zakay-Rones , Amos Panet , Charles Irving
发明人: Zichria Zakay-Rones , Amos Panet , Charles Irving
CPC分类号: C07K14/005 , A61K35/768 , A61K48/00 , C12N7/00 , C12N2760/18122 , C12N2760/18132 , C12N2760/18164
摘要: The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle Disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment of cancer by application of a clonal NDV strain to tumors. Another feature of the invention is the use of at least one isolated viral glycoprotein or a subunit or analog thereof or of an isolated polynucleotide encoding the same for the treatment of cancer.
摘要翻译: 本发明公开了用于治疗癌症的易感基因病毒株。 新城疫病毒(NDV)的优选病毒株特异性地表现在生物活性方面。 本发明还公开了通过将NDV菌株应用于肿瘤来治疗癌症。 本发明的另一个特征是使用至少一种分离的病毒糖蛋白或其亚单位或其类似物或编码其的分离的多核苷酸用于治疗癌症。
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公开(公告)号:US20050031642A1
公开(公告)日:2005-02-10
申请号:US10800256
申请日:2004-03-11
申请人: Zichria Zakay-Rones , Amos Panet , Charles Irving
发明人: Zichria Zakay-Rones , Amos Panet , Charles Irving
IPC分类号: C12N15/09 , A61K35/76 , A61K38/00 , A61K38/16 , A61K48/00 , A61P35/00 , C07K14/125 , C12N5/10 , C12N7/00 , C12N7/08 , A61K39/12 , A61K39/17
CPC分类号: C07K14/005 , A61K35/768 , A61K48/00 , C12N7/00 , C12N2760/18122 , C12N2760/18132 , C12N2760/18164
摘要: The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle Disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment of cancer by application of a clonal NDV strain to tumors. Another feature of the invention is the use of at least one isolated viral glycoprotein or a subunit or analog thereof or of an isolated polynucleotide encoding the same for the treatment of cancer.
摘要翻译: 本发明公开了用于治疗癌症的易感基因病毒株。 新城疫病毒(NDV)的优选病毒株特异性地表现在生物活性方面。 本发明还公开了通过将NDV菌株应用于肿瘤来治疗癌症。 本发明的另一个特征是使用至少一种分离的病毒糖蛋白或其亚单位或其类似物或编码其的分离的多核苷酸用于治疗癌症。
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公开(公告)号:US5639461A
公开(公告)日:1997-06-17
申请号:US661667
申请日:1996-06-11
申请人: Zichria Zakay-Rones , Reuven Levy
发明人: Zichria Zakay-Rones , Reuven Levy
IPC分类号: A61K39/145
CPC分类号: A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/543 , C12N2760/16134
摘要: The invention provides an influenza vaccine which comprises a heat inactivated whole virus influenza free of formalin and .beta.-propiolactone (BPL).
摘要翻译: 本发明提供一种流感疫苗,其包含不含福尔马林和β-丙内酯(BPL)的热灭活的全病毒流感。
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7.
公开(公告)号:US20050196472A1
公开(公告)日:2005-09-08
申请号:US11069041
申请日:2005-03-02
CPC分类号: A61K36/45 , A61K9/0043
摘要: The present invention concerns the use as anti-viral agents of isolated fractions from berry juice of the plant genus Vaccinium. Two specific fractions are provided: (a) polymeric material having a molecular weight ≧12,000; and (b) proanthocyanidins-containing fraction. Thus, the invention provides methods of treating a subject against a viral infection; the method comprises providing said subject with at least one of the above isolated fractions in an amount effective to prevent production of a viral infection in said subject. A specific and preferred viral infection according to the invention is an influenza virus infection.
摘要翻译: 本发明涉及作为牛痘植物属植物来自浆果汁的分离级分的抗病毒剂的用途。 提供两个特定的部分:(a)分子量> = 12,000的聚合物材料; 和(b)含原花青素的级分。 因此,本发明提供了针对病毒感染治疗受试者的方法; 所述方法包括以有效防止所述受试者的病毒感染产生的量向所述受试者提供上述分离级分中的至少一种。 根据本发明的特定且优选的病毒感染是流感病毒感染。
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公开(公告)号:US07390515B2
公开(公告)日:2008-06-24
申请号:US11069041
申请日:2005-03-02
IPC分类号: A61K36/04
CPC分类号: A61K36/45 , A61K9/0043
摘要: The present invention concerns the use as anti-viral agents of isolated fractions from berry juice of the plant genus Vaccinium. Two specific fractions are provided: (a) polymeric material having a molecular weight≧12,000; and (b) proanthocyanidins-containing fraction.Thus, the invention provides methods of treating a subject against a viral infection; the method comprises providing said subject with at least one of the above isolated fractions in an amount effective to prevent production of a viral infection in said subject.A specific and preferred viral infection according to the invention is an influenza virus infection.
摘要翻译: 本发明涉及作为牛痘植物属植物来自浆果汁的分离级分的抗病毒剂的用途。 提供两个特定的部分:(a)分子量> = 12,000的聚合物材料; 和(b)含原花青素的级分。 因此,本发明提供了针对病毒感染治疗受试者的方法; 所述方法包括以有效防止所述受试者的病毒感染产生的量向所述受试者提供上述分离级分中的至少一种。 根据本发明的特定且优选的病毒感染是流感病毒感染。
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